Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes by Kelly M. Schiabor Barrett, Natalie Telis, Lisa M. McEwen, Evanette K. Burrows, Basil Khuder, Daniel P. Judge, Pamala A. Pawloski, Joseph J. Grzymski, Nicole L. Washington, Alexandre Bolze, Elizabeth T. Cirulli

“…Methods To identify GCK variant carriers at the population level, we used both ACMG/AMP variant interpretation for GCK-MODY pathogenicity and a state-of-the-art variant interpretation strategy based on functional and statistical evidence to predict glucose elevations. …”
Get full text

Powers of local governments in the field of security of settlements on the example of flight permits: monitoring of legislation and law enforcement practice by Ekaterina S. Shugrina

“…More precise legal regulation is needed for such cases.One of the purposes of imposing the functions of flight permits on local governments is to ensure the security of the population, its life, health and safety of property. …”
Get full text

Atypical Presentation of Pediatric Systemic Lupus Erythematosus Complicated by Cryptococcal Meningitis by Heba Ezzat Hashem, Zakaria Hamza Ibrahim

“…Cryptococcal infection among non-HIV patients is a rare disease but can result in advanced medical complications which may be fatal. The disease should be suspected to be reliably diagnosed. Cryptococcus infection can be presented as a skin lesion which, if not treated properly at an earlier time, can result in dissemination and life-threatening consequences. …”
Get full text

A systematic review of the asymmetric inheritance of cellular organelles in eukaryotes: A critique of basic science validity and imprecision. by Anne Collins, Janine Ross, Shona H Lang

“…Future systematic reviews in basic or preclinical research should ensure the rigorous reporting of the statistical reliability of the results in addition to the validity of the methods. …”
Get full text

Triage implementation in Pakistan: a case of broken healthcare system by Misha Mansoor, Muhammad Hamza Shafiq, Mubashra Khalid

“…All the patients escorted and rescued from the place of incident should be sorted rapidly and given a colour-coded tag based on urgency. …”
Get full text

Glycodelin is a potential biomarker for malignant tumors by M. V. Mnikhovich, M. A. Shekhter, T. V. Bezuglova, K. Kh. Skafi, K. A. Artemyeva, E. S. Mishina

“…Further studies of the functional properties of glycodelin are needed to develop promising strategies in cancer therapy.…”
Get full text

Brake rigging dynamic simulation under braking on a track section with irregularities (the case of a passenger car) by I. A. Yaitskov, V. V. Kosarevskii

“…The results obtained can be used in the design of new rigging brake systems of passenger cars and modernization of existing ones at the engineering enterprises and railway-car repair works. This, in turn, should ensure uniform distribution of efforts across all brake rigging brakeblocks of a passenger car.…”
Get full text

Preliminary Investigation of GC–MS Profiling and Antibacterial Activities of Different Solvent Extracts From Litchi chinensis Sonn. Seed by Samia Sharmin, Ali Ahsan Muzahid, Md. Mohibul Islam, Mst. Sarmina Yeasmin, Amit Kumar Dey, Md. Jasim Uddin, G. M. Masud Rana, Jaytirmoy Barmon, Safaet Alam, Md. Nurul Huda Bhuiyan, Nazim Uddin Ahmed

“…Eventually, comprehending the potential biological functions of the detected compounds is explored. GC–MS analysis revealed a diverse array of chemical compounds, with 34, 35, and 25 compounds identified in the n-hexane, n-hexane–chloroform (2:1), and methanol extracts, respectively. …”
Get full text

Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy by G. N. Avakyan, D. V. Blinov, A. A. Alikhanov, E. M. Perepelova, V. A. Perepelov, S. G. Burd, A. V. Lebedeva, G. G. Avakyan

“…The MRI examination should be combined with EEG or EEG-video monitoring. …”
Get full text

Prevalence of insomnia among university students in Saudi Arabia: a systematic review and meta‑analysis by Mohamed Baklola, Mohamed Terra, Mohamed Al-barqi, Yaqeen Hasan AbdulHusain, Sohaila Ahmed Asiri, Norah Saad Jadaan, Ali Haroona, Sayed Almosawi, Sarah Saud Al Ahmari

