A Moderate Intake of Beer Improves Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in a High-Fat Diet (HFD)-Induced Mouse Model by Andrea Vornoli, Aymen Souid, Barbara Lazzari, Federica Turri, Flavia Pizzi, Emilia Bramanti, Beatrice Campanella, Cheherazade Trouki, Andrea Raffaelli, Marta Wójcik, Clara Maria Della Croce, Lucia Giorgetti, Vincenzo Longo, Emanuele Capra, Luisa Pozzo

“…This study aimed to evaluate beer’s anti-steatotic effects in a high-fat diet (HFD)-induced mouse model of Metabolic dysfunction-Associated Liver Disease (MASLD) and to explore the underlying mechanisms. …”
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Swimmer’s Head Detection Based on a Contrario and Scaled Composite JTC Approaches by D. Benarab, T. Napoléon, A. Alfalou, A. Verney, P. Hellard

“…In order to accompany the swimming coaches in evaluating high-level swimmers, we developed a prototype for instantaneous speed estimation. …”
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Identification and fungicide screening of Phyllosticta capitalensis causing leaf spot on sweet viburnum in China by Wen LI, Yixuan RUAN, Zhengping BIAN, Yueqiu HE, Kai FENG, Liang LIU, Zhilong WANG, Feng HUANG

“…Fungi were isolated from symptomatic leaves, and were identified using morphological characteristics and phylogenetic analyses of partial sequences of internal transcribed spacer (ITS), actin (act), and translation elongation factor 1-alpha (tef1-α), and were evaluated in pathogenicity tests. …”
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A panel of six immune-related mRNAs as biomarkers for tuberculosis diagnosis by Yutong Wei, Yutong Wei, Zilu Wen, Qinghua Xue, Lin Wang, Hui Chen, Lei Shi, Laiyi Wan, Leilei Li, Hongwei Li, Wentao Hao, Shulin Zhang, Shulin Zhang, Ka-Wing Wong, Xiaoli Yu, Yanzheng Song, Yanzheng Song

“…ObjectiveThis study aims to screen common immunological markers of lung tissues and blood for diagnosis of tuberculosis (TB).MethodsDifferentially expressed miRNAs (DEmRs) and mRNAs (DEGs) were obtained by whole-transcriptome sequencing profiles on 18F-FDG PET/CT high and low metabolic active regions in lung tissues of nine TB patients. …”
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Gut microbial predictors of first-line immunotherapy efficacy in advanced NSCLC patients by Anna Grenda, Ewelina Iwan, Barbara Kuźnar-Kamińska, Arkadiusz Bomba, Katarzyna Bielińska, Paweł Krawczyk, Izabela Chmielewska, Małgorzata Frąk, Michał Szczyrek, Anna Rolska-Kopińska, Tomasz Jankowski, Robert Kieszko, Janusz Milanowski

“…We performed 16S rRNA sequencing based on hypervariable regions. Stool samples were collected from 52 patients with advanced NSCLC treated with immunotherapy or chemoimmunotherapy before treatment. …”
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Triatoma rubrofasciata as a potential vector for bartonellosis by Peichao Deng, Binglian Qin, Anli Liang, Qingan Zhou, Xiaoyin Fu, Xiaoquan Liu, Chenghui Lao, Xiaoqin Li, Shanshan He, Lili Tang, Ziwen Zhao, Wenjie Chen, Dengyu Liu, Yanwen Li, Yunliang Shi

“…This study investigated the presence of Bartonella in Triatoma rubrofasciata from Guangxi and Hainan provinces in China, evaluating its potential as a vector. Bartonella was identified in T. rubrofasciata samples through PCR amplification and sequencing of the ITS, gltA, and rpoB genes. …”
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SaGP: identifying plant saline-alkali tolerance genes based on machine learning techniques by Baixue Qiao, Baixue Qiao, Baixue Qiao, Wentao Gao, Xudong Zhang, Xudong Zhang, Min Du, Min Du, Shuda Wang, Shuda Wang, Xuanrui Liu, Xuanrui Liu, Shaozi Pang, Shaozi Pang, Chunxue Yang, Jiang Wang, Jiang Wang, Yuming Zhao, Linan Xie, Linan Xie

