Non-invasive biomarkers for brain aging: the role of autophagy-related microRNAs in plasma exosomes by Qian Cheng, Shuyi Yu, Zhikang Cui, Hang Chen, Jing Fan, Qian Yu, Yan Jin, Yunshan Wang, Ming Li, Zhiming Lu

“…Exosomes were isolated, followed by small RNA sequencing (sRNA-seq) to identify differentially expressed miRNAs, and differentially expressed miRNAs related to autophagy were validated using quantitative real-time PCR (qRT-PCR). …”
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CD20×CD3 bispecific antibody achieved significant efficacy in patients with large B-cell lymphoma relapsing after or refractory to CAR-T therapy: a systematic review and meta-analy... by Jing Shen, Jingyi Zhang, Zhengyu Zhu, Haobo Ma, Xiayan Li, Junpeng Zhang, Fan Zhou, Hua Tian, Jinghua Liu

“…Several trials have evaluated CD20×CD3 bispecific antibodies (BsAbs) as subsequent therapy in R/R LBCL. …”
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A Novel ceRNA Axis LOC121818100/Novel‐miR‐400/SSRP1 Regulated Muscle Growth and Injury Repair in Sheep by Fan Yang, Runqing Chi, Runan Zhang, Kai Liu, Pingqing Wang, Ran Di, Xiaoyun He, Xiangyu Wang, Yufang Liu, Mingxing Chu

“…Methods Transcriptome sequencing (RNA‐seq) technology was used to analyse the RNA expression profile of longissimus dorsi muscle of different breeds of sheep. …”
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Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1 by Jiali Wang, Yunlong Jia, Tianxu Liu, Xinyan Liu, Shuxian Yin, Jiaqi Chen, Xiaoqing Xu, Yi Zhang, Lihua Liu

“…BIN1 expression levels in NSCLC tissues were evaluated, and their correlation with CD8+T cells infiltration and patient survival outcomes was examined. …”
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CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model by Mengran Du, Jiayuanyuan Fu, Jie Zhang, Ziyu Zhu, Xuekang Huang, Weilin Tan, Lian Liu, Zhijian Huang, Xin Liu, Qiuhao Tan, ZhengBu Liao, Yuan Cheng

“…Depression was evaluated using subjective and objective rating scales, and circSpna2 expression levels in plasma were measured. …”
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SYN-RIFT SANDSTONЕS: THE FEATURES OF BULK CHEMICAL COMPOSITIONS, AND POSITIONS ON PALEOGEODYNAMIC DISCRIMINANT DIAGRAMS by A. V. Maslov, V. N. Podkovyrov, E. Z. Gareev, N. D. Sergeeva

“…Contrariwise, on the high-silica DF1–DF2 diagram [Verma, Armstrong-Altrin, 2013], ~80 % of the objects from our database are localized in the field of syn-rift compositions and show a good correlation with the ‘percentage of consistency’ evaluated by the authors for the samples from similar settings (79–85 %). …”
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Assessment of Phenotypic Tools for Detection of OXA-48, KPC, and NDM in <i>Klebsiella pneumoniae</i> in Oman by Arwa AL Rujaibi, Zaaima AL Jabri, Amina Al Jardani, Azza AL Rashdi, Azza AL Mamari, Sara AL Sumri, Hiba Sami, Zakariya Al Muharrmi, Meher Rizvi

“…This study focused on evaluating in-house tools and commercial phenotypic tests for the detection of OXA-48-, KPC-, and NDM-like enzymes in <i>K. pneumoniae</i>, the predominant extremely drug-resistant pathogen in Oman. …”
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Modified Huanjingjian Prevents Chemotherapy-Induced Alopecia by Inhibiting Genomic DNA Methylation of the Wnt Signaling Pathway in Mice by Liu X, Du T, Xi R, Cheng L, Wang Y, Lu H, Guo D, Zhu J, Liu T, Li F

“…Reduced representation bisulfite sequencing (RRBS) was used to map DNA methylation patterns. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Mechanistic insights were gained through the analysis of the STAT3/HIF-1α/VEGF signaling pathway, tissue dual-fluorescence localization,chromatin immunoprecipitation sequencing (ChIP-seq), and dual-luciferase reporter (DLR) assays. …”
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DHLCA Alleviates Diabetic Kidney Disease via TGR5/FXR Activation and Gut Microbiota Remodeling by Zhou H, Mu X, Hu H, Zhao S, Hu N, Yang M, Jiang J

“…Kidney injury markers, as well as the expression of Takeda G protein-coupled receptor 5 (TGR5) and farnesoid X receptor (FXR), were evaluated. In addition, gut microbiota (GM) composition was analyzed via metagenomic sequencing following DHLCA treatment.Results: The plasma DHLCA levels were significantly lower in DKD with macroalbuminuria group compared to T2DM group and DKD with microalbuminuria group (P &lt; 0.01). …”
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Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer by Lin Shen, Xiaochen Zhao, Zhenghang Wang, Yuezong Bai, Feilong Zhao, Zhi Peng, Jinping Cai, Tong Xie, Shuang Tong, Xiaofan Wei

