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4601
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
Published 2019-01-01“…The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several clinical trials to have been completed while more are in development. …”
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4602
Inflammatory Markers in Cystic Fibrosis Patients with Lung Pseudomonas Aeruginosa Infection
Published 1999-01-01“…Chronic endobronchial inflammation and bacterial infection are the main causes of morbidity and mortality in cystic fibrosis (CF), an autosomal recessive genetic disorder associated with improper function of chloride channels. Inflammation in CF lung is greatly amplified after Pseudomonas aeruginosa infection. …”
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4603
Creating Balance on Bandwidth Consumption using Network Coding in Wireless Sensor Networks
Published 2024-02-01“…For this purpose, we need to calculate the derivative of the Lagrangian function relative to its variables, in order to determine the condition as a multi-excited multi-equation device. …”
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4604
Network analysis of memristive device circuits: dynamics, stability and correlations
Published 2025-01-01“…Surprisingly, analysis of the Lyapunov functions show that these circuits do not always have a stable equilibrium in the case of nonlinear resistance and window functions. …”
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4605
Dry eye: A hospital-based sociodemographic, risk and clinical classification profile
Published 2025-02-01“…Diabetes, hypertension and HIV were identified as significant risk factors for DED. Routine tear function evaluation should be an integral part of the assessment protocols of these highly susceptible patients. …”
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4606
Runt-related transcription factors: from pathogenesis to therapeutic targets in multiple-organ fibrosis
Published 2025-04-01“…Therefore, its significance in the fibrosis process should not be disregarded. The review begins with an objective description of the structure, transcriptional mechanism, and biological function of RUNX1, RUNX2, and RUNX3. …”
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4607
Evaluation of the Efficiency of Metaheuristic Algorithms in the Optimal Design of Pile Wall Retaining Systems
Published 2025-06-01“…The total cost of the retaining system is considered as an objective function that should be minimized in the design space of the variables. …”
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4608
Effectiveness of dietary interventions in managing pediatric gastroesophageal reflux disease: a comprehensive systematic review
Published 2025-07-01“…Probiotics emerged as a promising intervention, reducing GERD symptoms by enhancing gut barrier function and modulating inflammation. However, the studies varied in design, and adherence to dietary interventions was identified as a key challenge, particularly in pediatric populations. …”
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4609
Atypical Hemolytic Uremic Syndrome after Traumatic Rectal Injury: A Case Report
Published 2021-12-01“…After hemodialysis and subsequent supportive treatment, his urine output and renal function improved. The hemolytic anemia and thrombocytopenia also gradually improved. …”
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4610
Can the use of a free mobile phone inclinometer application improve the accuracy of coronal cup position during total hip arthroplasty?
Published 2025-03-01“…Background: Accurate acetabular cup positioning during THA has essential implications for function and long-term prosthesis survival. Low-volume hip arthroplasty surgeon is known to be a risk factor for malpositioning of the acetabular cup. …”
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4611
Financing immunisation in Kenya: examining bottlenecks in health sector planning and budgeting at the decentralised level
Published 2024-10-01“…Kenya adopted a devolved system of government where health services delivery became a function of the 47 semi-autonomous county governments with planning and budgeting functions practised at both levels of government. …”
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4612
Comparative analysis of the profit efficiency levels among the major actors in broiler value chain in Ghana
Published 2025-12-01“…Data collection was done with structured interview schedules, and analysed with translog profit function, Gross margin and ANOVA using R and IBM SPSS statistical packages. …”
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4613
Clinicopathological characteristics of non-steroid anti-inflammation drug acute kidney injury