“…Abstract Background Insomnia is a prevalent sleep disorder affecting cognitive functions critical to academic performance. University students, particularly in high-stress academic settings, are highly vulnerable. …”
Get full text

The acts of the EU tax law and double tax treaties: the problems of correlation in establishing anti-tax avoidance rules by E. A. Ponomareva

“…The specifics of the functioning of tax systems and the risk of double taxation require a solution to the issue of whether tax competence can remain only at the national level. …”
Get full text

Outcomes of different surgical procedures for optic disc pit: a meta-analysis by Hussain A. Khaqan, Raheela Naz, Hafiz A. ur Rehman, Laraib Hassan, Nabeel Akram, Hafiz M. Farooqui, Ahmad Fauzan, Asad M. Khan

“…Conclusion We did not find a significant difference in functional outcomes between the various surgical procedures used to treat OPM. …”
Get full text

Multi-Domain Environmental Quality of Indoor Mixed-Use Open Spaces and Insights into Healthy Living—A Quarantine Hotel Case Study by Han Wang, Wenjian Pan

“…Many hotels adopt mixed-use and open room spatial layouts, integrating diverse daily functions into a single tiny space, fostering flexible utilization and micro-scale space sharing; however, these also introduce potential health risks. …”
Get full text

Semantic web-based ontology: a comprehensive framework for cardiovascular knowledge representation by Sabahat Sabir, Fahad Maqbool, Muhammad Saad Razzaq, Dilawar Shah, Shujaat Ali, Muhammad Tahir, Hafiz Muhammad Faisal Shehzad

“…HDO is evaluated using OOPs Pitfall Scanner and Hermit Reasoner. Its functionality is validated by populating a use case and executing SPARQL queries. …”
Get full text

Assessing the Elderly Health-related Unmet Needs and Some Related Factors in Hamadan City, Iran by Fatemeh Mansouri-Shad, Parvin Cheraghi, Sediqheh Mafakheri-Bashmagh, Qhadir Nouri, Zahra Cheraghi

“…Finally, future studies should assess the health-related needs of all elderly residents in the community, including those in long-term care facilities.…”
Get full text

Urban Heritage Revitalization: Significance of Cultural Heritage: Attributes of Sense of Places for Kuala Lumpur by Saidatul Haziah Ramli, Zalina Samadi, Aidatul Fadzlin Bakri

“…The more pragmatic strategies, the higher the sense of place to revitalise the heritage place should be.  …”
Get full text

<i>Angelicae Pubescentis</i> Radix Remitted Intestine Damage in Mice Induced by <i>Escherichia coli</i> via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut... by Kehong Deng, Chang Xu, Qing He, Muhammad Safdar, Mudassar Nazar, Xiaocong Li, Kun Li

“…Additionally, these findings confirm APR’s role in addressing immediate effects rather than chronic adaptations. Future studies should investigate the prolonged effects of APR treatment beyond the acute phase.…”
Get full text

PEDAGOGICAL CONTENT THREE-FACTOR MODEL OF EDUCATING HIGH-SCHOOL STUDENTS FOR PROFESSIONAL ACTIVITIES by T. A. Lopatukhina, A. V. Rynkevich

“…In the long run, in the author’s opinion, this system should succeed in creating some special platform for student’s further self-upbringing and self-learning. …”
Get full text

Deep Learning in Glaucoma Detection and Progression Prediction: A Systematic Review and Meta-Analysis by Xiao Chun Ling, Henry Shen-Lih Chen, Po-Han Yeh, Yu-Chun Cheng, Chu-Yen Huang, Su-Chin Shen, Yung-Sung Lee

“…To enhance the prediction of glaucoma progression, future DL models should integrate multimodal data, including functional assessments, such as visual field measurements, and undergo extensive validation in real-world clinical settings.…”
Get full text

Tendencias cuánticas en empresas orientadas hacia el conocimiento: Análisis de caso de una experiencia costarricense. Quantic trends in knowledge-based companies: A case analysis o... by César Zúñiga Ramírez, Jennier Solano Cordero, Rolando Bolaños Garita

“…The inquiry supposes that a company of this nature, which is also taken as a case study in the Costa Rican business environment, should hold a closer position to the more recent administrative focuses, especially because its business orientation presents important administrative and environmental challenges. …”
Get full text