The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats by Xiaoyun Fan, Qing Zhang, Weiling Guo, Qi Wu, Jinpeng Hu, Wenjian Cheng, Xucong Lü, Pingfan Rao, Li Ni, Youting Chen, Lijiao Chen

“…This study aimed to evaluate the in vivo protective effects and possible mechanism of L. brevis FZU0713 on the disturbance of lipid metabolism in hyperlipidemic rats fed a high-fat diet (HFD). …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…Methods We analysed whole exome and bulk RNA sequencing data from a pan‐cancer cohort of 25 775 patients and cutaneous melanoma cohorts (untreated: n = 471, anti‐progressive disease [PD]‐1 treated: n = 212). …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…The functional role of RET was assessed by siRNA-mediated RET silencing and targeted inhibition with the FDA/EMA-approved RET-selective inhibitor selpercatinib in resistant breast cancer cells and patient-derived organoids (PDOs). RET silencing was evaluated mechanistically using global gene expression and pathway analysis. …”
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Deep phenotyping of patients with MASLD upon high-intensity interval training by Veera Houttu, Ulrika Boulund, Marian Troelstra, Susanne Csader, Daniela Stols-Gonçalves, Anne Linde Mak, Anne-Marieke van Dijk, Julia Bouts, Maaike Winkelmeijer, Xanthe Verdoes, Sandra van den Berg-Faay, Donne Lek, Ted Ronteltap, Ferdinand de Haan, Harald Jorstad, Ville Männistö, Kai Savonen, Heikki Pentikäinen, Kati Hanhineva, Ambrin Farizah Babu, Gianni Panagiotou, Otto van Delden, Joanne Verheij, Michial Doukas, Aart Nederveen, Ursula Schwab, Aldo Grefhorst, Max Nieuwdorp, Adriaan Georgius Holleboom

“…Change in maximal oxygen consumption (VO2max) and MRI-determined liver fat were compared with a control group of patients with MASLD (n = 22). RNA sequencing was performed on liver, muscle, and fat biopsies of patients in the exercise group. …”
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Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes by Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang

“…Methods Transcriptome sequencing was applied to evaluate the differential expression of USP families during hypoxia/reoxygenation (H/R) and validated in human and mouse heart samples and cardiomyocytes by performing quantitative polymerase chain reaction. …”
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Modeling of contribution of the Late Cretaceous-Miocene sediments of the Makran accretionary wedge to the petrogenesis of basalts from Makran volcanic arc, SE Iran by Ali Ahmadi, Mostafa Ghomashi, Zahra Firouzkouhi, Marzie Rastay zahedan

“…They are also deployed to construct binary melt-sediment mixing models in order to evaluate the postulated sediment contribution to the petrogenesis of the Makran basalts. …”
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Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy by Sadanand Dangari Akshay, Heli Upadhyaya, Nitin Shukla, Rohit Bhattacharjee, Sunilkumar Das, Urmi Vyas, Priyank Chavda, Nimesh Patel, Dixsha Jamkhandi, Pritesh Sabara, Neeta Khandelwal, Sumeeta Soni, Kamlesh Upadhyaya, Jayesh Katira, Geeti Maheshwari, Madhvi Joshi, Devarshi Gajjar, Chaitanya Joshi

“…Typhi, in Gujarat, this study evaluated the antibiotic resistance patterns of S. …”
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Genetic Variation and Assessment of Seven Salt-Tolerance Genes in an <i>Indica</i>/<i>Xian</i> Rice Population by Yuanhang Cheng, Tao Wang, Yeying Wen, Xingfei Zheng, Haifeng Liu, Xiangsong Chen, Ying Diao, Zhongli Hu, Wenjie Feng, Zhaohui Chu

“…On the basis of the SNPs, the population was categorized into 21 haplotypes (Haps), each of which contained at least four out of seven <i>ST</i> genes. To precisely evaluate each SNP, grouped rice varieties that only differed at one SNP were chosen from two Haps for salt treatment with 150 mM NaCl for 7 d. …”
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MYOCARDITIS AS A LEGITIMATE PHENOMENON IN NON-COMPACTION MYOCARDIUM: DIAGNOSTICS, MANAGEMENT AND INFLUENCE ON OUTCOMES by O. V. Blagova, E. V. Pavlenko, N. V. Varionchik, A. V. Nedostup, V. P. Sedov, Е. A. Kogan, V. А. Zaydenov, А. G. Kupriyanova, A. Е. Donnikov, V. V. Kadochnikova, N. V. Gagarina, E. A. Mershina, V. Е. Sinitsyn, М. Е. Polyak, E. V. Zaklyazminskaya

“…Aim. To evaluate the prevalence of myocarditis in adult patients with non-compaction myocardium (NCM) of the left ventricle (LV), and its influence on the disease course, results of treatment and outcomes.Material and methods. …”
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Design and Validation of a Multi-Epitope mRNA Vaccine Construct Against Human Monkeypox Virus (hMPXV) by Annotating Protein of Intracellular Mature Virus (IMV) Form of hMPXV by Mohammad Asrar Izhari, Siraj B. Alharthi, Raed A. Alharbi, Ahmad H. A. Almontasheri, Wael A. Alghamdi, Abdulmajeed Abdulghani A. Sindi, Ahmad Abdulmajed Salem, Ali Mahzari, Fahad Alghamdi, Ahmed R. A. Gosady

