COVID-19 hospitalization in vaccinated and non-vaccinated patients: Clinical profile and outcomes by Laura Holtman-Ferreira, Elessandra de Souza Bitencourt, Betina Mendez de Alcantara Gabardo, Susanne Edinger Pereira, Francine Teixeira, Diego da Silva Magatão, Vitor Loureiro Dias, Ricardo Petterle, Meri Bordignon Nogueira, Sonia Mara Raboni

“…They underscore the need to evaluate vaccine effectiveness against circulating variants and highlight the importance of complete vaccination schedules for improving patient outcomes.…”
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Cell-free DNA in the management of prostate cancer: Current status and future prospective by Wei He, Yutian Xiao, Shi Yan, Yasheng Zhu, Shancheng Ren

“…Methods: Relevant peer-reviewed manuscripts on cfDNA as a PCa marker were evaluated by PubMed search (2010–2022) to evaluate the roles of cfDNA in PCa diagnosis, prognosis, and prediction, respectively. …”
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De Novo Missense Variant in Bovine WDR33 Associated With a Complex Syndromic Form of Cleft Palate With Pentalogy of Fallot and Internal Hydrocephalus by Marilena Bolcato, Giovanni Romito, Irene M. Häfliger, Arcangelo Gentile, Cord Drögemüller, Joana G. P. Jacinto

“…Methods The affected animals were evaluated clinicopathologically. Paternal half‐sibling trio‐based whole genome sequencing (WGS) was performed using genomic DNA extracted from the blood of the two affected calves and both dams, and sperm of the common sire. …”
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Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models by Zuoyu Jiang, Xuetao Li, Zongyu Xiao, Wenjuan Gan, Xuewen Zhang, Yang Zhang, Weichao Wang, Qinzhi E, Yu Huang, Qikun Shi, Yi Tang, Jiaming Du, Hanmiao Dong, Jian Li, Yulun Huang

“…Patient-derived orthotopic xenograft models were used for in vivo efficacy evaluations. Lastly, transcriptome sequencing was used to elucidate the mechanism of action of the drugs, which was confirmed using western blotting. …”
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Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota by Xin Yang, Xin Yang, Canhui Hong, Canhui Hong, Tangfei Guan, ChengGui Zhang, ChengGui Zhang, Peiyun Xiao, Peiyun Xiao, Yongshou Yang, Yongshou Yang, Huai Xiao, Huai Xiao, Zhengchun He, Zhengchun He

“…We evaluated the protective effects of PAS840 on brain damage in IS rats through TTC (triphenyltetrazolium chloride), Nissl staining, and pathological section analysis. …”
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Life-course socioeconomic position and the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) by Monica A. Batalha, Madison N. LeCroy, Juan Lin, Brandilyn A. Peters, Qibin Qi, Zheng Wang, Tao Wang, Linda C. Gallo, Gregory A. Talavera, Amanda C. McClain, Bharat Thyagarajan, Martha L. Daviglus, Lifang Hou, Maria Llabre, Jianwen Cai, Robert C. Kaplan, Carmen R. Isasi

“…Socioeconomic position (SEP) in childhood and beyond may influence the gut microbiome, with implications for disease risk. Studies evaluating the relationship between life-course SEP and the gut microbiome are sparse, particularly among Hispanic/Latino individuals, who have a high prevalence of low SEP. …”
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Non-Coding RNAs: lncRNA, piRNA, and snoRNA as Robust Plasma Biomarkers of Alzheimer’s Disease by Ruomin Xin, Elizabeth Kim, Wei Tse Li, Jessica Wang-Rodriguez, Weg M. Ongkeko

“…In this study, we systematically profiled ncRNA expression from RNA sequencing data of 48 AD and 22 control blood tissue samples, aiming to evaluate their utility as biomarkers for AD classification. …”
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Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019–2024 by Martin Okitwi, Stephen Orena, Patrick K. Tumwebaze, Thomas Katairo, Yoweri Taremwa, Oswald Byaruhanga, Stephen Tukwasibwe, Samuel L. Nsobya, Jennifer Legac, Jeffrey A. Bailey, Roland A. Cooper, Melissa D. Conrad, Philip J. Rosenthal

“…We characterized ex vivo susceptibilities to nine drugs of isolates collected from individuals presenting with uncomplicated falciparum malaria in eastern (2019-2024) and northern (2021-2024) Uganda and performed deep sequencing, with analysis of 80 Plasmodium falciparum genes, to evaluate associations between susceptibilities and potential resistance markers for samples studied since 2016. …”
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Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition by Ting Zhang, Ye Zou, Sun-Han Zhang, Yuan-Yi Wang, Shuang He, Wei Yuan, Min Yang, Teng Liu, Shi-Hua Deng, Dong-Ming Wu, Ying Xu

“…In this study, our purpose was to evaluate taletrectinib-related cytotoxicity in vitro using two CRC cell lines, as well as in vivo in a mouse tumor model. …”
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Establishment of a set of St-group wheat-Thinopyrum ponticum derivative lines conferring resistance to powdery mildew by Xiaofang Cheng, Yue Guan, Jianing Zhao, Xiaoying Yang, Guangyi Wang, Tingdong Li, Tingdong Li, Pingchuan Deng, Pingchuan Deng, Chunhuan Chen, Chunhuan Chen, Jixin Zhao, Jixin Zhao, Changyou Wang, Changyou Wang, Xinlun Liu, Xinlun Liu, Wanquan Ji, Wanquan Ji

