Breed-specific responses to coccidiosis in chickens: identification of intestinal bacteria linked to disease resistance by Chace Broadwater, Jiaqing Guo, Jing Liu, Isabel Tobin, Melanie A. Whitmore, Michael G. Kaiser, Susan J. Lamont, Guolong Zhang

“…Body weight changes, small intestinal lesions, and fecal oocyst shedding were evaluated on d 17. Ileal and cecal digesta were collected from individual animals on d 17 and subjected to microbiome analysis using 16S rRNA gene sequencing.  …”
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Genome‐wide association studies on resistance to powdery mildew in cultivated emmer wheat by Dhondup Lhamo, Genqiao Li, George Song, Xuehui Li, Taner Z. Sen, Yong‐Qiang Gu, Xiangyang Xu, Steven S. Xu

“…To determine the genetic basis of Bgt resistance in the panel, genome‐wide association studies were performed using 46,383 single nucleotide polymorphisms (SNPs) from genotype‐by‐sequencing and 4331 SNPs from the 9K SNP Infinium array. …”
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Microbial and chemical stability of lumpfish (Cyclopterus lumpus) roe during refrigerated storage in acid-salt brines with or without antioxidants by Hanne Aarslev Jensen, Laura Garcia Plaza, Rannvá Høgnadóttir Houmann, Pernille Bak Andreasen, Niels Bøknæs, Martin Laage Kragh, Lisbeth Truelstrup Hansen, Ole Mejlholm, Charlotte Jacobsen, Paw Dalgaard, Ann-Dorit Moltke Sørensen

“…Therefore, the aim of this study was to evaluate the effect of five different brines comprised of combinations of salt, organic acids, and antioxidants on controlling microbial and chemical changes of the SIP, to be able to avoid the use of benzoic acid and reduce the salt content. …”
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Knocking down hypoxia-induced Semaphorin 6B may attenuate the progression of cervical cancer through regulating macrophage M2 polarization by Shuyan Yi, Sha Hu, Wenhan Li, Jing Cai, Liqiong Cai, Lufang Wang

“…Methods Macrophages were exposed to hypoxia, and next-generation sequencing was performed to analyze differentially expressed genes. …”
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CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach by Yue Peng, Qiang Ji, Qiang Ji, Xiangyu Guo, Weichunbai Zhang, Zixuan Yang, Wenbin Li, Wenbin Li

“…KEGG enrichment analysis identified biological pathways. Single-cell RNA sequencing from 20 glioblastoma cases was analyzed using CellChat and Monocle3 to explore CD9-mediated cell communication and lineage transitions. …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…Additionally, 16S rRNA high-throughput sequencing was conducted to examine alterations in the gut microbiota composition.Results: The results demonstrated that GQD alleviated the colitis symptoms in mice, as evidenced by an increase in goblet cell numbers, upregulation of ZO-1, MUC-2, and Occludin expression, and a decrease in apoptosis in intestinal epithelial cells. …”
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Transcriptomic and biometric parameters analysis in rainbow trout (Oncorhynchus mykiss) challenged with viral hemorrhagic septicemia virus (VHSV) by Mohammad Ghaderzadeh, Ghodrat Rahimi-Mianji, Ardeshir Nejati-Javaremi, Nastaran Shahbazian

“…Additionally, potential resistance genes and pathways were identified through RNA sequencing, providing valuable insights for improving trout breeding programs.…”
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CDKN1A as a target of senescence in heart failure: insights from a multiomics study by Rutao Bian, Rutao Bian, Li Zhang, Li Zhang, Dongyu Li, Dongyu Li, Xuegong Xu, Xuegong Xu

“…The application potential of therapeutic targets is ultimately assessed by evaluating their druggability.ResultsThe expression of 39 SRGs in cardiomyocytes was identified. …”
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Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration... by Sheng Li, Shiyi Lu, Jiahui Xiong, Liang Chen, Yanting Lin, Xiaohui Chen, Xinyi Wang, Lijing Lin, Xiaoliang Cai, Xiaoyu Yang

“…Here, we systematically evaluated the therapeutic efficacy and mechanisms of action of in-house synthesized hydroxyethyl starch-curcumin nanoparticles (HES-CUR NPs) in ulcerative colitis (UC). …”
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Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway by Xiaru Zhang, Ying Zheng, Gang Wang, Yuanlin Liu, Yang Wang, Xueyi Jiang, Yueqing Liang, Xinfeng Zhao, Ping Li, Yi Zhang

