Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study by Elke Rücker-Braun, Elke Rücker-Braun, Bose Falk, Henning Baldauf, Carolin Massalski, Gesine Schäfer, Heidi Altmann, Jürgen Sauter, Ute V. Solloch, Vinzenz Lange, Katharina Egger-Heidrich, Desiree Kunadt, Friedrich Stölzel, Christoph Röllig, Jan M. Middeke, Malte von Bonin, Christian Thiede, Alexander H. Schmidt, Alexander H. Schmidt, Alexander H. Schmidt, Martin Bornhäuser, Johannes Schetelig, Johannes Schetelig, Falk Heidenreich, Falk Heidenreich

“…DiscussionBased on these findings, further studies should confirm the presence and functionality of neoepitope-specific T cells and characterize specific T-cell receptors (TCR). …”
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EDEN: Exploring Disks Embedded in N-body Simulations of Milky Way–mass Halos from Symphony by Yunchong Wang, Philip Mansfield, Ethan O. Nadler, Elise Darragh-Ford, Risa H. Wechsler, Daneng Yang, Hai-Bo Yu

“…In all cases, the suppression we measure should be interpreted as stripping below the mass resolution limit rather than complete subhalo disruption. …”
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Soil phoD-harboring bacteria mediate the responses of phosphorus availability to N addition and mowing among soil aggregates by Haiying Cui, Shanling Wang, Tianyan Wei, Xuechen Yang, Xiuping Li, Mingcai Fan, Xiaochong Zhang, Wenzheng Song, Jian-Ying Ma, Wei Sun

“…Phosphorus (P), like nitrogen (N), is a major limiting nutrient for ecosystem structures and functions. Soils in grasslands commonly have limited P availability for organisms, especially under global change (i.e., N deposition) and land-use intensification (i.e., mowing or hay harvest). …”
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Effect of intravenous alteplase before endovascular therapy for atherothrombotic stroke-related large vessel occlusion: subanalysis of the RESCUE AT-LVO registry by Takanori Sano, Kenichi Todo, Nobuyuki Sakai, Hirotoshi Imamura, Shinichi Yoshimura, Hiroshi Yamagami, Kazutaka Uchida, Mikito Hayakawa, Kazunori Toyoda, Yuji Matsumaru, Yasushi Matsumoto, Kanta Tanaka, Makoto Nakajima, Masafumi Morimoto, Hiroyuki Ikeda, Mitsuharu Ueda, Hayato Araki, Fumihiro Sakakibara, Masataka Takeuchi, Seigo Shindo, Manabu Shirakawa, Mikiya Beppu, Shinzo Ota, Hideyuki Ishihara, Hiroto Kakita, Tatsufumi Nomura, Hirotaka Hayashi, Satoshi Namitome

“…Background Whether intravenous thrombolysis (IVT) should be administered prior to endovascular therapy (EVT) in patients with atherothrombotic stroke-related large vessel occlusion (AT-LVO) remains unclear. …”
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Regulation of plant gene expression by tsRNAs in response to abiotic stress by Chunmei Li, Jing Zhu, Han Jin, Haotian Feng, Haimin Zhuang, Zijun Du, Guolin Zhu, Haiyang He, Fuyang Ye, Zhaohui Mo, Qingtao Hu, Zhenbang Chen, Kai Liu, Xiaorong Wan

“…This review aims to summarize recent advances in the classification, biogenesis, and biological functions of tsRNAs, with a focus on their roles in plant stress responses and the methodologies for investigating these molecules. …”
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Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…We also observed >2-fold variation in the fraction of polyA+ RNA between life stages, which should be considered when quantifying transcripts and may also be relevant to understanding translational control during development.…”
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Barriers and facilitators to maternal death surveillance and response at a busy urban National Referral Hospital in Uganda [version 2; peer review: 2 approved] by Jolly Beyeza-Kashesya, Dan K.Kaye, Joseph Rujumba, Noah Kiwanuka, Moses Mukuru, Imelda Namagembe, Annettee Nakimuli, Josaphat Byamugisha, Ashley Moffett

