The Effect of the AQP1 Gene Knockout on the Diversity, Composition and Function of Gut Microbiota in Mice with Heart Failure by Haotian Li, Yubo Li, Jianqin Yang, Yanjun Liu

“…Additionally, the high-throughput sequencing of gut microbiota was performed to identify key microbial communities. …”
Get full text

Multimorbidity in Pediatric Dermatology: Clinical Case by Nikolay N. Murashkin, Alexander I. Materikin, Eduard T. Ambarchian, Roman V. Epishev, Leonid A. Opryatin, Roman A. Ivanov, Daria S. Kukoleva, Daria G. Kuptsova, Alexander A. Pushkov, Marina Yu. Pomazanova, Yana V. Kozyr

“…Molecular genetic testing with new generation sequencing (NGS) helps to finally establish the diagnosis and determine the further tactics for patient management.Conclusion. …”
Get full text

Divergent therapeutic and prognostic impacts of immunogenic features in undifferentiated pleomorphic sarcoma and myxofibrosarcoma by Siddh van Oost, Debora M. Meijer, Zeynep B. Erdem, Marieke E. IJsselsteijn, Jessica Roelands, Suk Wai Lam, Melissa S. Boejharat, Brendy E. W. M. van den Akker, Ruud van der Breggen, Inge H. Briare-de Bruijn, Lukas J. A. C. Hawinkels, Anouk A. Kruiswijk, Manon van der Ploeg, Pauline M. Wijers-Koster, Rick L. Haas, Michiel A. J. van den Sande, Noel F. C. C. de Miranda, Judith V. M. G. Bovee

“…Immune contextures were further evaluated in 14 UPS and 15 MFS using imaging mass cytometry. …”
Get full text

Population genomics and connectivity of Vazella pourtalesii sponge grounds of the northwest Atlantic with conservation implications of deep sea vulnerable marine ecosystems by Anna Patova, Pedro A. Ribeiro, Francisco J. Murillo, Ana Riesgo, Sergi Taboada, Shirley A. Pomponi, Hans Tore Rapp, Ellen Kenchington, Joana R. Xavier

“…Further, fishing pressure on genetic diversity was evaluated, within two Sponge Conservation Areas (SCAs) on the Scotian Shelf. …”
Get full text

A gap-free reference genome of Populus deltoides provides insights into karyotype evolution of Salicaceae by Changwei Bi, Ning Sun, Zhuangwei Hou, Xiaogang Dai, Huaitong Wu, Fuchuan Han, Zefu Wang, Tongming Yin

“…Following careful evaluations of genome accuracy and completeness, our assembly represents a substantial enhancement over the previously published genomes of P. deltoides, eliminating all gaps and rectifying numerous assembly errors. …”
Get full text

UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cells by Zhean Li, Yihan Wang, Ziqi Yu, Yujia Luo, Yixiang Zhao, Erfei Xue, Junfeng Zhan, Huimin Lu, Fei Sun

“…Through its SET and RING-associated (SRA) domain, UHRF1 identifies methylated cytosine-phosphate-guanine sequences and binds DNA methyltransferase 1 (DNMT1) directly to replicated DNA foci. …”
Get full text

Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis by Dijie Qiao, Lu Zhang, Yajie Zhong, Dongmei Liu, Zilin Chen, Wai Po Chong, Wai Po Chong, Wai Po Chong, Jun Chen

“…We previously introduced a therapeutic strategy involving the in vivo induction of retinal-antigen-specific regulatory T cells (Tregs) via αCD4 antibody injection followed by administration of the retinal self-peptide IRBP1-20, which effectively suppresses inflammation during the onset of experimental autoimmune uveitis (EAU).MethodsWe evaluated the long-term therapeutic efficacy of this approach in a chronic EAU model. …”
Get full text

Schizophrenia-associated alterations in fecal mycobiota and systemic immune dysfunction: a cohort study of elderly Chinese patients by Zongxin Ling, Yiwen Cheng, Xia Liu, Xiaocui Xu, Lingbin Wu, Li Shao, Zhangcheng Zhu, Wenwen Ding, Qinghai Song, Longyou Zhao, Guolin Jin

“…This study aimed to evaluate the gut mycobiota using internal transcribed spacer 1 (ITS1) amplicon sequencing and assess host immune responses via multiplex immunoassays in 87 elderly SZ patients and 64 age- and gender-matched healthy controls (HCs). …”
Get full text

PINK1 suppresses malignant phenotypes in esophageal squamous cell carcinoma by Xiangyun Lu, Yuhui Pei, Hao Peng, Man Li, Jing Li, Yongkun Yao, Lianghai Wang

“…Methods The expression levels of PINK1 in tumor samples and corresponding normal tissues were evaluated using RNA-sequencing and gene expression array datasets. …”
Get full text

ANALYSIS OF GENOTYPE, SUBGENOTYPE AND SEROTYPE OF OCCULT HEPATITIS B VIRUS by Bülent Çakal, Alp Atasoy, Bilger Çavuş, Aslı Çifcibaşı Örmeci, Mehveş Poda, Mesut Bulakçı, Mine Güllüoğlu, Mehmet Güven Günver, Filiz Akyüz

“…This study aimed to evaluate genotype, subgenotype and subtype profiles of HBVs obtained from patients with OBI. …”
Get full text

