EZH2 expression in colorectal carcinoma: an evaluation of clinicopathological and prognostic value by Diren Vuslat Cagatay, Mecdi Gurhan Balci, Gizem Issin, Fatih Demir

Get full text

A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria by Xiang Gao, Zixuan Wang, Xiang Li, Xiaoling Zhang, Shengqiang Du, Miaomiao Jia, Dailun Hu, Xianxian Jia, Bin Cong, Yan Zhang, Chunling Ma, Song Zhou, Jun Zhang

Get full text

Image Visual Quality: Sharpness Evaluation in the Logarithmic Image Processing Framework by Arnaud Pauwelyn, Maxime Carré, Michel Jourlin, Dominique Ginhac, Fabrice Meriaudeau

“…The logic of this work consists in evaluating the sharpness of an image by means of objective measures based on mathematical, physical, and optical justifications in connection with the human visual system. …”
Get full text

Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects by Dong R, Chen J, Guo N, Yang Y, Wu J, Wang X, Song Y, Zhang X

“…., Shijiazhuang, Hebei Province, 050035, People’s Republic of China, Tel +86-311-69085585, Email xueyuanzhang1987@163.comPurpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) and reference formulation (R) in healthy Chinese male subjects.Subjects and Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: a safety exploration design in lower dose (n = 14, 100 mg), part B: a pivotal comparative pharmacokinetic (PK) trial under fast condition (n = 44, 150 mg) and part C: a pivotal comparative PK trial under food condition (n = 44, 150 mg). …”
Get full text

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection by Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist

“…Leftover material from routinely collected stool samples from patients suspected of CDI was analyzed with the three immunoassays, nucleic acid amplification test (NAAT), and culture. Whole-genome sequencing was then used to evaluate C. difficile isolates recovered from the samples. …”
Get full text

Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. by Anandharaman Veerapathran, Gajalakshmi Dakshinamoorthy, Munirathinam Gnanasekar, Maryada Venkata Rami Reddy, Ramaswamy Kalyanasundaram

“…Brugia malayi GST and WbGST show significant sequence similarity. Therefore, to evaluate the vaccine potential of rWbGST, we used B. malayi L3 as challenge parasites. …”
Get full text

Comparative performance evaluation of bisulfite- and enzyme-based DNA conversion methods by Roy B. Simons, Faidra Karkala, Marta M. Kukk, Hieab H. H. Adams, Manfred Kayser, Athina Vidaki

Get full text

Comparative analysis of genome-wide sequences of the seed lot of the vaccine strain of Mycobacterium bovis BCG-1 (Russia) and daughter isolates obtained from children with BCG oste... by O. V. Narvskaya, A. A. Vyazovaya, V. Yu. Zhuravlev, D. A. Starkova, A. Yu. Mushkin, I. V. Mokrousov

“…The objective of the study: a comparative analysis of genome-wide sequences of seed lot (SL) 361 "sh" M. bovis BCG-1 (Russia) and its daughter isolates obtained from children with manifestations of BCG osteitis.Subjects and methods: genotyping; bioinformational analysis of genome-wide sequences of PS 361 "sh” vaccine BCG-1 (Russia) and its daughter isolates.Results. …”
Get full text

Construction and evaluation of recombinant Lactobacillus plantarum expressing Micropterus salmoides hepcidin by Cheng-long Zhang, Guangtao Chen, Xiang Shan Ji, Jian Teng, Zhi Lei Yao, Chun Lei Hu, Yan Zhao

“…The aim of this study is to construct a recombinant LP37 expressing hepcidin and evaluate its role in improving antibacterial ability and growth promotion in M. salmoides. …”
Get full text

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers by Yike Wang, Dai Li, Dai Li, Tong Zhang, Sumei Xu, Sumei Xu, Yanxin Zhang, Yanxin Zhang, Kaijing Zhao, Shaorong Li, Kai Shen, Xiaomin Li, Xiaomin Li, Pingsheng Xu, Pingsheng Xu

Get full text

Isolation and identification of Mycoplasma hyorhinis and virulence evaluation of its field isolates by Fan Yang, Fan Yang, Lijun Yang, Lijun Yang, Xuecheng Duan, Xuecheng Duan, Yulin Qian, Yulin Qian, Huifang Ma, Huifang Ma, Xue Jia, Xue Jia, Xinyu Huo, Xinyu Huo, Wenqi Dong, Wenqi Dong, Huanchun Chen, Huanchun Chen, Huanchun Chen, Chen Tan, Chen Tan, Chen Tan

