Regulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications by Wei Liu, Ziqing Xiong, Tianmei Fu, Juan Yang, Juan Zou, Yize Wu, Linju Kuang, Qian Wang, Song Li, Aiping Le

“…Key evaluations included renal injury assessment, ferroptosis indicator measurement, and m6A methylation analysis of PPARγ. …”
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Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators by Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu

“…Furthermore, flow cytometry with clustering analysis and transcriptome analysis with RNA‐sequencing are adopted to comprehensively evaluate the in vivo anti‐inflammation therapeutic effects. …”
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Functional and microbiological effects of a microencapsulated probiotic consortium on the ruminal microbiota in vivo and in vitro systems by Johanna Marcela Urán Velásquez, Mauricio Agudelo Rendón, Mariana Zapata, Wilyer García Arboleda, Sara Echeverri, Juan Camilo Arroyave Manco, Koen Venema, Juan Vasquez

“…Fistulated animals and rumen simulation systems are essential for evaluating the effects of ingredients like probiotics, proposed as sustainable alternatives to growth-promoting antibiotics in ruminant nutrition. …”
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An MLLM-Assisted Web Crawler Approach for Web Application Fuzzing by Wantong Yang, Enze Wang, Zhiwen Gui, Yuan Zhou, Baosheng Wang, Wei Xie

“…It includes three core components: page state mining, functionality analysis, and automatic operation generation. Evaluations show 163% code coverage improvements over SOTA work. …”
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Quality and composition control of complex TCM preparations through a novel “Herbs-in vivo Compounds-Targets-Pathways” network methodology: The case of Lianhuaqingwen capsules by Simian Chen, Hui Qi, Chunyan Zhu, Yiheng Zhao, Bo Jiao, Yun Tan, Yuexin Yang, Tongxing Wang, Yunlong Hou, Binxin Dai, Dandan Zhang, Hairong Zhang, Junyu Zhang, Xiaojuan Jiang, Xiaodan Guo, Xiaoyu Qian, Caixia Yuan, Xue Bai, Jiayun Chen, Suping Wang, Yu Cai, Jiarou Zhong, Yunqi Li, Qianqian Zhang, Zhenhua Jia, Caisheng Wu

“…Specifically, DRUG-seq was employed to evaluate gene expression alterations in peripheral blood mononuclear cells derived from healthy volunteers. …”
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Oral Colonization of Staphylococcus Species in a Peritoneal Dialysis Population: A Possible Reservoir for PD-Related Infections? by Liliana Simões-Silva, Susana Ferreira, Carla Santos-Araujo, Margarida Tabaio, Manuel Pestana, Isabel Soares-Silva, Benedita Sampaio-Maia

“…Saliva samples were plated in Mannitol salt, and isolates were identified by DnaJ gene sequencing. Staphylococci PD-related infections were recorded throughout the 4-year period following sample collection. …”
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Acute Effect of Short-Term Benzocaine Anesthesia on the Skin Mucus Microbiome of Atlantic salmon (<i>Salmo salar</i>) by Patrícia Martins, Tânia Pimentel, Nuno Ribeiro, Ricardo Calado

“…This study is the first to evaluate the influence of benzocaine, a widely used anesthetic, on the skin mucus bacterial microbiome of Atlantic salmon reared in a recirculating aquaculture system (RAS). …”
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The impact of dietary salt on the development of hypertension and gut microbiome dysbiosis in captive-bred vervet monkeys (Chlorocebus aethiops) by Zandisiwe Emilia Magwebu, Sanele Khoza, Mikateko Mazinu, Esme Jordaan, Meenu Ghai, Chesa Gift Chauke

“…Abstract Background The study was designed to establish a hypertensive nonhuman primate model to evaluate the role of dietary salt intake on blood pressure levels and gut microbiome regulation. …”
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Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment by Zhongyi Sun, Haibo Liu, Mengting Yin, Ningning Cheng, Wencheng Liu, Kangkang Zhao, Hua Zeng, Xuming Chen, Zijie Wang, Xuhui Zhou, Xinyu Zhao, Feng Chen

“…The radiation induced skin defect animal model is established to evaluate the RISD repair efficacy of our MSR@MN patch in comparison with γPGA‐MSR ointment and commercial product Orgotein. …”
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Comparison of metagenomic analysis of fecal and gastrointestinal tract samples for identifying beneficial gut microorganisms by Ji-Seon Ahn, Eui-Jeong Han, Hea-Jong Chung, Hea-Jong Chung, Hea-Jong Chung

“…Additionally, analyzing the broader diversity of microbial communities in the GI tract may enhance the identification of potentially beneficial microbiota.MethodsIn this study, we compare gut microbiome datasets obtained from fecal samples and GI samples (collected by pooling luminal contents and mucosal scrapings from the stomach to the end of the colon) of 6-month-old mice using 16S rRNA sequencing. We further investigate the associations between gut microbiota and motor, cognitive, and emotional functions in mice, examining differences between the two sample types. …”
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Detection of rotavirus and norovirus among children with acute gastroenteritis in Merida and Chihuahua cities, Mexico by Ana C Alcalá, Clotilde Cancio-Lonches, Joel Ramírez Ricardo, Julio Cesar Torres Romero, Rocio Infante-Ramírez, Ma. Carmen E Delgado-Gardea, Sofia L Alcaraz-Estrada, Julio Lara-Riegos, Ana Lorena Gutiérrez-Escolano

