Exploration of carotenoid-producing Rhodotorula yeasts from amazonian substrates for sustainable biotechnology applications by Raissa Sayumy Kataki Fonseca, Kevyn Melo Lotas, Ana Claudia Alves Cortez, Flávia da Silva Fernandes, Érica Simplício de Souza, Laurent Dufossé, João Vicente Braga de Souza

“…The three best producers were identified through nucleotide sequencing of the ITS1–5.8s-ITS4 rDNA region. The top producer underwent univariate experiments to evaluate the influence of different C/N sources. …”
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Anti-tumor and anti-metastatic effects of RRx-001 on hepatocellular carcinoma: mechanisms of action and therapeutic potential by Guohong Yan, Shuqi Zhao, Meifeng Chen, Shutian Mo, Hailian Huang, Yuan Liao, Ziyan Lu, Jiaming Liang, Shuxin Wei, Chuangye Han, Xinping Ye

“…Migration and invasion were evaluated using scratch and Transwell assays, and apoptosis was examined by apoptosis assays. …”
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Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study by Christoph Oster, Aylin Matyar, Teresa Schmidt, Thomas Hummel, Elke Hattingen, Martha Jokisch, Daniel Jokisch, Jana Grieger, Giorgio Cappello, Kathrin Kizina, Lazaros Lazaridis, Yahya Ahmadipour, Laurèl Rauschenbach, Martin Stuschke, Christoph Pöttgen, Nika Guberina, Tobias Tertel, Bernd Giebel, Gian Luca Dreizner, Francesco Barbato, Eva-Maria Skoda, Björn Scheffler, Michael Müther, Ken Herrmann, Christoph Kleinschnitz, Ulrich Sure, Cornelius Deuschl, Martin Glas, Sied Kebir

“…Perspective This is the first longitudinal study evaluating olfactory function as a prognostic biomarker in glioblastoma. …”
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HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke by Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

“…A mouse model of EHS was established and murine tissue damage was evaluated by H&E staining. HMGB1 localization and release were visualized using immunofluorescence staining. …”
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Impacts of Antiretroviral Therapy on the Oral Microbiome and Periodontal Health of Feline Immunodeficiency Virus-Positive Cats by Laura Bashor, Jennifer E. Rawlinson, Christopher P. Kozakiewicz, Elisa Behzadi, Craig Miller, Jeffrey Kim, Megan Cierzan, Mary Nehring, Scott Carver, Zaid Abdo, Sue VandeWoude

“…Using 16S rRNA sequencing, we evaluated gingival bacterial communities at four timepoints in uninfected and FIV-infected cats treated with either cART or placebo. …”
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Tannic acid-iron stabilized probiotic silver nano hybrids: Multi-target gut microbiota modulation and intestinal barrier restoration by Saisai Gong, Zhibo Zeng, Mingjue Liu, Xianfu Wang, Chuxian Quan, Muhammed Farhan Rahim, Yaping Wang, Aoyun Li, Md. F. Kulyar, Zhexue Lu, Jiakui Li

“…The aim of this study was to develop and evaluate a BL@TA-FeIII@AgNPs system with a view to provide synergistic efficacy against intestinal injury. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…The most potent inhibitor was evaluated in vivo in two animal models and the mechanisms of action were investigated by RNA sequencing, Western blotting and immunofluorescence staining. …”
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Efficacy of quadruple regimen with polaprezinc for gastric Helicobacter pylori infection eradication: protocol for a single-centre, single-blind, non-inferiority, randomised clinic... by Jun Li, Tingting Chen, Wen Chen, Yujing Liu, Dingkun Wu, Zhen Sun, Tingyuan Li, Qinwen Tan, Haidong Jiang, Zhiqiang Yuan, Yuqian Zhao

“…The 16S ribosomal RNA (16S rRNA) next-generation sequencing (NGS) is used to evaluate the effect of two different therapies on the distribution of the gastrointestinal microbiota.Ethics and dissemination This study was approved by the Ethics Committee of Sichuan Cancer Center & Hospital (No. …”
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ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity by Yiming Liu, Xingyu Jiang, Dongquan Jing, Yanting Lin, Rui Gao, Qixiang Zhao, Huijuan Da, Yiming Ren, Qiuhua Cao, Ning Liu, Xiaoyun Han, Juan Du, Xinghua Gao

“…Flow cytometry and immunofluorescence were used to evaluate immune cell infiltration. RNA sequencing and RT-PCR were employed to identify ACSL4-regulated signaling pathways. …”
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Assessing CO2 ${ ext{CO}}_{2}$ Migration Within Faults During Megatonne‐Scale Geologic Carbon Dioxide Storage in Offshore Texas by Lluís Saló‐Salgado, Josimar A. Silva, Lisa Lun, Christie M. Rogers, J. Steven Davis, Ruben Juanes

“…Here, we conduct flow simulations of megatonne‐scale CO2 injection next to a major, reservoir‐bounding growth fault, and evaluate (a) where fault sealing capacity is exceeded, and (b) where the CO2 migrates after it enters the fault zone. …”
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Clinical and genetic analysis of a case series of 12 Chinese families with hereditary ataxia by Liqi Guo, Liqi Guo, Fangrui Wu, Fangrui Wu, Yuxi Wang, Xiaoping Xiong, Min Zhong, Min Zhong

