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7881
Advancing Understanding and Therapeutic Strategies for NUT Sarcomas: Comprehensive Review of the Literature and Two Cases
Published 2025-03-01“…The median survival of the 21 patients evaluable for survival was 14 months. Finally, among 21 patients who received systemic therapy, only three patients receiving chemotherapy showed disease control, as defined by response or stability of the disease. …”
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7882
Neoadjuvant chemotherapy response in androgen receptor-positive triple-negative breast cancer: potential predictive biomarkers and genetic alterations
Published 2025-03-01“…Next-generation sequencing (NGS) was utilized to further investigate the molecular characteristics of 44 AR-positive TNBC patients. …”
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7883
A Proposed Genetic Risk Score for Dilated Cardiomyopathy Susceptibility in the Chinese Han Population
Published 2025-05-01“…The predictive power of the genetic risk score and a composite variable for DCM risk were evaluated using receiver operating characteristic curve analysis. …”
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7884
Geospatial assessment of heavy metal contamination and metal-resistant bacteria in Qarun Lake, Egypt
Published 2025-06-01“…These techniques can predict metal levels following biological treatment, thus offering a method to evaluate the effectiveness of bioremediation.…”
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7885
Single Nucleotide Polymorphisms of IL-33 Gene Correlated with Renal Allograft Fibrosis in Kidney Transplant Recipients
Published 2021-01-01“…Thirty-nine IL-33-related SNPs were identified in targeted sequencing, in which 26 tagger SNPs were found by linkage disequilibrium analysis for further analysis. …”
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7886
Cyclic Peptide MV6, an Aminoglycoside Efficacy Enhancer Against <i>Acinetobacter baumannii</i>
Published 2024-12-01“…Whole-genome sequencing and variant calling analysis were then performed. …”
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7887
The maintenance of competence of rural district hospital medical practitioners
Published 2006-04-01“…Expert opinion was sought to evaluate the topics requiring updating and the validity of the learning methods to maintain competence in practice. …”
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7888
Genome-wide association study reveals the QTLs and candidate genes associated with seed longevity in soybean (Glycine max (L.) Merrill)
Published 2025-07-01“…GWAS using 29,955 Genotyping-by-sequencing (GBS)-single nucleotide polymorphism (SNP) markers identified 71 significant SNPs linked to seed longevity traits. …”
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7889
Impact of Low-dose Imaging on PET Quantitative Accuracy and Image Quality
Published 2025-02-01“…Additionally, the influence of different acquisition durations on scatter fraction was evaluated, with a fixed imaging dose, and vice versa. …”
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7890
Stress-relieving plant growth-promoting bacterial co-inoculation enhances nodulation and nitrogen uptake in black gram under nitrogen-free saline conditions
Published 2025-01-01“…This study aimed to identify and evaluate native microbial communities from salt-affected regions to boost black gram (Vigna mungo) resilience against salinity, while improving plant growth, nitrogen uptake, and nodulation in saline environments. …”
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7891
Therapy Companion Mobile App for Acceptance and Commitment Therapy Exercises (ACTaide): Therapist and Client Co-Design Study
Published 2025-07-01“…Future research will focus on testing high-fidelity prototypes to evaluate acceptability, usability, and engagement.…”
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7892
Methylation of the UNC5C gene and its protein expression in colorectal cancer
Published 2017-04-01“…The methylation-specific polymerase chain reaction results were confirmed by bisulfite sequencing of UNC5C promoter region. UNC5C methylation was significantly higher in early tumor, node, metastasis stage (I + II) of colorectal cancers. …”
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7893
ALDH18A1 has carcinogenic functions and regulates alternative splicing events of DNA repair-related genes in esophageal carcinoma cells
Published 2025-08-01“…In this study, we silenced ALDH18A1 in KYSE150 cells using small interfering RNA (siALDH18A1), and evaluated its effect on cell characteristics. Finally, we conducted whole transcriptome sequencing (RNA-seq) and RNA immunoprecipitation (iRIP-seq) experiments to explore the downstream targets of ALDH18A1, and verified their change patterns using quantitative polymerase chain reaction. …”
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7894
Microglia in the aged brain develop a hypoactive molecular phenotype after surgery
Published 2024-12-01“…Cytokine concentrations in plasma and brain tissue were evaluated using enzyme-linked immunosorbent assays (ELISA). …”
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7895
Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study
Published 2025-06-01“…This study aimed to evaluate the utility of ultrashort echo time (UTE) MRI biomarkers, including macromolecular fraction (MMF), magnetization transfer ratio (MTR), and T2*, for in vivo quantification of OCJ changes in knee OA for the first time. …”
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7896
Selection of Probiotics for Honey Bees: The In Vitro Inhibition of <i>Paenibacillus larvae</i>, <i>Melissococcus plutonius</i>, and <i>Serratia marcescens</i> Strain Sicaria by Hos...
Published 2025-05-01“…Using 16S rRNA gene sequencing, the isolates were classified and tested in vitro against four <i>P. larvae</i> isolates, one <i>M. plutonius</i> isolate, and the <i>S. marcescens</i> strain sicaria in modified BHI medium. …”
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7897
Lactobacillus plantarum SAL delays aging-associated oxidative stress and gut microbiota dysbiosis in mice
Published 2025-06-01“…After the intervention, serum and liver tissues were collected to detect aging biomarkers (β-galactosidase) and oxidative stress markers.Colon tissue histopathological examination was performed, and fresh fecal samples were subjected to metagenomic sequencing and analysis. Additionally, Spearman correlation analysis was conducted to evaluate the relationships between genuslevel differential gut microbiota and oxidative stress markers in serum and liver tissues.ResultsCompared with the MOD group, the SAL group exhibited significantly reduced MDA levels in serum and liver tissues (all p < 0.05), elevated activities of SOD and T-AOC (all p < 0.05), and increased serum GSH-Px and CAT activities (all p < 0.05). …”
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7898
Utilizing Multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression.
Published 2025-01-01“…Additionally, both the ssGSEA algorithm and the CIBERSORT algorithm were utilized to evaluate changes and effects in immunological characteristics during gastric cancer pathogenesis.…”
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7899
Microbiome and Resistome in Poultry Litter-Fertilized and Unfertilized Agricultural Soils
Published 2025-03-01“…This study aimed to evaluate the impact of poultry litter use on the microbiome and resistome of agricultural soils. …”
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7900
Prognostic value of immuno-inflammatory biomarkers in esophageal squamous cell carcinoma patients receiving immunotherapy combined with chemoradiotherapy and its association with i...
Published 2024-12-01“…Pre-treatment tumor samples from 47 patients were collected for RNA sequencing to investigate the immune-related tumor microenvironment. …”
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