Cancer-associated fibroblasts in clear cell renal cell carcinoma: functional heterogeneity, tumor microenvironment crosstalk, and therapeutic opportunities by Man Wang, Yuanzhuo Zhao, Kangchun Xu, Chao Liu, Hui Zhong, You Wu, Ke Zhang, Shanzhai Wei

“…Combination therapies employing immune checkpoint inhibitors and VEGF antagonists exhibit promising synergistic effects, although the clinical translation remains hampered by CAF heterogeneity, dual functional roles, and the lack of specific biomarkers. …”
Get full text

Network relationship between cognitive function and quality of life in community-dwelling older adults: an observational study from Beijing by Yitian Ye, Yichun Zhang, Jiaju Ren, Yanbo Zhu, Yanbo Zhu

“…There were strong associations between role-physical and social functioning, physical functioning and role-physical, and vitality and mental health. …”
Get full text

Milkweed (Asclepias syriaca) invasion, forest-steppe fragment size and isolation jointly constrain arthropod communities and their functional traits by Róbert Gallé, Ágota Réka Szabó, Edina Török, Tamás Lakatos, Dávid Korányi, Attila Torma, Nikolett Gallé-Szpisjak, Péter Batáry

Get full text

Assessment of cognitive function in patients with schizophrenia based on virtual reality serious games: a prospective nonrandomized clinical trial by Chenxin Wu, Yu Zhuo, Jianying Yu, Xingxing Li, Wenting Zhao, Xiandong Meng

“…Participants reported high immersion (GEQ-Core immersion: 2.45/4) and minimal simulator sickness (SSQ total: 5.12/48).ConclusionFruit Pioneer provides a time-efficient (5-minute), ecologically valid tool for cognitive assessment in schizophrenia, demonstrating strong discriminative validity and user acceptability. Further validation should explore its clinical utility in broader populations and the association between its performance and functional outcomes.…”
Get full text

Substitution of physical activity for sedentary behaviour contributes to executive function improvement among young adults: a longitudinal study by Jianxiu Liu, Mengxian Wei, Xingtian Li, Alimjan ablitip, Shiqi Zhang, Hao Ding, Kefeng Zheng, Ruidong Liu, Xindong Ma

“…There is a lack of research on the effects of replacing sedentary behaviour with physical activity on executive function, as well as the dose–response relationship between physical activity and executive function among young adults, underscoring the critical need for prompt investigation. …”
Get full text

Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis by Yanyao Zhou, Na Dong, Letian Lei, Dorita H. F. Chang, Charlene L. M. Lam

“…Although findings have been mixed, resting-state functional connectivity (rsFC) at baseline shows promise as a predictive biomarker. …”
Get full text

Patterns of comorbidities differentially affect long-term functional evolution and disease activity in patients with ‘difficult to treat’ rheumatoid arthritis by Prodromos Sidiropoulos, George Bertsias, Argyro Repa, Eleni Kalogiannaki, Antonios Bertsias, Nestor Avgoustidis, Sofia Pitsigavdaki, Irini D Flouri

“…Long-term follow-up (total of 5872 person-years) revealed four groups of functional status evolution: 18.2% had stable, mildly compromised mHAQ (mean 0.41), 39.9% had gradual improvement (1.21–0.87) and two groups had either slow deterioration or stable significant functional impairment (HAQ>1). …”
Get full text

The relationship between sarcopenia, nutritional status, physical function, and quality of life in elderly cancer patients: a path analysis by Liyi Wang, Xuejun Dai, Jiao Ai, Xiaojuan Li, Aihua Deng, Xiaomei Yang, Ying Zhang, Dujuan Tian, Lang He

“…Abstract Objective This study investigates the associations between sarcopenia and quality of life in elderly cancer patients, with nutritional status and physical function as potential mediators. It also explores the interactions among sarcopenia, nutritional status, and physical function. …”
Get full text

HIV-related stressors and psychological functioning among adolescents living with perinatal HIV in KwaZulu-Natal, South Africa by Thabani Nyoni, Thabani Nyoni, Wendy Auslander

“…Descriptive statistics assessed psychological functioning and HIV-related stressors. Multivariate regression analyses examined associations between APH-perceived stigma, caregiver-experienced stigma, caregiver-reported burden of the child’s illness, and psychological functioning outcomes.ResultsMost APHs (M = 11.94 years, SD = 1.55, 52% female) reported high self-esteem (M = 86.3, SD = 10.1) despite experiencing elevated anxiety (M = 4.47, SD = 2.86) and depressive symptoms (M = 7.56, SD = 2.08). …”
Get full text

The twist of longevity: exploring the convergence of the health production function and life-cycle hypothesis in Malaysia's life expectancy through savings by Temitayo B. Majekodunmi, Mohd Shahidan Shaari, Abdul Rahim Ridzuan, K. P. Jaheer Mukthar, Nora Yusma Mohamed Yusoff, Mohd Juraij Abd Rani, J. Vennila, Mujeeb Saif Mohsen Al Absy