“…It is also linked to the porcine respiratory disease complex (PRDC).MethodsM. hyorhinis prevalence in 2022 Chinese lung samples was assessed by species-specific PCR, followed by isolation and purification of field strains, followed by genetic characterization via multilocus sequence typing (MLST). Pathogenicity evaluation of three isolates (ZZ-1, GD-1 and AH-1) was evaluated using controlled piglet infection trials.ResultsMhr detection in clinical lung samples showed 31.77% prevalence. …”
Get full text

Genomic and Gut Microbiome Evaluations of Growth and Feed Efficiency Traits in Broilers by Xia Xiong, Chunlin Yu, Mohan Qiu, Zengrong Zhang, Chenming Hu, Shiliang Zhu, Li Yang, Han Peng, Xiaoyan Song, Jialei Chen, Bo Xia, Jiangxian Wang, Yi Qing, Chaowu Yang

“…We obtained 47,872 high-quality genomic single-nucleotide polymorphisms (SNPs) by sequencing the genomes and 702 amplicon sequence variants (ASVs) of the gut microbiome by sequencing the 16S rRNA gene, both of which were used for analyses of linear mixed models. …”
Get full text

IDRdecoder: a machine learning approach for rational drug discovery toward intrinsically disordered regions by Clara Shionyu-Mitusyama, Satoshi Ohmori, Subaru Hirata, Hirokazu Ishida, Tsuyoshi Shirai, Tsuyoshi Shirai

“…In the first step, the neural net was trained as autoencoder by using 26,480,862 predicted IDR sequences. Then it was trained against 57,692 ligand-binding PDB sequences with higher IDR tendency via transfer learning for predict ligand interacting sites and ligand types.ResultsIDRdecoder was evaluated against 9 IDR sequences, which were experimentally detailed as drug targets. …”
Get full text

Health outcomes, utility and costs of returning incidental results from genomic sequencing in a Canadian cancer population: protocol for a mixed-methods randomised controlled trial by Mark Robson, Christine Elser, Wanrudee Isaranuwatchai, Melyssa Aronson, Salma Shickh, Marc Clausen, Chloe Mighton, Mariana Gutierrez Salazar, Kathleen-Rose Zakoor, Rita Kodida, Emma Reble, Andrea Eisen, Seema Panchal, Tracy Graham, Susan Randall Armel, Chantal F Morel, Ramzi Fattouh, Emily Glogowski, Kasmintan A Schrader, Jada G Hamilton, Kenneth Offit, June C Carroll, Raymond H Kim, Jordan Lerner-Ellis, Kevin E Thorpe, Andreas Laupacis, Yvonne Bombard

“…High-quality evidence evaluating health outcomes and costs of receiving incidental results is critical for the adoption of genomic sequencing into clinical care and to understand the unintended consequences of adoption of genomic sequencing. …”
Get full text

Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets by Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis

Get full text

Magnetic resonance angiography for cerebral arterial and venous visualization in dogs: a comparative study of time-of-flight, phase-contrast, and time-resolved imaging of contrast... by Sunghwa Hong, Sunghwa Hong, Soyeon Kim, Mire Namgoong, Minjoo Kwon, Junghee Yoon, Jihye Choi

“…The goal is to determine the most suitable MRA sequence for improving diagnostic accuracy in canine cerebral imaging. …”
Get full text

Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…This was consistent for both fly rearing lines used in the study. 16S rRNA sequencing corroborated the establishment of the specific strain but also revealed some species/strain-level variation of Enterobacter sequences associated with the flies. …”
Get full text

Genome-wide assessment of population structure and genetic diversity and development of a core germplasm set for sweet potato based on specific length amplified fragment (SLAF) seq... by Wenjin Su, Lianjun Wang, Jian Lei, Shasha Chai, Yi Liu, Yuanyuan Yang, Xinsun Yang, Chunhai Jiao

Get full text

Primordial follicle activation related genes screening and differential expressed analysis by transcriptome sequencing in buffalo ovary after PI3K and mTOR stimulators activated by Jingyuan Liang, Peng Zhu, Qiao Lv, Yu Pan, Ziyan Gao, Qinghua Xing, Ruimen Zhang, Yanfei Deng, Sufang Yang

“…In this study, buffalo cortical strips were cultured in vitro and activated with PI3K and mTOR stimulators, and the proportion of activated and developed follicles was evaluated and compared between groups . Furthermore, the key genes involved in primordial follicle activation were screened using RNA sequencing. …”
Get full text

Application value of dual-sequence MRI based nomogram of radiomics and morphologic features in predicting tumor differentiation degree and lymph node metastasis of Oral squamous ce... by Bozhong Zheng, Baoting Yu, Xuewei Zheng, Xiaolong Qu, Tong Li, Yun Zhang, Jun Ding

“…Radiomics features were extracted from T2-FS and DWI sequences, followed by feature selection and the establishment of Rad-scores using the LASSO method. …”
Get full text