Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine by Xiaoyu Cao, Yu Zhang, Qianqian Xu, Hai Yan

“…Comprehensive safety evaluations, including cytotoxicity assay and in vivo pathogenicity studies, must be conducted to rigorously assess its risks prior to practical utilization.…”
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Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals. by Monta Briviba, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins

“…Next generation sequencing-based transcriptome analysis revealed metformin-induced differential expression of genes involved in intestinal immune network for IgA production and cytokine-cytokine receptor interaction pathways. …”
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The audiological phenotype of patients with a variant in MYH9 and MYH14 genes by Seong Hoon Bae, Sun Young Joo, Seung Hyeon Jang, Sung Huhn Kim, Jae Young Choi, Dongju Won, Heon Yung Gee, Jinsei Jung

“…Thirteen patients with MYH9 or MYH14 mutations were identified through whole-exome or targeted sequencing and underwent audiometric evaluations. Both groups exhibited late-onset, high-frequency, progressive hearing loss. …”
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Tyrosine Kinase Inhibitors for Gastrointestinal Stromal Tumor After Imatinib Resistance by Xian-Hao Xiao, Qian-Shi Zhang, Ji-Yuan Hu, Yin-Xu Zhang, He Song

“…Ongoing research will be crucial for refining treatment sequencing and expanding therapeutic options, especially for rare GIST subtypes.…”
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Genetic dissection of hundred-kernel weight through combined genome-wide association study and linkage analysis in tropical maize by Mengfei Shi, Fuyan Jiang, Ranjan K. Shaw, Babar Ijaz, Jiachen Sun, Xingming Fan

“…Results Genotyping-by-sequencing (GBS) identified 591,483 high-quality single nucleotide polymorphisms (SNPs), which were used for a genome-wide association study (GWAS) and linkage analysis. …”
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Fecal Microbiome Does Not Represent Whole Gut Microbiome by Ji-Seon Ahn, Enkhchimeg Lkhagva, Sunjun Jung, Hyeon-Jin Kim, Hea-Jong Chung, Seong-Tshool Hong

“…Here, we comprehensively analyzed the composition of microbiome and metabolites in the feces and at 14 different locations of GI tracts of genetically homogenous sibling pigs to evaluate the validity of using feces as a proxy to the whole gut microbiome. …”
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Expanded non-invasive prenatal testing offers better detection of fetal copy number variations but not chromosomal aneuploidies. by Shaozhe Yang, Yuan Zhuang, Junfeng Li, Xiuhong Fu

“…<h4>Purpose</h4>To evaluate the clinical performance of expanded non-invasive prenatal testing (NIPT-plus) and compare its effectiveness in screening for chromosomal aneuploidies with that of NIPT.…”
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A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model by Fereshteh Esfandiarinezhad, Xiaoshu Zhan, Seang Lin Tan, Julang Li, Benjamin K. Tsang

“…Female rats were administered DHT to induce PCOS, and the expression of stem cell markers in OSE was assessed to evaluate the impact on stemness. Alterations in the gut microbiome composition were assessed using 16S rRNA gene Long-Read sequencing and changes in the microRNA profile of granulosa cells and plasma were analyzed using qPCR. …”
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Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens. by Lyndal Henden, Stuart Lee, Ivo Mueller, Alyssa Barry, Melanie Bahlo

“…Using the inferred IBD status at genomic locations, we have also developed a novel statistic for identifying loci under positive selection and propose relatedness networks as a means of exploring shared haplotypes within populations. We evaluate the performance of our methodologies for detecting IBD and selection, including comparisons with existing tools, then perform an exploratory analysis of whole genome sequencing data from a global Plasmodium falciparum dataset of more than 2500 genomes. …”
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Construction of oncolytic reporter influenza viral vectors and assessment of their safety following intracranial administration in rats by A. A. Pulkina, A. S. Mustafaeva, E. A. Romanovskaya-Romanko, M. A. Plotnikova, O. O. Ozhereleva, M. A. Shuklina, L. N. Kiseleva, Y. S. Alekseeva, N. S. Kurmazov, A. R. Muslimov, A.-P.S. Shurygina, M. A. Stukova

