Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

“…Background & Aims: Cellular heterogeneity of innate immune cells, such as macrophages, in the liver is a hallmark of metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis. …”
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Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) by Antonio Bernabe-Ortiz, Neil Pearce, Hans Kromhout, Pablo Perel, Liam Smeeth, Cristina O’Callaghan-Gordo, Jason Glaser, Kristina Jakobsson, Dorothea Nitsch, Ben Caplin, Nalika Gunawardena, Adeera Levin, Vidhya Venugopal, Marvin Gonzalez-Quiroz, Sophie Hamilton, Cristina O'Callaghan Gordo, Rajiv Saran, Ricardo Correa-Rotter, Ajay Singh, Giuseppe Remuzzi, Emmanuel Burdmann, Rick Johnson, Phabdheep Kaur, Pronpimolk Kongtip, Magdalena Madero Rovalo, Moffat Nyirenda, Dorairaj Prabhkaran, Narayan Prasad, Nalika Gunawardenan

“…In this paper, we propose a standardised minimum protocol for cohort studies in high-risk communities aimed at investigating the incidence of, and risk factors for, early kidney dysfunction.Methods and analysis This generic cohort protocol provides the information to establish a prospective population-based cohort study in low-income settings with a high prevalence of CKDu. …”
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The Impact of Medication Regimen Adjustment Ratio on Adherence and Glycemic Control in Patients with Type 2 Diabetes and Mild Cognitive Impairment by Xiaoqing Song, Jingwei Wu, Yan Yang, Weijie Xu, Xiaoli Shi, Kun Dong, Mengni Li, Xi Chen, Yuping Wang, Xuna Bian, Lianlian Gao, Xuefeng Yu, Delin Ma, Jing Tao

“…Type 2 diabetes mellitus (T2DM) and cognitive dysfunction have a bidirectional relationship. This study aims to explore the impact that adjusting antidiabetic medication regimens has on medication adherence, glycemic control, and cognitive function in patients with T2DM and mild cognitive impairment (MCI). …”
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Improvement of alexithymia in patients treated in mental health services for personality disorders: a longitudinal, observational study by Hanna Sayar, Theresa Wilberg, Theresa Wilberg, Ingeborg Ulltveit-Moe Eikenæs, Andreas Ekberg, Andreas Ekberg, Kai Leitemo, Katharina Teresa Enehaug Morken, Katharina Teresa Enehaug Morken, Eileen Oftedal, Eileen Oftedal, Siri Omvik, Dag Anders Ulvestad, Dag Anders Ulvestad, Geir Pedersen, Elfrida Hartveit Kvarstein, Elfrida Hartveit Kvarstein

“…The study demonstrates moderate improvement of alexithymia during treatment in specialized PD mental health services. Further research should evaluate the effectiveness of different treatments and interventions in reducing alexithymia among PD patients.…”
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Gender aspects of incidence of antibody-mediated rejection and allograft vasculopathy events after heart transplantation by N. N. Koloskova, V. N. Poptsov, V. М. Zakharevich, I. I. Muminov, N. P. Mozheyko, O. E. Gichkun, Е. А. Nikitina, V. S. Cvan, T. A. Khalilulin, A. R. Zakiryanov, A. O. Shevchenko

“…Women-recipients of transplanted heart should undergo These measures will help to identify in time the development of antibodymediated rejection and reduce the incidence of cardiac allograft vasculopathy after heart transplant.…”
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Excellent patient-reported long-term quality of life after an Ivor Lewis esophagectomy for cancer by Alisa N. Blumenthaler, Cyrus A. Feizpour, Shadia I. Jalal, Kevin J. Lopez, Neal K. Ramchandani, Joshua McAlister, Susan M. Perkins, Yan Han, Karen M. Rieger, JoAnn Brooks, Kenneth A. Kesler

