Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma by Naga Malleswara Rao Nakka, Hari Krishnareddy Rachamala, Ramcharan Singh Angom, Nagamalleswara Rao Indla, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Annadanam V. Sesha Sainath, Hani Babiker, Krishnendu Pal, Debabrata Mukhopadhyay

“…The TTP-PNPs in the form of empty polymer (P), single drug-loaded [P(Gem) and P(PTX)], and dual drug-loaded [P(Gem + PTX)] polymer nanoformulations exhibited stable and homogenous spherical shapes with 110–160 nm size. These nanoformulations demonstrated excellent stability under in vitro physiological conditions and led to an efficient release of the drugs in the presence of reduced glutathione (GSH). …”
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Traditional Architects’ Accounts of the Processes of Rural and Country Housing Design and Construction (Case Study of Garmsar & Surrounding Townships) by Akbar Zargar, Mohsen Sartipipour, Seyed Hassan Miri, Hamed Sheikhtaheri

“…The aim of this research is to identify policies for increasing the efficiency and durability of rural housing as well as promoting active participation of people in the processes of housing design and construction. …”
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Evolution, reconfiguration and low-carbon performance of green space pattern under diverse urban development scenarios: A machine learning-based simulation approach by Yujie Ren, Mengdie Zhou, Antian Zhu, Shucheng Shi, Hao Zhu, Yuzhu Chen, Shanshan Li, Tianhui Fan

“…The key findings include: (1) Wetlands, particularly those composed of shallow water bodies and land–water interfaces such as marshes and mangroves, are critical determinants of the low-carbon performance of green spaces, with their effects on carbon emissions and sequestration exhibiting significant temporal dynamics throughout different stages of ecological restoration. (2) The fragmentation and shape complexity of green spaces substantially influence carbon efficiency. …”
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Continuum topological derivative - A novel application tool for segmentation of CT and MRI images by Viswanath Muthukrishnan, Sandeep Jaipurkar, Nedumaran Damodaran

“…Results clearly demonstrate that the combination of CTD denoising and segmentation outperforms the other three established methods in terms of both efficiency and accuracy in delineating diseased or affected areas, as evidenced by the various case studies conducted in this research. …”
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THE NEED FOR IMPROVED METHODS OF PROSTHESIS DISTALLY UNLIMITED DEFECTS IN THE DENTITION by R. Kozak

“…Significantly reduced chewing efficiency both affected and on the opposite side. This necessitates a unilateral end prosthetics defects dentition for therapeutic and prophylactic purposes. …”
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A Multispecies Atmospheric Escape Model with Excited Hydrogen and Helium: Application to HD209458b by Anna Ruth Taylor, Tommi T. Koskinen, Luca Argenti, Nicholas Lewis, Chenliang Huang, Anthony Arfaux, Panayotis Lavvas

“…Atmospheric escape shapes exoplanet evolution and star–planet interactions, with He I 10830 Å absorption serving as a key tracer of mass loss in hot gas giants. …”
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A spatially-explicit assessment on equality of Urban Green Space Coverage across 32 major cities in China by P. Zhang, Q. Sun, H. Wu, J. Chen, J. Chen, H. Shang, H. Shang, X. Ji, X. Ji

“…These findings highlight the necessity of balancing efficiency and equity for urban planning, particularly through optimized greening policies for mitigating ecosystem service disparities and achieving sustainable development goals.…”
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Ground-Independent UAV Quantitative Mapping and In Situ Experimental Validation for Coral Reef Habitats by Enze Wang, Huaguo Zhang, Yunhan Ma, Han Tong, Juan Wang, Wenting Cao, Dongling Li

“…Remote sensing-derived bottom reflectance aligns with in situ measurements in both magnitude and spectral shape. Overall, the proposed UAV quantitative mapping method enhances the efficiency and diversity of coral reef monitoring, while the in situ survey approach ensures accuracy. …”
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Screening and Characterization of Wild <i>Sarcomyxa edulis</i> Strains from Heilongjiang, China, for Strain Development by Zitong Liu, Yanfeng Wang, Chunge Sheng, Fei Wang, Peng Zhang, Yuxin Qi, Jinhe Wang, Lei Shi, Haiyang Yu, Jing Zhao

“…Their fruiting body yield (281.15–342.03 g) and biological efficiency (56.23–68.40%) were high. Their fruiting body shape was good. …”
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Influence of ilmenite ore particles as pigment on the anticorrosion and mechanical performance properties of polyamine cured epoxy for internal coating of gas transmission pipeline... by A.M. Al-Sabagh, M.I. Abdou, M.A. Migahed, A.M. Fadl, Ahmed A. Farag, M.M. Mohammedy, S. Abd-Elwanees, A. Deiab

