HETEROGENEITY OF POLYCLONAL IMMUNOGLOBULINS NUCLEASE ACTIVITY IN RHEUMATOID AND REACTIVE ARTHRITIS by M. V. Volkova, A. V. Kunder, I. I. Generalov, D. M. Petrovich

“…The aim of present work is to determine DNase activity of the polyclonal class G immunoglobulins in rheumatoid and reactive arthritis using various methods.Different methods are used to evaluate nuclease activity. In this paper we present newly developed and modified techniques for determination of DNAse activity of polyclonal IgGs. …”
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Associations among HPV persistence, the vaginal microbiome, and cervical cancer recurrence by Despina Tsementzi, Rebecca Meador, Tony Eng, Joseph Shelton, Isabelle Scott, Konstantinos T. Konstantinidis, Susan Modesitt, Deborah Watkins Bruner

“…Patients were evaluated for CR up to 4 years following the end of treatment. …”
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Therapeutic efficacy of 5-alkylresorcinol on progression of colorectal cancer by activating HCLS1 and suppressing TLR4/MYD88/NF-κB signaling by Chun Yang, Jun Yang, Heng Li, Wan Fan, Jian Wang

“…Methods HCT116 cells were treated with 15 μmol/L 5ARs for 24 h, with both control and 5ARs-treated groups undergoing transcriptome sequencing. Hub genes were identified through GO and KEGG enrichment analyses. …”
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Genetic and epigenetic alterations affecting expression in cervical neoplasm among North Indian patients by Afreen Naseem, Zafar Iqbal Bhat, Ponnusamy Kalaiarasan, Bhupender Kumar, Gauri Gandhi, M. Moshahid Alam Rizvi

“…A total of 168 patient samples were processed for mutational analysis by single-strand conformation polymorphism, sequencing, and further in silico analysis of the identified mutations. …”
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A Cuproptosis-Related lncRNAs Signature Could Accurately Predict Prognosis in Patients with Clear Cell Renal Cell Carcinoma by Wei Zhang, Han Wang, Wei Wang, Haoqiang Xue, Maolin Qiao, Liying Song, Shuang Wang, Zhaoyu Ren, Zhifang Ma

“…The cuproptosis-related lncRNAs predictive signature was evaluated with receiver operating characteristic curves and subgroup analysis. …”
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Antimicrobial and molluscicidal activities of Egyptian soil-derived Streptomyces rochei by Nora Elfeky, Aya Abd Elsalam, Sabha El-sabbagh, Asmaa Abd El-Motleb

“…Isolate No. 10, later identified as Streptomyces rochei ASN (S. rochei ) via 16 S rDNA sequencing and phylogenetic analysis, exhibited broad-spectrum antimicrobial activity and was selected for further study. …”
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Molecular diagnosis of mtDNA syndromes in Egyptian pediatric patients: a hospital-based study by Dina Mehaney, Donia Abaas, Wajeet Sayed, Mai Sharawy, Laila Selim

“…To validate the abnormal patterns, direct sequencing was carried out. Results Of the 114 children evaluated, 54 were female and 60 were male, with a median age (range) of 3.5 years (7 months–16 years). 77 out of 114 (67.5%) patients were born into consanguineous marriages. …”
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BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis by Kaiyuan Li, Lingyu Han, Xiaowen Wang, Zhipeng Zheng, Min Sha, Jun Ye, Li Zhu

“…Furthermore, the findings were validated using single-cell sequencing datasets (GSE161470) and in vitro cell models to ascertain the expression patterns and functional roles of the identified key LRGs. …”
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Generative Adversarial and Transformer Network Synergy for Robust Intrusion Detection in IoT Environments by Pardis Sadatian Moghaddam, Ali Vaziri, Sarvenaz Sadat Khatami, Francisco Hernando-Gallego, Diego Martín

“…The model is trained and evaluated on the CIC-IoT-2023 and TON_IoT dataset, which contains a diverse range of real-world IoT traffic and attack scenarios. …”
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BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization by Solomon O. Alhassan, Zakaria Y. Abd Elmageed, Youssef Errami, Guangdi Wang, Joe A. Abi‐Rached, Emad Kandil, Mourad Zerfaoui