“…BackgroundLong-term health-related quality of life (HRQOL) may be impacted by upper gastrointestinal tract dysfunction following esophagectomy in up to two-thirds of patients. …”
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Epidemiological Analysis of Outcomes of Small Obstetric Operations by I. V. Taranenko, A. V. Lubimova

“…Many patients are afraid to address and ask questions about personal feelings and sexual life at the reception. Sexual dysfunction may be formed after performing obstetric benefits or injuries to the soft tissues of the birth canal, actually should be regarded as maternal morbidity. …”
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A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults by Angélica Y. Gómez-Arauz, Nallely Bueno-Hernández, Leon F. Palomera, Raúl Alcántara-Suárez, Karen L. De León, Lucía A. Méndez-García, Miguel Carrero-Aguirre, Aaron N. Manjarrez-Reyna, Camilo P. Martínez-Reyes, Marcela Esquivel-Velázquez, Alejandra Ruiz-Barranco, Neyla Baltazar-López, Sergio Islas-Andrade, Galileo Escobedo, Guillermo Meléndez

“…The apparently innocuous consumption of sucralose should be reexamined in light of these results.…”
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Lower respiratory rate during sleep in children with Angelman syndrome compared to age-matched controls by Leo Gschwind, Sebastian Camillo Holst, David Nobbs, Florian Lipsmeier, Katalin Buzasi, Ponghatai Boonsimma, Alexander Rotenberg, Vitaliy Kolodyazhniy, Jörg Felix Hipp

“…The successful use of the sleep mat device as a non-invasive physiological ambulatory monitoring tool demonstrates its potential as a digital health technology for detecting respiratory abnormalities in pediatric neurodevelopmental disorders. These findings should be further assessed and may have biomarker and clinical utility in AS, particularly in relation to seizure management and cognitive development.…”
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Impact of maternal microplastic exposure on offspring lung structure and function: Insights into transcriptional misregulation and the TGF-β/α-SMA pathway by Hong-Ren Yu, Mao-Meng Tiao, Shun-Chen Huang, Jim Jinn-Chyuan Sheu, You-Lin Tain, Jiunn-Ming Sheen, I.-Chun Lin, Ching-Chou Tsai, Li-Tung Huang, Chien-Ning Hsu, Chih-Min Tsai, Yu-Hsiu Lin, Pei-Fen Lee, Yu-Tsun Su

“…Public health measures should address the potential hazards of microplastics to fetal health.…”
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The Clinical Significance of Abnormal Electroencephalography (EEG) Patterns in Patients with Neuropsychiatric Disorders Due to Anti-NMDA Receptor Encephalitis: A Comparative Study by Alvaro Moreno-Avellán, Arely Juarez-Jaramillo, Maria del Carmen Fernandez Gonzalez-Aragon, Gerardo Quiñones-Pesqueira, Luz Maria Pineda-Centeno, Mariana Espinola-Nadurille, Victoria Martinez-Angeles, Francisco Martinez-Carrillo, Veronica Rivas-Alonso, Daniel San-Juan, Jose Flores-Rivera, Jesus Ramirez-Bermudez

“…Electroencephalography (EEG) is a widely available tool for detecting abnormalities that may aid in early detection of cases that should undergo a thorough approach. Although EEG has high sensitivity, its specificity remains a challenge. …”
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Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis by Gang Wang, Ming Chen, Yuheng Zhang, Dacheng Wang, Tao Gao, Jianfeng Duan, Huimin Lu, Minhua Cheng, Yun Xu, Xiaoyao Li, Yan Wang, Ke Cao, Wenkui Yu

“…Despite clinical recommendations for increased protein intake to counteract muscle wasting, the outcomes have been suboptimal, suggesting that anabolic resistance should be considered in addition to nutritional support. …”
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Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea by Lifeng Li, Qimeng Shi, Bowen Fang, Yuting Liu, Xiang Liu, Yongqiang Shu, Yingke Deng, Yumeng Liu, Haijun Li, Junjie Zhou, Dechang Peng

