Changes in microbiome composition after fecal microbiota transplantation via oral gavage and magnetic navigation technology-assisted proximal colon/cecum enema in antibiotic knock-... by Xian-Jie Bai, Yu-Chen Mei, Jia-Tong Zhao, Zhi-Ren Chen, Chen-Xi Yang, Xiao-Juan Dong, Jia-Wei Yu, Lin-Biao Xiang, Er-Zheng Zhou, Yong Chen, Jia-Yi Hao, Zhi-Jie Zhang, Yu-Xuan Liuyang, Lu Ren, Ying-Min Yao, Lei Zhang, Yi Lv, Qiang Lu

“…Future experimental designs should consider the colonization outcomes of critical microbial taxa to determine the optimal FMT delivery routes in scientific research as well as clinical practise.…”
Get full text

Legume-based green concentrate alleviates negative energy balance and enhances performance, metabolic health, and profitability in postpartum Holstein Friesian cows by Renny Fatmyah Utamy, Ambo Ako, Zyahrul Ramadan, Yasuyuki Ishii, Mohammad Mijanur Rahman, Kannika Umpuch, Azisah Nurfadilah, Gemal Umar Akmal Alkatiry, Muhammad Akram, Jiant Muthahra Maharani

“…Background and Aim: Negative energy balance (NEB) is a common metabolic disorder in postpartum dairy cows that compromises milk yield, metabolic health, and reproductive function. Sustainable nutritional interventions are essential to mitigate NEB without increasing production costs. …”
Get full text

THE ANALOGY OF STATUTE AND THE ANALOGY OF LAW AS DOCTRINAL INSTRUMENTS FOR LEGAL RESPONSE TO ECONOMIC CHALLENGES by Serhii Zavalniuk, Volodymyr Zavalniuk, Iryna Zavalniuk

“…The analogy of statute and the analogy of law should therefore be regarded as doctrinal instruments for overcoming such gaps within the legal system. …”
Get full text

Long-term survival after local immunotherapy for malignant gliomas: a retrospective study with 20 years follow-up by Hao Duan, Zhenqiang He, Zhenghe Chen, Yukun Chen, Wanming Hu, Ke Sai, Xiangheng Zhang, Jianchuan Xia, Yongqiang Li, Ranyi Liu, Chaowei Zou, Zhongping Chen, Yonggao Mou

“…Abstract Purpose Immunotherapy is a promising treatment for cancers but should be optimized for malignant gliomas. Because of immune privilege feature of the brain, local administration of immunotherapy may be a promising strategy for malignant glioma treatment. …”
Get full text

Application progress of integrative Chinese and Western medicine in home-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease (中西医结合肺康复在慢性阻塞性肺疾病居家... by TANG Sanhui (唐三辉), XUE Jingfeng (薛景凤), GONG Fanghua (龚放华)

“…The research indicates that the integrative approaches, combining core interventions such as exercise training and breathing training from Western medicine with Traditional Chinese Medicine practices like Qi Gong and manual therapies, has shown significant effects in improving lung function, enhancing exercise endurance, and alleviating clinical symptoms. …”
Get full text

Clinical Profile of Elderly Patients with COVID-19 hospitalised in Indonesia’s National General Hospital by Muhammad Khifzhon Azwar, Siti Setiati, Aulia Rizka, Ika Fitriana, Siti Rizny F Saldi, Eka Dian Safitri

“…We postulated that immunosenescence and sex-specific immunoregulatory function play an important role in causing death in this study cohort.   …”
Get full text

Association Between Genetic Variants in <i>TNF</i>, <i>IL6</i>, and <i>IL1B</i> Genes and Severity of COVID-19: A Cross-Sectional Study of Patients from Southern Brazil by Mariléa Furtado Feira, Renan Cesar Sbruzzi, Miriãn Ferrão Maciel-Fiuza, Vitória Carolina Griebeler, Tatiana Schaffer Gregianini, Letícia Garay Martins, Nathan Araujo Cadore, Jose Artur Bogo Chies, Thayne Woycinck Kowalski, Fernanda Sales Luiz Vianna

“…DNA was extracted from nasopharyngeal swabs and genotyped for functional variants selected based on evidence of regulatory function and prior associations with inflammatory outcomes—<i>IL1B</i> (rs4848306, rs1143623, rs16944, rs1143627), <i>IL6</i> (rs1800795, rs2069832, rs2069840, rs2069845), and <i>TNF</i> (rs1799964, rs1800630, rs1799724, rs1800629, rs361525). …”
Get full text