“…Furthermore, analysis was performed to evaluate dedifferentiation and early resistance signatures to understand melanoma drug‐induced plasticity. …”
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Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis by Le Xu, Jian Xu, Wanting Shi, Sa Zhang, Ting Guo, Shien Zou

“…Additionally, transcriptome sequencing was employed to analyze the intrinsic mechanisms involved. …”
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Comparative microbiome analysis of paired mucosal and fecal samples in Korean colorectal cancer patients by Younggwang Kim, Min Ki Kim, Sanghun Lee, Sanghun Lee, Sanghun Lee

“…Diagnostic performance was evaluated with ROC curves, and associations with clinical parameters were assessed via regression models.ResultsBeta diversity revealed significant compositional differences between fecal and mucosal samples (p = 0.001), with mucosal samples showing higher enrichment of CRC-associated taxa. …”
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Identification of three T cell-related genes as diagnostic and prognostic biomarkers for triple-negative breast cancer and exploration of potential mechanisms by Zhi-Chuan He, Zheng-Zheng Song, Zhe Wu, Peng-Fei Lin, Xin-Xing Wang

“…Immune cell infiltration patterns were analyzed between high- and low-LR score groups, and Kaplan–Meier analysis evaluated the prognostic significance of hub genes. …”
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Association of gene polymorphism in ERG rs2836411 with anemia and susceptibility to aortic dissection by Ying Wang, Gaoshan Li, Fangzheng Zeng, Kunyan Li, Wenxu Pan, Mingle Zhang, Hao Yang, Jun Jin

“…Method A case-control trial was conducted to evaluate the association between ERG rs2836411 polymorphism, anemia, and AD risk. …”
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Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load. by Art F Y Poon, Jeannette L Aldous, W Christopher Mathews, Mari Kitahata, James S Kahn, Michael S Saag, Benigno Rodríguez, Stephen L Boswell, Simon D W Frost, Richard H Haubrich

“…Pre-therapy clinical significance was quantified by plasma viral load (pVL) and CD4+ cell count (CD4) at baseline. Naïve bulk sequences of HIV-1 protease and reverse transcriptase (RT) were screened for resistance mutations as defined by the World Health Organization surveillance list. …”
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Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity by Yongfa Jing, Dongli Yan

“…Small intestinal injury was evaluated by hematoxylin and eosin (H&E) staining with epithelial damage scoring, while intestinal barrier integrity was assessed via Western blotting (WB) and immunohistochemistry. …”
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Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine by Qingling Zhai, Qihui Chen, Ning Zhang, Hongyan Li, Qijun Yu, Yonghui Pan

“…Behavioral assessments were conducted to evaluate vestibular dysfunction and pain in the VM and CM models. …”
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Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells. by Raven M Osborn, Justin Leach, Michelle Zanche, John M Ashton, ChinYi Chu, Juilee Thakar, Stephen Dewhurst, Sonia Rosenberger, Martin Pavelka, Gloria S Pryhuber, Thomas J Mariani, Christopher S Anderson

“…Direct assessment, detection, and quantitative analysis using high throughput methods like single-cell RNA sequencing (scRNAseq) is imperative to understanding the host response to SARS-CoV-2. …”
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Exploring the Interaction Dynamics of Growth-Promoting Bacterial Endophytes and Fertilizer on Oryza sativa L. Under Heat Stress by Wonder Nathi Dlamini, Kuo-Pin Yu, Wen-Ching Chen, Fo-Ting Shen

“…Isolates underwent thorough DNA extraction and 16 S rRNA gene sequencing for identification and were scrutinized for their plant growth-promoting (PGP) traits. …”
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Influence of System Type and Management Practices on Bacterial and Fungal Community Structure in Hydroponic Systems: Insights from Commercial Facilities in Ohio by Fiama Guevara, Timothy Frey, Antonino Malacrinò, Maria Soledad Benitez Ponce

“…Various studies have evaluated the occurrence of bacteria in the root zone and nutrient solution of hydroponically grown crops; however, bacterial and fungal communities have not been deeply described across commercial system types and hydroponic environments. …”
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