Exploring Suitable Nitrification Inhibitor in an Intensively Cultivated Greenhouse Soil and Its Effect on the Abundance and Community of Soil Ammonia Oxidizers by Xing Liu, Yanan Cheng, Ying Zhang, Fei Wang, Yonggang Li, Changwei Shen, Bihua Chen

“…Here, based on microcosm experiments, we evaluated the influence of three widely used NIs [Dicyandiamide, DCD; 3,4-Dimethylpyrazole phosphate, DMPP; 2-chloro-6-(trichloromethyl) pyridine, Nitrapyrin] on the nitrification activity of an intensively cultivated greenhouse soil. …”
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MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features by Felix Barajas Ordonez, Sebastian Gottschling, Kai Ina Eger, Jan Borggrefe, Dörthe Jechorek, Alexey Surov

“…Non-contrast and contrast-enhanced T1-weighted (T1-w) gradient echo (GRE) sequences were acquired before LM biopsy. RTE values among LM groups were compared by cancer type using analysis of variance. …”
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Molecular determinants of response to neoadjuvant pembrolizumab plus chemotherapy in patients with high-risk, early-stage, triple-negative breast cancer: exploratory analysis of th... by Rebecca Dent, Javier Cortés, Yeon Hee Park, Eva Muñoz-Couselo, Sung-Bae Kim, Joohyuk Sohn, Seock-Ah Im, Esther Holgado, Theodoros Foukakis, Sherko Kümmel, Jennifer Yearley, Anran Wang, Michael Nebozhyn, Lingkang Huang, Razvan Cristescu, Petar Jelinic, Vassiliki Karantza, Peter Schmid

“…This exploratory analysis evaluated features of the tumor microenvironment that might be predictive of response. …”
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Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures by Cheng Chen, Chengyuan Deng, Yanwen Li, Shuguang He, Yunhong Liu, Shuwen Pan, Wenqian Xu, Lu Fang, Yixi Zhu, Yingying Wang, Xiaoxin Jiang

“…Fecal samples were collected, followed by sequencing of the V3–V4 region of the 16S rRNA gene. …”
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Molecular characterization and immune role of TLR7 in Labeo rohita by Saswati Pani, Bristy Ganguly, Smruti Mahapatra, Smruti Prajnya Dash, Rakesh Das, Ashis Saha, Mrinal Samanta

“…The TLR7 gene was amplified by PCR, and the gel-purified product was cloned into the pGEM-T Easy vector. DNA sequencing and BLAST analysis confirmed the identity of the LrTLR7 gene. …”
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Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptot... by Shouqing Zhang, Jiajia Yu, Sule Bai, Shuhan Li, Quanyuan Qiu, Xiangshun Kong, Cen Xiang, Zhen Liu, Peng Yu, Yuou Teng

“…This study aimed to evaluate the therapeutic potential of compound <b>3d</b>, a novel elafibranor derivative, focusing on its dual mechanisms of PPAR pathway activation and p38 MAPK signaling inhibition. …”
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CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells by Lu Feng, Xinru Zou, Longyu Tang, Yijun Yuan, Tianwen He, Bin Su, Ying Tang, Jiang Wang, Kang Liu, Jun Li

“…Levels of GSH, MDA, and iron ions were measured using appropriate kits. qRT-PCR and Western blot analyses were performed to evaluate the expression of relevant RNAs and proteins. …”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Moreover, we employed RNA sequencing to investigate the effects of LDL stimulation and MAPK13 inhibition in CD8+ T cells.Results By using a tumor-bearing mouse model, we found that LDL-induced tumor-infiltrating TCF1+PD1+CD8+ T cells. …”
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Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of Blumea balsamif... by Yuan Yuan, Wei-Jie Tang, Wei-Jie Tang, Jia-Yuan Cao, Ke Zhong, Ke Zhong, Ze-Jun Mo, Ying Zhou, Yu-Xin Pang, Yu-Xin Pang

“…Physiological and biochemical assessments were performed to evaluate the growth and metabolic responses of the plants under these varying N conditions. …”
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Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment by David Liberg, Petter Skoog, Caitríona Grönberg, Nils Hansen, Pablo Peña-Martínez, Katrin Reinbach, Finja C Hansen, Susanne Larsson Faria, Kawther Abdilleh, Susanne Magnusson, Karin von Wachenfeldt, Camilla Rydberg Millrud, Marcus Järås

“…To study the underlying mechanisms of IL1RAP blockade ex vivo, co-cultured PDAC cells and CAFs were treated with nadunolimab prior to RNA sequencing. Migration assays were performed to assess how nadunolimab affects interactions between CAFs and myeloid immune cells. …”
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LPS pretreated dental follicle stem cell derived exosomes promote periodontal tissue regeneration via miR-184 and PPARα-Akt-JNK signaling pathway by Liangrui Chen, Jiaxiang Zhang, Jialu Yu, Shujuan Guo, Weidong Tian

