Moderating role of positive aspects of caregiving in the relationship between caring burden and suicidal ideation in family caregivers of community-dwelling older adults with neuro... by Zhaohua Huo, Benjamin Hon-Kei Yip, Allen Ting-Chun Lee, Sheung-Tak Cheng, Wai Chi Chan, Ada Wai-Tung Fung, Suk Ling Ma, Calvin Pak-Wing Cheng, Frank Ho-Yin Lai, Samuel Yeung-Shan Wong, Linda Chiu-Wa Lam

“…Psychological intervention that strengthens PAC should be integrated into comprehensive caregiver support programmes, particularly for those experiencing high burden and high distress.…”
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Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing by Yongfen Huang, Ping Yi, Ping Yi, Yixuan Wang, Lingling Wang, Yongqin Cao, Jingbo Lu, Kun Fang, Kun Fang, Yuexin Cheng, Yuqing Miao, Yuqing Miao

“…This study aims to construct a novel risk model for AML patient through comprehensive analysis of scRNA and bulk RNA data to optimize the precise treatment strategies for patients and improve prognosis.Methods and ResultsscRNA-seq classified cells into nine clusters, including Bcells, erythrocyte, granulocyte-macrophage progenitor (GMP), hematopoietic stem cell progenitors (HSC/Prog), monocyte/macrophagocyte (Mono/Macro), myelocyte, neutrophils, plasma, and T/NK cells. Functional analysis demonstrated the important role of inflammation immune response in the pathogenesis of AML, and the leukocyte transendothelial migration and adhesion in the process of inflammation should be noticed. ssGSEA method identified four core cells including GMP, HSC/Prog, Mono/Macro, and myelocyte for subsequent analysis, which contains 1,594 marker genes. …”
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Understanding the Educational and Social Difficulties in Children with Hemifacial Microsomia – A Literature Review by Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Zofia Czaplińska-Paszek, Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Róźycki

“…Studies on emotional functioning demonstrated a similar level of behavioral adjustment compared to control groups. …”
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Cross-cultural insights into internet addiction and mental health: a network analysis from China and Malawi by Mengze Li, Yidi Wang, Bin Liu, Xiaoli Ni, Zhujing Ma, Fengzhan Li, Tifei Yuan, Hongyi Chen, Zhongying Wu, Qiannan Jia, Lei Song, Yinchuan Jin, Qun Yang

“…In Malawi, addressing functional impairments related to academic and work performance is crucial, while in China, interventions should focus on emotional and relational aspects.…”
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Concept and Design of Cutting Tools for Osseodensification in Implant Dentistry by Alexander Isaev, Maria Isaeva, Oleg Yanushevich, Natella Krikheli, Olga Kramar, Aleksandr Tsitsiashvili, Sergey Grigoriev, Catherine Sotova, Pavel Peretyagin

“…It is known from the literature, that the osseodensification burs should operate in a clockwise direction to drill holes and in a counterclockwise direction to compact the osteotomy walls. …”
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Do Short-Term Improvements in Activities of Daily Living and Instrumental Activities of Daily Living Have Association With Return to Work in Workers With Occupational Injury? From... by Fa-Chen Lin, Chia-Pin Lin, Hung-Yi Chuang, Tse-Wei Wu, Peng-Ju Huang, Chen-Cheng Yang, Chao-Hung Kuo

“…Limited studies have been conducted on the specific correlation between RTW and functional assessments, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”
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Comparative analysis of AQP7 expression and cryotolerance in X- and Y-chromosome bearing bovine sperm by Jieru Wang, Jieru Wang, Ruchun Li, Fei Huang, Peng Niu, Yanling Zheng, Dongfang Yuan, Yan Du, Congcong Li, Mingcai Yang, Jiajia Suo, Jiajia Suo, Qinghua Gao, Qinghua Gao

“…Immunofluorescence revealed AQP7 localization to the post-acrosomal region, midpiece, and principal piece of Y-sperm with higher fluorescence intensity, whereas AQP3 distribution was comparable between groups.DiscussionThese findings imply a potential role for AQP7 in augmenting Y-sperm cryotolerance, providing molecular insights into sex-specific cryopreservation effects on fertility outcomes. Future research should elucidate AQP7’s functional mechanisms and explore implications for livestock breeding technologies.…”
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Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Pop... by Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

“…ConclusionsPreliminary results of this study demonstrate strong reliability of cognitive EMA, indicating that EMA is a promising tool for evaluating fluctuations in cognitive status in this population. Future work should refine and expand the utility of these digital tools, determine how variable EMA frequencies might better characterize changes in functioning as they relate to blood-based biomarkers, and validate a singular battery that could be rapidly administered at scale and in clinical trials to determine the progression of disease.…”
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MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances by Hongyun Mao, Hongyun Mao, Jing Hu, Chenshuo Yu, Sicong Xie, Cheng Chang, Juanjuan Peng, Yang Zhang

