Targeting EPAS-1/HIF-2α Pathway to Address Endocrine Resistance in Luminal A Type Breast Cancer by Enzhi Luo, Seongmin Lee, Neeraj manvi agarwal, Junjeong Choi

“…Methods: We performed a comprehensive multi-omics analysis using publicly available transcriptomics and whole-exome sequencing data from tamoxifen-sensitive and tamoxifen-resistant luminal A breast cancer patient samples. …”
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Intestinal helminth Schyzocotyle acheilognathi Yamaguti, 1934 infection ameliorate lipid metabolism of grass carp (Ctenopharyngodon idella) through immune and gut microbiota regula... by Xiaoao Yang, Denghui Zhu, Wenxiang Li, Peipei Fu

“…Helminth infection in mammals was inversely correlated with metabolic syndrome, but its effect in aquatic animals is unknown yet. Here, we evaluated the impacts of Schyzocotyle acheilognathi infection on lipid metabolism of grass carp fed with high-fat diet (HFD). …”
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Will gut, oral, and vaginal microbiota influence the outcome of FET or be influenced by FET? A pilot study by Zhao Zhang, Yiwen Zhang, Aihua Wu, Chengfang Xu, Zhe Li

“…Metabolomics and random forest were used for evaluating the relationship between gut microbiota and metabolites during FET. …”
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Effects of concurrent continuous aerobic and short rest resistance exercise training on metabolic biomarkers in type 2 diabetes patients: a systematic review and meta-analysis by Friew Amare, Alemmebrat Kiflu, Aschenaki Taddese

“…Abstract Objective This study aimed to systematically evaluate the impact of a 12-week concurrent training program combining continuous aerobic exercise and short-rest resistance training on metabolic biomarkers in type 2 diabetes mellitus (T2DM) patients through a meta-analysis of the available evidence. …”
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New therapeutic approaches for EGFR mutated non-small cell lung cancer on osimertinib era by Jaime Rubio-Perez, Roberto Hernandez, Carlota Santolaya, Maria Cruz Martin-Soberon, Sandra Zazo, Nerea Carvajal, Federico Rojo

“…Comprehensive genomic profiling was conducted using next-generation sequencing (NGS) to evaluate co-mutations. Kaplan-Meier survival curves and Cox regression were applied to assess progression-free survival (PFS) and overall survival (OS). …”
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Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma by Ruolan Zhang M.M., Jianlin Liu M.M., Hang Yang M.M., Jinsong Tan M.M., Rong Xiong M.M., Yun Liu MM, Gang Feng PhD, Guiqin Song PhD, Kang Liu PhD

“…Methods Upregulated circRNAs were identified through RNA sequencing, with circCYP24A1 being identified as the target circRNA. …”
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Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) was performed to evaluate the abundance of immune infiltrating cells. …”
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Altered Nasal Microbiota-Metabolome Interactions in Allergic Rhinitis: Implications for Inflammatory Dysregulation by Ma Q, Wang N, Zheng X, Liu J, Che Y, Wang J

“…Metabolomic alterations were evaluated using LC-MS/MS, and correlations between microbiota and metabolites were analyzed.Results: While α-diversity did not differ significantly between groups, β-diversity analysis revealed distinct microbial community shifts in AR patients. …”
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Transcriptomic insights into Candida albicans adaptation to an anaerobic environment by Karen D. Zeise, John R. Erb-Downward, Gary B. Huffnagle

“…In this study, we used RNA sequencing to compare the global transcriptomic profiles of two strains of C. albicans (SC5314 and CHN1) grown purely anaerobically to those grown aerobically. …”
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Genetic diversity of sarbecoviruses isolated from microbats in Southern Japan by Kosuke Okuya, Sho Sata, Mana Esaki, Isshu Kojima, Masahiro Kajihara, Shin Murakami, Takuji Sakata, Kimitake Funakoshi, Makoto Ozawa

“…Cross-species potential was evaluated in vivo through experimental infection in Syrian hamsters. …”
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Effects of long-term 2.65 GHz radiofrequency radiation on inflammatory response and intestinal microbiota in mice by LI Keqin, LI Keqin, HAO Yanhui, LIU Ying

“…Additionally, metagenomic sequencing was performed to assess alterations in the gut microbiota composition. …”
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Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering by Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C. Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig

“…Independently, two radiologists measured maximum and minimum vessel diameters (inner-edge) and evaluated image quality and motion artifacts on 5-point scales (5 = excellent) for the following levels: mid-graft, distal anastomosis, ascending aorta, aortic arch, and descending aorta. …”
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TGF-β Decreases NK Cell Mobility and Cytotoxic Efficacy in Complex in vitro Models of the Leukemia Microenvironment by Švubová V, Janstová L, Jedlička M, Mašínová E, Szabová J, Feglarová T, Kuglerová K, Bosáková V, Brodská B, Boráková K, Kundrát D, Trsová I, Böhmová M, Kuželová K, Hrdý J, Gašová Z, Vydra J, Dostálová Merkerová M, Hortová-Kohoutková M, Frič J

“…Bulk RNA sequencing (RNA-seq) was performed to analyze global gene expression changes in TGF-β-treated primary human NK cells. …”
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MiR‐146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia–reperfusion injury in lung transplantation by Xiucheng Yang, Shanchao Hong, Tao Yan, Mingzhao Liu, Mingyao Liu, Jin Zhao, Bingqing Yue, Di Wu, Jingbo Shao, Man Huang, Jingyu Chen

“…We utilised both a rat orthotopic LTx model and a cell cold preservation reperfusion model to evaluate the therapeutic efficacy of hucMSC‐EVs. Bulk‐RNA sequencing, single‐cell sequencing analysis, immunofluorescence and Western blot techniques were employed to assess NLRP3 inflammasome activation and inflammation. …”
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Near-infrared fluorescent nanoprobe enables noninvasive, longitudinal monitoring of graft outcome in RPE transplantation by Guanzhou Di, Chen Lu, Mengting Xue, Limin Zheng, Limin Zheng, Weiqi Li, Runmin Xie, Xinpei Yuan, Xu Zhen, Min Wu, Xiying Mao, Songtao Yuan

“…Immunofluorescence staining and single-cell RNA sequencing (scRNA-seq) were used to characterize the cell types showing the fluorescence signal of the nanoprobe and to determine the composition of the immune microenvironment associated with subretinal transplantation.ResultsThe spatial distribution of the fluorescence signal of the nanoprobe corresponded with the site of transplantation, but the signal intensity decreased over time, while the signal distribution extended to the choroid. …”
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Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer by Ziqi Chen, Zhipeng Zhang, Bei Ning Nie, Wei Huang, Ying Zhu, Long Zhang, Meng Xu, Mengfei Wang, Chenyue Yuan, Ningning Liu, Xinyi Wang, Jianhui Tian, Qian Ba, Ziliang Wang

“…This study aimed to delineate the microbiome characteristics that distinguish CRC patients from healthy individuals, while also evaluating the influence of aging, through a comprehensive metagenomic approach. …”
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Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer by Zhicheng Huang, Tianhui Zhang, Jinghua Pan, Guihao Zhang, Linjun Jiang, Huiming Jiang, Pei Wan, Ying Peng, Wenchao Zou, Qinghua Liu, Nanhui Chen

“…Additionally, the expression of specific immune‐related genes was evaluated for their association with HIPEC response. …”
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Enhanced Effect of IL-1β-Activated Adipose-Derived MSCs (ADMSCs) on Repair of Intestinal Ischemia-Reperfusion Injury via COX-2-PGE2 Signaling by Liu Liu, Yi Ren He, Shao Jun Liu, Lei Hu, Li Chuang Liang, Dong Liang Liu, Lin Liu, Zhi Qiang Zhu

“…Activated ADMSCs was transplanted into IR-injured intestine in a mouse model, and therapeutic effect was evaluated. In addition, to explore underlying mechanisms, COX-2 expression was silenced to investigate its role in activated ADMSCs for treatment of intestinal IR injury. …”
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Forecasting framework for dominant SARS-CoV-2 strains before clade replacement using phylogeny-informed genetic distances by Kyuyoung Lee, Atanas V. Demirev, Sangyi Lee, Seunghye Cho, Hyunbeen Kim, Junhyung Cho, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Woojin Shin, Soyoung Lee, Sejik Park, Philippe Lemey, Man-Seong Park, Man-Seong Park, Man-Seong Park, Jin Il Kim, Jin Il Kim, Jin Il Kim

“…Consequently, accurately predicting the next clade roots through global surveillance is crucial for effective prevention, control, and timely updates of vaccine antigen updates. This study evaluated the evolutionary dynamics of SARS-CoV-2 using phylogeny-informed genetic distances based on 394 complete genomes and spike (S) gene sequences. …”
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SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis by Huimou Chen, Jing Hu, Xilin Xiong, Hongling Chen, Qiaofang Liao, Biaojun Lin, Yusong Chen, Yanting Peng, Yang Li, Di Cheng, Zhihua Li

“…The molecular regulatory mechanisms of SETD8 in ES were examined through the application of RNA sequencing (RNA-seq) and mass spectrometry-based proteomic analysis. …”
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