“…Major facilitators were involving all health workers in the MDSR process, eliminate blame, strengthen leadership, implement recommendations from MDSR and functionalize lower health facilities (especially Health Centre -IVs). …”
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Observational longitudinal multicentre investigation of acute pancreatitis (GOULASH PLUS): follow-up of the GOULASH study, protocol by Péter Hegyi, Andrea Szentesi, Eszter Hegyi, Miklós Sahin-Tóth, Patrícia Sarlós, Bálint Erőss, Katalin Márta, Áron Vincze, László Czakó, Mária Papp, Ferenc Izbéki, Markus M Lerch, Ole H Petersen, Dezső Kelemen, Dániel Pécsi, László Gajdán, Alexandra Mikó, Péter Hegyi Jr, Beáta Bódis, Orsolya Nemes, Nándor Faluhelyi, Orsolya Farkas, Róbert Papp, János Novák

“…The exocrine and endocrine pancreatic, liver and kidney functions will be determined by laboratory tests, stool sample analyses and imaging. …”
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Anthropogenic Effects on Green Infrastructure Spatial Patterns in Kisangani City and Its Urban–Rural Gradient by Julien Bwazani Balandi, Jean-Pierre Pitchou Meniko To Hulu, Kouagou Raoul Sambieni, Yannick Useni Sikuzani, Jean-François Bastin, Charles Mumbere Musavandalo, Timothée Besisa Nguba, Roselande Jesuka, Carlo Sodalo, Léa Mukubu Pika, Jan Bogaert

“…These results raise concerns regarding the functions, services, and opportunities provided by mature and short forests in the context of global change. …”
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A comparison of floating catchment area parameters with applications to a dataset of clinics enrolled in a statewide child and adolescent psychiatric consultation program by Jocelyn Hunyadi, Jocelyn Hunyadi, Lara S. Savas, Kehe Zhang, Kehe Zhang, Jeanette E. Deason, Ryan Ramphul, Melissa F. Peskin, Erica L. Frost, Cici Bauer, Cici Bauer

“…In resource allocation settings, availability and accessibility of resources should be examined simultaneously. The two-step floating catchment area (2SFCA) method has been previously used to evaluate spatial accessibility to healthcare resources and services, and to address health-related disparities. …”
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Sex differences and rehabilitation needs after hospital discharge for COVID-19: an Italian cross-sectional study by Luca Braglia, Monica Denti, Stefania Fugazzaro, Stefania Costi, Carlotta Mainini, Monia Allisen Accogli, Ginevra Bedogni, Daniele Ghizzoni, Anna Bertolini, Otmen Esseroukh, Cecilia Gualdi, Margherita Schiavi

“…Female sex was significantly associated with worse outcomes for all symptoms.Conclusions Individuals who had moderate or severe COVID-19 may perceive persistent symptoms which may result in reduced social participation. Sex differences should be monitored, as women may recover more slowly than men.Trial registration number NCT04438239.…”
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POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers by Konstantinos Papadakis, Francesca Portelli, Karina Schultz, Hedvig Olsson Sterky, Ismini Vassilaki, Jan Lapins, Michael R. Sargen, Sofia Obolenski, David J. Adams, Muyi Yang, Veronica Höiom, Hildur Helgadottir

“…The population frequency of pathogenic variants (PVs) was assessed using the SweGen and the gnomAD databases. Functional evaluation was performed using a saturation genome editing (SGE) assay. …”
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Features of Lipid Spectrum and Insulin Resistance Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy and Appropriateness of Simvastatin and Omega... by Azhmi S., Serhiyenko V.

