IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…In vitro and in vivo functional studies were conducted to evaluate the role and mechanisms of IFITM3 in modulating tumor sensitivity to PD-1 inhibitors. …”
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Inherited Hypertrabeculation? Genetic and Clinical Insights in Blood Relatives of Genetically Affected Left Ventricular Excessive Trabeculation Patients by Balázs Mester, Zoltán Lipták, Kristóf Attila Farkas-Sütő, Kinga Grebur, Flóra Klára Gyulánczi, Alexandra Fábián, Bálint András Fekete, Tamás Attila György, Csaba Bödör, Attila Kovács, Béla Merkely, Andrea Szűcs

“…In addition to regular ECG parameters, Sokolow-Lyon Index (SLI) values were calculated. 2D ECHO images were analysed with TomTec Arena, evaluating LV volumetric, functional (EF) and strain parameters. …”
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Competitive antagonistic action of laccase between Trichoderma species and the newly identified wood pathogenic Ganoderma camelum by Aisha Umar, Aisha Umar, Mohamed S. Elshikh, Reem M. Aljowaie, Juma Mahmud Hussein, Laurent Dufossé, Chenghong Wu, Junxing Lu

“…Phylogenetic analysis and ITS rDNA sequences indicated that the species were Trichoderma and Ganoderma camelum. …”
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PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose by Yanjuan Jia, Yaling Li, Yan Li, Yonghong Li, Tao Qu, Zhuomin Fu, Yuanyuan Ma, Zhenhao Li, Wanxia Wang, Miao Yu, Xiaojie Jin, Xiaoling Gao, Yongqi Liu

“…Cellular and animal models were applied to validate the role of PYGO1 in GC. RNA sequencing, flow cytometry, and immunofluorescence explored the underlying mechanisms. …”
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A novel BCAP31 variant associated with nonsyndromic auditory neuropathy spectrum disorder: mitochondrial dysfunction, cisplatin sensitivity, and amenability to mitochondrial transp... by Yehree Kim, Yujin Kim, Bong Jik Kim, Shin-Hye Yu, Jin Hee Han, Minyoung Kim, Nayoung Yi, Seo-Eun Lee, Ju Ang Kim, Kyuboem Han, Chun-Hyung Kim, Young Cheol Kang, Byung Yoon Choi

“…Mitochondrial function was evaluated by measuring intracellular ATP, ROS and mitochondrial membrane potential in control and patient-derived lymphoblastoid cells (LCLs) before and after the administration of mitochondria isolated from human umbilical cord mesenchymal stem cells (UC-MSCs). …”
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Efficacy of Lycium barbarum (Goji berry) mouthwash for managing periodontitis: a randomized clinical trial [version 4; peer review: 2 approved, 1 approved with reservations] by Laasya Shettigar, Aditi Chopra, Richard Lobo, Amee Sanghavi, Shobha Ullas Kamath, Prajna P Nayak, Ashmeet Shah, Usha Y Nayak, Mangalore Shravya S, Padmaja A Shenoy, ShivaPrasada Gadag

“…Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing periodontitis. …”
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Multi-parametric MRI-based radiomics nomogram for predicting lymphovascular space invasion in early-stage cervical adenocarcinoma by Ke-Ying Wang, Mei-Ling Xiao, Mei-Ling Xiao, Yu-Han Fang, Yu-Han Fang, Jie-Jun Cheng, Zi-Jing Lin, Ying Li, Jin-Wei Qiang

“…Receiver operating characteristic (ROC) curves and areas under the curve (AUCs) were used to evaluate the performance of the clinical model, radiomics model, and nomogram. …”
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Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer by Min Li, Hui Shen, Feng Xie, Feng Lu, Jianxin Yang, Yuxiao Tang, Qicong Shen, Zelong Gao, Mengpu Wu, Chenghua Wu, Jicong Du, Changquan Ling, Yifeng Chai, Xin Dong, Jianxin Qian, Chenqi Li, Zhenhong Guo, Dongyao Wang

“…Tumor cells killing effects were evaluated by co-culture of tumor cells and CD8+ T cells.Results Targeting Annexin A2 effectively suppressed the progression of liver cancer. …”
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The Effects of Sourdough Fermentation on the Biochemical Properties, Aroma Profile and Leavening Capacity of Carob Flour by Gemma Sanmartín, Jose A. Prieto, Miguel Morard, Francisco Estruch, Josep Blasco-García, Francisca Randez-Gil

“…However, its high sugar content and the presence of undesirable compounds such as furans present challenges for its use in bread making. This study evaluated the effects of prolonged sourdough fermentation on roasted carob flour, with a focus on microbial dynamics and its functional and technological properties. …”
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THE EFFECTIVENESS OF PTPN11 GENE ANALYSIS IN THE PRENATAL DIAGNOSIS OF NOONAN SYNDROME by Güven Toksoy, Fatih Tepgeç, Tuğba Saraç Sivrikoz, İbrahim Halil Kalelioğlu, Selma Demir, Recep Has, Atıl Yüksel, Zehra Oya Uyguner, Seher Başaran