“…The mechanical performance properties for these films were investigated via adhesion pull-off, bend and impact coating tests to confirm their application efficiency. From the recorded results it was found that, the inhibition effect of various coating formulations was attributed to the flaky-like character of dispersed ilmenite particles which aligned parallel to the steel surface through the epoxy base matrix producing a shield of overlapping plates. …”
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Formulation and Evaluation of Polymeric Spherical Agglomerates-Based Porous Orodispersible Tablets of Cilnidipine by Yahya Alhamhoom, Sanjana S. Prakash, Avichal Kumar, Shivakumar Hagalavadi Nanjappa, Mohamed Rahamathulla, Megha S. Kamath, Syeda Ayesha Farhana, Mohammed Muqtader Ahmed, Thippeswamy Boreddy-Shivanandappa

“…The batch F4 composed of PEG 6000 emerged as the optimized batch as it displayed high percentage dissolution efficiency (57.01 ± 0.01%), which was significantly greater (<i>p</i> < 0.001) compared to CIL (26.27 ± 0.06%). …”
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Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca²⁺ Ions and Conformational Dynamics in Psychrophilicity by Malthe Kjær Bendtsen, Jan Stanislaw Nowak, Pedro Paiva, Marcos López Hernández, Pedro Ferreira, Jan Skov Pedersen, Nicolai Sundgaard Bekker, Elia Viezzi, Francesco Bisiak, Ditlev E. Brodersen, Lars Haastrup Pedersen, Athanasios Zervas, Pedro A. Fernandes, Maria Joao Ramos, Peter Stougaard, Mariane Schmidt Thøgersen, Daniel E. Otzen

“…Cold-active enzymes hold promise for energy-efficient processes. Amylases are widely used in household and industrial applications, but only a few are cold-active. …”
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Multiphysics modeling and validation of a microwave applicator with a three-stub tuner for the continuous flow pasteurization of fruit juices with low reflection by Guilherme Russo, Jorge A. W. Gut, Jorge A. W. Gut, Dorin Boldor

“…These advantages include rapid and volumetric heating, high energy efficiency allowing for using electricity from sustainable sources, and reduced sensory and quality loss. …”
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A dose–response meta-analysis of grape by-product effects on lamb growth performance, nutrient digestibility, and blood parameters by J. Bahrampour, A.H. Piray, A. Mousaie, M. H. Ghaffari

“…In conclusion, the intake of GBP shows a dose-dependent response that affects nutrient digestibility and may influence feed efficiency and health status of lambs. Intake of GBP in the range of 200–400 g/kg DM can improve feed conversion ratio and health but can also reduce the digestibility of certain feed components such as OM, DM, CP and NDF.…”
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Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension by Liu H, Liu S, Ma P, Ma L, Liu Y, Zhao F, Zhou R

“…Through a series of experiments including single-factor experimentation, transmission electron microscopy, high-performance liquid chromatography, in vivo pharmacokinetics, and tissue distribution studies, we assessed the physicochemical properties, drug release profiles, and in vitro and in vivo performance of this novel nanocarrier.Results: The prepared aloperine-loaded NLCs exhibited a milky white and translucent suspension appearance, presenting a quasi-spherical shape under a transmission electron microscope, with an average particle size of (509.48± 30.04) nm and an entrapment efficiency of (64.18± 1.14)%. …”
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Stability Assessment of Hazardous Rock Masses and Rockfall Trajectory Prediction Using LiDAR Point Clouds by Rao Zhu, Yonghua Xia, Shucai Zhang, Yingke Wang

“…The approach substantially improves the accuracy and efficiency of hazardous rock stability assessments and rockfall trajectory predictions, offering a quantifiable, reproducible mitigation framework for long slopes, large rock volumes, and densely fractured cliff faces.…”
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Development of novel thoracic retractor for resuscitative thoracotomy by Shoichiro Urabe, Junya Shimazaki, Tomohisa Izutani, Tsuyoshi Hata, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Kiyokazu Nakajima

“…Methods The novel retractor was designed with an arrow-shaped hook for improved intercostal insertion and a continuously rotatable handle to enhance procedural efficiency. …”
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Experimental analysis of swirl number and nozzle design for scale-up of partially cracked ammonia flames by Jordan Davies, Daisuke Sato, Syed Mashruk, Agustin Valera-Medina

“…However, with a widened flame brush, careful consideration must be given to confinement diameter to avoid flame impingement which has potential to increase local heat loss and hence reduce combustion efficiency, resulting in an increase in unburned NH3 emissions. …”
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Laboratory and Field Experimental Study on the Vacuum Preloading Method with Pumping and Discharging by Fuhai Zhang, Yu Chen, Zhengrong Liu, Lei Chen, Yanhui Bai, Liang Chen

“…Test results show that the loss of vacuum pressure along the drainage path was relatively smaller in the new physical vapor deposition (PVD), and the pressure transfer efficiency was increased. Deep soil mass was reinforced effectively by using the new PVD. …”
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Development of a Method for Obtaining Nanoscale Magnesium Carbonate Stabilized with Chitosan as the Basis of Scaffold Matrices for Regenerative Medicine by A. V. Blinov, Z. A. Rekhman, A. A. Gvozdenko, M. A. Yasnaya, M. A. Kolodkin, M. A. Taravanov

“…Implementation of this solution in medical practice will improve the efficiency of bone tissue restoration.…”
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