Navigating the Dry Eye Therapeutic Puzzle: A Mechanism-Based Overview of Current Treatments by Jason Betz, Anat Galor

“…<b>Background/Objectives</b>: Dry eye disease (DED) is a multifactorial condition with complex pathophysiology involving tear film instability, ocular surface inflammation, and nerve dysfunction. This review summarizes current evidence on the different available therapies targeting these mechanisms. …”
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Pathophysiology and potential treatment modalities in women with recurrent urinary tract infection by Wei-Ju Liao, Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Yu Khun Lee, Cheng-Ling Lee, Tien-Lin Chang, Hann-Chorng Kuo

“…Hence, to improve the clinical outcomes and quality of life of patients with rUTIs, future research should focus on refining the use of PRP, exploring combination therapies, and validating biomarkers.…”
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Molecular mechanism of phytochemical compounds in mitigating hypertension by Putri Cahaya Situmorang, Syahputra Wibowo, Masitta Tanjung, Raden Jokokuncoroningrat Susilo, Ananda, Rizal Mukra, Alexander Patera Nugraha, Wida Akasah

“…Conclusion: Phytochemicals offer a multi-targeted and sustainable strategy for hypertension management. Future research should prioritize clinical trials, pharmacokinetics, personalized approaches, and advanced delivery systems to translate preclinical findings into clinical practice and improve outcomes in hypertensive populations.…”
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A systematic review of Alzheimer's disease: exploring genetic and environmental risk factors, biomarkers, and future pharmacotherapy for cognitive decline and neurodegeneration by Debraj Dey, Deepannita Roy Mukherjee, Abu Shoeb, Pinki Biswas, Saikat Santra

“…Aging is the primary risk factor, but metabolic, genetic, and environmental influences, including inflammation and vascular dysfunction, significantly contribute to disease onset and progression. …”
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Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation by Ao Liu, Mengting Huang, Yuwen Xi, Xiaoling Deng, Keshu Xu

“…Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a global health burden, however, therapeutic advancements remain hindered by incomplete insights on mechanisms and suboptimal clinical interventions. …”
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Persistent Angina With Nonobstructive Coronary Artery Disease by Philip Macanovic, BSc, MBBS, Kevin Cheng, MA, BMBCh, Anantharaman Ramasamy, MBChB, PhD, John Baksi, BSc, MBBS, PhD, Ranil de Silva, MBBS, BSc, PhD

“…Background: Coronary microvascular dysfunction (CMD) is frequently the cause of patients presenting with angina with nonobstructed coronary arteries and may have increased prevalence in cancer survivors. …”
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Risk Factors for MAFLD and Advanced Liver Fibrosis in Adult-Onset Craniopharyngioma Patients: A Cross-Sectional Study by Chen L, Wu W, Ye H

“…Strategies such as controlling weight gain, maintaining optimal blood glucose and blood pressure levels, appropriate hormone replacement, and avoiding excessive glucocorticoid use should be implemented to prevent and delay the onset and progression of MAFLD and ALF.Keywords: craniopharyngioma, adult-onset, hypopituitarism, metabolic dysfunction-associated fatty liver disease, advanced liver fibrosis…”
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Understanding Post-COVID-19: Mechanisms, Neurological Complications, Current Treatments, and Emerging Therapies by Zambrano K, Castillo K, Peñaherrera S, Vasconez HC, Caicedo A, Gavilanes AWD

“…Keywords: post-acute COVID-19 syndrome, PACS, long COVID-19, cognitive dysfunction, mitochondrial therapy…”
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Women-specific reference ranges for serum TSH in Liguria: the impact of age and year of collection in a single-center cross-sectional study by Massimo Giusti, Marilena Sidoti

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Petroleum Jelly Versus Tea Tree Oil and Tea Tree Facial Wash Lid Scrub in Patients with Blepharitis Associated with Above-normal Demodex Count by Karen Angela L. Tiuseco, MD, Ruben Lim Bon Siong, MD, Johann Michael Reyes, MD, Eleonor B. Iguban, MD

