Real-world analysis of leuprorelin acetate microspheres-based neoadjuvant therapy for patients with high-risk prostate cancer by Changde Fu, Jun Xin, Jinjin Lai, Xu Zeng, Yongnan Wang, Wei Zhang

“…Meanwhile, alkaline phosphatase before neoadjuvant therapy, at one month (M1), 3 months (M3), 6 months (M6), and 12 months (M12) after surgery tended to be increased (P=0.029), but this increment lacks clinical significance, while the glomerular filtration rate (P=0.441) and albumin (P=0.548) did not vary among different time points. Erectile dysfunction and loss of libido was the most common adverse event, with incidences of 84.9% during neoadjuvant therapy, 79.2% at M1, 71.7% at M3, 67.9% at M6, and 56.6% at M12.ConclusionBoennuokang® leuprorelin acetate microspheres-based treatment as neoadjuvant therapy decreases PSA, testosterone, and prostate volume, with acceptable positive surgical margin rate in patients with high-risk prostate cancer and its safety profiles should be validated.…”
Get full text

African Americans with a family history of cardiovascular disease show lower endothelial‐dependent vasodilation by Julian F. Thayer, Darcianne K. Watanabe, Julia Birenbaum, Julian Koenig, Marc Jarczok, DeWayne P. Williams, Gaston K. Kapuku

“…Future prospective studies are needed and should consider measures of sympathetic activity and potential moderators, including discrimination.…”
Get full text

Decoding Parkinson’s diagnosis: An OCT-based explainable AI with SHAP/LIME transparency from the Persian Cohort Study by Zohreh Ganji, Farzaneh Nikparast, Naser Shoeibi, Ali Shoeibi, Hoda Zare

“…The integration of multimodal data, explainability, and imbalance robustness positions it as a scalable tool for resource-limited settings. Future work should validate biomarkers across diverse populations and standardize OCT protocols.…”
Get full text

Effectiveness of Ultrasonographic Unilateral Dual Transversus Abdominis Plane Block in Pain Control in Pediatric Renal Transplantation: A Randomized Controlled Trial by Sherif M. Soaida, Heba M. Nassar, Ahmed Hazem, Pierre Zarif Tawadros, Hany A. Morsi, Ahmed I. Shoukry, Ahmed M. Shouman, Fatina I. Fadel, Hafez M. Bazaraa, Doaa M. Salah, Mohamed A. Abdel Mawla, Dina A. Salah, Mohamed A. Selim

“…Conclusion: Ultrasound-guided unilateral dual TAP block is an effective and safe regional anesthesia technique that reduces postoperative opioid requirements and provides stable intraoperative hemodynamics in pediatric renal transplant recipients. It should be considered part of a multimodal analgesia strategy in this high-risk population.…”
Get full text

Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces by Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Masaki Hiramoto, Satoru Yamagishi, Takayasu Mishima, Shin’ichiro Yasunaga, Yoshio Tsuboi, Nobutaka Hattori, Jane Y. Wu

“…It is well-established that age is a major risk factor for neurodegeneration. Future research should address how aging and neuronal guidance signaling interact to influence an individual’s susceptibility to various late-onset neurological diseases and how the progression of these diseases could be therapeutically blocked by targeting neuronal guidance pathways.…”
Get full text

Efficacy of transbronchial biopsy and frequency of pneumothorax in lung transplant recipients: single center experience by Ertan Sarıbaş, Ayse Nigar Halis, Sevinç Çıtak, Gonca Gecmen, Ahmet Murat Kazan, Musatafa Vayvada, Murat Ersin Cardak, Ahmet Erdal Taşçı

“…Given its diagnostic value, we believe that the procedure should not be avoided due to the risks of complications.…”
Get full text

HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“…Conclusion: In patients with dengue infection, trend of hematological parameters should be be monitored closely on ......... …”
Get full text

Inotropes and Vasopressors Use in Critical Care and Perioperative Medicine: Evidence-Based Approach (Review) by A. Belletti, M. L. Azzolini, L. Baldetti, G. Landoni, A. Franco, A. Zangrillo

“…Norepinephrine has been traditionally considered contraindicated in patients with ventricular dysfunction, but recent trials suggested hemodynamic effects similar to epinephrine in patients with cardiogenic shock. …”
Get full text

The Role of Cystatin C in the Prediction of Contrast-Induced Acute Kidney Injury Following Coronary Procedures: A Systematic Review by Azad Mojahedi, Andreas P. Kalogeropoulos, On Chen, Hal Skopicki

