Associations of dose to the urethra and long-term patient-reported outcomes after radiotherapy with EBRT and HDR brachytherapy boost for prostate cancer by Lars Haack, David Krug, Justus Domschikowski, Olaf Wittenstein, Severin Rodler, Philipp Nuhn, Christof van der Horst, Claudia Schmalz, Christian Schulz, Oliver Blanck, Frank-André Siebert, Alexander Fabian

“…Per univariable analysis, a higher near maximum point dose of the urethra (DU0.1cc) was associated with worse urinary incontinence (r = -0.32; CI = −0.48 − -0.13; p < 0.001) and worse overall urinary function (r = -0.21; CI = −0.38 − -0.03; p = 0.02) of the respective EPIC-26 domains. …”
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Use of relative Patlak plot Ki′ images as an alternative to standard Patlak plot Ki images in clinical practice by Masatoyo Nakajo, Hirofumi Kawakami, Yutaro Kiyao, Mitsuho Hirahara, Akie Katsuki, Atushi Tani, Yukari Eizuru, Koji Takumi, Kiyohisa Kamimura, Fumiko Kanzaki, Takashi Yoshiura

“…Ki′-49 min images retained accuracy but required longer scans. Future work should assess alternatives such as PBIF or dual-window protocols for clinical streamlining.…”
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Risk factors of low bone mass in young patients with transfusion-dependent beta-thalassemia by Wei Zhang, Wei Zhang, Rongrong Liu, Rongrong Liu, Rongrong Liu, Siping He, Jihua Huang, Liting Wu, Cuifeng Huang, Yuzhen Liang, Yongrong Lai, Yongrong Lai, Yongrong Lai

“…The corrected model further identified normal BMI (OR=0.383) and ALB (OR=0.866) as protective factors, while IGF-1 levels &lt; -2 SD (OR=1.832) and hypogonadism (OR=2.990) emerged as significant risks in the uncorrected model. Clinical management should prioritize height-adjusted BMD evaluation and integrated interventions targeting growth hormone axis function, gonadal status, and nutritional indicators to optimize bone health in TDT patients.…”
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Clinical and histopathological features of lupus nephritis and the risk of long-term kidney outcomes in Indonesia by Ni Made Hustrini, Ni Made Hustrini, Endang Susalit, Monik Ediana Miranda, Meilania Saraswati, Y. K. Onno Teng, Merel van Diepen, Joris I. Rotmans

“…A linear mixed-model analysis was performed to assess the association between lupus nephritis class and kidney function decline.ResultsThis study included 268 patients, with a mean age of 28.7 + 8.5 years, and 94.8% were female. …”
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Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) by Antonio Bernabe-Ortiz, Neil Pearce, Hans Kromhout, Pablo Perel, Liam Smeeth, Cristina O’Callaghan-Gordo, Jason Glaser, Kristina Jakobsson, Dorothea Nitsch, Ben Caplin, Nalika Gunawardena, Adeera Levin, Vidhya Venugopal, Marvin Gonzalez-Quiroz, Sophie Hamilton, Cristina O'Callaghan Gordo, Rajiv Saran, Ricardo Correa-Rotter, Ajay Singh, Giuseppe Remuzzi, Emmanuel Burdmann, Rick Johnson, Phabdheep Kaur, Pronpimolk Kongtip, Magdalena Madero Rovalo, Moffat Nyirenda, Dorairaj Prabhkaran, Narayan Prasad, Nalika Gunawardenan

“…Local capacity to measure serum creatinine will be required so that immediate feedback on kidney function can be provided to participants. After completion of follow-up, repeat measures of creatinine should be conducted in a central laboratory, using reference standards traceable to isotope dilution mass spectrometry (IDMS) quality control material to quantify the main outcome of eGFR decline over time, alongside a description of the early evolution of disease and risk factors for eGFR decline.Ethics and dissemination Ethical approval will be obtained by local researchers, and participants will provide informed consent before the study commences. …”
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Role of LncRNA in Trauma Susceptibility and Resilience to Post-Traumatic Stress Disorder (PTSD): A Pilot Study in the African American Population by Sadhukhan T, Rai N, Misiak-Christian M, Hipolito MMS, Sadhukhan S, Shelby M, Mejía Mondragón CI, Idowu A, Gondringer A, Kalejaiye A, Li J, Islam MN, Ressom HW, Nwulia EA

