METTL3-mediated m6A modification promotes intervertebral disc degeneration by Qinghua Yang, Feihong Huang, Congyang Wang, Xiao Liang, Longao Huang, Hongyuan Xu, Jianwei Liu, Qingjun Wei, Hua Jiang

“…Moreover, gain- and loss-of-function experiments in NP cells were conducted to explore the impact of METTL3 on IDD. …”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…Therefore, the diagnosis, tactics of treatment and prevention of dental anomalies and deformities should be considered in the context of the integrity of the unformed organism of the child, the interdependence of the form and functions of its organs and systems. …”
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A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain by Lorio MP, Beall DP, Myers TJ, Naidu RK, McRoberts WP, Davis TT, Gage EG, Calodney AK, Verrills P, De Palma MJ, Amirdelfan K, Block JE

“…Recognizing that the management program for patients with lumbar discogenic pain can be highly personalized, the treatment options recommended by this algorithm should be considered general guidance.Conclusion: The proposed algorithm offers an easy-to-use clinical tool for identifying, evaluating and treating patients with lumbar discogenic pain. …”
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Cell-free hemoglobin is associated with microcirculatory perfusion disturbances and acute kidney injury in rats on extracorporeal membrane oxygenation by Carolien Volleman, Dionne P. C. Dubelaar, Philippa G. Phelp, Roselique Ibelings, Anita M. Tuip-de Boer, Chantal A. Polet, Walter M. van den Bergh, Alexander P. J. Vlaar, Charissa E. van den Brom

“…Our findings suggest that CFHb plays an important role in the pathophysiology of AKI, possibly via endothelial damage. Future studies should clarify the causal relationship between CFHb and endothelial damage, and explore whether targeting CFHb can improve microvascular perfusion and preserve kidney function during ECMO support.…”
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The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy by Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Xin Su, Zigan Li, Yuxuan Cai, Tangbin Hu, Maoxiao Feng, Xiaoyan Liu, Ming Xia, Jun Tai, Yana Zhang, Yunshan Wang, Mo Wang

“…Furthermore, the review highlights the influence of immunometabolic reprogramming on immune cell function and plaque phenotype, illustrating how metabolic states shape inflammatory outcomes. …”
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‘We’re not there yet!’: a qualitative study exploring the commissioning of adult Community Health Services in England to support the avoidance of hospital admissions by Rachel Meacock, Kath Checkland, Pauline Allen, Donna Bramwell, Mhorag Goff

“…Participants from all sites reported that the reorganisation of the NHS away from Clinical Commissioning Groups to Integrated Care Boards has resulted in confusion around the commissioning function, with a lack of clarity about current roles and responsibilities. …”
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Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towards the Identification of <i>1639 G>A</i> Genetic Polymorphism by Tiago Barbosa, Stephanie L. Morais, Renato Carvalho, Júlia M. C. S. Magalhães, Valentina F. Domingues, Cristina Delerue-Matos, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Marlene Santos, Maria Fátima Barroso

“…Genetic factors, such as polymorphisms, can change the natural function of VKORC1, causing variations in the medication reaction among individuals. …”
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International Natural Uranium Price Prediction Based on TF-CNN-BiLSTM Model by YANG Jingzhe, XUE Xiaogang

“…The study meticulously constructed and trained the TF-CNN-BiLSTM model using TensorFlow with the Adam optimizer and mean squared error loss function. The training process was optimized with learning rate reduction and early stopping callbacks to prevent overfitting. …”

LANDSCAPE APPROACH IN CITY-PLANNING by Boris I. Kochurov, Yulia A. Khaziakhmetova, Irina V. Ivashkina, Ekaterina A. Sukmanova

“…When taking actions to transform natural landscapes should be taken into account their structure and functioning, as well as the limits of possible impacts and the likely consequences of these changes. …”
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Implementation of public management mechanisms for the development of higher education in Ukraine by B.V., O.O.

