Test and treat—impact of microbiological testing on antibiotic prescribing for Legionnaires’ disease in Switzerland: results of the multicentre SwissLEGIO study by Melina Bigler, Florian Zacher, Sarah Dräger, Werner C. Albrich, Daniel Mäusezahl, the SwissLEGIO Hospital Network

“…Future antimicrobial stewardship efforts should sensitise physicians that a shorter duration of antibiotic treatment for CALD of 5 to 7 days according to the latest Swiss CAP guidelines is sufficient and safe.…”
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Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study by Dina A. Hammouda, Alaa M. Mansour, Ahmed R. Zaher, Mohammed E. Grawish

“…Abstract Background Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for dentin-pulp complex or whole pulp regeneration. …”
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End-to-End Mandarin Speech Reconstruction Based on Ultrasound Tongue Images Using Deep Learning by Fengji Li, Fei Shen, Ding Ma, Jie Zhou, Shaochuan Zhang, Li Wang, Fan Fan, Tao Liu, Xiaohong Chen, Tomoki Toda, Haijun Niu

“…The loss of speech function following a laryngectomy usually leads to severe physiological and psychological distress for laryngectomees. …”
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Spatio-temporal changes in atmospheric aridity over the arid region of Central Asia during 1979–2019 by Moyan Li, Junqiang Yao, Jianghua Zheng

“…The first four leading modes revealed by empirical orthogonal function (EOF) analysis represented the patterns by explaining 81.4 % of the total variance. …”
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How equitable is digital rehabilitation for people after stroke? A systematic review using an equity approach by Rachel C. Stockley, Yasemin Hirst, Chantelle Hayes, Kimberley E. Watkins, Peter C. Goodwin

“…Rehabilitation after stroke seeks to restore function and independence and may utilise digital technologies to augment usual care. …”
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Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol by Joht Singh Chandan, Emmanuela Gakidou, Jaidev Kaur Chandan, Nicholas Metheny, Mariam Khalil, Cory N Spencer, María Jose Baeza, Alexandra Debure, Molly Herbert, Teresa Jewell, Rachel Qian Hui Lim, Sonica Minhas

“…Reviewers will first screen titles and abstracts, and eligible articles will then be full-text screened and accepted should they meet all inclusion criteria. Data will be extracted using a standardised form with fields to capture study characteristics and estimates of association between violence exposure and health outcomes. …”
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Plumbagin, a natural derivative of 1,4-naphthoquinone, induces cyclopic phenomenon via increased apoptosis and ROS generation in the early stage of zebrafish embryos by Yeonju Lim, Chaeeun Kim, Donghyeon Kim, Myoung-Jin Kim, Ji-Woo Yu, Min-Ho Song, Yurim Kim, Junhee Son, Ji-Ho Lee, Sung-Eun Lee

“…Metabolomic activity in PL-treated embryos was also severely disrupted, and even surviving individuals would likely not retain proper function. Thus, plants should be monitored for the presence of PL, given its strong cyclopia-inducing effects on animals. …”
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Report on Witteveen-Kolk syndrome caused by large fragment deletion in the 15q24.1 - q24.2 region in infants with early onset and literature review by Hanlin Tang, Jiaxuan Xu, Ling Ge, Qunting Gao, Xinlu Tan, Qicheng Qiao, Ruihan Liu, Qingxia Kong, Qiubo Li, Xiufang Jiang

“…Abstract Background WITKOS is a rare neurodevelopmental disorder caused by heterozygous loss-of-function variants in the 15q24.1 - q24.2 region, includeing switch-insensitive 3 transcription regulator family member A (SIN3 A). …”
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Critical technical parameters of large-diameter multi-stage casing drilling for mine rescue by Chao XU, Ningping YAO, Lei JIANG, Hongjie TIAN, Zhi LIU, Ning ZHU

“…Furthermore, this study investigated the critical drilling parameters, aiming to provide a basis for the function development and parameter formulation of rescue equipment. …”
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Comparison of Markowitz Model and DCC-tCopula-LVaR for Portfolio Optimization in the Tehran Stock Exchange by Gholamreza Taghizadegan, Gholamreza Zomorodian, Mirfeiz Fallahshams, Rasoul Saadi

“…Then, the marginal distributions of assets were estimated using Student's t-copula function. In the following, DCC-tCopula-LVaR values were calculated using the parametric method. …”
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Sensorimotor dysfunction and postural instability in older adults with type 2 diabetes mellitus: the role of proprioception and neuropathy by Saleh M. Kardm, Abdulmohsen Saeed Kardm, Ziad Ahmed Alanazi, Hani Hassan Alnakhli, Batool Abdulelah Alkhamis, Ravi Shankar Reddy

