N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness by Estefani Y. Hernández-Cruz, Omar E. Aparicio-Trejo, Fadi A. Hammami, Daniel Bar-Shalom, Martin Tepel, Jose Pedraza-Chaverri, Alexandra Scholze

“…Furthermore, studies suggest that very high concentrations of NAC should be avoided because they could exert reductive stress. …”
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Complex lupus management: when multiple organs demand precision by Hirushi S. Jayasekera, Ayman Askari, Sourabh Chand

“…Management required significant consideration because of high disease activity (SLEDAI 16) complicated by pancytopenia and liver dysfunction.Therapeutic options were systematically evaluated to balance efficacy and safety given the patient's pancytopenia, liver dysfunction and renal involvement.3,7. …”
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Transplantation and Pregnancy by Pinar Erkan Uc, Sermet Sagol

“…Ideally, preconception counseling should begin in the period before transplantation. …”
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Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis by Zheng T, Pei Z, Huang X

“…To advance research in this field, more rigorous and scientific multi-center studies should be designed and further cooperation and academic exchange should be strengthened.Keywords: perioperative medicine, dexmedetomidine, bibliometrics, anesthesia…”
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Martial law in Ukraine as a risk factor for gestational disorders by L. Markin, M. Malachynska, O. Korytko

“…Stress should be carefully operationalized and include the protective role of resilience. …”
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Metabolic Syndrome: the Influence of Adipokines on the L-Arginine-NO Synthase-Nitric Oxide Signaling Pathway by L. A. Kuznetsova

“…They either activate an enzyme involving 5-AMP protein kinase or Akt kinase, increasing its activity and synthesis of NO in the tissues of healthy patients: adiponectin, adipolin, omentin, or inhibit the activity of eNOS, which leads to a decrease in NO-synthase and suppression of mRNA bioavailability: vaspin, visfatin, apelin in metabolic syndrome, and a decrease in its activity leads to dissociation and endothelial dysfunction. It should be noted that the bioavailability of NO formed by NO-synthase is affected at many levels, including: the expression ofNO-synthase mRNA and its protein; the concentration of L-arginine; the level of cofactors of the reaction; and to detect the maximum activity of endothelial NO-synthase, dimerization of the enzyme is required, posttranslational modifications are important, in particular, phosphorylation of endothelial NO-synthase by serine 1177 with the participation of 5-AMP protein kinase, Akt kinase and other kinases. …”
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Lumbar-peritoneal shunt for idiopathic normal pressure hydrocephalus and secondary normal pressure hydrocephalus by Chia-Lin Liao, Pao-Hui Tseng, Hsin-Yi Huang, Tsung-Lang Chiu, Shinn-Zong Lin, Sheng-Tzung Tsai

“…Lumbar drainage test provides prerequisite outcome prediction and should be considered to identify NPH patients planned to receive LP shunt.…”
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ECOLOGICAL APPROACH TO THE ANALYSIS OF CONDITIONS OF FAMILY LIFE by E. V. Goltcova

“…Therefore, the family, which has appeared as a result of the crisis of civilization in the midst of all the negative, crisis processes, should be the center of attention of scientists, public figures and politicians, legislative and executive branches. …”
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The choice of blood transfusion strategy in severe traumatic brain injury by D. V. Oleniuk, O. V. Tsarov

“…One of the main directions of treatment for patients with TBI is to prevent the development of secondary brain damage due to systemic dysfunction. Anemia occupies an important place among them. …”
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Advanced Ultrasound Screening for Temporomandibular Joint (TMJ) Internal Derangement by Saul N. Friedman, Miriam Grushka, Hussam K. Beituni, Madhu Rehman, Hart B. Bressler, Lawrence Friedman

“…If a component of medial disc displacement is suspected, MRI should be performed despite a normal screening US.…”
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Clinical efficacy and safety of nerve-sparing radical hysterectomy for cervical cancer: a systematic review and meta-analysis. by Ying Long, De-Sheng Yao, Xin-Wei Pan, Ting-Yu Ou

“…The findings should be verified in larger, well-designed studies.…”
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Coronary vasospasm testing: escape from the cath lab! by Ana Djordjevic Dikic, Srdjan Dedic, Nikola Boskovic, Vojislav Giga

“…Association between coronary flow, global longitudinal strain and microvascular dysfunction (MVD) and impaired values at hyperemia was previously demonstrated. …”
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Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective by Seyed Ali Reza Mortazavi, Abdollah Jafarzadeh, Abdolkarim Ghadimi-Moghadam, Seyed Mohammad Javad Mortazavi, Masoud Haghani, Ali Ghadimi-Moghadam, Lembit Sihver

“…The effectiveness of physical treatment methods, e.g., Low Dose Radiation Therapy (LDRT) should be compared to pharmacological treatments.…”
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Is chronic neck pain related to scapular dyskinesia? A systematic review by Norollah Javdaneh, AmirHossein Barati, Sadredin Shojaedin, Roohollah Mohammadi Mirzaei

“…Conclusions The study implies that physical therapy practices should consider assessing and addressing scapular kinematics in patients with neck pain, as scapular dysfunction may contribute to their symptoms. …”
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Modern aspects of management of patients with polycystic ovary syndrome by N. V. Avramenko, O. V. Kabachenko, D. Ye. Barkovskyi, К. V. Sierykh

“…At stage 2, thyroid pathology should be excluded. This includes the following tests and examinations: thyroid-stimulating hormone, thyroidglobulin antibodies, Peroxidasa antibodies, ultrasound examination, hyperprolactinemia (prolactinoma), congenital suprarenal dysfunction (21-hydroxylase deficiency), Itsenko–Cushing’s syndrome, acromegaly, virilizing tumors. …”
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Correlation between binocular vision function and visual fatigue in school-age children with myopic anisometropia by Yingpin Cao, Jiajia Ye, Aiqin Nie, Dan Sun, Ming-ming Yang

“…Clinically, binocular accommodation and vergence function should be carefully assessed in myopic patients, especially those with anisometropia, and visual fatigue interventions should include training of accommodative and vergence facility to enhance visual quality.…”
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Strongyloides stercoralis Dissemination and Hyperinfection Associated with Long-Term Steroid Treatment in a Neurosurgical Population by Mariana Constante, João Domingos, Francisco Neves Coelho, Teresa Baptista Fernandes, Teresa Baptista, Marta Maio Herculano

“…Preventive strategies and subsequent treatment should be considered in patients with a risk of acquisition or dissemination. …”
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Investigating the relationship between plasma natriuretic peptide levels and chronic kidney disease stages in patients with and without concurrent heart failure by Umesh Kumar Pandey, Shivendra Singh, Uttam Kumar Singh, Nikhil Chaudhary

“…However a stage based or eGFR based cut off should be used for analysis.…”
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Effects of propofol on the cognition and hippocampal N-methyl-D-aspartate subunits expression in an MPTP-induced Parkinson’s disease rat model by Ping Zhu, Yongyan Zhang, Hua Xu, Yu Ren

“…Our current data demonstrate a correlation, not direct causation, between NR2A/NR2B dysregulation and cognitive impairment. Future studies should probe whether this imbalance is a driver or consequence of synaptic dysfunction.…”
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Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain by Changming Wang, Leying Gu, Yonglan Ruan, Tana Gegen, Lei Yu, Chan Zhu, Yan Yang, Yuan Zhou, Guang Yu, Zongxiang Tang

“…Finally, we found that the pain behavior attenuated in dysfunction of both Pirt and TRPV1 was much stronger than in dysfunction of Pirt or TRPV1 only in a CCI model in vitro study. …”
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