Integrated Phenotypic and Genotypic Approaches for Accurate Diagnosis of G6PD Deficiency: Implications for Drug Safety in Thailand by Natnicha Pengsuk, Kamonwan Chamchoy, Chatnapa Duangdee, Jantawan Satayarak, Naowarat Saralamba, Wang Nguitragool, Usa Boonyuen

“…Providing accurate and reliable G6PD status is vital to ensuring safe treatment, reducing complications, and improving healthcare outcomes in these populations. This study evaluated the integration of phenotypic and genotypic diagnostic methods for identifying G6PD deficiency in 2953 participants in Thailand. …”
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EEA for sellar chodrosarcomas: case series with literature review by GuoFo Ma, Ning Qiao, Wentao Wu, BoChao Zhang, Kefan Cai, SongBai Gui

“…In this article, we summarized our case series and reviewed the previous papers to evaluate the clinical outcomes of neuroendoscopic resection for sellar chondrosarcomas. …”
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Characterization and DNA barcoding of Zambian plant species used as inoculum in the traditional fermentation of Munkoyo; a cereal-based beverage by Mubonda Kalumbilo, David Chuba, Agripina Banda, Eddy J. Smid, Sijmen E. Schoustra, Gerlinde B. De Deyn

“…To validate their identification, we evaluated three DNA barcoding markers (matK, rbcL, and ITS2) for species discrimination. …”
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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques. by Christopher T Edwards, Kirti A Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L Pellegrini, Matthew R Burnett, Christopher Cole Honeycutt, Stacey A Lapp, Thang Ton, Mark C Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E Scheuermann, Amelia Wilkes, Jennifer S Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A Upadhyay, Ian N Moore, Nicholas J Maness, Daniel C Douek, Anne Piantadosi, Raiees Andrabi, Thomas R Rogers, Dennis R Burton, Steven E Bosinger

“…We observed a significant reduction in inflammatory cytokines and macrophages within the lower airway of animals infused with 10mg/kg and 1mg/kg doses of CC40.8. Viral genome sequencing demonstrated a lack of escape mutations in the CC40.8 epitope. …”
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Enrichment and Identification of Pancreas Lipase Inhibitory Peptides from Food Protein Hydrolysate Using Group-Selective Peptide Adsorption Support by Yuta Matsunaga, Hirokazu Akiyama, Kazunori Shimizu, Hiroyuki Honda

“…To assess the enrichment effect, we calculated the enrichment ratio and synthesized 20 peptides with the highest enrichment ratios to evaluate their PLI activity. Nine of these peptides exhibited PLI activity, revealing a trend that peptides with higher enrichment ratios tended to show stronger activity. …”
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<i>Persea americana</i> Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut–Joint Axis by Doha A. Mohamed, Asmaa A. Ramadan, Hoda B. Mabrok, Gamil E. Ibrahim, Shaimaa E. Mohammed

“…The impact of APN on the plasma lipid profile, oxidative and inflammatory markers, and the indices of coronary risk and atherogenicity as CVD markers were evaluated. The gene expression of COX-2, IL-6, IL-1β, IL-10, and TNF-α in liver and spleen tissues were measured. …”
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Mitochondrial DNA methylation is involved in contrast-induced renal tubular epithelial cell injury by Meiling Lv, Manyu Zhang, Sha Chen, Sheng Lu, Dingwei Yang

“…We stimulated HK-2 cells with iohexol to establish an in vitro model and analyzed the methylation level of mtDNA by bisulfite amplicon sequencing. The mitochondrial membrane potential, mitochondrial reactive oxygen species (mtROS), intracellular ROS, and changes in mitochondrial ultrastructure were evaluated as indicators of mitochondrial damage. …”
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ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma by Andong Liu, Xia Lu, Yanyang Song, Jiaying Pei, Ruozheng Wei

“…LLPS properties were evaluated using time-lapse imaging, photobleaching, optoDroplet assays, and in vitro droplet formation assays. …”
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Extracellular vesicles in osteoarthritis synovial fluid contain both transmembrane and intravesical TNF-α by Xin Zhang, Virginia Byers Kraus

“…CZ CELLxGENE and OA joint tissue-derived single-cell and single-nuclei RNA sequencing data were used to analyze TNF gene expression. …”
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Activation of Nrf2 pathway by 4-Octyl itaconate enhances donor lung function in cold preservation settings by Xinliang Gao, Mingbo Tang, Jialin Li, Jianzun Ma, Zhengrui Liu, Wei Liu

“…ALI-airway and lung transplantation organoid models evaluated improvements in bronchial epithelial morphology and function due to 4-OI. …”
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TIPE regulates glucometabolic reprogramming by modulating LDHA expression in triple-negative breast cancer by HU Wei, REN Xiaomeng, WANG Yang, ZHAO Peiqing, CAO Kai