“…These alterations correlate with upper airway dysfunction and cognitive impairments, increasing accident risks. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast aging in AMA placenta remain unclear, posing a significant limitation to provide effective guidance for prenatal healthcare in clinical settings. …”
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Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protect... by John P Bourke, Gillian Watson, Francesco Muntoni, Stefan Spinty, Helen Roper, Michela Guglieri, Chris Speed, Elaine McColl, Ashish Chikermane, Sandeep Jayawant, Satish Adwani, Tracey Willis, Jennifer Wilkinson, Andrew Bryant, Thomas Chadwick, Ruth Wood, Kate Bushby

“…Fundamental questions remain as to whether prophylactic therapy is justified and convincingly superior to prompt deployment of the same therapies once left ventricular (LV) dysfunction is detected. Even if it were, at what age should therapy be introduced and with what specific drugs?…”
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YHWH as the Temporary Sanctuary in Ez.11:16 (miqdāš mĕʿaṭ): Discontinuity with Traditional Understanding of the Sacred Place-Space in the Book of Ezekiel by Vladimir LUKIN

“…The first group was influenced by the reduced form of God’s presence — the life and ministry of the prophet Ezekiel. The second group should regard the consequences associated with captivity, as a special marker of His presence with them. …”
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Headaches as somatoform disorders in children and adolescents by Anna Kostorz, Ilona Kopyta, Barbara Szwed-Białożyt, Ewa Widera-Emich, Beata Kazek

“…In diagnostically difficult cases it is recommended that analysis of biological and situational risk factors be performed with special attention paid to chronic disease of the patient and/or in his immediate family, the patient’s psychological disorders and dysfunctional or low social status families. The creation of separate criteria for somatoform disorders of the developmental age should be considered.…”
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A landscape of liver cirrhosis and transplantation in Mexico: Changing leading causes and transplant as response by Icela Palma-Lara, María Guadalupe Ortiz-López, José Bonilla-Delgado, Juanita Pérez-Escobar, Ricardo Godínez-Aguilar, Claudia Luévano-Contreras, Ana María Espinosa-García, Javier Pérez-Durán, Patricia García Alonso-Themann, Manuel Nolasco-Quiroga, Javier Flores-Estrada, Paulina Carpinteyro-Espin, Daniel Juárez-Ascencio, Nayeli Goreti Nieto-Velazquez, Carmen Palacios-Reyes

“…These efforts are necessary, whereas preventive strategies should be implemented according to leading causes.…”
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Fulminant myocarditis associated with human rhinovirus A66 infection: a case report by Shuaibing Han, Shuaibing Han, Jing Liu, Jing Liu, Ziheng Feng, Ziheng Feng, Yiyang Mao, Yiyang Mao, Hengmiao Gao, Hengmiao Gao, Zhengde Xie, Zhengde Xie, Suyun Qian, Suyun Qian, Lili Xu, Lili Xu

“…The child developed severe cardiac dysfunction and tissue hypoperfusion, and the cardiogenic shock could not be corrected despite active drug therapy. …”
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Lymphatic mapping Of Oropharyngeal Cancer (LOOC): protocol for a phase II surgical imaging trial to evaluate contralateral drainage and occult metastasis in oropharyngeal cancer by David Walker, Gareth Ambler, Chris Brew-Graves, Jason Fleming, Vinidh Paleri, Richard Shaw, Mark McGurk, Enyi Ofo, Clare Schilling, Karl Payne, Simon Wan, Alex Weller, Gopinath Gnanasegaran, Mandeep Bajwa

“…The number of contralateral nodes on SPECT/CT will be used as the denominator in calculating the sensitivity of fhSPECT in independently verified images. fhSPECT should achieve sensitivity >94%. A minimum number of 20/75 patients will be required to demonstrate contralateral drainage to proceed to the surgical stage. …”
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