“…Moreover, we utilized SaGP to evaluate three recently published genes: GhAG2, MdBPR6, and TaCCD1. …”
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Regorafenib plus sintilimab as a salvage treatment for microsatellite stable metastatic colorectal cancer: a single-arm, open-label, phase II clinical trial by Rui Liu, Zhi Ji, Xia Wang, Lila Zhu, Jiaqi Xin, Lijun Ma, Jiayu Zhang, Shaohua Ge, Le Zhang, Yuchong Yang, Tao Ning, Ming Bai, Jingjing Duan, Feixue Wang, Yansha Sun, Hongli Li, Ting Deng, Yi Ba, Jihui Hao

“…Biomarker analysis, including transcriptome sequencing and multiplex immunohistochemistry staining are performed. …”
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Distinct gut microbial signature and altered short chain fatty acid metabolism at disease onset in a rat preclinical model of superimposed preeclampsia by Moumen M. Alhasan, María S. Landa, Silvia I. García, Roman G. Gerlach, Hani Harb, Fabian B. Fahlbusch, Melanie L. Conrad, Gabriela Barrientos

“…The blood pressure profile, renal function parameters and fetal phenotype were evaluated in pregnant Stroke-prone Spontaneously Hypertensive Rats (SHRSP) and their normotensive controls. …”
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Familial osteochondrodysplastic and cardiomyopathic syndrome in Chianina cattle by Joana G. P. Jacinto, Tolulope G. Ogundipe, Cinzia Benazzi, Irene M. Häfliger, Luisa V. Muscatello, Marilena Bolcato, Riccardo Rinnovati, Arcangelo Gentile, Cord Drögemüller

“…Hypothesis/Objectives To characterize the disease phenotype, to evaluate its genetic cause, and to determine the prevalence of the deleterious alleles in the Chianina population. …”
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Enhancement on selenium volatilization for phytoremediation: role of plant and soil microbe interaction by Ranju R. Karna, Samantha T. Kumara, Vance J. McCracken, Thomas J. Fowler, Zhi-Qing Lin, Zhi-Qing Lin

“…Thus, inoculation of the soil with B. cereus substantially enhanced Se removal via biogenic volatilization in the soil-Indian mustard system. This study evaluated the role of B. cereus in enhancing Se volatilization in soil-plant systems, and demonstrated the importance of plant and soil microbial interaction for Se phytoremediation.…”
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Phenotypical and Molecular Characterization of <i>Acinetobacter baumannii</i> Isolated from Hospitalized Patients During the COVID-19 Pandemic in Brazil by Paula Araujo de Souza, Milena Cristina Nunes dos Santos, Rebeca Vitória da Silva Lage de Miranda, Luciana Veloso da Costa, Raphael Paiva Paschoal da Silva, Cátia Aparecida Chaia de Miranda, Greice Maria Silva da Conceição, Stephen James Forsythe, Maria Helena Simões Villas Bôas, Marcelo Luiz Lima Brandão

“…The goal of the present study was to analyze <i>Acinetobacter baumannii</i> strains isolated from hospitalized patients in the period of the COVID-19 pandemic by phenotypic and molecular methods and evaluate their antimicrobial resistance patterns and biofilm production. …”
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Bacteriocin KvarM versus conventional antibiotics: comparative effectiveness in treating Klebsiella pneumoniae infections in murine intestinal models by Indre Karaliute, Deimante Tilinde, Rima Ramonaite, Rokas Lukosevicius, Darja Nikitina, Jurga Bernatoniene, Irma Kuliaviene, Irena Valantiene, Dalius Petrauskas, Vilma Zigmantaite, Vilma Zigmantaite, Audrius Misiunas, Erna Denkovskiene, Ausra Razanskiene, Yuri Gleba, Juozas Kupcinskas, Juozas Kupcinskas, Jurgita Skieceviciene