“…Methods: Stable TIPE-knockdown MDA-MB-231 cell lines were established using a lentiviral shRNA system and selected with puromycin. Transcriptome sequencing was used to analyze TIPE's impact on TNBC glycolytic pathways. …”
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Effects of different proportions of organic substitution for mineral fertilizers on soil methanogenic and methanotrophic communities in paddy fields by Dandan Yuan, Keke Dang, Jing Yin, Han Liu, Tingting Ma, Jia Liu, Xingjia Xiang

“…This study comprehensively evaluated the effects of organic substitution for mineral fertilizers, providing an essential theoretical basis for the sustainable development of agriculture.…”
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Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers by Yue Su, Miaomiao Wang, Zhiyong Wu, Peng Huang, Jianguo Zeng

“…The effects of sanguinarine and its metabolites on the intestinal immune function of broiler chickens were evaluated using 16S rRNA gene amplicon sequencing and tryptophan metabolomics approaches. …”
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Xianyu capsule ameliorates neuroinflammatory and glycerophospholipid metabolism in lithium-pilocarpine-induced acute epilepsy by Dongsheng Yu, Shuang Li, Xiaoping Li, Xiaodan Zhang, Xiaodan Zhang, Danfeng Guo, Danfeng Guo

“…This research employed a multi-omics approach to systematically evaluate the anti-epileptic efficacy of XYC and elucidate its underlying mechanisms.MethodsEpilepsy rat model was established by lithium-pilocarpine hydrochloride injection. …”
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Antimicrobial Susceptibility and Toxin Gene Profiles of Commensal <i>Clostridium perfringens</i> Isolates from Turkeys in Hungarian Poultry Farms (2022–2023) by Ádám Kerek, Ábel Szabó, Franciska Barnácz, Bence Csirmaz, László Kovács, Ákos Jerzsele

“…Future studies should include larger sample sizes and employ next-generation sequencing to further investigate multidrug-resistant strains.…”
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Dissecting genomes of multiple yak populations: unveiling ancestry and high-altitude adaptation through whole-genome resequencing analysis by Sheikh Firdous Ahmad, Munish Gangwar, Amit Kumar, Amod Kumar, Mahesh Shivanand Dige, Girish Kumar Jha, Gyanendra Kumar Gaur, Triveni Dutt

“…Abstract The present study was undertaken to elucidate the population structure and differentiation of Indian yak from Chinese and wild cohorts on genome-wide scale by identifying the selection sweeps and genomic basis of their adaptation across different comparisons while analyzing whole genome sequencing (WGS) data using latest bioinformatics tools. …”
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Multiparameter MRI-based model integrating radiomics and deep learning for preoperative staging of laryngeal squamous cell carcinoma by Kai Xie, Huan Jiang, Xinwei Chen, Youquan Ning, Qiang Yu, Fajin Lv, Rui Liu, Yuan Zhou, Lin Xu, Qiang Yue, Juan Peng

“…The predictive capability of the combined model for Progression-Free Survival (PFS) was evaluated via Kaplan–Meier survival analysis and the Harrell’s Concordance Index (C-index). …”
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COPD RISK IN PAKISTANI PUNJABI POPULATION: ROLE OF GATM, PSMA4, AND CHRNA5-A3-B4 GENE VARIANTS by Samra Kousar, Atif Mahmood, Mohsin Sajjad, Atia Rehman, Ujala Tayyab, Ayesha Shahbaz Khan, Mariam Shahid

“…After a literature review and with the help of bioinformatics tools, risk-associated deleterious SNPs residing within or among genes GATM, PSMA4, CHRNA3, CHRNA5, and CHRNB4 were selected to evaluate their association with COPD. Following the mini-sequencing technique, the disease’s association analysis was done using PLINK v1.9 and SHEsis Plus. …”
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Fungicide resistance profiles of Alternaria spp. associated with fruit rot of blueberry in Georgia, USA by Mirza Ashikul Beg, Md. Aktaruzzaman, Kippy J. Lewis, Jonathan E. Oliver

“…Fungicide applications from bloom through harvest are typically recommended for management of fruit rots, however fungicide resistance development has the potential to complicate management activities by reducing fungicide efficacy. To evaluate fungicide resistance issues in Georgia, 46 isolates of Alternaria spp. from ripe blueberry fruit from four major blueberry-producing counties were collected and identified by morphological and molecular features. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Immunohistochemical analysis was performed to evaluate activin A and T‐cell markers CD8 and FoxP3 at the protein level. …”
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