“…Hence, future research should focus on standardizing CysC cut-off values and further explore their implications in broader clinical settings and guidelines.…”
Get full text

Androgenic anabolic steroid-induced liver injury: two case reports assessed for causality by the updated Roussel Uclaf Causality Assessment Method (RUCAM) score and a comprehensive... by Mark R Thursz, Robin Daniel Abeles, Matthew Foxton, Shahid Khan, Robert Goldin, Belinda Smith, Suman Verma

“…Causality assessment using the updated RUCAM should be performed but defining indications and proving efficacy for therapies remains challenging.…”
Get full text

Pre-hospital cooling in community-acquired heat stroke (CAHS): evidence, challenges, and strategies by Shu Cong, Guangxin Zheng, Xiaojuan Liang, Jianjun Gui, Hong Zhang, Jun Wang

“…Abstract Background Heat stroke (HS) is a critical medical emergency characterized by severe hyperthermia and central nervous system dysfunction, occurring predominantly in conditions of high ambient temperatures or through physical exertion. …”
Get full text

Lumbopelvic Stability and Trunk Muscle Contractility of Individuals with Chronic Ankle Instability by Ryan S McCann, Kelly Johnson, Ashley M B Suttmiller

“…# Background Chronic ankle instability (CAI) results in hip neuromuscular impairments that can perpetuate dysfunction through reduced lumbopelvic stability and subsequent malpositioning of the lower body during functional movement. …”
Get full text

Steroid-responsive autoimmune psychosis with cerebrospinal fluid-restricted oligoclonal bands and positive tissue-based assay findings: a case series of three patients by Yuanyuan Luo, Hao Sun, Jian Fan, Xu Zhang, Ying He

“…Autoimmune psychosis should be considered when antipsychotic drugs or modified electroconvulsive therapy are not effective in patients with psychotic disorders.…”
Get full text

Supervised—not voluntary—upper limb exercise enhances vestibular function in Parkinson’s disease by Federica Ginanneschi, David Cioncoloni, Carla Battisti, Armando Bucciarelli, Federica Dominici, Roberto Marconi, Alessandro Rossi, Lucia Monti

“…BackgroundGait dysfunction has emerged as the greatest challenge in Parkinson disease (PD) management. …”
Get full text

HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“…Conclusion: In patients with dengue infection, trend of hematological parameters should be be monitored closely on ......... …”
Get full text

Hemoglobin cast nephropathy: a rare but serious complication of hemolysis in a pediatric patient by Demet Baltu, Nihan Avcu Oral, Selman Kesici, Rezan Topaloğlu, Osman İlhami Özcebe, Tekin Aksu, Diclehan Orhan, Fatih Özaltın

“…Therefore, pediatricians should be aware of this rare clinical entity during clinical practice. …”
Get full text

Encephalopathy Associated with Severe Cytomegalovirus Infection in an Immunocompetent Young Woman by Syuichi Tetsuka, Tomohiro Suzuki, Tomoko Ogawa, Ritsuo Hashimoto, Hiroyuki Kato

“…Considering such a background, clinicians should keep severe primary CMV infection in mind as a differential diagnosis in the clinical setting.…”
Get full text

Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up by Hiroaki Kanno, Kyoko Ishida, Wataru Yamada, Ikumi Shiraki, Hiroki Murase, Yuka Yamagishi, Kiyofumi Mochizuki

“…HLA-DR4 or the allele of DRB1∗04 was present in all (100%) patients. Conclusions. TINU should be considered in the differential diagnosis in young patients with uveitis of unknown origin and renal dysfunction. …”
Get full text

Non-surgical treatment of cervical radiculopathy in outpatient settings. Case report by Aleksei I. Isaikin, Ekaterina K. Kerimova, Kinan Mouki

“…When assessing radicular compression, neuroimaging data should be interpreted only in the context of clinical presentation. …”
Get full text

Perioperative Management of a Patient with Hereditary Angioedema and Intestinal Obstruction Secondary to an Ileal Tumor: A Case Report by Antony Peter Gatheru, Anne Kasyoka Barasa, Isaac Karogo Mwangi, Stanley Ngare, Dan Kiptoon, Edwin Oloo Walong

“…Hereditary angioedema (HAE) is a rare genetic disorder resulting from deficiency or dysfunction of the C1-esterase inhibitor (C1-INH, C1-inhibitor) protein. …”
Get full text