Trastuzumab emtansine in locally advanced or metastatic HER2 positive breast cancer; GENESIS-SEFH drug evaluation report by Patricia Miranda Romero, Roberto Marín Gil

“…On the contrary increases significantly severe thrombocytopenia; bleeding risk and liver function should also be monitored. With the current import price T-DM1 has a cost per QALY of over 120,000 €. …”
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Valbenazine for the Treatment of Adults with Tardive Dyskinesia by Harshit Gupta, Alycee R. Moity, Allison Jumonville, Sarah Kaufman, Amber N. Edinoff, Alan D. Kaye

“…However, further research, including additional direct comparison studies, should be conducted to fully evaluate this drug’s usefulness.…”
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Dynamic MRI to quantify musculoskeletal motion: A systematic review of concurrent validity and reliability, and perspectives for evaluation of musculoskeletal disorders. by Bhushan Borotikar, Mathieu Lempereur, Mathieu Lelievre, Valérie Burdin, Douraied Ben Salem, Sylvain Brochard

“…<h4>Purpose</h4>To report evidence for the concurrent validity and reliability of dynamic MRI techniques to evaluate in vivo joint and muscle mechanics, and to propose recommendations for their use in the assessment of normal and impaired musculoskeletal function.<h4>Materials and methods</h4>The search was conducted on articles published in Web of science, PubMed, Scopus, Academic search Premier, and Cochrane Library between 1990 and August 2017. …”
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Electronic Health for Kidney Transplant Recipients; A Literature Review by Sareh Kargar, Mona Kargar, Abasat Mirzaei

“…Due to the importance of preserving the transplanted organ function, transplant recipients should follow certain self-care practices after transplantation. …”
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A survey of reinforcement and deep reinforcement learning for coordination in intelligent traffic light control by Aicha Saadi, Noureddine Abghour, Zouhair Chiba, Khalid Moussaid, Saadi Ali

“…Abstract Intelligent traffic signal control is required for a transportation system to function properly. In contrast to existing traffic signals, where rules are typically developed manually, an intelligent traffic signal control system should dynamically adapt to real-time traffic. …”
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Late Presentation of Cauda Equina Syndrome with Isolated Bladder Bowel Incontinence in Massive Lower Lumbar Disc Herniation: A Series of Three Cases by Kiran Dhole, Kuber Sakhare, Nilesh Sakharkar, Pravin Agrawal, Sumedh Chaudhary, Vishal Giri

“…Bladder ultrasonography was done preoperatively and postoperatively. Bladder and bowel function improved in all three patients, but recovery duration was different in all three cases. …”
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Concurrent brain infection of herpes simplex virus and tuberculous meningitis complicated by tuberculous abscess: a case report by Esraa Alsaadi, Saja Karaja, William Borghol, Marah Abou Hala, Anas Jouhar

“…Conclusion Although the presentations of herpes simplex encephalitis and tuberculous meningitis are similar, clinicians should not exclude one diagnosis when the other is confirmed, as both conditions can coexist in the same patient, as our case report demonstrates.…”
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Economics of Plantain Production among Farmers in Northeast Nigeria by Love Joel, Abubakar Alhaji Umaru Jongur, Elizabeth Femi Adebayo, Amurtiya Michael

“…Therefore, it was recommended that agricultural extension agents should be encouraged to reach plantain farmers with the required production technologies to promote production efficiency.…”
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ENDOTHELIAL DYSFUNCTION IN STABLE ANGINA AND MYOCARDIAL INFARCTION COMBINED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE by M. A. Popova, N. N. Terentyeva, D. A. Dolgopolova, T. V. Marenina

“…Expressed depression functional vascular reserve in patients with CHD associated with COPD, should be taken into account when conducting individualized therapy of these patients.…”
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E-Government Effectiveness and Efficiency in EU-28 and COVID-19 by Sabina Hodžić, Dejan Ravšelj, Dubravka Jurlina Alibegović

