Genetic and vascular risk factors for ischemic stroke and cortical morphometry in individuals without a history of stroke: A UK Biobank observational cohort study by Jiawei Liu, Yingying Xie, Feng Liu, Wen Qin, Chunshui Yu

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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

“…To mitigate the dependence on intravenous fluid- and nutrient administration and attain enteral autonomy in SBS-IF patients, the use of recombinant glucagon-like peptide-2 (GLP-2) is justified as exerting a pronounced trophic effect on the epithelial regenerative potential as well as structural and functional adaptation of intestinal mucosa. The SBS-IF patients prescribed with home parenteral nutrition and/or their caregivers should be trained in a special programme that covers the catheter care, preparation of infusion solutions and nutrient mixture container, infusion pump operation as well as the prevention, recognition and management of complications. …”
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Sustainability of small dams for livestock and farming, a case study from Chitongo dam, rural Zambia by Livia Serrao, Livia Serrao, Simone Caridi, Ali Farrokhi, Diego Avesani, Muyaka Kamamba, Mireille Galli, Chalwe Chibwe, Federica Medici, Sara Treccani, Joel Kabika, Kawawa Banda, Marco Bezzi, Massimo Zortea, Maybin Ng’ambi, Guido Zolezzi, Guido Zolezzi

“…Such a scalable approach can be adopted to support the development of regional programs for rural water security in drylands, which should engage local actors in water allocation and reservoir maintenance plans for ensuring its functioning and fair benefits distribution for a reasonable time span.…”
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Vascular Malformations of the External Ear: A Systematic Review of Clinical Presentation, Diagnosis, and Management by Abdullah M. Alhusain, MBBS, Malak Alsaif, MBBS, Ali M. Alkhathami, MBBS, Sultan Alshaalan, MBBS, Abdulaziz M. Alghamdi, MBBS, Muhannad Alqirnas, MBBS, Jullanar Alkhunein, MBBS, Siham Alsalamah, MBBS, Fatima Alhije, MBBS, Fay Alaowid, MBBS, Asma M. Zaki, MBBS, SB-Plast

“…Arteriovenous malformations of the external ear are extremely rare but can have significant aesthetic and functional implications. These malformations often originate from disruptions in the embryological development of the external ear, presenting as swelling accompanied by a bruit, bleeding, and a pulsatile mass. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…There are also widely divergent views on whether core autistic traits should be a target for intervention or rather that societies and environments should be more flexible to accommodate neurodivergence (or both). …”
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Cultivating crayfish (Procambarus clarkii) significantly enhances the quantity and diversity of soil microorganisms: evidence from the comparison of rice-wheat and rice-crayfish ro... by Hui Xu, Hui Xu, Dan Wang, Dan Wang, Dan Wang, Xuguang Li, Xuguang Li, Jiajia Li, Jiajia Li, Yu Xu, Yu Xu, Zhiqiang Xu, Zhiqiang Xu

“…Streptomyces, Kribbella, and Paludibacter could serve as potential biomarker genera. Functional Annotation of Prokaryotic Taxa (FAPROTAX) analysis revealed that the dominant bacterial functions in the rice-wheat rotation model were aerobic chemoheterotrophy and chemoheterotrophy. …”
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Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices by Andrew M. Hughes, Alisha Lindsey, Jeffrey Annis, Kelly Burke, Hiral Master, Luke G. Silverman‐Lloyd, Jonah D. Garry, Michael J. Blaha, Erika S. Berman Rosenzweig, Robert P. Frantz, Paul M. Hassoun, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Brett Larive, Nicholas S. Hill, Serpil C. Erzurum, Gerald J. Beck, Anna R. Hemnes, Evan L. Brittain

“…In conclusion, our study demonstrated the potential clinical value of wearable devices by showing that activity and sleep quality are reduced in PAH compared to matched controls and these measures decline over time. Future studies should investigate if monitoring these health behaviors detects early functional decline and whether targeted interventions may improve outcomes.…”
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Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensit... by Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van derPloeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan

“…Conclusion This work highlights important host and parasite factors that contribute to ADCC efficacy that should be considered in the design of ADCC assays.…”
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Prevalence of Extended-Spectrum β-Lactamase-Producing <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Enterobacter cloacae</i> in Wastewater Effluent in Blantyre, Mala... by Edna Ibrahim, Charity Mkwanda, Edward Masoambeta, Luigia Scudeller, Tomislav Kostyanev, Hussein H. Twabi, Yohane K. Diness, Jobiba Chinkhumba, Janelisa Musaya, Rajhab S. Mkakosya, Surbhi Malhotra-Kumar, Chantal M. Morel, Save Kumwenda, Chisomo L. Msefula

“…<b>Conclusions</b>: The study demonstrated ongoing environmental contamination with antibiotic-resistant bacteria from sewage effluent. Therefore, the functionality of WWTPs should be improved to minimize the release of these organisms into the environment.…”
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Comparative Analysis of Fully Guided and Free-Hand Orthognathic Surgery: Advancements, Precision, and Clinical Outcomes by Sophia Tsokkou, Ioannis Konstantinidis, Antonios Keramas, Georgios Kiosis, Kanellos Skourtsidis, Danai Alexiou, Georgia-Nektaria Keskesiadou, Sofia Karachrysafi, Theodora Papamitsou, Ioannis Chatzistefanou