“…The true nature and functionality of the education system is best revealed by a systemic approach. …”
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Early reconstruction of bone defect created after initial surgery of a large keratocystic odontogenic tumor: A case report by Matijević Stevo, Damjanović Zoran, Cerović Snežana

“…Adequate and early reconstruction of the existing jaw defect and appropriate aesthetic and functional rehabilitation of the patient should be the primary goal in the treatment of KCOT, having in mind the need for a long-term post-surgical follow-up.…”
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Die 1983 Afrikaanse Bybelvertaling in die lig van huidige tendense en behoeftes by A. H. Snyman

“…In line with the  experience of the new Dutch translation project, there is a specific need for a translation that reflects the literary forms and structures of the source texts and retains as much as possible imagery and metaphor, if functional, in contemporary Afrikaans. The Church Advisory Committee: Afrikaans Translations recommended to churches that a new translation should not be undertaken at this stage, but that research continue and proof translations be published in order to reach consensus on the type of translation needed. …”
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A cross-sectional study on prevalence of self-reported morbidity among elderly aged above 60 years residing in urban slums of Kurnool District, Andhra Pradesh, India by S. Cynthia Subhaprada, Mullangi Thanuja, U. Venkateswarlu

“…Morbidity was determined by self-reported symptoms of the study participants. Physical functioning limitation was assessed by the Medical Outcome Study-Physical Functioning Scale, and mental health was assessed by the Geriatric Depression Scale. …”
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Use of Different Statistic Approaches on Variability in Hydrologic Variables by Kadri Yürekli, Müberra Erdoğan, Ömer Faruk Karaca

“…The unnatural change in the globe under influence of devastating global warming has been quashing the overall functioning of ecosystem since industrial revolution. …”
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Renewables in Countries of North Africa: Problems and Prospects of Use by SHKVARYA Lyudmila Vasilievna

“…In this regard, the task of developing green energy should not be more significant than the task of maintaining the functioning of the energy industry as a whole, and renewable energy sources should not replace but only complement traditional energy. …”
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Peculiarities of legal regulation of activities of the National Police of Ukraine in the field of ensuring information security in Ukraine by I. D. Kazanchuk, V. P. Yatsenko

“…Taking into account the specifics of the tasks, the author has provided characteristics of the functions of cyberpolice units in the information sphere, which should be divided according to the purpose into: 1) basic (external), which are focused on law enforcement and preventive aspects; 2) auxiliary (intrasystem), which are focused on promoting the implementation of basic functions, the introduction of appropriate management mechanisms within the system. …”
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Strategies in complex reconstructions of the scalp and forehead: a series of 22 cases by Caio Alcobaça Marcondes, Salustiano Gomes de Pinho Pessoa, Breno Bezerra Gomes de Pinho Pessoa

“…Ideally, scalp closure should provide a better functional and aesthetic outcome, as well as low morbidity at the donor site. …”
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Forest management in Nigeria: Case study of Yantumaki Forest Reserve, Katsina State by Ladan Suleiman Iguda, Tukur Rabiu

“…The paper recommends a number of measures that should be adopted towards ensuring the effective management of the forest reserve. …”
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Examining antecedents affecting Indian consumers’ adoption of mobile apps by Neerja Arora, Garima Malik

“…This research aims to integrate the functional, social, security, and personal dimensions to study mobile app usage antecedents in the Northern Capital Region of India. …”
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Nursing Care of Patient with Acromegaly Disease — Case Report by Seçil Erden Melikoğlu, Yeliz Çulha, Hatice Kaya, Necmettin Tanrıöver

“…Diagnosis, treatment, care and follow-up of the disease; It requires a approach to multidisciplinary from endocrine to neurosurgery. The nurse should know the signs and symptoms of the disease, treatment, side effects that may be caused by the treatment, complications and the care interventions to solve the problems that arise and should plan the individualized care to improve the psychological health and quality of life by increasing the individual’s biophysiological functions. …”
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