Pregnancy-Associated Plasma Protein-A and Free β-Human Chorionic Gonadotrophin in Relation with Oxidative Stress in Obese Pregnant Women: A Clinical Cross-Sectional Study by Vanja Dimitrov, Maria Mikerova, Vladimir Reshetnikov, Victor Mikhailovsky, Sasa Raicevic, Sergey Bolevich, Vladimir Jakovljevic, Tamara Nikolic Turnic

“…<b>Conclusions</b>: The determination of systemic parameters of OS in early pregnancy could be a good methodological approach in the screening/treatment of obesity during pregnancy and this approach should be followed for the screening of endothelial dysfunction in pregnancy which needs further monitoring and/or treatment.…”
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Compatibility of pulse–pulse intervals with R–R intervals in assessing cardiac autonomic function and its relation to risks of atherosclerosis by Cheuk-Kwan Sun, Cyuan-Cin Liu, Wei-Min Liu, Hsien-Tsai Wu, Ruay-Ming Huang, An-Bang Liu

“…Conclusion: PPI may be an alternative parameter for effectively assessing cardiac autonomic function in nonoverweight healthy individuals. It should be used carefully in overweight, elderly, or diabetic individuals.…”
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The Phosphatase PHLPP2 Plays a Key Role in the Regulation of Pancreatic Beta-Cell Survival by Marta Letizia Hribal, Elettra Mancuso, Gaetano Paride Arcidiacono, Annalisa Greco, Donatella Musca, Teresa Procopio, Mariafrancesca Ruffo, Giorgio Sesti

“…They also contribute to shed some light on β-cell dysfunction, a complex and unsatisfactorily characterized phenomenon that has a central causative role in the pathogenesis of type 2 diabetes.…”
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Uncovering Factors Related to Pancreatic Beta-Cell Function. by Aoife M Curran, Miriam F Ryan, Elaine Drummond, Eileen R Gibney, Michael J Gibney, Helen M Roche, Lorraine Brennan

“…<h4>Aim</h4>The incidence of type 2 diabetes has increased rapidly on a global scale. Beta-cell dysfunction contributes to the overall pathogenesis of type 2 diabetes. …”
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Redo inferior pubectomy for failed anastomotic urethroplasty in pelvic fracture urethral injury by Lin Wang, Wenxiong Song, Xufeng Peng, Rong Lyu, Jijian Wang, Chongrui Jin, Chao Feng, Xiangguo Lyu, Yinglong Sa, Yidong Liu

“…In complicated cases, it should be known and mastered.…”
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Combination of chronic myocarditis and progressive coronary artery disease: differential diagnosis and stepwise treatment by Yu. A. Lutokhina, O. V. Blagova, V. P. Sedov, V. A. Zaidenov, A. V. Nedostup

“…The presence of moderate coronary atherosclerosis without signs of ischemia and myocardial infarction should not be considered as the only cause of severe systolic myocardial dysfunction. …”
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Stent-assisted coiling of hepatic artery pseudoaneurysm in a liver transplant recipient by Shubham Suryavanshi, Akhil Baby, Sudheer Pargewar, Rochan Pant, Rajesh Sasidharan

“…Case presentation We report a case of a 45-year-old male with metabolic dysfunction-associated steatotic liver disease who underwent living donor liver transplantation using a right lobe graft. …”
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Intracerebral Hemorrhage: A Fatal Complication of Severe Preeclampsia&amp;mdash;A Rare Case Report in a Resource-Limited Setting by Mohamed IA, Omar AA, Hassan MM, Hassan MA, Adan ZM, Mohamed ZA

“…The underlying mechanisms include endothelial dysfunction, cerebral autoregulation failure, and breakdown of the blood-brain barrier. …”
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Modern view on hepatic encephalopathy: basic terms and concepts of pathogenesis by T. V. Shulyatnikova, V. A. Shavrin

“…In case of hepatic dysfunction and/or portosystemic shunting, the concentration of ammonia in blood increases up to 10 times and the main load for its detoxification is shifted to myocytes and astroglia. …”
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Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment by Shurui Zhang, Jingwen Li, Xinyu Hu, Hanshu Liu, Qinwei Yu, Guiying Kuang, Long Liu, Danfang Yu, Zhicheng Lin, Nian Xiong