Published 2015-01-01“…Objective To further understand the characteristics of non-steroid anti-inflammatory drugs(NSAIDs) acute kidney injury(AKI).Methods Twenty-seven cases of NSAIDs-induced renal injury diagnosed from Jan 1st,2000 to Dec 31 st 2012 were enrolled,and followed up for more than one year to exclude kidney diseases induced by other drugs and origins.Characteristics of pathogenetic drugs,laboratory examinations and clinical presentations of the renal injury were analyzed.Results Acute renal injury to varying degrees was diagnosed in 27 cases.Serum creatinine were 109.8 ~730.1 μmol/L at the time of diagnosis.One patient presented minimal change disease accompanied by tubulointestitial nephritis.The main causative drugs included acetaminophen,aminopyrine,and ibuprofen,accounting for 66.7%,14.8% and 11.1%respectively.The renal injury occurred after 1 to even 60 days of drug exposure.Only 40.8% of patients with acute renal injury could be early diagnosed within 2 weeks.There were 26 cases of tubulointerstitial nephritis.Renal glucoseuria and obvious urinary α1-microglobulin could be observed.The average urinary protein was(1.1 ± 0.6)g/d.Fourteen cases were confirmed pathologically afterwards.One female patient presenting nephrotic syndrome had both minimal change disease and tubulointerstitial nephritis.All patients were given prednisone(25-40 mg/d) for a total of 3-6 months,and 18.5% of them were given prednisone in combination with immunosuppressants.During a follow-up period of one year,ten(37.0%) patients remained CKD 3-4.One patient with hepatitis B died because of severe hepatopathy.Conclusions All the NSAIDs administrated before AKI should be suspected as the causative agents,and be avoided afterwards.Among them,acetaminophen was the most frequent Tubulointerstitial nephritis was the main clinical-pathological finding,with or without minimal changes of glomerulus.Urinalysis and renal function need to be closely monitored.Timely drug withdrawal combined with prednisone was recommended on the basis of an early diagnosis.…”
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4614
Extreme genetic fragility of the HIV-1 capsid.
Published 2013-01-01“…Genetic robustness, or fragility, is defined as the ability, or lack thereof, of a biological entity to maintain function in the face of mutations. Viruses that replicate via RNA intermediates exhibit high mutation rates, and robustness should be particularly advantageous to them. …”
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4615
Correct understanding of the definition and management strategies for refractory hydrocephalus
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4616
Lipoprotein (a) Screening, and What's Next?
Published 2024-12-01“…The concentration of Lp(a) is predominantly genetically determined, governed by the expression of the LPA gene, and remains relatively stable from early adulthood. The physiological function of Lp(a) is unknown. Lp(a) is recognized as a main carrier of oxidized phospholipids and has strong atherogenic, prothrombotic, and pro-inflammatory properties. …”
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4617
Randomized Controlled Trial of Gastrocnemius Muscle Analysis Using Surface Electromyography and Ultrasound in Different Striking Patterns of Young Women’s Barefoot Running
Published 2024-11-01“…One limitation of this study is that inferring greater muscle explosive force solely based on muscle thickness and fiber length may be insufficient. Future research should incorporate biomechanical indicators, such as force plate testing, to better understand the relationship between muscle structure and function across different running styles.…”
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4618
Case Report: Pediatric CNS-isolated hemophagocytic lymphohistiocytosis secondary to uniparental disomy of PRF1 mutation
Published 2025-07-01“…Genetic analyses were performed using whole-exome sequencing (WES). NK cell function testing, Granzyme B staining, perforin staining, CD107a mobilization, and soluble CD25 levels were determined.ResultsWe report the case of a 5-year-old girl who presented with involuntary movements, an unsteady gait, and a progressively irritable temper. …”
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4619
The Longitudinal Neurophysiological Adaptation of a Division I Female Lacrosse Player Following Anterior Cruciate Rupture and Repair: A Case Report
Published 2023-04-01“…Progressive enhanced brain efficiency and functional task progressions associated with ACLR rehabilitation had notable simultaneous improvements. …”
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4620
The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease
Published 2025-04-01“…It also discusses therapeutic strategies targeting intestinal barriers, including dietary and microbiota-based interventions, while acknowledging the challenges of personalized treatment approaches. Future research should focus on multi-omics technologies and the safety and efficacy of microbiota-targeted therapies in MASLD management.…”
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