Get full text

Sport-specific impacts of ball games on adolescent brain function: a network meta-analysis of executive cognitive tasks by Yang Wang, Zixuan Luo, Tongyan Zhang, Muyan Zhang, Leonid Kapilevich, Jiale Wang

“…Abstract Background Adolescence represents a sensitive developmental window for brain maturation, particularly for executive functions, which are crucial for goal-directed behavior and long-term mental health. …”
Get full text

Investigating the gut bacteria structure and function of hibernating bats through 16S rRNA high-throughput sequencing and culturomics by Jian Zhou, Ying Liu, Tao Gu, Jingzhu Zhou, Fengming Chen, Shijun Li

“…Future research should focus on longitudinal studies to elucidate these intricate interactions.…”
Get full text

The older sibling effect: comparing social functioning outcomes for autistic children with typically developing siblings, no siblings, and autistic siblings by Yonat Rum, Adi Dolev, Ofri Reichmann, Ditza A. Zachor, Ditza A. Zachor, Einat Avni, Michal Ilan, Michal Ilan, Gal Meiri, Gal Meiri, Judah Koller

“…These speculative explanations should be directly examined in future research.…”
Get full text

Hazard screening of colloidal silica nanomaterials with varying degrees of silane surface functionalization: a safe-by-design case study by Nienke Ruijter, Ilaria Zanoni, Daniel Persson, Josje Arts, Marie Carriere, Arnaud Guiot, Michael Persson, Alberto Katsumiti, Jessica Marshall, Matthew Boyles, Flemming R. Cassee, Hedwig Braakhuis

“…In vitro cytotoxic, pro-inflammatory and oxidative stress responses can be reduced with increasing surface silane functionalization. The reduced deposition efficiency with increasing silane functionalization, however, highlights that thorough characterization of particle behaviour in cell culture medium should always be performed for SSbD hazard testing. …”
Get full text

Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis by Yuchen Wang, Yuchen Wang, Mengqi Li, Mengqi Li, Yuye Jiang, Yuye Jiang, Qiuhong Ji

“…This study utilized a network meta-analysis (NMA) to systematically compare the efficacy of neuroprotective agents in improving neurological function and prognosis in stroke patients.MethodsThis study adhered to PRISMA guidelines and the Cochrane Handbook for systematic reviews. …”
Get full text

The Effects of Glucagon‐Like Peptide‐1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review by Victoria J. Old, Melanie J. Davies, Dimitris Papamargaritis, Pratik Choudhary, Emma L. Watson

“…Outcomes of interest were skeletal muscle respiratory function either in the form of measurements of mass, number, content, oxidative capacity/respiratory function, mitochondrial dynamics, mitochondrial biogenesis and mitophagy. …”
Get full text

Upper extremity function and disability recovery with vibration therapy after stroke: a systematic review and meta-analysis of RCTs by Yueh-Hsun Lu, Hung-Ju Chen, Chun-De Liao, Po-Jung Chen, Xin-Miao Wang, Chieh-Hsiang Yu, Po-Yin Chen, Chueh-Ho Lin

“…Conclusions Vibration therapy may be a reliable rehabilitation program to improve upper extremity motor functions and disabilities. Furthermore, vibration therapy should be performed at the earliest possibility after stroke for at least 4–8 weeks. …”
Get full text

Evaluating Clinical and Sociodemographic Risk for Symptom Burden Associated Interference With Daily Functioning in the Primary Brain Tumor Patient Population by Bennett A. McIver, Tara S. Davis, Kimberly Reinhart, Elizabeth Vera, Alvina Acquaye‐Mallory, Anna Choi, Tricia Kunst, Morgan Johnson, Ewa Grajkowska, Hope Miller, Jennifer Reyes, Mark R. Gilbert, Terri S. Armstrong, Michelle L. Wright

“…ABSTRACT Introduction Symptom burden associated with interference in daily functioning is worse in those with progression or higher‐grade glial tumors. …”
Get full text

Investigating the associations between personality functioning, cognitive biases, and (non-)perceptive clinical high-risk symptoms of psychosis in the community by Giulia Rinaldi, Stefan Lerch, Frauke Schultze-Lutter, Stefanie Julia Schmidt, Marialuisa Cavelti, Michael Kaess, Chantal Michel

“… Abstract Background Beyond psychosis prediction, clinical high-risk (CHR-P) symptoms show clinical relevance by their association with functional impairments and psychopathology, including personality pathology. …”
Get full text

Spatiotemporal evolution and driving factors of soil erosion function in a typical basin of the alpine region in the upper Yellow River by Xiaomei Kou, Qi Li, Zhen Song, Zhen Song, Qin Yu, Qin Yu, Baicheng Niu, Baicheng Niu, Baicheng Niu, Shan Wang, Shan Wang, Kaifang Mu, Kaifang Mu, Wenlin Du

“…Regarding the soil conservation function, the main influencing factors were elevation and precipitation, with the interaction dominated by elevation. …”
Get full text