Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. by Alexandra-Chloé Villani, Mathieu Lemire, Edouard Louis, Mark S Silverberg, Catherine Collette, Geneviève Fortin, Elaine R Nimmo, Yannick Renaud, Sébastien Brunet, Cécile Libioulle, Jacques Belaiche, Alain Bitton, Daniel Gaudet, Albert Cohen, Diane Langelier, John D Rioux, Ian D R Arnott, Gary E Wild, Paul Rutgeerts, Jack Satsangi, Séverine Vermeire, Thomas J Hudson, Denis Franchimont

“…We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.…”
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Gut microbiota modulation and immunity enhancement by Bacillus amyloliquefaciens NL1.2: A fiber-degrading probiotic isolated from native Thai swine by Kittiya Khongkool, Malai Taweechotipatr, Sunchai Payungporn, Vorthon Sawaswong, Monthon Lertworapreecha

“…The most promising strain, Bacillus amyloliquefaciens NL1.2, was subjected to in vivo safety and efficacy evaluations in a mouse model, including assessments of toxicity, histopathology, secretory immunoglobulin A (IgA) levels, and gut microbiome modulation through full-length 16S ribosomal RNA sequencing. …”
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Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…The immune microenvironment of HVEM KO mice bearing mouse lung cancer cell was also evaluated. Co-cultured system and phenotype assays facilitated the examination of Jurkat T cells’ effect on A549 and H1299 lung cancer cells. …”
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Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosid... by Chandana Kumari V B, Ramith Ramu, Prithvi S. Shirahatti, Perwez Alam, Ling Shing Wong

“…Molecular identification using 16S rRNA sequencing. Evaluations included hydrophobicity, auto-aggregation, HT-29 cell line adhesion, antimicrobial activity, and antibiotic susceptibility. …”
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REST contributes to renal fibrosis through inducing mitochondrial energy metabolism imbalance in tubular epithelial cells by Yingxian Yang, Shuiqin Gong, Chun Zhou, Wang Xin, Shaozong Qin, Mengying Yao, Qigang Lan, Wenhao Liao, Jinghong Zhao, Yinghui Huang

“…RNA sequencing was performed to elucidate the mechanism. …”
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SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways by Lipeng Wu, Meng Yu, Huosheng Liang, Long Lin, Huajian Li, Guangyang Chen, Halimulati Muhetaer, Jingjing Li, Bo Wu, Xuejing Jia, Yuanye Dang, Guodong Zheng, Chuwen Li

“…Gene expression variations were ascertained through RNA sequencing, followed by the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology pathway enrichment evaluations. …”
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Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted... by Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group

“…Cross-correlation analysis explored temporal associations between HOI and non-HOI trends. Whole-genome sequencing and PERMANOVA evaluated the genomic structure of ST512/KPC-3 isolates. …”
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Contrast-enhanced MRI-based intratumoral heterogeneity assessment for predicting lymph node metastasis in resectable pancreatic ductal adenocarcinoma by Junjian Shen, Qing Li, Lei Li, Tianyu Lu, Jun Han, Zongyu Xie, Peng Wang, Zirui Cao, Mengsu Zeng, Jianjun Zhou, Tianzhu Yu, Yaolin Xu, Haitao Sun

“…Habitat models on enhanced ratio mapping and single sequences, radiomic models, and clinical models were developed for evaluating LN metastasis. …”
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Chemoresistant tumor cell secretome potentiates immune suppression in triple negative breast cancer by Eleni Skourti, Kotryna Seip, Nadia Mensali, Shakila Jabeen, Siri Juell, Inger Øynebråten, Solveig Pettersen, Olav Engebraaten, Alexandre Corthay, Else Marit Inderberg, Helmut Dolznig, Gunhild Mari Mælandsmo, Eivind Valen Egeland, Lina Prasmickaite

“…The influence on the immune cell phenotype and activity was evaluated by measuring molecular markers and performing functional assays. …”
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Ad‐E6/7‐HR vaccine improves the prophylactic and therapeutic efficacy in HPV‐associated cancers by Yu Zhang, Ke Qiu, Jiayuan Ai, Maosen Xu, Binhan Wang, Aqu Alu, Chunjun Ye, Xiya Huang, Yu Zhang, Yingqiong Zhou, Zhiruo Song, Jie Shi, Yishan Lu, Yuquan Wei, Jianjun Ren, Yu Zhao, Ping Cheng, Xiawei Wei

“…Further clinical investigation is warranted to evaluate its potential in human trials.…”
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Dihydroartemisinin enhances remyelination by switching microglia to the reparative phenotype by Li Liu, Lina Yang, Xinke Du, Xiaoxi Kan, Qingsen Ran, Yang Zhang, Manjing Li, Qingwu Liu, Yujie Li, Qing Yang, Ying Chen, Keshan Dong, Xiaoxin Zhu, Qi Li

