Comprehensive genomic analysis in sporadic early-onset colorectal adenocarcinoma patients by Ben Ponvilawan, Phuwanat Sakornsakolpat, Ananya Pongpaibul, Ekkapong Roothumnong, Charuwan Akewanlop, Manop Pithukpakorn, Krittiya Korphaisarn

“…Abstract Background The incidence of colorectal cancer (CRC) in young adults has increased worldwide. Our study aimed to evaluate genomic alterations in early-onset (aged 15–39 years) sporadic CRC. …”
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116 Acute inorganic arsenic exposure and antibiotic perturbation of the murine gut microbiome induce interindividual susceptibility to a sepsis-like disease by Trenton Wolfe, Barbara A. Roggenbeck, Qian Wang, Lu Wang, Emma Dardenne-Ankringa, Andreina Rodoni, Nick V. Pinkham, Reece Erickson, Seth T. Walk

“…We also anticipate that 16S sequencing results of cecal contents will further support findings by providing evidence of a bacterial infection in the ceca of sick mice. …”
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Epidemiological and genetic factors affecting severe epizootic hemorrhagic disease in Spanish Holstein cattle during the Southern Europe outbreak of 2023 by O. González-Recio, A. Fernández, J.A. Jiménez Montero

“…The genetic component of EHD was evaluated using REML procedures, and a GWAS was conducted to investigate genomic regions associated with the disease. …”
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Current pattern of antibiotic resistance and molecular characterization of virulence genes in Klebsiella pneumoniae obtained from urinary tract infection (UTIs) patients, Peshawar. by Zeeshan Khan, Qaisar Ali, Sadiq Azam, Ibrar Khan, Jamila Javed, Noor Rehman, Mesaik M Ahmed, Jalal Uddin, Ajmal Khan, Ahmed Al-Harrasi

“…The current study's finding is to evaluate the rise of antibiotic resistance in hospital settings, which highly demands the focus of health authorities and clinicians to manage the burden of the disease effectively.…”
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Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning by Changjin Wei, Yongfeng Zhu, Caiming Chen, Feipeng Li, Li Zheng

“…Differences between the immune microenvironment of COPD and normal samples were analyzed using the ESTIMATE algorithm, the CIBERSORT method, and single-cell sequencing data. COPD patients were clustered using the ConsensusClusterPlus algorithm, and the pathway activity differences of different inflammatory subtypes were analyzed using GSVA. …”
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Prenatal genetic detection in foetus with gallbladder size anomalies: cohort study and systematic review of the literature by Yimo Zeng, Rong Hu, Jian Lu, Yiming Qi, Dan Chen, Chaoxiang Yang, Jing Wu

“…All these patients underwent chromosomal microarray and/or karyotyping, and 37 cases also underwent whole exome sequencing (WES). Two hundred and eight cases were followed up for postnatal outcomes. …”
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Expression and clinical significance of histamine receptors in pediatric AML by Bi Zhou, WenPeng Wang, Pao Yu, Yang Yang, DaWei Mi, YuanYuan Tian, Ying Li, Feng Zhu

“…Background This study investigates the expression and clinical significance of the histamine receptor family (HRs) in the bone marrow of children with newly diagnosed acute myeloid leukemia (AML).Methods RNA sequencing was performed to assess the expression levels of HR family members (HRH1, HRH2, HRH3, and HRH4) in the bone marrow of 140 pediatric AML patients prior to chemotherapy. …”
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Intravoxel incoherent motion and diffusion kurtosis imaging for subtype differentiation in salivary gland tumors: a diagnostic performance study by Jinru Yu, Huimin Huang, Jiawen Gao, Han Zhang, Shuo Shao, Ning Zheng

“…Abstract Objective Salivary gland tumors (SGTs) have complex anatomy and diverse pathological types in the head and neck. Our study evaluates the diagnostic efficacy of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) models in differentiating benign from malignant salivary gland tumors (SGTs) and characterizing tumor subtypes. …”
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Characteristic genes and immune landscape of interstitial cystitis. by Junhao Wang, Yan Zhou, Jie Hu, Jianpeng Han, Jianyong Feng, Kuo Guo, Wenbin Chen, Yanrui Yun, Yongzhang Li

“…<h4>Methods</h4>RNA sequencing data sets on IC were downloaded from Gene Expression Omnibus (GEO) database, including GSE57560, GSE11783 and GSE621, whose corresponding platforms were GPL16699, GPL570 and GPL262 respectively. …”
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Development of a multi-targeted real-time PCR assay for the detection of the grapevine pathogen Xylophilus ampelinus by Aleksander Benčič, Alexandra Bogožalec Košir, Janja Matičič, Manca Pirc, Neža Turnšek, Tanja Dreo

