Risk factors and a nomogram for predicting valproic acid-induced liver injury : A nested case-control study by Yue Chen, Yadong Wang, Runan Xia, Yi Chen, Xuefeng Xie

“…Risk factors were analyzed using logistic regression, and a nomogram model was developed and evaluated. A total of 256 cases were included in the study: 64 in the VPA-induced liver injury group and 192 in the control group. …”
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Integrated reservoir characterization of the Permo-Triassic gas reservoirs in the Central Persian Gulf by Milad Moradi, Ali Kadkhodaie, Hossain Rahimpour-Bonab, Rahim Kadkhodaie

“…The primary purpose of this research is to model and evaluate the relationship between hydraulic flow units (HFUs), electrofacies and microfacies with systems tracts of Permian-Triassic sequences. …”
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Tracing distinct learning trajectories in introductory programming course: a sequence analysis of score, engagement, and code metrics for novice computer science vs. math cohorts by Zhizezhang Gao, Haochen Yan, Jiaqi Liu, Xiao Zhang, Yuxiang Lin, Yingzhi Zhang, Xia Sun, Jun Feng

“…Previous studies predominantly relied on outcome-based assessments, focusing on summative evaluations and surveys while providing little insight into the real learning process and differences therein. …”
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Maturity-onset Diabetes of the Young (MODY): How Much Can We Detect? by Gökhan UYGUN, Akif AYAZ, Mustafa KANAT

“…In particular, individuals diagnosed with diabetes at a young age, with negative autoantibodies and measurable serum C-peptide levels, should be evaluated for MODY.…”
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Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. by Maher A Noureddine, Daniel Menendez, Michelle R Campbell, Omari J Bandele, Monica M Horvath, Xuting Wang, Gary S Pittman, Brian N Chorley, Michael A Resnick, Douglas A Bell

“…Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative functional evaluation. To examine the relationship between RE sequence variation -- including polymorphisms -- and p53 binding, we have developed a multiplex format microsphere assay of protein-DNA binding (MAPD) for p53 in nuclear extracts. …”
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Next-Generation-Sequencing of the Human B-Cell Receptor Improves Detection and Diagnosis and Enhances Disease Monitoring in Patients with Gastric Mucosa-Associated Lymphoid Tissue... by Chidimma Agatha Akpa, Cora Husemann, Chris Allen, Ann-Christin von Brünneck, Jana Ihlow, Michael Hummel

“…We examined clonally rearranged immunoglobulin heavy- and light-chain gene sequences of 36 genomic DNA samples from six different patients obtained at different time points over the course of several years using the Oncomine^TM B-cell receptor pan-clonality next-generation sequencing (NGS) assay. …”
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Genotypic and phenotypic characterization of thermo-sensitive genic male sterile (TGMS) rice lines using simple sequence repeat (SSR) markers and population structure analysis by B Nagendra Naidu, Manonmani Swaminathan, Pushpam Ramamoorthy, Kumaresan Dharmalingam, Raveendran Muthurajan, Selvi Duraisamy, Nivedha Rakkimuthu, Abirami Subramanian, Rithesh Natarajan, Bonipas Antony John

“…Molecular diversity analysis using simple sequence repeat (SSR) markers identified 90 alleles and eight genetic clusters. …”
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Evaluation of Vibration Performance Variation of Rolling Bearing based on Fuzzy-set Theory by Xia Xintao, Chen Xiangfeng, Cheng Li

“…Firstly,the original data sequence of the rolling bearing vibration is divided into the sample sequences,and then the intrinsic sequence is selected to calculate the standard deviation of each sample sequence and the absolute correlation degree,the gray confidence level and the closeness degree relative to the intrinsic sequence as new sample values. …”
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Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…Methods After a clinical evaluation of two affected siblings, DNA isolated from peripheral whole blood of the affected patients and their parents underwent Exome Sequencing (ES). …”
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Evaluating Handwritten Answers Using DeepSeek: A Comparative Analysis of Deep Learning-Based Assessment by Sanskar Bansal, Vinay Gupta, Eshita Gupta, Peeyush Garg

“…Although sequence-to-sequence neural networks and other existing AI evaluation methods have demonstrated promise, they are constrained by their reliance on high-performance hardware, such as GPUs, lengthy training periods, and challenges in managing a variety of scenarios. …”
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Examination and Presentation of a Glaucoma Case by Arshi Singh, Kirti Singh, Divya Jain

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Prediction of exacerbation frequency of AECOPD based on next-generation sequencing and its relationship with imbalance of lung and gut microbiota: a protocol of a prospective cohor... by Yinji Xu, Li Deng, Jiali Yan, Huachong Xu, Chunzhen Huang, Yiwen Lv, Qianxin Wu, Xiaoyin Chen