“…Methods High-throughput miRNA sequencing was performed on DFSCs and PDLSCs derived exosomes under both Porphyromonas gingivalis (P.g) LPS pretreatment and normal conditions. …”
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Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study by Denys Kozakov, Denys Kozakov, Nazarii Kobyliak, Nazarii Kobyliak, Sofiia Livshun, Oleksii Seleznov, Oleksii Seleznov, Olena Koshyk, Olena Koshyk, Alina Matvieieva, Yaroslav Shparyk, Oleksii Kolesnik, Oleksii Kolesnik, Yuliia Moskalenko, Oleksandr Vynnychenko, Roman Moskalenko, Serhii Kropyvko, Anna Khmel, Bogdana Shkarupii, Bogdana Shkarupii, Oksana Sulaieva, Oksana Sulaieva, Oksana Sulaieva

“…Finally, T-cytotoxic lymphocytes (CD8+) and tumor-associated macrophages (CD163+) were evaluated in samples with EGFR and KRAS mutations, ALK rearrangements and LUAD with no genetic findings. …”
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Reduction of alternative polarization of macrophages by short-term activated hepatic stellate cell-derived small extracellular vesicles by Yufeng Sun, Min Zhao, Li Cheng, Xiaoqian He, Shiqi Shen, Jiaying Lv, Junyu Zhang, Qian Shao, Wenxuan Yin, Fengbo Zhao, Rui Sun, Peng Lu, Yuhua Ji, Xin Wei Wang, Juling Ji

“…The effects of sEVs from short-term activated and long-term activated HSCs on liver macrophages was studied. Small RNA sequencing analyses were performed to obtain differential miRNAs transported by the short-term and long-term activated HSC- sEVs. …”
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Outcomes of switching from protease inhibitor-based antiretroviral therapy to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in virologically suppressed adults with nucl... by Collins Iwuji, Laura Waters, Ana Milinkovic, Chloe Orkin, Julie Fox, Frank Post, Nicky Perry, Chloe Bruce, Natalie Dailey, Ye To, Stephen Bremner, Duncan Churchill, Anna Maria Geretti

“…Baseline RAMs were explored by retrospective sequencing of cellular HIV-1 DNA. Participants were randomised (1:1) to switching to B/F/TAF either immediately or after 24 weeks. …”
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The Application of <inline-formula><math display="inline"><semantics><mrow><msubsup><mrow><mi mathvariant="bold">S</mi></mrow><mrow><mi mathvariant="bold">n</mi></mrow><mrow><mn ma... by Yingxue Sun, Xiaolei Zhang, Chenli Ye, Ziying He, Hongjie Wang, Ji Li

“…Various polysulfides were used as electron donors in an aerobic/anoxic sequencing batch reactor (SBR) to simulate nitrification and denitrification processes. …”
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Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis by Zizhen Zhang, Shengde Liu, Ting Xu, Nan Chen, Cheng Liu, Hong Yang, Yuanmeng Shi, Zhiwei Li, Xujiao Feng, Yanhong Yao, Xiaorui Duan, Gehan Xu, Cheng Zhang, Zhenghang Wang, Jian Li, Lin Shen

“…Additionally, we conducted assays for cell migration, invasion, angiogenesis, and ELISA to evaluate VEGFA production, all to confirm the functional role of SLC9A2. …”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…Transcriptomic profiling via RNA sequencing (RNA-seq) was performed to identify downstream targets of SMYD2. …”
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Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer by Yu-Chin Liu, Tsung-Jen Lin, Kowit-Yu Chong, Guan-Ying Chen, Chia-Yu Kuo, Yi-Yun Lin, Chia-Wei Chang, Ting-Feng Hsiao, Chih-Liang Wang, Yo-Chen Shih, Chia-Jung Yu

“…Methods We integrated genetic knockout (KO) of golgin-97, animal models (zebrafish and xenograft mice), multi-omics analysis (next-generation sequencing and proteomics), bioinformatics analysis, and kinase inhibitor treatment to evaluate the effects of golgin-97 KO in triple-negative breast cancer cells. …”
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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis by Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, Pan Liao, Bo Yan, Wei Zhang, Fang-Yuan Cheng, Ya-Ru Liu, Zi-Han Zhang, Cheng Wei, Jie Zhou, Fang-Lian Chen, Ping Lei, Xin-Tong Ge

“…Finally, the cognitive effects of intranasal administration of IL-33 were evaluated in mice. Results IL-33KO mice exhibited pronounced cognitive impairment after rmTBI. …”
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Poor clinical outcomes and immunoevasive contexture in CD161+CD8+ T cells barren human pancreatic cancer by Jun Yu, Liang Liu, Hanlin Yin, Qiangda Chen, Siyao Liu, Wenchuan Wu, Ning Pu, Wenhui Lou, Zhenlai Jiang, Taochen He, Yuqi Xie, Weilin Mao, Jiande Han, Joseph R Habib

“…Flow cytometry and single-cell RNA sequencing were used to evaluate their functional status.Results We observed significant associations between tumor-infiltrating CD161+CD8+ T cells and clinicopathological factors, such as tumor differentiation, perineural invasion, and serum CA19-9 levels. …”
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