“…Specific markers for the St-homoeologous groups were developed through genome sequencing, achieving a development efficiency of 47.5%. …”
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A novel Mg-Zn-Nd-Zr alloy lumbar interbody fusion cage: An in vitro and in vivo study by Pengfei Chi, Wen Yu, Bing Wu, Ming Gao, Kai Song, Kaige Mao, Bo Li, Xuanhui Liu, Haoming Liu, Chuyue Zhang, Jianheng Liu, Yang Yu, Qiaoling Chen, Ruoxin Zhao, Ning Yu, Keya Mao, Ke Yang, Lili Tan, Yan Wang, Zheng Wang

“…This study aimed to evaluate the degradation profile and osteoinductive potential of biodegradable Mg-Zn-Nd-Zr cages with/without micro-arc oxidation (MAO) coatings. …”
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Cell Counting and Cell Cycle Analysis of Simple Non-Cultured Endothelial Cell Injection (SNEC-I) Therapy: Characterization for Clinical Translation by Darren S. J. Ting, Gary S. L. Peh, Dawn J. H. Neo, Xiao Yu Ng, Belinda Y. L. Tan, Raymond C. B. Wong, Hon Shing Ong, Jodhbir S. Mehta

“…This study aimed to develop a robust and semi-automated approach for cell counting, characterize the extent of cellular manipulation, and evaluate the translational workflow. To address this, we evaluated manual and automated cell counting approaches and characterized the extent of manipulation of CEnCs through the analysis of cell cycle status, gene expressions, and transcriptomic profiles with single-cell RNA-sequencing. …”
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The Paraguayan gut microbiome contains high abundance of the phylum Actinobacteriota and reveals the influence of health and lifestyle factors by Mauricio Molinas-Vera, Gonzalo Ferreira-Sanabria, Pablo Peña, Walter J. Sandoval-Espinola

“…However, this overlooks the role played by host genetics, lifestyle, and diet, highlighting the need to evaluate under-represented populations. Thus, we performed the first gut microbiome study from a Paraguayan cohort via 16S rRNA sequencing and PICRUSt2 analysis. …”
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Impact of different concentrations of biogas slurry as a fertilizer substitute on the structure and gene distribution of microbial communities in oilseed rape soil by Xue Yang, Kai Zhang, YaYing Chen, Cancai Zheng, Chunlong Lei, Xiaoqin Song, Bin Wen, Xin Yuan, Hanyang Liu, Jiawen Zhu

“…Soil bacterial community diversity and composition were systematically evaluated using Illumina MiSeq high throughput sequencing, focusing on interrelationships and changes at the genetic level. …”
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scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers by Peng Tian, Jie Zheng, Keying Qiao, Yuxiao Fan, Yue Xu, Tao Wu, Shuting Chen, Yinuo Zhang, Bingyue Zhang, Chiara Ambrogio, Haiyun Wang

“…Its superior performance and computational efficiency are confirmed through comparative evaluations with other single‐cell prediction tools. …”
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Rubidium ions as a novel therapeutic approach for glioblastoma by Zairan Wang, Zhimin Li, Ran Yang, Yu Wang, Wenbin Ma, Xiang Lv, Jun Gao, Yongning Li

“…RNA sequencing and Western blot analyses were employed to investigate molecular mechanisms, while in vivo models were used to evaluate therapeutic efficacy and safety. …”
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Deep learning-based debris flow hazard detection and recognition system: a case study by Fei Wu, Jianlin Zhang, Dunlong Liu, Andreas Maier, Vincent Christlein

“…All the networks are optimized and evaluated on a newly annotated image dataset called Debrisflow23. …”
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Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma by Cecilia Lezcano, Li Luo, Ronglai Shen, Irene Orlow, Nancy E. Thomas, Marianne Berwick, Klaus J. Busam

“…Methods: Primary cutaneous melanomas from 469 AJCC (8th edition) stage II and III patients with clinical annotation including outcome at 5 years of diagnosis were histopathologically evaluated for solar elastosis. Next-generation sequencing assay MSK-IMPACTTM was employed to determine TMB. …”
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Preclinical Efficacy and Safety of an Oncolytic Adenovirus KD01 for the Treatment of Bladder Cancer by Jin Guo, Shengfeng Xiong, Xinyuan Zhang, Wei Gong, Yao Si, Ding Ma, Fei Li, Yingyan Han

“…<b>Methods</b>: The cytotoxic effects and anti-tumor efficacy of KD01 were systematically evaluated across human bladder cancer cell lines, and cell death pathways were investigated by RNA sequencing and validated. …”
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Association Between CD147 Expression, RAS Mutational Status, and Local Recurrence in Resected Locally Advanced Rectal Cancer by Anaëlle Isnard, Laure‐Amandine Cramier, Rémi Vergara, Mehdi Boubaddi, Donatien Fouche, Benjamin Fernandez, Nathalie Senant, Quentin Denost, Éric Rullier, Pierre Dubus, Sandrine Dabernat, Charles Dupin, Véronique Vendrely, Anne Rullier, Samuel Amintas

“…Mutational status was assessed by next‐generation sequencing. Correlations with LR rates were evaluated. …”
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