Langerhans cell histiocytosis confined to extrahepatic bile duct causing sclerosing cholangitis in child: a case report by Masakazu Murakami, Shun Onishi, Yuki Ohya, Seiichi Kawabata, Kaori Isono, Yasuhiko Sugawara, Tsuguharu Asato, Yumi Honda, Yoshiki Mikami, Yukihiro Inomata, Taizo Hibi, Satoshi Ieiri

“…Abstract Background Langerhans cell histiocytosis (LCH) is an abnormal accumulation of Langerhans cells in various organs that sometimes induces organ dysfunction. LCH can affect the liver, resulting in sclerosing cholangitis and biliary cirrhosis. …”
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Characteristics and Features of the Circulatory System Status in Patients with Liver Cirrhosis as a Disease of Multiple Organ Lesions: Pathogenesis; Diagnostics; Principles of thei... by Farmaha M., Abrahamovych M., Ferko M.

“…Treatment of such patients should be individualized, aiming at the support of myocardial function and prevention of circulatory decompensation. …”
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Exploration of bioactive variants of the BMP7-derived p[63–82] peptide for ameliorating the OA-associated chondrocyte phenotype by Jessica S. J. Steijns, Tim J. M. Welting, Andy Cremers, Guus G. H. van den Akker, Pieter J. Emans, Lodewijk W. van Rhijn, Marjolein M. J. Caron

“…This research underscores that while cyclization and other structural changes may offer benefits, they should be carefully evaluated on a case-by-case basis.…”
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Dupuytren’s contracture of hand and its medical and social review by V. O. Vishnevskiy

“…In our opinion, aponeuroectomia should be regarded as complex microsurgical operation, by using rational approaches and obligatory plastic substitution of the defects of the skin. …”
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Guideline‐Recommended Therapies and Clinical Outcomes According to the Risk for Recurrent Cardiovascular Events After an Acute Coronary Syndrome by Yoav Hammer, Zaza Iakobishvili, David Hasdai, Ilan Goldenberg, Nir Shlomo, Michal Einhorn, Tamir Bental, Guy Witberg, Ran Kornowski, Alon Eisen

“…Nevertheless, the outcome of high‐risk patients after ACS has significantly improved in the past decade, thus they should not be denied these therapies.…”
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Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report by Kantoku Nagakawa, Akihiko Soyama, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Michi Morita, Sakaya Kuba, Tomohiko Adachi, Masaaki Hidaka, Hisamitsu Miyaaki, Satoru Akazawa, Ichiro Horie, Motohiro Sekino, Tetsuya Hara, Shinji Okano, Kazuhiko Nakao, Susumu Eguchi

“…Abstract Background Thyroid storm can be complicated by liver dysfunction, which may occasionally progress to acute liver failure. …”
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The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023 by Miaomiao Zhao, Miaomiao Zhao, Haoxiang Chang, Haoxiang Chang, Yuxu Yue, Yuxu Yue, Xinyue Zeng, Xinyue Zeng, Shaobang Wu, Shaobang Wu, Xiuyun Ren, Xiuyun Ren

“…BackgroundPeriodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of the teeth triggered by bacterial infection and is recognized to promote systemic inflammation, leading to dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, gestational diabetes and preeclampsia, are linked to pregnancy complications. …”
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Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population by Tharanga Mudalige, Vindya Pathiraja, Gayathri Delanerolle, Heitor Cavalini, Shuqi Wu, Julie Taylor, Om Kurmi, Kathryn Elliot, Sharron Hinchliff, Carol Atkinson, Kristina Potocnik, Paula Briggs, Lucky Saraswat, Helen Felicity Kemp, George Eleje, Toh Teck Hock, Cristina Laguna Benetti‐Pinto, Irfan Muhammad, Rabia Kareem, Yassine Bouchareb, Peter Phiri, Ruishu Zhang, Yunfei Weng, Ieera Aggarwal, Jian Qing Shi, Ashish Shetty, Ian Litchfield, Nirmala Rathnayake, Sohier Elneil

“…The review highlighted a lack of diversity in terms of ethnicity, age and comorbidity status, which are essential to fully understanding the impact of POP. Future research should focus on these underrepresented factors.…”
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Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation by Christophe Tribouilloy, Yohann Bohbot, Benjamin Essayagh, Giovanni Benfari, Jeroen J. Bax, Thierry Le Tourneau, Yan Topilsky, Clemence Antoine, Dan Rusinaru, Francesco Grigioni, Nina Ajmone Marsan, Aniek vanWijngaarden, Aviram Hochstadt, Jean Christian Roussel, Prabin Thapa, Michelena Hector I, Maurice Enriquez‐Sarano

“…These findings suggest that ≥moderate FTR should lead to consideration of early mitral surgery to improve outcomes.…”
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Immunological cluster complexes in kidney transplantation by S. V. Zybleva, S. L. Zyblev