“…Purpose: To determine the effectiveness of lid scrub with petroleum jelly versus lid scrub with tea tree oil and tea tree facial wash in patients with symptomatic blepharitis associated with above-normal Demodex counts Methods: Patients with symptomatic anterior blepharitis (AB), meibomian gland dysfunction (MGD), or mixed blepharitis (MB) were recruited into the study. …”
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Risk factors for cardiovascular diseases in patients received complex treatment for cranial and craniospinal tumors in childhood by A. I. Novikova, M. G. Poltavskaya, M. G. Pavlova, P. Sh. Chomakhidze, V. M. Sotnikov, N. A. Potemkina, A. A. Bykova, Z. K. Salpagarova, Z. Z. Fashafsha, T. V. Soboleva, O. V. Andreeva, O. G. Zheludkova, D. А. Andreev

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Sexual distress with partnered face-to-face sexual activity: an exploratory qualitative study with heterosexual cis people who seek and do not seek professional help by Patrícia M. Pascoal, Patrícia M. Pascoal, Patrícia M. Pascoal, Patrícia M. Pascoal, Gerhard Andersson, Gerhard Andersson, Gerhard Andersson, Gerhard Andersson, Vinicius J. Fischer, Vinicius J. Fischer, Andreia A. Manão, Cátia Oliveira, Catarina F. Raposo, Catarina F. Raposo, Pedro J. Rosa, Pedro J. Rosa, Magda Sofia Roberto, Graça Santos, Nuno Tomada, Nuno Tomada, Annamaria Giraldi, Annamaria Giraldi

“…IntroductionSexual distress is interrelated with mental health and relationship quality and is fundamental for establishing a diagnosis of sexual dysfunction, even though it also affects people who do not seek professional clinical help. …”
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Domestic Violence, Family Relationships and Problem Behavior in Childhood and Adolescent Age by Petar Neshev

“…The symptoms of the dysfunctional family are indicated. Domestic violence and faulty parenting patterns can lead children and adolescents to traumatic experiences and sufferers should be given support and professional help. …”
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Precision medicine in the diagnosis and treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia by Jing-Liang Chen, Yuan-Hong Jiang, Cheng-Ling Lee, Hann-Chorng Kuo

“…The pathophysiology of male LUTSs might be bladder outlet dysfunctions such as bladder neck (BN) dysfunction, benign prostatic obstruction, and poor relaxation of external sphincter and bladder dysfunctions such as detrusor overactivity (DO), detrusor underactivity, DO, and inadequate contractility. …”
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Symptoms of herpesvirus infection in reproductive disorders in married couples by E. K. Shushakova, V. S. Markina, S. V. Nikolaeva, T. A. Ruzhencova

“…Complaints, anamnesis and examination data should be taken into account to confirm or exclude significant infection with herpes simplex virus. …”
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Case report:Acute hepatic and renal failure caused by alcohol and acetaminophen poisoning by Liu Yiyang, He Xinhua

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The Effects of the COVID-19 Pandemic on Abnormal Uterine Bleeding According to the PALM-COEIN Classification by Onur Bektas, Kivilcim Bektas, Sirin Aydin, Gulsen Dogan Durdag, Husnu Celik

“…CONCLUSIONS: In the relationship between COVID-19, ovulatory dysfunction, and endometrial issues, several factors should be considered. …”
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IGF-1 as a Biomarker for Symptom Severity in Adult Traumatic Brain Injury: Evidence from an Observational Study by Justin Weppner, Kimberly Rosenthal, Jennifer Bath, Tonja Locklear, Melissa Martinez

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Burden of disease and risk factors for primary liver cancer by etiology in the United States, 1990-2021: Results from the Global Burden of Disease study, 2021 by Duanyu Wang, Minghao Tan, Socheat Touch, Samnang Kouy, Syphanna Sou, Kun Liu, Youwen Zhu, Hong Zhu, Pengkhun Nov

“…As such, targeted prevention and control strategies should be developed to address these unique disease characteristics.…”
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Three‐dimensional endovaginal ultrasound assessment using the levator ani deficiency score in primiparas: A replication study by Emilia Rotstein, Vilhelmina Ullemar, Marianne Starck, Gunilla Tegerstedt

“…Abstract Introduction It is essential to assess the levator ani properly as part of clinical care in patients presenting with pelvic floor dysfunction. The levator ani deficiency scoring system is a previously published method to assess levator ani defects with three‐dimensional endovaginal ultrasound. …”
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