“…Methodology: HuNoVs were detected and characterized by RT-PCR and sequencing, while RVs were detected by RNA electrophoresis. …”
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Enhancement of Apostichopus japonicus peptide flavor through bacterial and enzyme co-fermentation (BECF) and the identification of novel antioxidant peptides in the fermented produ... by Zhiqiang Shu, Gongming Wang, Yuexin Jing, Chunna Jiao, Leilei Sun, Hui Huang, Yue Li, Jian Zhang

“…Additionally, various analytical techniques were employed to determine the volatile flavor compounds, amino acid composition, and peptide sequences of the fermented product. The antioxidant activities of 10 peptides were evaluated via free radical scavenging assays. …”
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Microbiome variability and role of Candida albicans in site-specific dental plaques in orthodontic adolescent patients with white spot lesions by Hao Yang, Hongyu Gao, Xianju Xie, Hongmei Wang, Xiaowei Li, Qingchen Qiao, Yansong Ma, Yuxing Bai

“…Supragingival microbiome composition was evaluated using 16S rRNA sequencing, and C. albicans colonization was identified using fungal culture methods. …”
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Groundwaterscapes: A Global Classification and Mapping of Groundwater's Large‐Scale Socioeconomic, Ecological, and Earth System Functions by Xander Huggins, Tom Gleeson, Karen G. Villholth, Juan C. Rocha, James S. Famiglietti

“…Groundwaterscapes are derived using a novel application of sequenced self‐organizing maps that capture patterns in groundwater system functions at the grid cell level (∼10 km), including groundwater‐dependent ecosystem type and density, storage capacity, irrigation, safe drinking water access, and national governance. …”
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Anti-epileptic and gut-protective effects of trioctanoin and the critical role of gut microbiota in a mouse model of epilepsy by Fei Yu, Jia-Lin Ji, Ying Wang, Yi-Di Liu, Yi-Mei Lian, Meng-Zhen Wang, Zheng-Xu Cai

“…Recent research suggests the association of the gut-brain axis with epilepsy pathogenesis, thus offering potential new therapeutic targets. This study evaluated the anti-epileptic effect of trioctanoin and explored the potential role of the gut microbiota in a chronic pentylentetrazol (PTZ)-induced seizure mouse model. …”
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Two Outbreaks of Invasive Pneumococcal Disease in Nursing Homes in Gipuzkoa, Northern Spain by José María Marimón, Ayla Manzanal, Olatz Mokoroa, Lorea Alvarez, Maite Rekalde, Diego Vicente

“…Pneumococcal isolates were characterized by whole-genome sequencing. <b>Results</b>: The outbreaks involved five and six residents, respectively. …”
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Volume of the hypothalamus and its subunits in patients with episodic migraine without aura during interictal periods by Irene Giardina, Antonio Di Renzo, Davide Chiffi, Francesca Giovannini, Giada Giuliani, Gabriele Sebastianelli, Francesco Casillo, Chiara Abagnale, Marta Altieri, Vittorio Di Piero, Gianluca Coppola, Francesca Caramia

“…Volumetric segmentation was performed of both hypothalamic subunits (anterior-inferior, anterior-superior, posterior, tubular inferior, and tubular superior) and the entire hypothalamus using magnetic resonance imaging (MRI) with T1-weighted sequences. General linear models were employed to evaluate volumetric differences after controlling for age, sex, and total brain volume. …”
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Grading chondroid tumors through MRI radiomics: enchondroma, low-grade chondrosarcoma and higher-grade chondrosarcoma by Hyerim Park, Jooyeon Lee, Seungeun Lee, Joon-Yong Jung

“…Results The LASSO + RF model based on all sequences achieved the highest accuracy (0.826 ± 0.065) and AUC (0.967 ± 0.027). …”
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A Trypanosoma cruzi strain from southern Mexico is more virulent for male mice in part by blocking the immune response by Celeste Amaranta Palma-González, Héctor Israel Recinos-Vázquez, Julio César Burguete-Gutiérrez, José Antonio De Fuentes-Vicente, María Adelina Schlie-Guzmán, Dolores Guadalupe Vidal-López, Jesús Díaz-Gómez, Jorge Eugenio Vidal, Javier Gutiérrez-Jiménez

“…The objective of this study was to evaluate the pathogenicity of a T. cruzi strain in mice of both sexes and to assess certain elements of the immune response in the infected animals. …”
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Investigating the correlation between tertiary lymphoid structures and clinical outcomes in pancreatic ductal adenocarcinoma: insights into tumor immunology by Lingbo Hu, Lingbo Hu, Lingbo Hu, Yanhong Xiao, Yanhong Xiao, Yanhong Xiao, Ning Jiang, Ning Jiang, Yufen Hu, Liewang Qiu, Bo Geng

“…We analyzed clinical data from 65 PDAC patients and RNA sequencing data from The Cancer Genome Atlas (TCGA) to evaluate the presence of TLS and its impact on overall survival (OS) and recurrence-free survival (RFS). …”
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