A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report by Ruiqi Zhong, Ziyi Chang, Xiuhong Wang, Dingrong Zhong

“…After thorough postoperative pathology, immunohistochemistry, and next-generation sequencing, we hypothesized that it might be a new ductal carcinoma in situ subtype with tall cells and reversed polarity of the mammary gland. …”
Get full text

Gut and intraocular fluid dysbiosis in people with type 2 diabetes-related retinopathy in India: A case for further research by Taraprasad Das, Brijesh Takkar, Shalem R Padakandala, Sisinthy Shivaji

“…Design: Multiple case-control studies. Methods: We evaluated three groups of people: healthy controls (HC), people with T2DM without retinopathy, and those with DR. …”
Get full text

Leveraging CAR macrophages targeting c-Met for precision immunotherapy in pancreatic cancer: insights from single-cell multi-omics by Lingyu Hu, Xiaoguang Wang, Zhengwei Song, Fei Chen, Bin Wu

“…Methods We employed single-cell RNA sequencing to analyze pancreatic cancer tissue, identifying c-Met as a key marker of CSCs. …”
Get full text

Antagonistic Potential of Soil Streptomyces Isolates from Southern Thailand to Inhibit Foodborne Bacterial Pathogens by Waenurama Chemoh, Wahida Bin-Ismail, Sawitree Dueramae

“…The partial nucleotide sequences of the 16S rRNA gene led to identifying both active isolates as Streptomyces species. …”
Get full text

Multi-task glioma segmentation and IDH mutation and 1p19q codeletion classification via a deep learning model on multimodal MRI by Erin Beate Bjørkeli, Morteza Esmaeili

“…Segmentation performance was evaluated using mean Dice Score (mDS) and mean Intersection over Union (mIoU). …”
Get full text

M2-Macrophage-Derived Exosomes Promote Meningioma Progression through TGF-β Signaling Pathway by Xiao-Hong Fu, Jian-Ping Li, Xue-Ying Li, Yan Tan, Min Zhao, Shao-Fu Zhang, Xue-Dong Wu, Jian-Guo Xu

“…Three-dimensional tumorspheres and xenograft tumor models were used to evaluate the effects of M2-MDEs on meningioma tumorigenesis and development. …”
Get full text

Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts by Leiguang Ye, Yang Qiao, Peisan Wang, Wei Li, Xianwen Wang, Yiqun Zhang, Zhennan Yuan

“…This ROS generation was substantially amplified through synergistic photothermal acceleration of reaction kinetics and PEITC-mediated glutathione (GSH) depletion, which effectively disabled the antioxidant defense system. Systematic evaluations, including in vitro cytotoxicity assays, transcriptomic sequencing, and murine xenograft models, confirmed the platform’s superior tumor suppression ability and favorable biosafety profile. …”
Get full text

Stock movement prediction with multimodal stable fusion via gated cross-attention mechanism by Chang Zong, Jian Wan, Lucia Cascone, Hang Zhou

“…Empirical evaluations demonstrate that the MSGCA framework exceeds current leading methods, achieving performance gains of 8.1%, 6.1%, 21.7% and 31.6% on four multimodal datasets, respectively, attributed to its enhanced multimodal fusion stability.…”
Get full text

A high-resolution haplotype collection uncovers somatic hybridization, recombination and intercontinental movement in oat crown rust. by Eva C Henningsen, David Lewis, Eric S Nazareno, Hayley Mangelson, Monica Sanchez, Kyle Langford, Yung-Fen Huang, Brian J Steffenson, Brendan Boesen, Shahryar F Kianian, Ivan Liachko, Eric Stone, Peter N Dodds, Jana Sperschneider, Melania Figueroa

“…We expanded the existing resources for USA and South African populations by generating whole genome sequencing data of Taiwanese and Australian isolates. …”
Get full text

Growth and selenium bioaccumulation in rape seedlings promoted by strain Limosilactobacillus sp. LF-17 by Haifeng Li, Fengjiao Li, Mengyu Wang, Caibo Hou, Feng Jia, Xifeng Wang, Mingjun Li

