Temperature-dependent shifts in gut microbiota and metabolome of olive flounder (Paralichthys olivaceus): implications for cold-water aquaculture expansion and probiotic applicatio... by Che-Chun Chen, Yu-Ping Chen, Hsiao-Tsu Yang, Yu-Ling Chen, Chen-Wei Wu, Hong-Yi Gong, Yuan-Shing Ho, Ying-Ning Ho

“…Higher temperatures diversified gut bacterial communities and altered metabolite profiles, with reductions in PUFAs and PC-related compounds linked to specific bacterial genera. …”
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Carotenoid and peptide supplementation from Caulerpa sp. (sea grapes) extract mitigate metabolic syndrome in cholesterol-enriched diet rats via modulation of gut microbiota by Rudy Kurniawan, Fahrul Nurkolis, Agussalim Bukhari, Andi Yasmin Syauki, Burhanudin Bahar, Andi Makbul Aman, Nurpudji Astuti Taslim

“…Additionally, gut microbiota composition was analyzed using high-throughput sequencing techniques. Results Supplementation with Caulerpa sp. extracts significantly improved metabolic markers, including reductions in body weight gain, triglycerides, total cholesterol, low-density lipoprotein (LDL), and blood glucose levels, while increasing high-density lipoprotein (HDL) (p < 0.05). …”
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Evaluation of the Effects of the Quaternary Ammonium Silane K21 on Zebrafish Viability, Toxicity, Growth, and Development by Surendra K. Rajpurohit, Devan Anmol S. Manhiani, Ashwin Ajith, Pragya Rajpurohit, Simran Hotwani, Sai Nasanally, Arsha Sreekumar, Keshu Bhat, Aiden Van Derhei, Rohan Pasi, Arishia Mishra, Kirk Kimmerling, Clifton M. Carey

“…Single-cell RNA sequencing further validated the biological impacts of K21, revealing the potential activation of a novel pathway that accelerates zebrafish growth. …”
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Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection by Huan Zhang, Daoyuan Song, Qiulin Luo, Jiangkun Yu, Yingpu Wei, Di Chen, Guangjuan Wu, Zhi Zhang, Zhao Li, Hongchao Jiang, Jingquan Gan, Deyao Deng, Hui Li, Wenli Yuan

“…Our analysis is focused on 16S rRNA gene sequencing, metabolomics of colon contents, and transcriptomics of colon tissues, examining the intestinal barrier, inflammatory responses, and immune cell infiltration.ResultsThis study observed that down-regulation of programmed cell death 1 (PD-1) in colon tissues is likely linked to the progression from C. albicans colonization to translocated infection. …”
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Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes by Toshiya Takahashi, Dinh Ha Duy Thuy, Shingo Takenaka, Sayaka Ono, Maya Fukui, Yasushi Okada, Tomohiko Asada, Kan Niimi, Kaku Kimura, Akio Ikeda, Ryosuke Takahashi, Riki Matsumoto, Hidenao Fukuyama

“…MRI scans were acquired at baseline and at 6, 9, and 12 months using three-dimensional T1-weighted, pseudo-continuous arterial spin labeling (pCASL), and DTI sequences. Changes in whole-brain and regional indices were assessed using the Wilcoxon signed-rank test.ResultsCompared to baseline, brain volume showed significant reductions at all follow-up points across all examined regions, including the whole brain, hippocampus, posterior cingulate cortex, and precuneus. …”
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Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted... by Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group

“…Cross-correlation analysis explored temporal associations between HOI and non-HOI trends. Whole-genome sequencing and PERMANOVA evaluated the genomic structure of ST512/KPC-3 isolates. …”
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MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study by Shengbo Yang, Litao Zhang, Mingli Hu, Weina He

“…Each 1-unit increase in MIND diet score was significantly associated with reductions in fasting insulin (β = −0.20 μU/mL; p &lt; 0.001), HOMA-IR (β = −2.11; p &lt; 0.001), CRP (β = −2.12; p &lt; 0.001), LPS (β = −8.52; p &lt; 0.001). …”
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Molecular Characterization, Oxidative Stress-Mediated Genotoxicity, and Hemato-Biochemical Changes in Domestic Water Buffaloes Naturally Infected with <i>Trypanosoma evansi</i> Und... by Waqas Ahmad, Muhammad Yasin Tipu, Muti ur Rehman Khan, Haroon Akbar, Aftab Ahmad Anjum, Muhammad Ovais Omer

“…Phylogenetic analysis based on ITS-1 region sequences of the identified isolates showed close genetic associations with Indian isolates. …”
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The roles of NHEJ and TLS pathways in genomic alterations and phenotypic evolution in the yeast Yarrowia lipolytica by Cen Yan, Ye-Ke Wang, Yuan-Ru Xiong, Xin-Qiu Zhou, Yuan-Chun Fang, Ruo-Tian Nie, Cunqi Ye, Ke Zhang, Dao-Qiong Zheng