“…Single-cell sequencing and microglial depletion with PLX3397 in vivo were used to reveal the dependency between DHA and microglia. …”
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Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer by Qingyu Xu, Ling Ma, Alexander Streuer, Eva Altrock, Nanni Schmitt, Felicitas Rapp, Alessa Klär, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Hong-hu Zhu, Wolf-Karsten Hofmann, Daniel Nowak, Vladimir Riabov

“…This study comprehensively evaluates LOX/LOXL expression in cancer and highlights cancer types where targeting these enzymes and developing LOX/LOXL-based prognostic models could have significant clinical relevance. …”
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The role of CD24hiCD27+ regulatory B cells in human chronic rhinosinusitis with/without nasal polyps by Shiyu Tian, Jiao Xia, Ke Liu, Youxiang Ma, Hao Tian, Weiwei Wang, Ruxiang Zhang, Chunli Zhao, Shusheng Gong

“…CD19+CD24hiCD27+ B cells (B10 cells) were isolated by flow cytometry, followed by RNA sequencing (RNA-seq). Finally, IL-10 secreted by B10 cells were evaluated through the intracellular stain. …”
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The research on cycloastragenol in the treatment of brain metastases from lung cancer: mechanistic exploration of radiotherapy sensitization and amelioration of brain injury by Yanyan Tao, Jingwen Chang, Jingwen Chang, Xinyi Zhu, Xinyi Zhu, Jingjing Han, Jingjing Han, Xinru Wang, Xinru Wang, Yun Sheng, Yun Sheng, Ziyi Sun, Ziyi Sun, Fang Liu, Fang Liu, Yu Tao, Yu Tao, Hongyan Wu, Chen Yu, Hao Liu, Hao Liu, Fangtian Fan, Fangtian Fan

“…Small-animal in vivo imaging was employed to evaluate antitumor efficacy and radiosensitization. …”
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Transcriptomics and metabolomics reveal the mechanism of cognitive impairment induced by long-term selenium deficiency in miceMendeley Data by Wanpeng Cheng, Yani Wang, Peiyue Sa, Luyun Liang, Lantian Zhang, Guangyan Shen, Jincheng Luo, Mengdi Li

“…In this research, male C57BL/6 J mice were given either a normal diet (0.2 mg/kg Se) or a selenium-deficient diet (0.02 mg/kg Se) for 24 weeks to evaluate the impact of long-term selenium insufficiency on their cognitive abilities. …”
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Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors by Yusuke Tomita, Yoshihiko Goto, Shinya Sakata, Kosuke Imamura, Ayaka Minemura, Kentaro Oka, Atsushi Hayashi, Takayuki Jodai, Kimitaka Akaike, Moriyasu Anai, Shohei Hamada, Shinji Iyama, Koichi Saruwatari, Sho Saeki, Motomichi Takahashi, Tokunori Ikeda, Takuro Sakagami

“…To address this issue, we retrospectively evaluated 118 advanced or recurrent non-small cell lung cancer (NSCLC) patients treated with ICB and analyzed 80 fecal samples of patients with lung cancer by 16S metagenomic sequencing. …”
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MiR-2284b regulation of α-s1 casein synthesis in mammary epithelial cells of dairy goats by Jinxing Hou, Wenfei Li, Xiaolong Xu, Ao Sun, Ganggang Xu, Zefang Cheng, Haoyuan Zhang, Xiaopeng An

“…The lactation character of dairy goats is the most important characteristic, and milk protein is an important index to evaluate milk quality. Casein accounts for more than 80% of the total milk protein in goat milk and is the main component of milk protein. …”
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Antibacterial potential and chromatographic profiling of bioactive compounds from endophytic Streptomyces sp. strain MIRK71 isolated from Mirabilis jalapa (L.) by Lalrokimi, Purbajyoti Deka, William Carrie, Lallawmsangi, Christine Vanlalbiakdiki Sailo, Lalrosangpuii, Felicia Lalremruati, Awmpuizeli Fanai, Yasangam Umbon, Esther Lalnunmawii, Zothanpuia

“…Molecular characterization using 16S rRNA gene sequencing identified MIRK71 as a Streptomyces species. …”
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Outcomes of cochlear implants in patients with PCDH15 mutations: a clinical study by Qingling Bi, Zhongyan Chen, Baoling Kang, Yong Lv, Yongyi Yuan, Yang Liu, Jianfeng Liu, Yuan Li

“…ObjectivesTo explore molecular diagnoses in cochlear implantation (CI) recipients and evaluate CI outcomes in patients with PCDH15 mutations.MethodsWhole-exome sequencing and biomedical informatics were used to identify potential genetic causes in 467 individuals with congenital sensorineural hearing loss. …”
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Identification of gastric cancer subtypes based on disulfidptosis-related genes: GPC3 as a novel biomarker for prognosis prediction by Nan Yi, Xindong Yin, Xiao Feng, Ming Ren, Chaoqun Ma

“…The GC samples were segregated into high-risk (HR) and low-risk (LR) groups according to their risk scores. We then evaluated the genes screened with the model in terms of prognosis, tumor, and immune cell infiltration. …”
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