“…While free-hand methods remain viable for simpler cases, fully guided approaches optimize surgical execution. Future research should explore hybrid strategies combining digital precision with manual adaptability to further refine surgical techniques.…”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Similarly, preclinical studies should be designed as much as possible to model the intended clinical setting. …”
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Categorization of the flora and fauna: A study from the Uttara region, Dhaka, Bangladesh by Mollah Naimuzzaman, Nafisa Quader Chowdhury, Zizan Sharrad Anusha, Faizur Rahman, Sajib Mia, Jakia Sultana, Jannatun Naim, Istiaque Ahmed Isti, Faiyaz Ahmed, Ferdousi Begum, Probir Kumar Mittra, Md. Omar Sharif, Swapan Kumar Roy

“…To enhance the floral diversity and ecological balance of the area, it is necessary to implement sustainable management practices, public awareness, and participation in plant conservation activities, and should introduce sustainable native plant species. …”
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Wastewater Treatment Using a Combination of <i>Pumpkin seed</i> Waste After Extraction of Essential Oils (Bio-Coagulant) and Ferric Chloride (Chemical Coagulant): Optimization and... by Abderrezzaq Benalia, Ouiem Baatache, Katr Enada Zerguine, Amel Khediri, Kerroum Derbal, Nawal Ferroudj, Amel Khalfaoui, Antonio Pizzi

“…In this study, Fourier-transform infrared spectrometer (FTIR) and scanning electron microscope (SEM) characterization of the bio-coagulant proved the presence of the active functional groups responsible for coagulation, namely carboxyl group.…”
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Behavioral and neural effects of temporoparietal high-definition transcranial direct current stimulation in logopenic variant primary progressive aphasia: a preliminary study by Elias D. Granadillo, Elias D. Granadillo, Mason Fellmeth, Vahab Youssofzadeh, Joseph Heffernan, Priyanka P. Shah-Basak, Sara B. Pillay, Candida Ustine, Peter Kraegel, Shelby Schold, Kimberly D. Mueller, Kimberly D. Mueller, Chrysanthy Ikonomidou, Ozioma Okonkwo, Manoj Raghavan, Jeffrey R. Binder

“…Changes in resting-state functional connectivity within the phonological network were analyzed using fMRI. …”
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Prognostic value of myocardial bridging versus non-obstructive CAD: a long-term follow-up study by Zengfa Huang, Beibei Cao, Yang Yang, Yi Ding, Xinyu Du, Wanpeng Wang, Mei Li, Zuoqin Li, Xi Wang, Xu Zhao, Xiang Wang

“…Prospective registries in the future should include validated quality of life measures and CT-FFR with long-term outcomes to enhance the understanding of symptomatic burden and functional assessment in MB risk stratification.…”
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Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…Preventive measures such as child-resistant packaging, public education campaigns, and cannabis use screening during pregnancy are essential to mitigate risks. Clinicians should consider THC exposure in the differential diagnosis of children presenting with unexplained neurological, immune, or metabolic symptoms.…”
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Diagnostic, Therapeutic, and Prognostic Applications of Artificial Intelligence (AI) in the Clinical Management of Brain Metastases (BMs) by Kyriacos Evangelou, Panagiotis Zemperligkos, Anastasios Politis, Evgenia Lani, Enrique Gutierrez-Valencia, Ioannis Kotsantis, Georgios Velonakis, Efstathios Boviatsis, Lampis C. Stavrinou, Aristotelis Kalyvas

“…Intraoperatively, AI-driven systems can enable optimal tumor resection by integrating functional brain maps into preoperative imaging, thus facilitating the identification and safeguarding of eloquent brain regions through augmented reality (AR)-assisted neuronavigation. …”
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Evaluating an early Interdisciplinary Multimodal Assessment for Patients at Risk of Developing Chronic Pain: Results of a Multicentre RCT in Germany by Daniel Szczotkowski, Sandra Meyer-Moock, Thomas Kohlmann, Karin Deppe, Anne Gärtner, Greta Hoffmann, Thomas Isenberg, Gabriele Lindena, Ursula Marschall, Carolin Martin, Beatrice Metz-Oster, Lena Milch, André Möller, Bernd Nagel, Frank Petzke, Anke Preissler, Julia Pritzke-Michael, Leonie Schouten, Katja Schwenk, Catharina Schumacher, Anja Waidner, Ulrike Kaiser

“…An early interdisciplinary multimodal assessment (IMA) includes a systematically integrated view of medical, psychosocial and functional factors to direct patients to need-based treatment services. …”
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Genetic variations in the IDUA gene in Tunisian MPS I families: Identification of a novel microdeletion disrupting substrate binding and structural insights by Mariem Rebai, Yessine Amri, Chaima Sahli, Hajer Foddha, Taieb Messaoud, Hela Boudabous, Hassen Ben Abdennebi, Salima Ferchichi, Latifa Chkioua

“…This study aimed to identify genetic mutations in the IDUA gene among Tunisian families and assess their structural and functional implications. Patients and methods: Genomic DNA was extracted from blood samples of four patients including two siblings from three Tunisian families. …”
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