“…A NHEJ-deficient mutant (ku70) and three TLS-deficient mutants (rev1, rev3, and rad30) are subjected to mutation accumulation experiments, followed by whole-genome sequencing. Our results show that the deletion of KU70 has no significant effect on the rates of spontaneous single-nucleotide variations (SNVs), small insertions and deletions, or chromosomal rearrangements, while the deletion of REV1 and REV3 leads to significant reductions in spontaneous SNV rates. …”
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Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility by Yifei Hu, Shunjie Zheng, Jing Xu, Yufang Zhao, Jianbao Wang, Zenghui Fang, Lanfang Zhou

“…These alterations were accompanied by significant reductions in fecal SCFAs, particularly acetate (49.30%), butyrate (41.00%), and propionate (17.83%). …”
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Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept by Min Wang, Xiao Ma, Junjie He, Jiaxing Sun, Feng Cai, Chuanxin Liu, Jiajia Duan

“…Furthermore, 16S rRNA gene sequencing analysis revealed significant increases of Akkermansia, Escherichia-Shigella, and Bacteroides in both intestinal contents and lung tissue of PPT-treated animals, concomitant with notable elevations in short-chain fatty acids (SCFAs) such as isobutyric acid and isovaleric acid, and reductions in acetic acid, propionic acid, and butyric acid. …”
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Extracellular vesicles from human‐induced pluripotent stem cell‐derived neural stem cells alleviate proinflammatory cascades within disease‐associated microglia in Alzheimer's dise... by Leelavathi N. Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J. Cai, Ashok K. Shetty

“…IN administered hiPSC‐NSC‐EVs incorporated into microglia, including plaque‐associated microglia, and encountered astrocyte soma and processes in the brain. Single‐cell RNA sequencing revealed transcriptomic changes indicative of diminished activation of microglia and astrocytes. …”
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Genomic Insights of Wheat Root-Associated <i>Lysinibacillus fusiformis</i> Reveal Its Related Functional Traits for Bioremediation of Soil Contaminated with Petroleum Products by Roderic Gilles Claret Diabankana, Akerke Altaikyzy Zhamalbekova, Aigerim Erbolkyzy Shakirova, Valeriia Igorevna Vasiuk, Maria Nikolaevna Filimonova, Shamil Zavdatovich Validov, Radik Ilyasovich Safin, Daniel Mawuena Afordanyi

“…In this study, we evaluated the ability of wheat root-associated <i>L. fusiformis</i> MGMM7 to degrade xenobiotic contaminants such as crude oil, phenol, and azo dyes. We sequenced the whole genome of MGMM7 and provided insights into the genomic structure of related strains isolated from contaminated sources. …”
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Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone by Sanghoon Bae, Van‐Hieu Mai, Seyoung Mun, Dalong Dong, Kyudong Han, Sunghyouk Park, Jung Keun Hyun

“…Molecular mechanisms were explored through RNA sequencing and Western blotting to assess changes in mitochondrial function and muscle signalling pathways. …”
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Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…In human samples, significant reductions in Lachnospiraceae and Ruminococcaceae, representative butyrate-producing bacteria, were seen in PTB cases. …”
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Effect of dietary supplementation with Brevibacillus laterosporus on broiler growth performance, meat quality and gut microbiome by Haixia Han, Haixia Han, Haixia Han, Haixia Han, Li Fu, Jie Wang, Jie Wang, Jie Wang, Jie Wang, Yan Sun, Yan Sun, Yan Sun, Yan Sun, Dingguo Cao, Dingguo Cao, Dingguo Cao, Dingguo Cao, Qiuxia Lei, Qiuxia Lei, Qiuxia Lei, Qiuxia Lei, Yan Zhou, Yan Zhou, Yan Zhou, Yan Zhou, Fuwei Li, Fuwei Li, Fuwei Li, Fuwei Li, Wei Liu, Wei Liu, Wei Liu, Wei Liu, Dapeng Li, Dapeng Li, Dapeng Li, Dan Hao, Dan Hao, Dan Hao, Dan Hao, Jie Liu, Jie Liu, Jie Liu, Jie Liu

“…The LBL group saw significant reductions in the proportion of C18:1n9t and C20:1. …”
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Modified Huanjingjian Prevents Chemotherapy-Induced Alopecia by Inhibiting Genomic DNA Methylation of the Wnt Signaling Pathway in Mice by Liu X, Du T, Xi R, Cheng L, Wang Y, Lu H, Guo D, Zhu J, Liu T, Li F

“…Reduced representation bisulfite sequencing (RRBS) was used to map DNA methylation patterns. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Body composition changes, reductions in alanine aminotransferase, liver steatosis, and disease activity were similar following both treatments. …”
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Isolation and identification of strawberry anthracnose and fungicide screening in Henan province by SUN Wenbin, ZHANG Jingjing, SONG Yanhong, ZHAO Xia, LI Gang, ZHOU Houcheng, LIU Lifeng

“…Specifically recorded measurements for root length (3.72 cm), fresh weight (0.452 g), and dry weight (0.082 g) reflected significant reductions of 40.7%, 43.7%, and 64.6% respectively when compared with healthy control groups. …”
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