“…Results The newly designed real-time PCR assays were evaluated via high throughput testing for specificity and sensitivity and compared with a reference assay. …”
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MMP1-induced NF-κB activation promotes epithelial–mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancer by Letian Chen, Yinghuan Cen, Keyang Qian, Wang Yang, Wenbin Zhou, Yaping Yang

“…Functional assays were conducted to evaluate cell viability, proliferation, invasion, and migration. …”
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Association of knockdown resistance mutations with pyrethroid resistance in Aedes aegypti, a major arbovirus vector in Cameroon by Christophe R. Keumeni, Aurelie P. Yougang, Flobert Njiokou, Sian E. Clarke, Jo Lines, Charles Wondji, Basile Kamgang

“…This study aimed to address this issue by updating the resistance profile of A. aegypti and evaluating the role of known knockdown resistance (kdr) mutations in the observed phenotypic resistance in Ae. aegypti in Cameroon. …”
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State-of-the-Art Evidence for Clinical Outcomes and Therapeutic Implications of Janus Kinase Inhibitors in Moderate-to-Severe Ulcerative Colitis: A Narrative Review by Yunseok Choi, Suhyun Lee, Hyeon Ji Kim, Taemin Park, Won Gun Kwack, Seungwon Yang, Eun Kyoung Chung

“…Future studies are needed to clarify optimal sequencing, long-term safety, and the role of emerging agents or combination therapies.…”
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Deciphering the microbial communities in ticks of Inner Mongolia: ecological determinants and pathogen profiles by Chunfu Li, Rui Ma, Ai Gao, Na Jiang, Chunli Sang, Yanli Zhang, Haoqiang Tian, Jian Li, Wei Hu, Xinyu Feng

“…Alpha diversity was assessed using Chao1, ACE, and Shannon indices, while beta diversity was evaluated using Bray-Curtis dissimilarity matrices. …”
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Dynamic profiling of Cell-free DNA fragmentation uncovers postprandial metabolic and immune alterations by Ziting Zhu, Tao Chen, Manting Zhang, Xiaodi Shi, Pan Yu, Jianai Liu, Xiuzhi Duan, Zhihua Tao, Xuchu Wang

“…Methods We performed shallow whole-genome sequencing of 30 plasma samples from 10 healthy individuals at fasting and postprandial (30-min and 2-h time points). …”
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Peripheral T lymphocyte immune characteristics dictate response to transarterial chemoembolization in unresectable hepatocellular carcinoma by Lei Peng, Qi Liang, Peng Fei Rong, Shengwang Zhang, Huan Chen, Huaping Liu, Xiaoqian Ma, Wei Wang

“…Methods: A total of 50 patients who underwent standard TACE-based therapy between January 2020 and December 2022 were included in this study. TACE response was evaluated within 1–3 months following two consecutive TACE sessions. …”
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KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma by Qingyuan Yang, Shiyin Wei, Cen Qiu, Chenjie Han, Zunguo Du, Ning Wu

“…In this study, protein levels in ESCC tissues were evaluated by immunostaining of tissue microarrays. …”
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Enhancing knee MRI bone marrow lesion detection with artificial intelligence: An external validation study by Kevin Maarek, Philippine Cordelle, Tom Vesoul, Pascal Zille, Gaspard d'Assignies, Antoine Feydy, Guillaume Herpe

“…Purpose: This study evaluated artificial intelligence's (AI) impact on enhancing general radiologists' diagnostic accuracy for bone marrow edema detection in knee MRI. …”
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Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats by Xing Wang, Dongmei Long, Xingcan Peng, Jiaxuan Li, Maoting Zhou, Yu Wang, Xianghong Hu

“…Additionally, 16S rRNA high-throughput sequencing was used to evaluate the diversity and composition of the intestinal flora in feces.ResultsThe results showed DPDS and metformin improved the DKD in STZ rats, as evidenced by decreased blood glucose, BUN, urine volume, urine microalbumin, urinary β2 microglobulin, and improvement of renal pathological morphology. …”
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ELK3-CYFIP2 axis-mediated actin remodeling modulates metastasis and natural killer cell responses in triple-negative breast cancer by Seung Hee Choi, Hye Jung Jang, Joo Dong Park, Ki Seo Ryu, Eunchong Maeng, Seohyun Cho, Hail Park, Hae-Yun Jung, Kyung-Soon Park

“…The immune response of TNBC to NK cells was evaluated through imaging and flow cytometry analyses. …”
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