Microtubule-modulating drugs alter sensitivity to isoflurane in mice by Na Li, Zerong You, Yang Ren, Hyung Hwan Kim, Jinsheng Yang, Ge Li, Jason T. Doheny, Weihua Ding, Suyun Xia, Shiyu Wang, Xue Zhou, Xinbo Wu, Shiqian Shen, Yuanlin Dong, Zhongcong Xie, Lucy Chen, Jianren Mao, J. A. Jeevendra Martyn

“…Microtubule-targeting chemotherapy drugs and opioids affect MT stability and function. However, the impact of prolonged administration of these drugs on anesthetic potency and anesthesia induction and emergence times remain unelucidated. …”
Get full text

The Effect of Different Levels of CLA and Omega-3 Supplements Along with Essential Oils of Fennel, Peppermint, and Eucalyptus Medicinal Plants on Production Performance, Blood Para... by Yadollah Chashnidel, Matin Movagharnezhad, Mehdi Jafary charati

“…A good source of oil or fat should have an ideal ratio of saturated and unsaturated fatty acids. …”
Get full text

Gaps in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: a citation analysis reveals a need for updated ethics guidelines by Cory E. Goldstein, Jessica du Toit, Nicholas B. Murphy, Stuart G. Nicholls, Julia F. Shaw, Fernando Althabe, Ariella Binik, Jamie Brehaut, Sandra Eldridge, Rashida A. Ferrand, Katie Gillies, Bruno Giraudeau, Rieke van der Graaf, Lars G. Hemkens, Karla Hemming, Mira Johri, Scott Y. H. Kim, Emily Largent, Alex John London, Lawrence Mbuagbaw, Susan L. Mitchell, Maureen Smith, Peter Tugwell, Shaun Treweek, Vivian A. Welch, Monica Taljaard, Charles Weijer

“…Alongside additional gaps identified in ongoing empirical work and through engagement with our patient and public partners, the gaps identified through this citation analysis should be considered in the forthcoming Ottawa Statement update.…”
Get full text

B and T lymphocyte attenuator (BTLA) and PD-1 pathway dual blockade promotes antitumor immune responses by reversing CD8+ T-cell exhaustion in non-small cell lung cancer by Yang Zhang, Yang Zhang, Yang Yang, Yang Yang, Yuanyuan Zeng, Yuanyuan Zeng, Qiuxia Qu, Dan Shen, Chuanyong Mu, Wei Lei, Meiqin Su, Jingyu Mao, Lirong Gao, Zeyi Liu, Zeyi Liu, Cheng Chen, Jian-an Huang, Jian-an Huang

“…In addition, distribution and function of immune cells were analyzed by flow cytometry. …”
Get full text

Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…Under certain indications the patient should undergo EGDS with esophageal biopsy and histological examination of biopsy specimens to rule out the Barret's esophagus, esophageal adenocarcinoma and/or eosinophilic esophagitis; intraesophageal 24­hour pH­metry or pH­impedance measurement; high resolution esophageal manometry; X­ray study of the esophagus and stomach. …”
Get full text

Effectiveness of different physical activity programs in improving older adults’ physical capacities: a randomized controlled trial by Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Víctor Hernández-Beltrán, Orlando Fernandes, Orlando Fernandes, Cláudia Mendes, Cláudia Mendes, Cláudia Mendes, José M. Gamonales, José M. Gamonales, José M. Gamonales, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, José A. Parraca, José A. Parraca

“…Effective exercise programs for older people should address age-related physical challenges while remaining safe and accessible.ObjectiveThis study aims to identify the most effective PA program to enhance the physical capacities of older people. …”
Get full text

Haematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Northwest Ethiopia by Abraham Belete Temesgen, Tadegegn Mitiku, Mastewal Birhan, Mersha Chanie Kebede, Mohammed Yesuf, Muluken Yayeh Mekonnen, Moges Maru Alemayehu, Birhan Anagaw Malede, Abdo Megra Geda, Aregash Wendimu Tumebo, Kefale Ambachew Shiferaw, Zerihun Getie Wassie, Genetu Kassahun Berie, Bemrew Admassu Mengistu, Melaku Getahun Feleke, Fikadu Edenshaw, Mulusew Tesfaye Yitie, Gashaw Enbiyale Kasse, Elias Melkamu Tsehay, Samuel Atalay Shiferaw

