Discovering Human Presence Activities with Smartphones Using Nonintrusive Wi-Fi Sniffer Sensors: The Big Data Prospective by Weijun Qin, Jiadi Zhang, Bo Li, Limin Sun

“…In this paper, we propose an optimized Wi-Fi channel detection and selection method to switch the best channels automatically to aggregate the Wi-Fi messages based on channel data transmission weights and human presence activity classification method based on the features of human dwell duration sequences in order to evaluate the user engagement index. …”
Get full text

Axial Field of View Expansion by Switchable Halbach Dipole Rings: A Simulation Study by Berghausen Katharina, Aderhold Eric, Graeser Matthias

“…Through adequate rotation of the Halbach dipoles the FFR can be moved continuously along the cylinder axis. To understand and evaluate the movement of the FFR for different sequences of dipole rotations a simulation study is conducted. …”
Get full text

An interdomain sector mediating allostery in Hsp70 molecular chaperones by Robert G Smock, Olivier Rivoire, William P Russ, Joanna F Swain, Stanislas Leibler, Rama Ranganathan, Lila M Gierasch

“…Here, we generalize the statistical coupling analysis to simultaneously evaluate co‐evolution between protein residues and functional divergence between sequences in protein sub‐families. …”
Get full text

Deep learning for endometrial cancer subtyping and predicting tumor mutational burden from histopathological slides by Ching-Wei Wang, Nabila Puspita Firdi, Yu-Ching Lee, Tzu-Chiao Chu, Hikam Muzakky, Tzu-Chien Liu, Po-Jen Lai, Tai-Kuang Chao

“…Traditional TMB prediction methods, such as sequencing exomes or whole genomes, are costly and often unavailable in clinical settings. …”
Get full text

A Start Codon Variant in NOG Underlies Symphalangism and Ossicular Chain Malformations Affecting Both the Incus and the Stapes by Nathan R. Lindquist, Eric N. Appelbaum, Anushree Acharya, Jeffrey T. Vrabec, Suzanne M. Leal, Isabelle Schrauwen

“…We performed exome sequencing to evaluate the underlying molecular cause of a patient with bilateral conductive hearing loss due to multiple ossicular abnormalities as well as symphalangism of the fifth digits. …”
Get full text

Development and validation of a multiplex PCR assay with melt curve analysis for detecting simian Plasmodium in wild Macaca fascicularis by Thitiluck Swangsri, Rucksak Rucksaken, Wanat Sricharern, Wang Nguitragool, Naowarat Saralamba

“…Amplification efficiency was within acceptable ranges, with R2 > 0.90 across standard curves. The assay was evaluated using 191 archived blood samples from wild M. fascicularis collected across three provinces in Thailand, with P. knowlesi detected in two samples. …”
Get full text

Case Report: A novel missense variant in ZC4H2, c.196C>T p.(Leu66Phe), is associated with a mild, ZC4H2-related X-linked syndromic intellectual disability (ZARD) phenotype by Ria Garg, Ria Garg, Wenying Zhang, Wenying Zhang, Julianne E. Hartmann, Anne Slavotinek, Anne Slavotinek

“…Exome sequencing identified a hemizygous, missense variant in ZC4H2, NM_018684.4:c.196C>T p.…”
Get full text

Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue by Rhys E. De Sota, Stephen R. Quake, John J. Sninsky, Shusuke Toden

“…Despite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited compared to other RNA classes. …”
Get full text

Mutations in transcription factor as rare causes of diabetes in pregnancy by Natalia A. Zubkova, Fatima F. Burumkulova, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Evgeny V. Vasilyev, Vasily M. Petrov, Nina A. Makretskaya, Anatoliy N. Tyulpakov

“…A custom NGS panel targeting 28 diabetes causative genes was used for sequencing. Heterozygous mutations in HNF4A and HNF1A genes were detected in 3% of cases. …”
Get full text

A THERP/ATHEANA Analysis of the Latent Operator Error in Leaving EFW Valves Closed in the TMI-2 Accident by Renato A. Fonseca, Antonio Carlos M. Alvim, Paulo Fernando F. Frutuoso e Melo, Marco Antonio B. Alvarenga

“…This integration provides a more realistic and comprehensive modeling of accident sequences by considering preaccidental and postaccidental contexts, which, in turn, can contribute to more realistic PSA (Probabilistic Safety Assessment) evaluations and decision making.…”
Get full text

Investigative needle core biopsies support multimodal deep-data generation in glioblastoma by Kenny K. H. Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev, Sonali Jindal, Michael S. Regan, Zaki Abou-Mrad, Michael C. Prabhu, Marc J. Williams, Alicia D. D’Souza, Seth W. Malinowski, Kelsey Hopland, Yuval Elhanati, Sylwia A. Stopka, Alexei Stortchevoi, Charles Couturier, Zhong He, Jingjing Sun, Yulong Chen, Alexsandra B. Espejo, Kin Hoe Chow, Smitha Yerrum, Pei-Lun Kao, Brittany Parker Kerrigan, Lisa Norberg, Douglas Nielsen, The GBM TeamLab, Vinay K. Puduvalli, Jason Huse, Rameen Beroukhim, Betty Y. S. Kim, Sangeeta Goswami, Adrienne Boire, Sarah Frisken, Michael J. Cima, Matthias Holdhoff, Calixto-Hope G. Lucas, Chetan Bettegowda, Stuart S. Levine, Tejus A. Bale, Cameron Brennan, David A. Reardon, Frederick F. Lang, E. Antonio Chiocca, Keith L. Ligon, Forest M. White, Padmanee Sharma, Viviane Tabar, Nathalie Y. R. Agar