“…It is obvious that the foreground should be the therapy aimed at lifestyle modification, reducing insulin resistance (IR), correction of hyperglycemia, dyslipoproteinemia (DLP), symptomatic treatment of concomitant diseases and syndromes. …”
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Exercise Capacity Following Pulmonary Embolism in Children and AdolescentsTake-home Points by Mackenzie Parker, MD, Joshua Greer, PhD, Surendranath Veeram Reddy, MD, Maria Bano, MD, Manal Al-Qahtani, MD, Jeannie Dillenbeck, MD, Sean Rinzler, MD, Michael D. Nelson, PhD, Ang Gao, PhD, Song Zhang, PhD, Andrew R. Tomlinson, MD, Tony G. Babb, PhD, Ayesha Zia, MD, MSCS

“…Cardiorespiratory fitness should be formally considered to develop rehabilitation interventions after pediatric PE.…”
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Risk Factors for Stiffness After Fixation of Tibial Tubercle Fractures: A Multicenter Study From the TITUS Group by Konstantin Brnjoš, MD, O. Folorunsho Edobor-Osula, MD, MPH, John S. Blanco, MD, Lindsay M. Crawford, MD, Dustin A. Greenhill, MD, FAOA, Alexander H. Griffith, BS, Neil K. Kaushal, MD, David M. Kell, BA, Abhi Rashiwala, MD, John A. Schlechter, DO, Evelyn S. Thomas, DO, Haley N. Tornberg, BS, Brendan A. Williams, MD, Neeraj M. Patel, MD, MPH, MBS

“…Persistent stiffness after operative treatment of tibial tubercle fractures (TTFs) can inhibit functional recovery and interfere with activities of daily living. …”
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Trends in the development of nuclear medicine in the Russian Federation for 2015–2020 by L. A. Chipiga, E. R. Ladanova, A. V. Vodovatov, I. A. Zvonova, A. A. Mosunov, L. T. Naurzbaeva, S. A. Ryzhov

“…For detailed and reliable assessment of the nuclear medicine in the country, it is necessary to conduct a separate survey to determine the types of nuclear medicine examinations, the gender and age profile of patients and patient doses. That survey should be conducted in St. Petersburg or Moscow, as model subjects of the Russian Federation.…”
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Association between transcranial direct current stimulation and disability and quality of life in individuals with Parkinsonism: cross-sectional study by Ravi Shankar Reddy, Ravi Shankar Reddy, Jaya Shanker Tedla, Jaya Shanker Tedla, Irshad Ahmad, Venkata Nagaraj Kakaraparthi, Snehil Dixit, Kumar Gular, Paul Silvian Samuel, Suhail Mansour Aljehani, Feras Ahmed Alarabi

“…Transcranial direct current stimulation (tDCS) has shown promise in improving motor and cognitive functions when combined with physical therapy. This study aimed to explore the association between tDCS exposure and disability levels, as well as its impact on self-reported QoL in individuals with Parkinsonism undergoing physical therapy.MethodsThis cross-sectional study enrolled 51 participants diagnosed with Parkinsonism from a tertiary care hospital’s neurology outpatient clinic. …”
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Investigation of the efficiency of different reprocessing methods on disposable laryngeal masks contaminated with HBV DNA by Gökahmetoğlu, Günhan, Renders, Duygu Perçin, Gökahmetoğlu, Selma, Biçer, Cihangir, Aksu, Recep, Çevik, Şerife

“…After the decontamination procedures, the functioning control of the LM was controlled.Results: The HBV DNA level in the simulated saliva samples was 100,000 IU/mL (lg 5). …”
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Metallurgical Waste for Sustainable Agriculture: Converter Slag and Blast-Furnace Sludge Increase Oat Yield in Acidic Soils by Olga V. Zakharova, Peter A. Baranchikov, Svetlana P. Chebotaryova, Gregory V. Grigoriev, Nataliya S. Strekalova, Tatiana A. Grodetskaya, Igor N. Burmistrov, Sergey V. Volokhov, Denis V. Kuznetsov, Alexander A. Gusev

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Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population by Andrea Méndez-García, Adriana Aguilar-Galarza, Willebaldo García-Muñoz, Juan Brandon Araujo-Mendoza, Teresa García-Gasca, Miriam Aracely Anaya-Loyola, Aarón Kuri-García, Nerina Veyna-Salazar, Lorenza Haddad-Talancón, Ma. de Lourdes Anzures-Cortés, Ulisses Moreno-Celis, Víctor Manuel Rodríguez-García

“…Sex-specific effects emphasize the need for tailored approaches in genetic risk assessment. Future research should focus on functional validation of these SNPs and their integration into precision medicine strategies for metabolic disease prevention.…”
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