“…A series of experiments, including single-cell sequencing, flow cytometry, quantitative real-time polymerase chain reaction, and western blotting, were carried out to evaluate the characteristic and adipogenic–osteogenic differentiation potential of IL-32 overexpression HuMSCs (IL-32highHuMSCs) through mediating the P38 signaling pathway. …”
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Active peptides of TSP-1 inhibit retinal angiogenesis through the CD36 pathway in a rat model of choroidal neovascularization. by Yadi Li, Aiping Deng, Kangwei Jiao, Jie Yan, Wandong Zuo, Yujie Dong, Wenrong Xu, Yuting Li, Chunming Guo, Maorong Chen, Run Tian, Zhulin Hu

“…<h4>Methods</h4>Wound healing, CCK-8, and 5-ethynyl-2'-deoxyuridine (EdU) assays were employed to evaluate the proliferation and migration ability of cells. …”
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Mutations in reverse transcriptase region of HBV affect Hepatitis B surface antigen titers and its correlation with HBV DNA by Hongyu Shen, Chunhua Chen, Chunyan Ye, Hongyu Zhang, Shuangxiong Hang, Min Chen, Zhen Zhu, Yuan Xue, Longgen Liu

“…Conclusions: Serum HBsAg titer and its correlation with HBV DNA may be affected by mutations in the reverse transcriptase region of HBV, that should be re-evaluated in patients with antiviral resistance. …”
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Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis by Hongming Wei, Lu Zhan, Xinhuang Lv, Yan Lin, Jie Zheng, Wenwen Yang, Jiaming Liu, Jing Sun, Songfang Chen

“…Subsequently, the neurological deficit, pathological damages and blood-brain barrier disruption were evaluated. Moreover, the levels of ROS, inflammatory cytokines, NF-𝜿B pathway related protein, and vascular density markers were determined. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…In vitro and in vivo experiments were carried out to evaluate the impact of HSF1 on liver cancer cell proliferation. …”
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Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway by Mouying Du, Chun Yao, Qinke Lv, Aimei Gong, Yonghua Zhu, Jiayuan Li, Jian Zhong

“…The histopathological changes of rat kidney and its function were evaluated 14 days post-UUO. miRNA sequencing and differential gene analysis identified miR-210 as a potential target of YHF treatment. …”
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Dynamic Impact of One-Year Integrated Rice–Crayfish Farming on Bacterioplankton Communities in Paddy Water by Yiran Hou, Qiancheng Xu, Yanhong Yang, Rui Jia, Xiongjian Huang, Linjun Zhou, Bing Li, Jian Zhu

“…Environmental factors and planktonic bacterial communities were evaluated during the tillering, jointing, flowering, and grain-filling stages on August 24, September 5, September 24, and October 16, respectively. …”
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A micro-alloyed Mg-Zn-Ge alloy as promising anode for primary Mg-air batteries by Pingli Jiang, Depeng Li, Ruiqing Hou, Hong Yang, Junjie Yang, Shijie Zhu, Liguo Wang, Shaokang Guan

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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights by Lei Shi, Ziying Zhang, Song Mei, Zerui Wang, Zhe Xu, Weiqi Yao, Limin Liu, Mengqi Yuan, Yuefei Pan, Kaidi Zhu, Kai Liu, Fanglin Meng, Jiao Sun, Wenying Liu, Xiaohui Xie, Tengyun Dong, Lei Huang, Fanping Meng, Jun-Liang Fu, Yuanyuan Li, Chao Zhang, Xing Fan, Ming Shi, Yu Zhang, Yonggang Li, Wei-Fen Xie, Peng Zhang, Fu-Sheng Wang

“…Patients were followed up on Days 7, 14, 21, and 28 to further evaluate the safety and feasibility of multiple-dose regimens. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…The antitumor effect was evaluated via several murine or humanized solid tumor models. …”
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Itaconate and obesity-related hormones promote tumor progression – new insights on metabolic dysfunction in early-onset colon cancer by Katharina M. Scheurlen, Jacob Hallion, Dylan L. Snook, Anne MacLeod, Robert J. Beal, Mary A. Parks, Andrew B. Littlefield, Eliah Hiken, Adrian T. Billeter, Jeannette Bensen, Jeremy T. Gaskins, Julia Chariker, Eric C. Rouchka, Susan Galandiuk

“…RNA sequencing data from 5 sources in the USA and Europe were obtained to perform IRG1-related differential expression analysis (n=178), IRG1-related survival analysis (n=185), and differential expression analysis and survival analysis related to genes of the NOTCH4-GATA4-IRG1 pathway (n=371). …”
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