“…In conclusion, investigative biopsies provide data-rich insight into disease processes and may be useful in evaluating treatment responses.…”
Get full text

Endolysin selectively kills Gardnerella ex vivo in vaginal samples from women with bacterial vaginosis by Lenka Podpera Tisakova, Timo Schwebs, Rocío Berdaguer, Marina von Freyberg, Philipp Foessleitner, Ann-Katrin Kieninger, Albina Poljak, Lorenzo Corsini, Alex Farr

“…Whole genome sequencing confirmed BV-associated community state types IV-B and III, with Gardnerella dominating in 53% of samples and present in 86%. …”
Get full text

Antimicrobial Resistance Profiling of Pathogens from Cooked Donkey Meat Products in Beijing Area in One Health Context by Yiting Liu, Hongyun Duan, Luo Yang, Hong Chen, Rongzheng Wu, Yi Li, Yiping Zhu, Jing Li

“…Molecular identification was performed through polymerase chain reaction (PCR) amplification and sequencing targeting the 16S rDNA gene. The antimicrobial susceptibility of the isolates was evaluated using the disk diffusion method. …”
Get full text

Nanoliposome-encapsulated MAGE peptides: A promising melanoma vaccine to activate human dendritic cells by Azin Bavafa, Niloufar Salimian, Zeina Khazaei Koohpar, Amir Gholamzad, Hossein Fahimi, Maliheh Entezari, Ali Jebali, Najma Farahani, Mehrdad Hashemi

“…Methods: MAGE-A and MAGE-B peptide sequences were selected based on bioinformatics analysis. …”
Get full text

Microbial diversity in drug-naïve Parkinson's disease patients. by Eliša Papić, Valentino Rački, Mario Hero, Ana Nyasha Zimani, Mojca Čižek Sajko, Gloria Rožmarić, Nada Starčević Čizmarević, Saša Ostojić, Miljenko Kapović, Goran Hauser, Aleš Maver, Borut Peterlin, Anja Kovanda, Vladimira Vuletić

“…While previous research has shown several differences in the microbiome of PD patients under therapy as opposed to healthy controls, few prospective studies have included drug-naïve patients. In order to evaluate the gut microbiome composition prior to therapy initiation, we collected and performed 16S rRNA gene sequencing of the stool samples from 49 drug-naïve PD patients and compared them to 34 diet and lifestyle-matched controls from the Croatian population (GiOPARK Project). …”
Get full text

Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant. by Jennifer VanOudenhove, Yuxin Liu, Raman Nelakanti, Dongjoo Kim, Emma Busarello, Natalia Tijaro Ovalle, Zhihong Qi, Padmavathi Mamillapalli, Alexa Siddon, Zhiliang Bai, Alfredo Axtmayer, Cheryl Corso, Shalin Kothari, Francine Foss, Iris Isufi, Toma Tebaldi, Lohith Gowda, Rong Fan, Stuart Seropian, Stephanie Halene

“…Patients were selected based on humoral and cellular responses for single-cell RNA with TCR and BCR sequencing. Our studies revealed defects in memory T cells that correlated with an absence of cellular response despite nearly universal humoral response. …”
Get full text

Exploring a pico-well based scRNA-seq method (HIVE) for simplified processing of equine bronchoalveolar lavage cells. by Kim Fegraeus, Miia Riihimäki, Jessica Nordlund, Srinivas Akula, Sara Wernersson, Amanda Raine

“…Single-cell RNA sequencing (scRNA-seq) is a valuable tool for investigating cellular heterogeneity in diseases such as equine asthma (EA). …”
Get full text

Improved Hierarchical Convolutional Features for Robust Visual Object Tracking by Jinping Sun

“…The proposed tracker is evaluated by simulation analysis on TC-128/OTB2015 benchmarks including more than 100 video sequences. …”
Get full text

An Iranian Congenital Adrenal Hypoplasia Patient with Elevated Testosterone in Infancy due to a Novel Pathogenic Frameshift Variant in NR0B1 by Samira Kalayinia, Saeed Talebi, Mohammad Miryounesi, Peymaneh Sarkhail, Nejat Mahdieh

“…Clinical evaluations and pedigree drawing were performed. Point mutations, gene conversions, and large deletions of the CYP21A2 gene were checked. …”
Get full text

Single-cell analysis reveals the spatiotemporal effects of long-term electromagnetic field exposure on the liver by Mingming Zhang, Zhichun Lv, Lingping Zhao, Quan Zeng, Yunqiang Wu, Junnian Zhou, Jiafei Xi, Xuetao Pei, Haiyang Wang, Changyan Li, Wen Yue

“…Furthermore, EMF-induced liver transcriptome variations were investigated using single-cell RNA sequencing and a spatiotemporally resolved analysis.ResultsDifferent hepatic cells exhibited diverse sensitivities and response patterns. …”
Get full text