“…This study used metagenomic next-generation sequencing (mNGS) technology to explore the microbial characteristics of the intestinal tract and airways of patients with COPD, and analyse the correlation between the sequencing results and inflammatory factors, immune factors and nutritional factors.Methods and analysis This will be a prospective cohort study. …”
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Expression of PSMD14 in lung adenocarcinoma and its impact on immune cell infiltration and prognosis: a comprehensive analysis based on RNA and single-cell RNA sequencing by Jing Zhang, Bohao Sun, Jiabin Lai, Weike Kong, Nan Wang, Panyuan Li, Yichen Wu, Zhaochang Jiang

“…A multifaceted approach was adopted, which included the analysis of RNA sequencing (RNA-seq) data, assessment of immune cell infiltration, survival analysis, gene enrichment analysis, and integration of single-cell RNA-seq data to thoroughly evaluate the biological relevance of PSMD14. …”
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Validation and implementation of whole-genome sequencing-based analytical methods for molecular surveillance and relatedness analysis of Mycobacterium tuberculosis complex isolates... by Diana Espadinha, Emma Roycroft, Peter R. Flanagan, Simone Mok, Eleanor McNamara, Thomas R. Rogers, Margaret M. Fitzgibbon

“…Whole genome sequencing-based methodologies have become extremely relevant for the molecular surveillance of human pathogens and are being increasingly introduced into national reference laboratory services. …”
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Tracing Emergence of SARS-CoV-2 Variants: Insights from Comprehensive Assessment Using Reverse Transcription Polymerase Chain Reaction and Whole Genome Sequencing by Duyeon Na, Yuna Hong, Chaeyeon Lee, Myungshin Kim

“…The emergence and evolution of SARS-CoV-2 variants, such as Delta and Omicron, pose significant challenges to pandemic management. This study evaluated the effectiveness of reverse-transcription polymerase chain reaction (RT-PCR) and whole-genome sequencing (WGS) in detecting and characterizing SARS-CoV-2 variants using 624 samples collected in South Korea from mid-2021 to mid-2022. …”
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Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study by Xiangxin Huang, Ying Wang, Bei Li, Xiaoqun Shen, Xuexia Tao, Wenwen Zheng, Qi Luo, Lei Xiong, Lin Wang, Shufan Cai

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Direct Bisulfite Sequencing and Methylation Specific PCR to Detect Methylation of p15INK4b and F7 genes in Coronary Artery Disease Patients by M. Yari, A. Movafagh, A. Sayad, M. D. Omrani, M. A. Broumand, K. Majidzadeh-A, R. Mirfakhraie, A. Khoshdel, K. Amini

“…To quantitative analysis of methylation, direct bisulfite sequencing method revealed 6 methylated CpGs islands. …”
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Comparative prospective study on the clinical utility of G‐banding and next‐generation sequencing for chromosomal analysis of products of conception under Advanced Medical Care A i... by Hidemine Honda, Tsuyoshi Takiuchi, Mika Handa, Nao Wakui, Saori Tsuji, Takeshi Goto, Shota Suzuki, Fumie Saji, Tatsuya Miyake, Sakae Goto, Satomi Okamura, Tomomi Yamada, Michiko Kodama, Tadashi Kimura

“…Abstract Purpose To compare the clinical utility of G‐banding and next‐generation sequencing (NGS) for chromosomal analysis of products of conception (POC), a crucial tool for detecting fetal chromosomal abnormalities which are major causes of miscarriage and stillbirth. …”
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Variation in HIV-1 Tat and Vpr protein amino acid sequences and its association with vascular health measures in a South African cohort: an exploratory study by Esmé Jansen van Vuren, Yolandi Breet, Adriaan Jacobs, Iolanthé M. Kruger, Monray Edward Williams

“…Given the diverse clinical outcomes related to different HIV subtypes, it is crucial to evaluate the variations in the sequence of Tat and Vpr amino acids in geographical regions where subtype C predominates, such as South Africa. …”
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Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to... by Jane Gibson, Reuben J. Pengelly, Amatta Mirandari, Konstantinos Boukas, Sophia Stanford, Thomas Desmond Cecil, Faheez Mohamed, Sanjeev Paul Dayal, Alexios Tzivanakis, Brendan John Moran, Alex Mirnezami, Norman John Carr, Sarah Ennis

“…Sequencing data from 223 patients were analysed. Results The median follow‐up interval was 48 months. …”
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