“…Material and Method: PTPN11 analysis with different approaches in 246 normal karyotyped prenatal cases with NS-associated USG findings were retrospectively evaluated. The targeted PTPN11 regions in 200 and the whole gene structure of 46 cases were examined by Sanger sequencing. …”
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The potential regulatory role of mannose phosphotransferase system EII in alkaline resistance of Enterococcus faecalis by Runze Liu, Yi Luo, Pei Liu, Shuo Xiao, Wei Fan, Bing Fan

“…The effects of mptD on the expression of other Man-PTS EII components and membrane transport-related genes were evaluated by RT-qPCR at pH 10. In addition, six clinical strains were isolated. …”
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Norcholic Acid Promotes M1 Macrophage Polarization in Acute Pancreatitis by Activating the Wnt/β-Catenin Pathway by Xingyu Liu, Jun Yu, Junning Liu, Qing Zhou, Linfeng Yang, Qian Dai, Jianshui Li, Chuan Lan, Dawei Deng

“…To evaluate NorCA’s regulatory effect on M1 macrophage polarization through the Wnt/β-catenin signaling pathway in AP development, we employed flow cytometry, western blotting, and qRT-PCR analyses. …”
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MRI radiomics and nutritional-inflammatory biomarkers: a powerful combination for predicting progression-free survival in cervical cancer patients undergoing concurrent chemoradiot... by Qi Yan, Menghan- Wu, Jing Zhang, Jiayang- Yang, Guannan- Lv, Baojun- Qu, Yanping- Zhang, Xia Yan, Jianbo- Song

“…Radiomic features from three MRI sequences were extracted and selected for predictive value. …”
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Aquaponics model can provide better productivity: Microorganisms affect the growth and health of tilapia by Dingyue Fan, Huimin Xu, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Dandan Li, Longxiang Fang, Zhuping Liu, Xuwen Bing

“…In the present study, three aquaponics systems were established, and three same sized recirculating aquaculture systems (RAS) were constructed to act as controls. To evaluate bacterial community diversity and compositions across different microhabitats in the two systems, we used amplicon-based high-throughput sequencing technique targeting the 16S rRNA gene. …”
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Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity by Duo Gao, Yimin Zhuang, Shuai Liu, Boyan Ma, Yiming Xu, Hongxing Zhang, Yiliyaer Nuermaimaiti, Tianyu Chen, Guobin Hou, Wenli Guo, Jingtao You, Zhiyu Huang, Jianxin Xiao, Wei Wang, Mengmeng Li, Shengli Li, Zhijun Cao

“…Using a multi-omics approach, we performed 16S rRNA gene sequencing to evaluate microbial diversity, conducted metagenomic analysis to identify functional bacteria, and utilized untargeted metabolomics to profile serum metabolites. …”
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Quantifying the chemical composition of weathering products of Hainan basalts with reflectance spectroscopy and its implications for Mars by Xing Wu, JiaCheng Liu, WeiChao Sun, Yang Liu, Joseph Michalski, Wei Tan, XiaoRong Qin, YongLiao Zou

“…With the development of the hyperspectral remote sensing technique, extensive chemical weathering profiles have been identified on Mars. These weathering sequences, formed through precipitation-driven leaching processes, can reflect the paleoenvironments and paleoclimates during pedogenic processes. …”
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Nutritional and nutraceutical components of four Cantharellus species (Cantharellaceae, Cantharellales) from the Mountain Region, Veracruz, Mexico by Edgar Josúe Hernández Marañón, Antonio Andrade-Torres, Jie Chen, Rosalía Núñez-Pastrana, Jesús Pérez-Moreno, Anahí Hernández-Marañón, Régulo Carlos Llarena-Hernández

“…The ITS and tef-1α regions were amplified and sequenced. Species were identified molecularly based on the BLAST results. …”
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Atf3 + senescent chondrocytes mediate meniscus degeneration in aging by Jing-Yi Wang, Yao-Hui Liu, Xiao Wang, Min Ma, Zhang-Yi Pan, Ao-Yuan Fan, Lai-Ya Lu, Zheng Liu, Kun Tao, Feng Yin

“…We aimed to characterize age-related changes in the rat meniscus using single-cell RNA sequencing (scRNA-seq) and identify key pathogenic cell populations and pathways. …”
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Plant growth-promoting bacteria as biological control agents for sustainable agriculture: targeting root-knot nematodes by Adriana S. Mata, Carlos Cruz, João Rodrigues Gaspar, Isabel Abrantes, Isabel Luci Conceição, Paula V. Morais, Diogo Neves Proença, Diogo Neves Proença

“…The genomes of the strains were sequenced and analyzed for PGPB traits, and phenotypic assays were also performed. …”
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Characterization of zoonotic hepatitis E virus in domestic pigs and wild boar in Vietnam: Implications for public health by Le Chi Cao, Le Nguyen Nhat Ha, Tran Thi Giang, Vo Minh Tiep, Ngo Thi Minh Chau, Ton Nu Phuong Anh, Pham Khanh Duy, Le Phuc Nhan, Nguyen Thi Thu Hoai, Le Thi Kieu Linh, Nourhane Hafza, C. Thomas Bock, Truong Nhat My, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, Thirumalaisamy P. Velavan

“…Further investigations involving occupationally exposed individuals in high-prevalence areas are warranted to evaluate the human health impact of zoonotic hepatitis E and inform preventive measures. …”
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