“…Additionally, to evaluate the impact of peripheral neuropathy on sensorimotor function.MethodsA cross-sectional study included 66 individuals with T2DM and 66 age- and sex-matched healthy controls. …”
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Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study by He L, Zhou R, Hou S, Huang D, Zhao X, Wang M, Huang M, Yin T, Yin H, Yu S

“…The findings indicate that acupuncture and moxibustion serve as effective non-pharmacological therapies for pain management, offering valuable insights into their underlying analgesic mechanisms. Future research should focus on further elucidating these mechanisms and optimizing clinical applications.Keywords: acupuncture, moxibustion, analgesia, neuroimaging, brain regions…”
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Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model by Markus Kraller, Julia Faßbender, Ammar Jabali, Joseph Kroeger, Barbara Fink, Bastian Popper, Martin Ungerer, Miriam A. Christlmeier

“…In addition, anti-hTREM2 antibodies should be optimized for both, efficacy and safety. …”
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A focal extramedullary hematopoiesis of the spleen in a patient with essential thrombocythemia presenting with a complicated postoperative course: a case report by Kiyotaka Hosoda, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Shinsuke Sugenoya, Koya Yasukawa, Hikaru Hayashi, Ryoichiro Kobayashi, Yuji Soejima

“…Abstract Background Extramedullary hematopoiesis is a compensatory response occurring secondary to inadequate bone marrow function and is occasionally observed in essential thrombocythemia (ET). …”
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Excretion and clearance of Sabin-like type 3 poliovirus in a child diagnosed with severe combined immunodeficiency by Ning Yao, Yang Liu, Zhi-Yong Zhang, Min Tian, Wu-Juan Xie, Hua Zhao, Hong Yang, Lance E. Rodewald, Ning Wen, Zun-Dong Yin, Fu-Zhen Wang, Qing Wang, Jia-Wei Xu

“…Graft versus host disease (GVHD) and poor graft function (PGF) occurred after HSCT, resulting in failure of hematopoiesis and immune system reconstitution. …”
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The TFRC as a prognostic biomarker and potential therapeutic target in cervical cancer: a preliminary study by Jing Wang, Wen An, Ziyao Pang, Manyin Zhao, Anli Xu, Junwei Zhao

“…In addition, the molecular function and mechanisms of TFRC were revealed by gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis. …”
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A Scoping Review of Factors Influencing Smoking Cessation in Patients with Chronic Obstructive Pulmonary Disease by Tong Huimin, Tian Zheng, He Jingchun, Liu Dajun, Zhang Zhijun, Li Yuan, Zhang Nan, Wang Lan

“…Healthcare professionals should avoid critical education of COPD patients in the process of smoking cessation management, pay attention to the adverse effects of medication side effects on patients, emphasize the improvement of patients’ health beliefs and self-efficacy in smoking cessation, and help patients to establish a correct cognition of smoking cessation.…”
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Gait Speed and All‐Cause Mortality in Whole‐Spectrum Chronic Kidney Disease: A Systematic Review and Meta‐Analysis Included 6217 Participants by Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

“…Gait speed assessment should be incorporated into routine clinical evaluations to identify high‐risk patients and guide interventions aimed at improving physical function and survival outcomes. …”
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Untrained perceptual loss for image denoising of line-like structures in MR images. by Elisabeth Pfaehler, Daniel Pflugfelder, Hanno Scharr

“…In conclusion, for images containing line-like structures, uPL is an alternative to other loss functions for 3D image denoising. We observe that small uPL networks have better or equal performance than very large network architectures while requiring lower computational costs and should therefore be preferred.…”
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Phosphomannomutase 2-congenital disorder of glycosylation: exploring the role of N-glycosylation on the endocrine axes by Giulia Del Medico, Lorenzo Ferri, Elena Procopio, Giosuè Annibalini, Elena Barbieri, Elena Barbieri, Rita Barone, Rita Barone, Renzo Guerrini, Renzo Guerrini, Amelia Morrone, Amelia Morrone, Stefano Stagi, Stefano Stagi

“…Hypoglycosylation can alter hormonal function on multiple levels. As a result, endocrinopathies are frequently part of the clinical spectrum of PMM2-CDG, particularly hypergonadotrophic hypogonadism and pubertal abnormalities in female patients. …”
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