“…<b>Conclusions</b>: Based on the evaluated parameters, the MPXV-2-Beta designed in this study exhibited significant potential as an effective candidate against hMPXV. …”
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Characteristic of Viral and Bacterial Contaminationin Objects of the Infection Hospital Environment of the Hospital for the Treatment of Patients with COVID-19 During the Pandemic... by I. A. Egorov, S. S. Smirnova, V. A. Mishchenko, I. V. Vialykh, A. Yu. Markarian, N. N. Zhuikov, S. V. Romanov, A. V. Ponomareva, I. V. Chistiakova, A. S. Kiliachina, O. Yu. Averianov, V. A. Smirnova, А. N. Bolshakova, E. V. Vernik, N. A. Pushkareva, A. V. Semenov

“…The study used epidemiological (descriptive­evaluative and analytical), molecular genetic (SARS-­CoV­-2 PCR­RT, sequencing), bacteriological (isolation, cultivation and MALDI­TOF identification of bacterial cultures) methods. …”
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Probiotic Bifico Ameliorates Depression- and Anxiety-Like Behaviors Induced by Estrogen Deficiency via NLRP3 Inflammasome Inhibition by Yu X, Yu X, Yang Y, Cheng W, Shi M, Chen L, Zhang X, Xu Y

“…Furthermore, 16S rRNA sequencing was used to analyze changes in gut microbiota. …”
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Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model by Wang X, Li M, Liu X, Sun G, Zhang D, Sun L, Yin Y, Zhang W, Hao J

“…This study aims to identify effective methods for isolating quiescent and activated murine PSCs (mPSCs) and to evaluate the potential of caerulein in inducing mPSC activation in an ex vivo model.Methods: Pancreatic tissue from mice was digested with collagenase P (1.17 U/mL), Pronase (0.5 mg/mL), and DNase I (0.01 mg/mL). …”
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Co-Production of KPC-2 and NDM-5 in a Carbapenem-Resistant Klebsiella Pneumoniae Clinical Isolate: Genetic Insights and Risks by Xia Y, Zhou P, Gao H, Wu X, Zhou Y, Han W, Wan C, Wu Q, Ding J, Yu F

“…Virulence phenotypes were evaluated through siderophore production (CAS assay), capsule quantification (uronic acid), serum resistance, and Galleria mellonella infection models. …”
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Molecular characteristics of hepatitis B virus among students and pregnant women in Chad by Nalda Debsikréo, Nafissatou Leye, Gora Lo, Maire Dehainsala, Odan Debsikréo, Ndeye Aminata Diaw, Diao Ba, Diabou Diagne, Abdoulaye Souare, Ndeye Dieynaba Diouf, N’da Kouamé Nazaire Kouadio, Isaac Darko Otchere, Ali Mahamat Moussa, Ndèye Coumba Toure-Kane, Françoise Lunel-Fabiani

“…These results highlight the need to evaluate hepatitis B vaccination coverage and efficiency in Chad.…”
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Creating Goal Scoring Opportunitites in Men and Women UEFA Champions League Soccer Matches. Tactical Similarities and Differences (Creación de Ocasiones de Gol en la UEFA Champion... by Michalis Mitrotasios, Joaquin González-Rodenas, Vasilis Armatas, Rafael Aranda Malavés

“…A total of 17 tactical indicators related to the start, development and the end of the team possessions were evaluated by observational methodology. An independent samples T Test was used to analyze the differences between gender. …”
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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…Finally, lithocholic acid (LCA), the key bile acid, was administered via gavage to evaluate its effect on colonic inflammation and mucosal barrier integrity. …”
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Role and Therapeutic Potential of miR-301b-3p in Regulating the PI3K-AKT Pathway via PIK3CB in Eosinophilic Chronic Rhinosinusitis by Shu F, Wang Y, Jiang Y, Li L, Mu Z, Shi L, Gong X, Zhang B, Zhang F, Mao D

“…This study aimed to explore the regulatory role of miR-301b-3p in these mechanisms and evaluate its therapeutic potential.Methods: High-throughput miRNA sequencing of human and mouse nasal mucosa tissues identified miR-301b-3p as a key candidate molecule. …”
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Genetic association studies in critically ill patients: a systematic reviewResearch in context by Wenbo Zhang, Nam Nguyen-Hoang, Sean C.S. Rivrud, Anne-Fleur Zandbergen, Yalan Yan, Eline G.M. Cox, Eva Suarez-Pajes, Amanda Y. Chong, Alexander J. Mentzer, Carlos Flores, Gerton Lunter, Frederik Keus, Harold Snieder

“…Findings: We identified a total of 61 studies that evaluated genetic variants with various traits in adult intensive care patients, encompassing a total of 126 genetic loci and focussing on six clustered critical care-related traits. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Background &amp; Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS). …”
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