“…The value of EBV infection for predicting ICB efficacy was evaluated among 95 patients with advanced or metastatic GC receiving ICB. …”
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Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells by P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo

“…We compared marrow cell counts and HH yields by diagnosis, evaluated clones making only FLC by flow and by dimer/monomer (D/M) ratios in vitro and in vivo, and sequenced FLC genes with RT-PCR. …”
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Therapeutic effects and mechanism analysis of Paeonia lactiflora extract (PLE) in menopausal rats with hot flashes by Weilin Cui, Tingting Song, Dongmei Gao, Xiaoyu Wang, Ya Sun, Liyu Fu, Yichao Han, Jieqiong Wang

“…However, its pharmacologic mechanism is unclear.Aim of the studyThis study aims to comprehensively evaluate the effect of PLE on menopausal hot flashes, and to analyze the mechanism of action of PLE in the treatment of menopausal hot flashes from the perspective of neural pathways, to provide a research strategy and experimental basis for the study of similar new drugs and the pathogenesis of MPS.Materials and methodsFirst, we screened menopausal rats through the natural aging model. …”
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Knockdown of <i>FLT4</i>, <i>Nup98</i>, and <i>Nup205</i> cellular genes as a suppressor for the viral activity of Influenza A/WSN/33 (H1N1) in A549 cell culture by E. A. Pashkov, E. B. Faizuloev, E. R. Korchevaya, A. A. Rtishchev, B. S. Cherepovich, А. V. Sidorov, A. V. Poddubikov, Е. P. Bystritskaya, Yu. E. Dronina, A. S. Bykov, O. А. Svitich, V. V. Zverev

“…Objectives. To evaluate the effect of cellular genes FLT4, Nup98, and Nup205 on the reproduction of the influenza A virus in A549 human lung cancer cell line.Methods. …”
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Decitabine regulates the resistance of HCC to sorafenib through demethylation by Miao Zhang, Xiaolei Zhou, Zhenzhen Li, TianYu Zhao, Yu Miao, Sen Liu, Qiaoqiao Han, Libo Wang, Yongdeng Xu, Tao Cui, Ze Wang, Xiulin Yi, Fengying Yan, Xiaoliang Wang

“…Abstract Purpose To evaluate the efficacy of sorafenib in combination with the DNA methylation inhibitor decitabine (DAC) for the treatment of hepatocellular carcinoma (HCC), and to investigate the mechanism of sorafenib resistance from an epigenetic perspective, aiming to provide new insights and strategies for HCC therapy. …”
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AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury by Xiaoxu Huang, Tongqi Li, Guanran Zhang, Jieqiong Chen, Tong Li, Shiqi Yang, Qiyu Bo, Xiaohuan Zhao, Xiaoling Wan, Xinyue Zhu, Bo Yu, Xiaodong Sun, Junran Sun

“…Transcriptome sequencing was used to detect the differentially expressed genes between Aβ1-40 group and control group. …”
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CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K‐AKT Pathway by Zhenfei Xiang, Senquan Yu, Yuxin Xu, Huacai Xiong, Danfei Hu, Qun Li, Zhenhua Wu

“…Materials and Methods To find out key regulatory genes involved in LSCC development, we downloaded LSCC‐related sequencing datasets for bioinformatics analysis. WGCNA was performed on GSE142083 and differential analysis was conducted on GSE51985 and TCGA‐HNSC. …”
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Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis by Hesong Wang, Chenguang Wang, Ruihao Qin, Jia He, Xuan Zhang, Chenjing Ma, Shi Li, Lijun Fan, Liuying Wang, Lei Cao

“…Protein-protein interactions (PPI) and molecular docking were used to evaluate druggability. <b>Results:</b> MR analysis identified 13 proteins significantly associated with PsO risk (<i>p</i> < <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.56</mn><mo>×</mo><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>5</mn></mrow></msup></mrow></semantics></math></inline-formula>), including 10 proteins associated with PsO subtypes. …”
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Chaperonin‐containing TCP1 subunit 6A inhibition via TRIM21‐mediated K48‐linked ubiquitination suppresses triple‐negative breast cancer progression through the AKT signalling pathw... by Mengdi Yang, Jianing Cao, Tiantian Liu, Bin Li, Jinyan Wang, Shuangyue Pan, Duancheng Guo, Zhonghua Tao, Xichun Hu

“…To further explore the mechanism of action of CCT6A, RNA sequencing and co‐immunoprecipitation–mass spectrometry analyses were utilized. …”
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Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity by Feifei Wang, Feifei Wang, Yongxia Mao, Yongxia Mao, Chenlei Li, Chenlei Li, Yanfen Ma, Yanfen Ma, Yansheng Guo, Yansheng Guo

“…Techniques including in vitro ruminal fermentation, gas chromatography, and 16S rRNA high-throughput sequencing were employed to evaluate their effects on the structure of the rumen microbiota. …”
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