“…OBJECTIVE: To develop reporter influenza A viruses expressing NanoLuc luciferase and evaluate their safety following intracranial administration in rats. …”
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Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products. by Shivam H Patel, Christopher L Mendias, Chad C Carroll

“…However, the extent that AGEs impact the tendon cell transcriptome has not been evaluated.<h4>Objective</h4>The purpose of this study was to investigate transcriptome-wide changes that occur to tendon-derived fibroblasts following treatment with AGEs. …”
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PRDX1 knockdown promotes erastin-induced ferroptosis and impedes diffuse large B-cell lymphoma development by inhibiting the MAPK/ERK pathway by Chuanming Lin, Shuiling Xie, Menger Wang, Jianzhen Shen

“…The purpose of this research was to evaluate the role and molecular mechanism of peroxiredoxin 1 (PRDX1) on ferroptosis in DLBCL. …”
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Virulence genes in Moraxella spp. isolates from infectious bovine keratoconjunctivitis cases by Vanessa Sosa, Ana Umpierrez, Sofia Acquistapace, Pablo Zunino

“…Regarding genetic diversity, the tolC nucleotide sequences were the less diverse within all M. bovis and mbxA were the less diverse within all M. bovis and M. bovoculi strains. …”
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Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools by Zhiquan Liu, Siyu Chen, Yang Sun

“…We optimized BE, PE, and CE systems in vitro using Pde6b-L659P cell models and compared their editing via deep sequencing. BE and PE had similar efficiency, but PE was the most precise, minimizing bystander edits. …”
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Commercial bioinoculants improve colonization but do not alter the arbuscular mycorrhizal fungal community of greenhouse-grown grapevine roots by Mariam P. Berdeja, Nicole K. Reynolds, Teresa Pawlowska, Justine E. Vanden Heuvel

“…In a greenhouse experiment, we evaluated the influence of five different bioinoculants on the composition of native AMF communities of young Cabernet Sauvignon vines grown in a non-sterile soil. …”
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Variations in Gut Microbiome Profiles Based on Different DNA Extraction Methods: A Comparative Study by Yameng Liu, Xianchun Zhong, Yibin Wang, Kanglong Wang, Cuina Li, Xinyu Liang, Suqin Lin, Ru Zhou, Cen Xie

“…Three commercial kits from QIAamp, TIANamp, and MAGEN, together with the classic cetyltrimethylammonium bromide (CTAB) method, were evaluated for their performance in extracting bacterial DNA from the gut microbiota of five mammals, including humans (Homo sapiens), macaques (Macaca mulatta), dogs (Canis lupus familiaris), golden hamsters (Mesocricetus auratus), and mice (Mus musculus). …”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…Additionally, four immune-related hub genes were screened using a protein–protein interaction (PPI) network and evaluated through the receiver operating characteristic (ROC) curve. …”
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Linking pathogenic microbiota with farm-level application of organic resources to crop, livestock and human health: A One-Health perspective by Tauro Tonny, Ruvimbo Kaliyati Joyce, Kadzviti Faith, Nyamasoka-Magonziwa Blessing, Matyanga Celia, Macheka Lesley, Tumbure Akinson, Hove Tawanda, Mtambanengwe Florence, Mapfumo Paul

“…Culturing and DNA-based sequencing (Illumina and Pacbio) methods were used to examine fungal and bacteria communities in Crotalaria juncea L., Calliandra calothyrsus Meissn., cattle manure, Zea mays L. stover and Pinus patula Schiede & Schltdl. & Cham sawdust biomass from Domboshawa Training Centre in Zimbabwe. …”
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Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations by Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng

“…Mice were euthanized at 3 h and 48 h post irradiation to assess acute normal tissue damage and perform transcriptome sequencing. Furthermore, a subset of mice was monitored for 30 days to evaluate survival. …”
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JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction by Dewei Peng, Xiaoli He, Bowen Ren, Qian Wang, Lulu Peng, Yue Jiang, Shengqi Huo, Lintong Men, Wei Shi, Pengcheng Luo, Mengyin Zhu, Cuntai Zhang, Jiagao Lv, Li Lin, Sheng Li

“…Results RNA sequencing showed significant upregulation of HMGCS2 mRNA in hyperuricemic mouse cardiac tissue. …”
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