“…The clinical manifestations, pedigree analysis, neuroimaging, and laboratory evaluations of the probands were systematically examined. …”
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Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease by Rachel E. Twomey, Stuart J. Perper, Susan V. Westmoreland, Swetha Srinivasan, Suzanne L. Mathieu, Kristine E. Frank, Jozsef Karman, Andrew J. Long, William J. Housley, Stephen H. Clarke

“…Methods Efficacy of ABT‐317 was evaluated using NZB/W‐F1 mice treated prophylactically and therapeutically. …”
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Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment by Eric A. Smith, Rachel L. Belote, Nelly M. Cruz, Tarek E. Moustafa, Carly A. Becker, Amanda Jiang, Shukran Alizada, Anastasia Prokofyeva, Tsz Yin Chan, Tori A. Seasor, Michael Balatico, Emilio Cortes-Sanchez, David H. Lum, John R. Hyngstrom, Hanlin Zeng, Dekker C. Deacon, Allie H. Grossmann, Richard M. White, Thomas A. Zangle, Robert L. Judson-Torres

“…Methods An independent analysis of published sequencing data was performed to evaluate the frequency of receptor tyrosine kinase (RTK) ligands and adapter protein gene variants and expression. …”
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CD8+ T cells in breast cancer tumors and draining lymph nodes: PD-1 levels, effector functions and prognostic relevance by Carolina Abrate, Fernando P. Canale, Sabrina N. Bossio, Jimena Tosello Boari, María C. Ramello, Nicolas Nuñez, Wilfrid Richer, Christine Sedlik, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes

“…However, in all tissues evaluated, most CD8+ T cells exhibited a pre-exhausted phenotype (PD-1Int CD8+) or did not express PD-1. …”
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Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway by Sanaa Dekkar, Kamilia Mahloul, Amandine Falco, Karidia Konate, Romane Pisteur, Sarah Maurel, Laurent Maïmoun, Norbert Chauvet, Prisca Boisguérin, David Nocca, Ariane Sultan, Florian Pallot, Guillaume Walther, Nicolas Cenac, Cyril Breuker, Sandrine Faure, Pascal de Santa Barbara

“…Global lipidomic and RNA sequencing analyses were performed. The findings were evaluated in patients with obesity, using gastric samples from individuals who underwent sleeve gastrectomy, to evaluate their clinical relevance. …”
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Injectable and Assembled Calcium Sulfate/Magnesium Silicate 3D Scaffold Promotes Bone Repair by In Situ Osteoinduction by Wei Zhu, Tianhao Zhao, Han Wang, Guangli Liu, Yixin Bian, Qi Wang, Wei Xia, Siyi Cai, Xisheng Weng

“…Transcriptome sequencing identified bone development-related pathways. …”
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Physiological responses of young Italian worker bees (Apis mellifera ligustica Spin.) induced by different pollen diets by Pier Paolo Danieli, F. Manganello, I. Ghaffar, F. Lazzari, F. Petrocchi Jasinski, V. Malagnini, N. Cherrered, A. Mohammedi

“…In-cage feeding trials were conducted over two weeks, evaluating daily intake, body composition (crude protein and lipid content), hypopharyngeal gland development, ovary maturation, and Vairimorpha apis and V. ceranae spore loads using RT-PCR and sequencing. …”
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Ruminococcus bromii-generated acetate alleviated Clonorchis sinensis-induced liver fibrosis in mice by Chun Li, Changsheng Cheng, Liping Jiang, Xin Zhong, Guoyang Huang, Gang Mo, Deping Cao, Xiaohong Peng, Xiaohong Peng

“…Furthermore, it is uncertain whether targeting the gut microbiota, based on the concept of the gut-liver axis, could be a potential therapeutic strategy for alleviating liver fibrosis.MethodsThe gut microbiota alterations in C. sinensis-infected mice at multiple time points were analyzed through 16S rDNA high-throughput sequencing. Ruminococcus bromii (R.bromii) therapeutic effect on C. sinensis infected mice was evaluated. …”
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Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis by Ann-Kathrin Daum, Lisa Schlicker, Marc A. Schneider, Thomas Muley, Ursula Klingmüller, Almut Schulze, Michael Thomas, Petros Christopoulos, Holger Sültmann

“…The therapeutic potential of targeting metabolic vulnerabilities was evaluated using pharmacological inhibition of lipid metabolism and by ferroptosis induction. …”
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Pretreatment HIV‐1 Drug Resistance Among Newly Diagnosed People in Eastern Ethiopia by Abdella Gemechu, Adane Mihret, Mesfin Mengesha, Dawit Hailu Alemayehu, Eleni Kidane, Abraham Aseffa, Rawleigh Howe, Berhanu Seyoum, Andargachew Mulu

“…Among the isolates successfully sequenced, three HIV‐1 strains were detected, of which 97.1% had HIV‐1 subtype C, 1.4% A1C, and 1.4% CF1 recombinant. …”
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