“…Evidence suggests that the peripheral olfactory system, which is accessible in the nose, regulates the structure and function of olfactory regions relevant to stress biology. …”
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Construction of a circRNA-miRNA-mRNA Regulatory Network for the Immune Regulation of Lung Adenocarcinoma by Hanyi Li, Xin Jin, Wei Li, Fan Ren, Tong Li, Xuanguang Li, Haochuan Yu, Dianxun Fu, Zuoqing Song, Song Xu

“…Protein-protein interaction (PPI) networks were constructed using Cytoscape software. The DAVID functional annotation tool was utilized to explore potential biological processes, molecular functions, and KEGG pathways associated with LUAD. …”
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Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions by Yichen Wang, Minghui Shi, Jiahui Wu, Xiangyu Han, Mengqi Li, Yining Wu, Yuanlin Jiang, Haonan Zhang, Shuqiang Liu, Defu Hu

“…In addition, the PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States) function prediction results indicated that FSD were less capable than FRD and FWLD in the functional category of nutrient metabolism, and FWLD were less capable than FSD and FRD in the functional category of intestinal absorption. …”
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UMOD Genotype and Determinants of Urinary Uromodulin in African Populations by Michél Strauss-Kruger, Eric Olinger, Patrick Hofmann, Ian J. Wilson, Carina Mels, Ruan Kruger, Lebo F. Gafane-Matemane, John A. Sayer, Cristian Ricci, Aletta E. Schutte, Olivier Devuyst

“…Conclusion: We evidenced ethnic differences in clinical and genetic determinants of uUMOD levels, in particular an interaction of ethnicity on the relationship between CKD-risk SNPs and uUMOD. These differences should be considered when analyzing the role of uromodulin in kidney function, interpreting genome-wide association studies (GWAS), and precision medicine recommendations.…”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases by Tesson, Florian, Planel, Rémi, Egorov, Artyom A, Georjon, Héloïse, Vaysset, Hugo, Brancotte, Bryan, Néron, Bertrand, Mordret, Ernest, Atkinson, Gemma Catherine, Bernheim, Aude, Cury, Jean

“…Moreover, the rapid development of sequence-based predictions of structures offers novel possibilities of analysis and should be easily available. To overcome these challenges, we present a hub of resources on defense systems, including: 1) an updated version of DefenseFinder with a web-service search function, 2) a community-curated repository of knowledge on the systems, and 3) precomputed databases, which include annotations done on RefSeq genomes and structure predictions generated by AlphaFold. …”
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A non-small cell lung cancer fragile elderly patient treated with immunotherapy and non-ablative radiation therapy: a case report of a winning combination by Jessica Saddi, David Alberto Santos Hernandez, David Alberto Santos Hernandez, David Alberto Santos Hernandez, Giulia Maria Stella, Giulia Maria Stella, Giulia Galli, Giulia Galli, Sabrina Borgetto, Elisabetta Bonzano, Andrea Lancia, Salvatore La Mattina, Sara Colombo, Luigi Squillace, Guido Baietto, Chandra Bortolotto, Chandra Bortolotto, Gioacchino D’Ambrosio, Laura Mantovani, Paolo Pedrazzoli, Paolo Pedrazzoli, Francesco Agustoni, Francesco Agustoni

“…Complete response was observed without severe side effects (his poor respiratory function did not change during both treatments).ConclusionIn this case report we showed that the association of immunotherapy and non-ablative radiation regimens may represent a safe and effective strategy to achieve complete response also in fragile patients, in whom the burden of side effects should be prioritized.…”
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Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition by Jessica K. Kaufeld, Lucas Kühne, Ulf Schönermarck, Jan Hinrich Bräsen, Constantin von Kaisenberg, Bodo B. Beck, Florian Erger, Carsten Bergmann, A.N.K.E. von Bergwelt-Baildon, Paul T. Brinkkötter, Linus A. Völker, Jan Menne

“…Conclusion: Based on our findings, we suggest a pragmatic approach toward limited and short-term anticomplement therapy for patients with a clinical diagnosis of p-aHUS, which should be stopped once causes of TMA other than genetic complement abnormalities emerge.…”
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Evaluating analytic strategies to obtain high-resolution, vertex-level measures of cortical neuroanatomy in children in low- and middle-income countries by Charlotte M. Pretzsch, František Váša, Michael Brammer, Lucy Brink, Mandy Potter, Wendy Mackay, Petrusa Smit, Carolina Du Plessis, Marcelle Wagner, Deborah Jonker, Kirsten A. Donald, Freda Scheffler, Cindy Pham, Viola Hollestein, Eva Loth, Declan GM Murphy, Hein J. Odendaal, Elizabeth R. Sowell, Priscilla E. Springer, Dan J. Stein, Christine Ecker