“…Brain-derived extracellular vesicles contribute to disease progression through multiple mechanisms, including autophagy-lysosome dysfunction, neuroinflammation, and oxidative stress, collectively driving neurodegeneration in Parkinson’s disease. …”
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Macrotroponin interference and association with cardiotoxicity in patients receiving cardiotoxic breast cancer therapy: a pilot study by Andrea Soosaipillai, Inbar Nardi-Agmon, Davor Brinc, Anselmo Fabros, Peter A. Kavsak, Paaladinesh Thavendiranathan, Ashley Di Meo

“…Abstract Background Cancer therapy-related cardiac dysfunction (CTRCD) is an important adverse effect in patients receiving potential cardiotoxic cancer therapies. …”
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Long-term dental follow-up in hematological stem cells transplantation children by Luiz Alberto Valente Júnior, Paulo Sérgio da Silva Santos, Fabio Luiz Coracin, Alexandre Viana Frascino, Marcelo Fava, Vicente Odone Filho

“…Further investigations should be performed to provide accurate information for patients, parents and health care professionals. …”
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Clinical features of macrophage activation syndrome in adult dermatomyositis: A single‐center retrospective case‐control study by Dingxian Zhu, Shuni Ying, Changyi Yang, Sheng Li, Shunli Tang, Chuanyin Sun, Hong Fang, Jianjun Qiao

“…When RP‐ILD is present in dermatomyositis patients with abnormal laboratory findings, such as cytopenia and hyperferritinemia, the presence of MAS should be considered.…”
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New discoveries in therapeutic targets and drug development pathways for type 2 diabetes mellitus under the guidance of precision medicine by Xinyi Tian, Liuqing Wang, Lu Zhang, Xiao Chen, Wenjun Wang, Kaiqi Zhang, Xiaolei Ge, Zhengrong Luo, Xu Zhai, Huaqiang Shao

“…Abstract Type 2 diabetes mellitus (T2DM) is a complex metabolic disease involving multiple pathophysiological mechanisms, such as insulin resistance and β-cell dysfunction. Recently, the emergence of precision medicine has ushered in new ideas and strategies for the treatment of T2DM. …”
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Identification of Risk Factors and Predictive Indicators for Tigecycline‐Associated Hypofibrinogenemia by Xiaohui Liu, Xuefeng Yuan, Long Wen, Xin Tan, Qian Sui, Jiheng Liu

“…Healthcare professionals should be aware that the administration of tigecycline may be associated with hypofibrinogenemia and severe adverse reactions. …”
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The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells by Tetiana Katrii, Tanya Freywald, Malkon G. Estrada, Amr El Zawily, Behzad Toosi, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, Scot C. Leary

“…Conclusion Our data collectively suggest that FIS1 targeting should allow for the suppression of TICs in TNBC tumors without compromising mitochondrial functionality or causing major, systemic toxicity. …”
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Insights into the Incidence, Course, and Management of Lithium-Induced Hypothyroidism in Real-World Psychiatric Practice in Italy by Simone Pardossi, Mario Pinzi, Matteo Cattolico, Maria Beatrice Rescalli, Lorenzo Nicchi, Benedetta Tuci, Elisa Mariantoni, Alessandro Cuomo

“…However, lithium use requires careful monitoring of thyroid function due to associated dysfunctions. The aim of our real-world study is to retrospectively evaluate the impact of lithium on thyroid function and how these thyroid alterations can be measured and managed. …”
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Acute kidney injury caused by ureteral obstruction after Deflux® injection treatment for vesicoureteral reflux after pediatric kidney transplantation: a case report by Yujiro Aoki, Yuko Hamasaki, Junya Hashimoto, Ayuko Zaitsu, Maho Maeda, Masaki Muramatsu, Takeshi Kawamura, Seiichiro Shishido, Ken Sakai

“…At 4 months after KT, VUR (grade IV) and bladder dysfunction worsening were detected by voiding cystourethrography. …”
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Diagnosis and Treatment of Low Anterior Resection Syndrome by Masaaki Miyo, Emi Akizuki, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Ichiro Takemasa

“…Future surgical treatment should focus not only on the radical cure of cancer and safety of treatment but also on the maintenance and improvement of QOL, with particular attention to the preservation of function. …”
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Cre recombinase affects calcium dynamics already in young mice by János Levin Liffers, Jan Peter Reinhardt, Matthias Dodo Seidl, Uwe Kirchhefer, Frank Ulrich Müller, Jan Sebastian Schulte

“…Because changes in intracellular Ca2+ dynamics can affect gene expression through altered excitation-transcription coupling, researchers should be aware of these subtle changes that precede the prominent phenotype at 6 months of age. …”
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