Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…An offer of research enrollment that is unfair or exploitative remains unethical regardless of whether the subject stands to benefit. Nor should benefit be expected in early-phase research. …”
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Frailty screening should be nursing business: Planning care, not just predicting outcomes by Andrea Taylor

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What Should a Good Concept of Labour Do? The Case of Digital Labour by Miguel Rudolf-Cibien, Marc-Antoine Pencolé

“…This paper argues that to advance the debate on the nature of digital labour, we must shift the discussion to the meta-semantic level and examine the functions of the concept of labour. It is not enough to simply ask “What is labour?” …”
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"An impediment to living life": why and how should we measure stiffness in polymyalgia rheumatica? by Sarah Louise Mackie, Rodney Hughes, Margaret Walsh, John Day, Marion Newton, Colin Pease, John Kirwan, Marianne Morris

“…Stiffness is closely related to function and often regarded as interchangeable with pain. …”
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Steroids and/or Cytotoxic Agents Should Be Used Early in the Management of Patients with IPF -- The Con Argument by Stephen K Field

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Why, When and How Should Clinicians Use Physiology in Patients with Acute Coronary Syndromes? by Roberto Scarsini, Dimitrios Terentes-Printzios, Giovanni Luigi De Maria, Flavio Ribichini, Adrian Banning

“…Conversely, the functional assessment of bystander coronary disease is favoured by the available evidence, aiming to achieve complete revascularisation. …”
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The trap of presumed equivalence: Artificial General Intelligence should not be assessed on the scale of human intelligence by Serge Dolgikh

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Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

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SHOULD DISEASE-MODIFYING THERAPY BE STOPPED IN PATIENTS WITH RHEUMATOID ARTHRITIS BEFORE ENDOPROSTHETIC JOINT REPLACEMENT? by N. A. Savenkova, V. N. Amirdzhanova, S. A. Makarov, A. L. Logunov, M. A. Makarov, V. V. Kolomatsky, D. V. Goryachev

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Presence of ´isolated´ tricuspid regurgitation should prompt the suspicion of heart failure with preserved ejection fraction. by Julia Mascherbauer, Andreas A Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Franz Duca, Daniel Dalos, Susanne Winkler, Matthias Schneider, Jutta Bergler-Klein, Diana Bonderman

“…<h4>Conclusions</h4>The presence of ´isolated´ functional TR should prompt the suspicion of HFpEF. …”
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Diabetes, Endothelial Dysfunction, and Vascular Repair: What Should a Diabetologist Keep His Eye on? by V. Altabas

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Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction? by Georgiana Pintea Bentea, Ahmad Awada, Brahim Berdaoui

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The default mode of chronic pain: What does it mean and how should we frame it to our patients? by Elin Johansson, Iris Coppieters, Jo Nijs

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Monoclonal antibodies against beta-amyloid protein (lecanemab and donanemab) should not be used in the treatment of Alzheimer's disease by Ricardo Nitrini, Adalberto Studart-Neto

“…These mAbs remove amyloid protein from the brain and cause statistically significant improvement in cognitive/functional tests, meaning a change in evolution of AD. …”
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How often should sitting and rising from a chair be evaluated in patients with Duchenne muscular dystrophy? by Michele Emy Hukuda, Fátima Aparecida Caromano, Renata Escorcio, Eduardo Vital de Carvalho, Silvana Maria Blascovi-Assis, Mariana Callil Voos

“…ABSTRACT Objective To determine how often sitting/rising from a chair should be assessed in Duchenne muscular dystrophy (DMD) patients to avoid redundant/missing data. …”
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Whether the Indications for Reverse Shoulder Arthroplasty Should Continue to Be Expanded? A Systematic Review and Meta‐Analysis by Huankun Li, Hangsheng Bao, Zhidong Yang, Baijun Hu, Yaocheng Pan, Yi Wang, Jiayi Chen, Hongjun Chen, Bisheng Shen, Yonggen Zou

“…Overall, the decision to use RTSA should be carefully evaluated based on the extent of the patient's rotator cuff injury.…”
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Case Reports of Patients Diagnosed with Familial Hypocalciuric Hypercalcemia, A Disorder That Should be Kept in Mind in Hypercalcemia Cases by Ayşe Derya Buluş, Yüksel Yaşartekin, Ahmet Cevdet Ceylan

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Do STEM education problem-solving tasks trigger learners’ epistemic curiosity? And why we should be astonished by Sebastian Stuppan, Markus Rehm, Tessa J. P. van Schijndel, Markus Wilhelm

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Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy? by Wenchuan Wu, Xiuzhong Yao, Chao Lin, Dayong Jin, Dansong Wang, Wenhui Lou, Xinyu Qin

“…All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. …”
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Increased Measured GFR and Proteinuria in Children with Previous Infection by SARS-CoV-2: Should We Be Concerned? by Alessia Marcellino, Silvia Bloise, Carmelo Pirone, Giulia Brandino, Antonio Barberi, Emanuela Del Giudice, Vanessa Martucci, Mariateresa Sanseviero, Flavia Ventriglia, Riccardo Lubrano

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