“…The haemolysin gene (khe) was chosen as the qualitative marker for Klebsiella genus identification, and 16S rRNA gene sequencing of V1-V2 hypervariable region was performed for analyses of gut microbiota.ResultsOur results demonstrated that KvarM was highly effective in reducing K. pneumoniae colonization, showing the same efficacy as ciprofloxacin. …”
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TensorTrack: Tensor Decomposition for Video Object Tracking by Yuntao Gu, Pengfei Zhao, Lan Cheng, Yuanjun Guo, Haikuan Wang, Wenjun Ding, Yu Liu

“…By applying L1-norm tensor decomposition, video sequences are represented as four-mode tensors, and a real-time background subtraction algorithm is introduced, allowing for effective modeling of the target–background relationship and adaptation to environmental changes, leading to accurate and robust tracking. …”
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Inhibition of PNCK inflames tumor microenvironment and sensitizes head and neck squamous cell carcinoma to immune checkpoint inhibitors by Ying Li, Jianmin Wang, Tingting Lin, Qin Ding, Youliang Weng, Wanzun Lin, Xiaosan Lin, Hanxuan Yang, Wenqian Xu, Hongmei Ying, Sufang Qiu

“…Recent research has underscored the pivotal role of PNCK in cancer progression, yet its relationship with immunotherapy remains elusive.Methods We leveraged sequencing data from our cohort and public databases to evaluate PNCK expression, prognostic significance, and immune efficacy prediction. …”
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Circulating tumor DNA monitoring detects minimal residual disease and predicts outcomes in patients with esophageal adenocarcinoma or squamous cell carcinoma after esophagectomy by Qingjiang Hu, Yasue Kimura, Shinichiro Ikeda, Yasushi Tanaka, Tomonori Nakanoko, Mitsuhiko Ota, Tomoharu Yoshizumi, Masatoshi Eto, Eiji Oki

“…Plasma samples (n = 124) were collected at six time points, and ctDNA was assessed by next-generation sequencing using an in-house cancer panel. Associations with clinical outcomes were analyzed. …”
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BioInnovate AI: A Machine Learning Platform for Rapid PCR Assay Design in Emerging Infectious Disease Diagnostics by Hung-Hsin Lin, Hsing-Yi Chung, Tai-Han Lin, Chih-Kai Chang, Cherng-Lih Perng, Kuo-Sheng Hung, Katsunori Yanagihara, Hung-Sheng Shang, Ming-Jr Jian

“…Conventional diagnostic techniques that rely on sequencing and polymerase chain reactions (PCR) frequently lack the speed necessary to efficiently respond to rapidly evolving pathogens. …”
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Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…Using longitudinal, genetically determined expression, we implement a predictive causality framework, evaluating the prediction of future values of a target gene expression using prior values of a putative regulatory gene. …”
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Seasonal anti-androgen activity in the brackish Baltic waters in relation to the gene expression profiles of the blue mussel Mytilus trossulus by Paulina Goździk, Katarzyna Smolarz, Magda Caban, Anna Hallmann

“…The Baltic Sea, with its high anthropogenic pressure and unique ecological conditions, is particularly vulnerable to EDs contamination. Our study aimed to evaluate the endocrine-disrupting, metabolism-impairing, and cytotoxic effects of water samples collected seasonally from a sewage treatment plant outlet in the Gulf of Gdańsk (Poland). …”
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Psoralen-mediated regulation of osteogenic differentiation of periodontal ligament stem cells: involvement of the mTOR pathway by Yujia Wang, Hongbo Zhang, Jie Yu, Jin Jing, Zhaojiang Fu, Yuanping Hao, Qihang Huang, Ruibin Ma, Yingjie Xu, Yingtao Wu

“…Pso-loaded mesoporous polydopamine (MPDA-Pso) nanoparticles were constructed and evaluated in vitro, and in vivo osteogenesis was assessed in rats with alveolar bone defects.ResultsNetwork pharmacology analysis revealed that the mammalian target of rapamycin (mTOR) was a potential target of Pso, and Pso significantly modulated the expression levels of mTOR in PDLSCs and markedly enhanced osteogenic differentiation. …”
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