“…A deeper understanding of this regulatory network provides a solid theoretical foundation for developing novel miRNA-based diagnostic biomarkers and intervention strategies to manage AIC. Future research should focus on validating clinical biomarker panels and optimizing targeted delivery systems.…”
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Comparison of ultra-ultrabrief and ultrabrief pulse widths in right unilateral electroconvulsive therapy: A randomized trial by Jana Žaludová Heidingerová, Jakub Albrecht, Martin Anders, Daniel Divácký, Gabriela Jirečková, Thai Le Hong, Tadeáš Mareš, Václav Čapek, Harold A. Sackeim, Jozef Buday

“…Comprehensive studies should determine whether ultra-ultrabrief stimulation replaces ultrabrief stimulation as a default parameter for ECT.…”
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Metabolic pathway activation and immune microenvironment features in non-small cell lung cancer: insights from single-cell transcriptomics by Yanru Liu, Yanru Liu, Yanru Liu, Hanmin Liu, Hanmin Liu, Ying Xiong, Ying Xiong

“…However, future research should further explore the specific mechanisms of these metabolic pathways and their application potentials in clinical practice.…”
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Critical risks of haemoadsorption for COVID-19 patients and directions for future evaluations: a nationwide propensity score matched cohort study by Jan Andreas Kloka, Thomas Jasny, Oliver Old, Elina Nürenberg-Goloub, Christina Scharf, Patrick Meybohm, Alexander Supady, Kai Zacharowski, Benjamin Friedrichson

“…Two-sided probability values for group comparisons and regression models with spline functions controlling for non-linear relationships and medically relevant interaction variables were calculated. …”
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Examining Children’s Perceptions of Covid-19 Through Drawings: A Case Control Study by Mehmet Erdem Uzun, Utku Beyazıt, İrem Erdem Atak, Yeşim Yurdakul, Hande Şirin, Muharrem Bostancı, Arzu Ekici, Aynur Bütün Ayhan

“…Additionally, the external reality experienced by children during the pandemic prevented them from accurately reflecting their actual mental functionality in their responses. Upon comprehensive evaluation of the study results, it was determined that children in both groups exhibited signs of fear, anxiety, depression, aggression, insecurity, introversion, and regression.Conclusions: The findings of the present study may be beneficial for understanding the psychological effects of the Covid-19 pandemic on children from their own perspectives and may have implications for clinical practise regarding the support that should be offered to children. …”
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Methodological quality of multivariate prognostic models for intracranial haemorrhages in intensive care units: a systematic review by Denis Frasca, Fanny Feuillet, Maxime Leger, Raphaël Cinotti, Yohann Foucher, Jeanne Simon-Pimmel, Laetitia Bodet-Contentin, Etienne Dantan

“…Rather than developing new scores, future authors should focus on externally validating and updating existing scores with large and recent cohorts.…”
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Irony comprehension in first-degree relatives of patients with bipolar affective disorder – a preliminary fMRI study by András Sándor Hajnal, Eszter Varga, Tamás Tényi, Borbála Pethő, Noémi Albert, Márton Herold, Márton Áron Kovács, Tímea Csulak, Dóra Hebling, Róbert Herold

“…Altered neural activation during irony processing may serve as an endophenotypic marker for bipolar disorder. Future research should explore these findings in larger cohorts and assess additional cognitive factors.…”
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Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications by Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai

“…The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate proteoglycan, viral protein assembly in conjunction with the N and E genes, and enhanced glucose transport. …”
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Greater impacts of reduced than oxidized nitrogen enrichment on plant diversity losses in a temperate grassland by Suxian Ren, Tianci Huo, Xin Jing, Weixing Liu, Xiaowei Gou, Xun Sun, Ru Hou, Junyi Liang

“…Therefore, appropriate measures should be adopted to mitigate species losses.…”
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Duodenal tuberculosis with gastric outlet obstruction: a case report of successful diagnosis and treatment, with review of literature by Nami Sato, Masayuki Shiobara, Kazuo Wakatsuki, Kosuke Suda, Kotaro Miyazawa, Toshiaki Aida, Yoshihiro Watanabe, Katsunobu Tawada, Yoshiki Matsubara, Yohei Hosokawa, Shigeru Yoshioka

“…Conclusions An aggressive biopsy should be performed to diagnose duodenal TB. EUS-FNA has proven to be a useful tool in this regard. …”
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METABOLISM FEATURES IN HIGHLY TRAINED HOCKEY-PLAYERS DURING CONTEST SEASON by S. A. KOLESOV, R. S. RAKHMANOV, T. V. BLINOVA, L. A. STRAKHOVA, R. Sh. KHAYROV

“…Performed biochemical analyses showed unfavorable changes of metabolism in functioning of hockey-players’ organisms. The sportsmen were overtrained during the most part of competition period. …”
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Value of the 6 min walk test in detecting cardiopulmonary involvement in patients with systemic sclerosis by Sytske Anne Bergstra, Oliver Distler, Cosimo Bruni, Jeska De Vries-Bouwstra, Tom WJ Huizinga, Suzana Jordan, Saad Ahmed, Jacopo Ciaffi, Maarten Ninaber, Sophie I E Liem, Eva M Hoekstra, A A Schouffoer, D Ueckert, Hubert Vliegen

“…The 6 min walk test (6MWT) is widely used to assess functional capacity, but its ability to detect incident CPI remains uncertain. …”
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