“…Haematology and biochemical tests should be part of routine diagnosis for early detection and liver function assessment, while histopathology confirms the infection stage. …”
Get full text

High‐Density Lipoprotein‐Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin‐Deficient Limb–Girdle Muscular Dystrophy Type R2 by Zoe White, Laura Rufibach, Heather Gordish Dressman, Heather Hilsden, Dan Cox, Simone Spuler, John W. Day, Kristi J. Jones, Diana X. Bharucha‐Goebel, Emmanuelle Salort‐Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Madoka Mori‐Yoshimura, Elena Bravver, Jordi Diaz‐Manera, Elena Pegoraro, Jerry R. Mendell, the Jain COS Consortium, Volker Straub, Pascal Bernatchez

“…Conclusions Data from the largest natural history cohort of LGMDR2 patients support the concept that dyslipidemia is a comorbidity of LGMDR2, and the causal role of cholesterol abnormalities in muscle death should be further investigated.…”
Get full text

Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials by Andrew R. DiNardo, Andrew R. DiNardo, Wilbert Sabiiti, Stephen H. Gillespie, Sophia B. Georghiou, Norbert Heinrich, Norbert Heinrich, Norbert Hittel, Sami Taghlabi, Danna Carrero Longlax, Mikashmi Kohli, Ursula Panzner, Ursula Panzner, Collins Musia, Christoph Lange, Christoph Lange, Christoph Lange, Christoph Lange, Anca Vasiliu, Anca Vasiliu, Anca Vasiliu, Rob J. W. Arts, Anna M. Mandalakas, Anna M. Mandalakas, Anna M. Mandalakas, Morten Ruhwald, Lieven J. Stuyver, Reinout van Crevel, Reinout van Crevel

“…Beyond antimicrobial efficacy, parameters such as morbidity and mortality related to lung function, cardiovascular health, and cancer should be prioritized. …”
Get full text

New approaches to diagnosis and management of patients with metabolic-associated steatotic liver disease with immune response to SARS-CоV-2 by V.I. Didenko, S.L. Melanich, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko, H.I. Bocharov

“…All patients’ serum parameters of immunological profile, liver function, and prothrombotic environment were determined. …”
Get full text

Psychotherapies for adults with complex presentations of PTSD: a clinical guideline and five systematic reviews with meta-analyses by Ole Jakob Storebø, Sophie Juul, Stephen Fitzgerald Austin, Maria Quistgaard, Julie Perrine Schaug, Lise Møller, Nina Reinholt, Dyveke Bové Illum, Frida Lau Græbe, Line Bang Mikkelsen, Nina Nørrelykke Paulsen, Adrian Maria Tremel Porsing, Oliver Rumle Hovmand, Mie Sedoc Jørgensen, Ida-Marie Terese Pereira Arendt, Magnus Tang Kristensen, Sidsel Christine Buskbjerg Døssing, Bent Rosenbaum, Nicole Gremaud Rosenberg, Sidse Marie Arnfred

Get full text

Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis by Xianying Lu, Ran Xu, Xiaohui Dong, Dingxi Bai, Wenting Ji, Xinyu Chen, Huan Chen, Chaoming Hou, Jing Gao

“…Conclusions Exosome therapy provides a novel therapeutic strategy for the benefit of neurovascular remodeling and functional recovery of DPN, especially when used in conjunction with exosome modification and novel dressings. …”
Get full text

Mindfulness vs. sleep education during autologous hematopoietic cell transplantation for multiple myeloma: Feasibility of a randomized controlled pilot study by Elisabeth C. Henley, Hannah A. Liphart, Keayra J. Morris, Iwalola Awoyinka, Michael R. Irwin, Erin S. Costanzo, Diana Winston, Anita D'Souza, Melinda Stolley, Binod Dhakal, Meera Mohan, Marcelo C. Pasquini, Steven W. Cole, Erin S. Doerwald, Peyton C. Bendis, Kelly E. Rentscher, Meredith E. Rumble, Aniko Szabo, Sridhar Rao, Jennifer M. Knight

“…While enrollment met feasibility criteria, most patients felt too overwhelmed or sick in the peri-transplant period to complete the intervention and associated study tasks. Future research should investigate MBIs at other time points throughout HCT. …”
Get full text