“…Based on the empirical results, we can conclude that e-government is inevitable and should ensure the proper functioning of public administration during the Covid-19 pandemic.   …”
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NEURAL NETWORK MODEL OF DIAGNOSTICS OF STAGES OF DEVELOPING CORPORATE BANKRUPTCY by S. A. Gorbatkov, S. A. Farkhieva

“…The purpose of the article is to create a model that allows diagnostic of the stages of developing corporate crisis in difficult conditions of incomplete and noisy data. The model should serve as a tool for improving the objectivity and quality of decisions on the restructuring of corporate debt. …”
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Molecular characteristics and regulatory role of insulin-like growth factor 1 gene in testicular Leydig cells of Tibetan sheep by Yi Wu, Qiao Li, Xingcai Qi, Zilong Liu, Chunhui Wang, Xingxu Zhao, Youji Ma

“…First, we cloned IGF1 gene for bioinformatics analysis, and the primary Leydig cells (LCs) of Tibetan sheep were isolated to explore its effect on the proliferation, apoptosis and function of LCs. Finally, the specific regulatory mechanism of IGF1 on LCs was analyzed by transcriptome sequencing. …”
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The effects of dopamine receptor 1 and 2 agonists and antagonists on sexual and aggressive behaviors in male green anoles. by Alexandra N Smith, David Kabelik

“…However, the D1 agonist treatment was also found to impair motor function, suggesting that those effects were likely nonspecific. …”
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Robust and sensitive analysis of mouse knockout phenotypes. by Natasha A Karp, David Melvin, Sanger Mouse Genetics Project, Richard F Mott

“…We highlight how application of traditional methods, such as a Student's t-Test or a 2-way ANOVA, in these situations give flawed results and should not be used. We explore the use of mixed models using worked examples from Sanger Mouse Genome Project focusing on Dual-Energy X-Ray Absorptiometry data for the analysis of mouse knockout data and compare to a reference range approach. …”
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Establishing laboratory-specific reference intervals for TSH and fT4 by use of the indirect Hoffman method. by Sylwia Płaczkowska, Małgorzata Terpińska, Agnieszka Piwowar

“…Each medical laboratory should confirm their RIs. Up-to-date reference intervals for thyroid function hormones are still a matter of ongoing controversy. …”
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Incidence Of Acute Kidney Injury In Mild, Moderate And Severe Cases Of Coronavirus Disease by Mahvesh Mahmud, Ashok Kumar, Khurram Baqai

“…Long-term follow-up for COVID-19 patients should be done to evaluate its influence on renal outcome, and larger samples are required to elucidate the association between COVID-19 and renal damage. …”
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Evaluation of solution and rheological properties for hydrophobically associated polyacrylamide copolymer as a promised enhanced oil recovery candidate by A.N. El-hoshoudy, S.E.M. Desouky, A.M. Al-Sabagh, M.A. Betiha, M.Y. El-kady, S. Mahmoud

“…For successful application of these polymers, one should evaluate rheological and solution properties at simulated reservoir conditions as a function of polymer concentration, salinity, temperature and shear rate. …”
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GLOBAL GROWTH OF THE IMPORTANCE OF THE JUDICIARY IN THE WORLD: ON THE QUES- TION OF THE ROLE OF THE “RULE OF JURISTOCRACY” by Mykhaylo O. Baymuratov, Natalia V. Bocharova

“…It is emphasized that after the Second World War, in the conditions of the widespread use of constitutional justice, courts deviate from the control function defined by G. Kelsen and begin to impose their interpretation of law on the executive and legislative bodies. …”
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Ebstein Anomaly in Pregnancy by Lusiani Rusdi, Syahrir Azizi, Christopher Suwita, Astrid Karina, Sally A Nasution

“…Medical treatment may be followed for many years in patients with mild forms of Ebstein’s anomaly. Surgery should be considered if there is objective evidence of debasement such as significant enlargement of heart size, reduction of systolic function in echocardiography. …”
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Use of bacterial drugs for allergic diseases treatment: pros and cons by A. V. Chornomydz, O. R. Boiarchuk, O. M. Oleschuk, I. B. Chornomydz

“…Numerous studies have confirmed the important role of microbiota in the immune system development and function as well as in allergic diseases occurrence. …”
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