“…To assess the immune response in allogeneic kidney transplantation, a set of immune cells with a phenotype should be determined: CD3+CD4+CD25+highCD127+low, CD3+CD4-CD8-, CD3+CD4+CD69+, CD3+CD16+CD56+, CD19+CD5+, LIN-HLA-DR+CD11c-CD123+, CD3+CD8+CD69+, CD3+CD4+CD8+, CD3+CD8+CD38+, CD19+CD86+, CD19+IgD+CD27-, CD3-CD16+CD56+, CD3+CD38+, CD14+lowCD86+, LIN-HLA-DR+CD11c+CD123-. …”
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Association Between Platelet and Cerebral Small Vessel Disease: A Secondary Analysis Based on a Retrospective Cross‐Sectional Study in Korean Adults by Shujuan Huang, Hanbo Chen, Linbo Cai, Zhaoxi Liu, Zhanbo Yu, Yuqin Dan, Danghan Xu, Yunxuan Huang

“…Additionally, future research should investigate the biological mechanisms linking platelet count to CSVD, particularly the roles of platelet activation, inflammation, and endothelial dysfunction, to provide a more comprehensive understanding of this association.…”
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The role of melatonin in the regulation of the immune system and reproductive health: mechanisms and prospects for clinical application by M. M. Zhelavskyi, S. P. Kernychnyi, O. Ya. Dmytriv, T. V. Betlinska

“…Future research should focus on clinical applications of melatonin supplementation in treating infertility, pregnancy-related complications, and immune-mediated diseases. …”
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Unusual Presentation of Metastatic Medullary Thyroid Cancer Involving Bone Marrow, Kidneys, and Adrenal Gland: A Literature Review Based on a Case Report by Pouya Ebrahimi, Moloud Payab, Alireza Shariati, Neda Alipour, Aysan Nozheh, Seyed Mohammad Tavangar, Homa Taheri, Mahbube Ebrahimpur

“…In cases of unjustifiable pancytopenia or adrenal dysfunction in MTC‐positive patients, these possibilities should be considered and ruled out by some specific evaluations, such as bone marrow biopsy and contrast‐enhanced imaging.…”
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Functional immune profiling of hyper- and hypo-inflammatory subphenotypes of critical illness: a secondary analysis by E. Scott Halstead, E. Scott Halstead, E. Scott Halstead, Daniel J. McKeone, Daniel J. McKeone, Abigail M. Samuelsen, Shouhao Zhou, Anthony S. Bonavia, Anthony S. Bonavia, Anthony S. Bonavia

“…Future investigations should focus on prospective validation of this panel for prognostic enrichment of clinical research studies.…”
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Influence of the metabolic and inflammatory profile in patients with frozen shoulder – systematic review and meta-analysis by Dina Hamed-Hamed, Celia Rodríguez-Pérez, Leo Pruimboom, Santiago Navarro-Ledesma

“…Conclusion This meta-analysis highlights the role of metabolic dysfunction and chronic inflammation in the pathogenesis of FS. …”
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Effects of sleep deprivation on heart rate variability: a systematic review and meta-analysis by Suling Zhang, Xiaodan Niu, Jinke Ma, Jinke Ma, Xin Wei, Xin Wei, Jun Zhang, Jun Zhang, Weiping Du

“…These findings imply a potential disruption of the dynamic balance between sympathetic and parasympathetic activity following sleep deprivation. Future research should adopt standardized HRV measurement protocols to validate these findings and further explore the underlying physiological mechanisms. …”
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Biomarkers and therapeutic targets in early Alzheimer’s disease: an Olink proteomics study by Jianan Wei, Hui Ni, Weiwei Liu, Hui Xu, Chen Wang, Geng Geng, Zhongwei He, Guofang Chen, Guofang Chen

“…Future large-scale longitudinal studies should validate their clinical utility.…”
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Advances in Development of PM2.5-Exposed Animal Models and Their Application in Reproductive Toxicity Research by TIAN Fang, PAN Bin, SHI Jiayi, XU Yanyi, LI Weihua

“…For female reproductive toxicity, the primary indicators are reduced ovarian reserve, endocrine dysfunction, endometrial damage, and adverse perinatal reactions. …”
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Abstract 126: Bilateral Limb Shaking TIA secondary to Severe Bilateral Carotid Stenosis by Muhannad Seyam, Michael Hehir, Fatemeh Sobhani

“…The constellation of “limb shaking” spells precipitated upon standing or physical activity with resolution after activity cessation should raise suspicion for limb‐shaking TIA and warrant vascular imaging. …”
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A bibliometric analysis of targeted therapy cardiotoxicity research in cancer patients (2004–2024) by Guoming Chen, Guang Chen, Huiping Zhou, Qingyi Yang, Yifan Shang, Rui Qin, Yingyue Hou, Cheng Zhang, Jiarui Lin, Xuan Ye, Ning Wang, Yibin Feng

“…By identifying key research priorities, this analysis addresses critical gaps in current knowledge. Future endeavors should prioritize translational innovations and multidisciplinary clinical frameworks to enhance therapeutic safety.…”
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