Investigation of clonal relationships of K. pneumoniae isolates from neonatal intensive care units by PFGE and rep-PCR by Mehmet Koroglu, Ahmet Ozbek, Tayfur Demiray, Taner Hafizoglu, Ertugrul Guclu, Mustafa Altindis, Oguz Karabay, Riza Durmaz

“…All identified bacterial strains were confirmed by 16S rDNA sequencing and analyzed by PFGE and the DL system. …”
Get full text

Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway by Tingting Ding, Tingting Ding, Minkang Wu, Li Zhao, Hu Liu, Xuanke Cao, Jing Guo, Xingchen Zhu, Lamei Zhao, Heping Zhang, Yaohui Gao, Qing Wei

“…We then treated CRC cells and tissues with F. nucleatum and its metabolites. RNA sequencing was used to evaluate the involved pathways, and non-targeted metabolomics was employed to analyze the metabolites regulating MLH1. …”
Get full text

RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia by Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Shuyang Lin, Jared S. Fowles, Daniel A. C. Fisher, Sherwin Ng, Wei Yang, Fan He, Minyoung Youn, Kailen Mark, Ana San Jose, Jingxian Liu, Alexander B. Kim, Maggie J. Cox, Mary C. Fulbright, Aarthi Jayanthan, Gerrit Los, Stacey L. Rentschler, Li Ding, Kathleen M. Sakamoto, Sandra E. Dunn, Grant A. Challen, Stephen T. Oh

“…Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes. …”
Get full text

An unusual presentation of Huntington’s disease-like syndrome in a patient with Xeroderma pigmentosum type F: Case report and review of the literature by Nicolas De Cleene, Federico Carbone, Clancy Cerejo, Marina Peball, Franco Stanzial, Francesco Benedicenti, Renate Lunzer, Klaus Seppi, Beatrice Heim

“…The clinical phenotyping of these patients was carefully evaluated, listed and analysed. In addition, available genetic data was systematically collected and reviewed. …”
Get full text

Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in <i>C. elegans</i> by Hong-Jia Zhang, Hai-Quan Lan, Meng-Ying Wang, Cai-Feng Wang, Lu-Gang Wei, Chen Xu

“…Methods: We conducted lifespan analysis and measured lipofuscin accumulation in <i>C. elegans</i> model to evaluate the effects of NL on aging. Additionally, we identified differentially expressed genes (DEGs) through comprehensive RNA-sequencing (RNA-seq) analysis and performed gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGGs) pathway analyses to elucidate the molecular mechanisms underlying NL’s effects. …”
Get full text

Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia by Yilin Zhao, Xiaodan Xu, Shaowen Liu, Xueting Wang, Jiayinaxi Musha, Tengfei Li, Liang Ge, Yan Sun, Shujian Zhang, Li Zhao, Jianghua Zhan

“…Butyrate intervention was performed in bile duct ligation (BDL) mice, and alterations in the gut microbiota were analyzed using fecal 16S rRNA sequencing. The impact of butyrate and related pathways on liver fibrosis in BDL mice was further evaluated. …”
Get full text

Validated KASP Markers for drought tolerance in cotton enable efficient trait selection and preliminary mechanism analysis by Wenju Gao, Hu Zhang, Qin Chen, Ning Wang, Jianbin Shi, Yibin Zhang, Qinghua Xu, Jieyin Zhao, Quanjia Chen, Gentu Yan

“…A total of 502 core germplasm accessions were genotyped and evaluated for drought tolerance under controlled conditions. …”
Get full text

A Case Series Report on the Effect of Tofacitinib on Joint Inflammation and Gut Microbiota Composition in Psoriatic Arthritis Patients Naive to Biologic Agents by Andrea Picchianti Diamanti, Concetta Panebianco, Valeria Di Gioia, Ilaria Anna Bellofatto, Simonetta Salemi, Roberta Di Rosa, Giorgio Sesti, Gabriele Nalli, Gerardo Salerno, Etta Finocchiaro, Bruno Laganà

“…The clinical response was assessed using validated scores (DAPSA, ASDAS, and BASDAI), laboratory tests, and US assessment of the target joint and enthesis. Finally, we evaluated changes in the composition of the intestinal microbiota using next-generation sequencing analysis of fecal samples. …”
Get full text

Epidemiology of norovirus disease in the first 2 years of life: A prospective multisite cohort study in Lima, Peru by Claudio F. Lanata, Giselle Soto, Ana I. Gil, Joan Neyra, Rubelio Cornejo, Candice Romero, Lucie Ecker, Maria L. Huaylinos, Sayda La Rosa, Ana Goios, Astrid Borkowski, John Weil

“…We aim to document the norovirus-related AGE incidence in peri-urban areas of Lima (Peru), evaluating the potential impact of a norovirus vaccine introduction. …”
Get full text

<i>Faecalibacterium prausnitzii</i> Is Associated with Disease Severity in MASLD but Its Supplementation Does Not Improve Diet-Induced Steatohepatitis in Mice by Eliane Münte, Greta Viebahn, Amit Khurana, Jumpei Fujiki, Tomohiro Nakamura, Sonja Lang, Münevver Demir, Bernd Schnabl, Phillipp Hartmann

“…In this study, we aimed to evaluate the role of the butyrate-producing bacterium <i>Faecalibacterium prausnitzii</i> in MASLD and whether supplementation with butyrate-producing bacteria, in particular <i>Faecalibacterium prausnitzii</i>, can ameliorate diet-induced steatohepatitis in mice. …”
Get full text