“…Abstract High-field magnetic resonance imaging to explore brain structure and function remains limited to high-resource settings. …”
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Pituitary Involvement in Granulomatosis with Polyangiitis: A Retrospective Analysis in a Single Chinese Hospital and a Literature Review by Shixuan Liu, Yan Xu, Naishi Li, Shi Chen, Shangzhu Zhang, Linyi Peng, Wei Bai, Jinglan Wang, Jinming Gao, Xiaofeng Zeng, Juhong Shi, Mengzhao Wang

“…After treatment with glucocorticoids and cyclophosphamide (CYC), all patients showed clinical improvement but pituitary function did not resume. Literature review identified 66 additional patients with pituitary involvement in GPA; diabetes insipidus (57/66, 86.4%) and hypogonadism (34/66, 51.5%) were the most frequent pituitary disorders, and the most frequent imaging lesion was an enlarged pituitary (25/64, 39.1%). …”
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Sensus Fidei as a Gift of the Holy Spirit to the Church by Leon Sawicki

“…Sensus fidei needs the Magisterium, similarly the teachings of Magisterium should also take into consideration the fruits of sensus fidelium. …”
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Ballpark Estimates of Budget Space for Health Workforce Investments in the 47 Countries of the WHO African Region: A Modelling Study by James Avoka Asamani, San Boris Kouadjo Bediakon, Hamza Ismaila, Sunny Okoroafor, Regina Titi-Ofei, Adam Ahmat, Juliet Nabyonga-Orem, Ogochukwu Chukwujekwu, Kasonde Mwinga

“…Conclusion: Better prioritising health within the overall government expenditure coupled with highly prioritising the health workforce to at least regional average levels of 43% within the health budget could make a difference in the investments needed to tackle the health workforce challenges. This should, however, be underpinned by ensuring efficient and accountable use of the resources.…”
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Experiences of pacing to reduce symptoms among adults living with Long COVID in Canada, Ireland, the United Kingdom and the United States by Kiera McDuff, Darren A. Brown, Natalie St. Clair-Sullivan, Soo Chan Carusone, Kristine M. Erlandson, Lisa Avery, Ciaran Bannan, Colm Bergin, Angela M. Cheung, Susie Goulding, Richard Harding, Mary Kelly, Jessica M. Martin, Lisa McCorkell, Sarah O’Connell, Imelda O’Donovan, Margaret E. O’Hara, Niamh Roche, Ruth Stokes, Catherine Thomson, Liam Townsend, Jaimie H. Vera, Hannah Wei, Patricia Solomon, Kelly K. O’Brien

“…Abstract Background Long COVID is a multisystem condition that negatively impacts daily function. Pacing is a self-management strategy to mitigate symptoms. …”
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The Association Between Sleep Duration and Clinical Measures of Concussion at Baseline and Postinjury in the United States Service Academy Cadets and Midshipmen by Michael J. Aderman, Megan H. Roach, Steven R. Malvasi, Jeremy Ross, Steven J. Svoboda, Joel B. Robb, Gerald T. McGinty, Jonathan C. Jackson, Darren E. Campbell, Carlos A. Estevez, Rachel Brodeur, Kathryn Van Pelt, Adam Susmarski, Steven Broglio, Michael McCrea, Thomas W. McAllister, Paul F. Pasquina, Kenneth L. Cameron

“…Increased sleep may be associated with improved clinical assessment outcomes and should be considered when evaluating these assessments.…”
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Optimization of Eugenol, Camphor, and Terpineol Mixture Using Simplex-Centroid Design for Targeted Inhibition of Key Antidiabetic Enzymes by Amine Elbouzidi, Mohamed Jeddi, Abdellah Baraich, Mohamed Taibi, Mounir Haddou, Naoufal El Hachlafi, Meryem Idrissi Yahyaoui, Reda Bellaouchi, Bouchra El Guerrouj, Khalid Chaabane, Mohamed Addi

“…A simplex-centroid design was applied to evaluate the combined effects of eugenol, camphor, and terpineol on AAI _IC50, AGI _IC50, LIP _IC50, and ALR _IC50 responses. The desirability function was used to determine the ideal composition. …”
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Applications of BCI and VR in cognitive diagnosis and treatment by Xianglong WAN, Anfeng FU, Yiduo YAO, Tiange LIU, Dingna DUAN, Xueguang XIE, Hao YU, Danyang LI, Dong WEN

“…This paper suggests that future research should focus on the miniaturization and cost reduction of BCI‒VR devices, the development of multimodal BCI systems, and the application of large language models to enhance the functionality and accessibility of these technologies. …”
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