“…However, many individuals worldwide suffer from Se deficiency diseases. This study aims to evaluate the impact of Se-tolerant LF-17 agents and exogenous Na2SeO3 application on the growth, enzyme activity, and metabolic characteristics of rape seedlings. …”
Get full text

Antioxidant Properties and Bioactivity of Streptomyces albus DR57 by E. Devi, R. Bharathidasan, P. Priya Dharsini

“…The antioxidant properties of the crude extract, including total phenol content, absolute antioxidant capacity, free radical neutralization power, and overall reducing power, were evaluated. All experiments were conducted in triplicate. …”
Get full text

A new Tec family-based clinical model predicts survival in differentiated thyroid cancer patients via machine learning by Ziyu Luo, Wenhan Li, Jianhui Li, Ying Zhang

“…The validity of the prediction model was evaluated via receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and fivefold and 200-fold cross-validation. …”
Get full text

Bioinformatics-based analysis of the relationship between STC1 expression and immune infiltration in gastric cancer by Weijun Ma, Xiaoli Ma, Yaoqi Li

“…Its relation to clinicopathological characteristics and prognosis was evaluated using univariate and multivariate Cox regression. …”
Get full text

Genetic variability in CLU and its association with Alzheimer's disease. by Rita J Guerreiro, John Beck, J Raphael Gibbs, Isabel Santana, Martin N Rossor, Jonathan M Schott, Michael A Nalls, Helena Ribeiro, Beatriz Santiago, Nick C Fox, Catarina Oliveira, John Collinge, Simon Mead, Andrew Singleton, John Hardy

“…<h4>Methodology/principal findings</h4>To further characterize this association we have sequenced the coding region of this gene in a total of 495 AD cases and 330 healthy controls. …”
Get full text

Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia. by Pedro Pereira, Velma Aho, Johanna Arola, Sonja Boyd, Kalle Jokelainen, Lars Paulin, Petri Auvinen, Martti Färkkilä

“…DNA isolation, amplification, and Illumina MiSeq sequencing were performed for the V1-V3 regions of the bacterial 16S rRNA gene.…”
Get full text

Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome by Maija Suvanto, Timo Jahnukainen, Marjo Kestilä, Hannu Jalanko

“…We genotyped variants using PCR and direct sequencing and evaluated estimated haplotypes of MDR1 variants. …”
Get full text

Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis by Linda Ye, Ian Dick, Bruce W. Robinson, Jenette Creaney, Alec Redwood

“…Abstract Background Neoantigen-specific immune responses may help prevent cancer recurrence. We evaluated whether neoantigen load and/or properties could predict survival in early-stage non-small cell lung cancer (NSCLC). …”
Get full text

A severe early presentation of cystic fibrosis in an infant with a homozygous c.1375_1383del CFTR variant- a case report by Abdullah Yousef, Abdullah Yousef

“…This highlights the importance of early recognition and genotype-specific management to maximize patient outcomes and improve quality of life.Case ReportWe present a 10-month-old female infant born to consanguineous parents with a significant medical history of chronic cough, cyanosis, failure to thrive, poor feeding, and irritability who ultimately required multiple hospitalizations for severe infections requiring mechanical ventilation and intravenous antibiotics. Initial evaluations included thorough clinical assessments and several diagnostic tests, including whole-exome sequencing, which revealed a homozygous c.1375_1383del variant in the CFTR gene. …”
Get full text

Colquhounia Root Tablet Promotes Autophagy and Inhibits Apoptosis in Diabetic Nephropathy by Suppressing CD36 Expression In Vivo and In Vitro by Han Li, Baiju Wang, Changbao Wu, Dandan Xie, Jizhen Li, Na Wang, Hanwen Chen, Lei Liu

“…The pathological changes of the rat kidney were investigated, and RNA sequencing was performed for each group. Renal tissue apoptosis was detected using the TUNEL assay. …”
Get full text

Pan-cancer analysis of phagocytosis regulators in female-specific cancers: a focus on HMGB2 by Xiaoqin Lu, Dan Ren, Panpan Zhao, Yanfang Li, Zhenhui Wang, Jingyan Zhang

“…Additionally, immune modulators, immune cell infiltration, and single-cell sequencing were used to explore alterations in phagocytosis and their cellular origins. …”
Get full text