Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a sing... by Shiao-Pei Weathers, Xiqi Li, Haifeng Zhu, Ashish V. Damania, Mark Knafl, Brian McKinley, Heather Lin, Rebecca A. Harrison, Nazanin K. Majd, Barbara J. O’Brien, Marta Penas-Prado, Monica Loghin, Carlos Kamiya-Matsuoka, W. K. Alfred Yung, Luisa M. Solis Soto, Dipen M. Maru, Ignacio Wistuba, Edwin R. Parra Cuentas, Sharia Hernandez, Andrew Futreal, Jennifer A. Wargo, Katja Schulze, Walter C. Darbonne, Nadim J. Ajami, Scott E. Woodman, John F. de Groot

“…Abstract This phase I/II trial aims to evaluate the efficacy of concurrent atezolizumab with radiation therapy and temozolomide (TMZ) followed by adjuvant atezolizumab and TMZ in newly diagnosed glioblastoma (GBM) patients and to identify pre-treatment correlates with outcome (N = 60). …”
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MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells by Christine Chauveau, Veronique Nerriere-Daguin, Maeva Fourny, Cynthia Fourgeux, Thibaut Larcher, Laurence Delbos, Martin Braud, Lucas Brusselle, Olivia Rousseau, Jeremie Poschmann, Julien Verdier, Fabienne Haspot, Gilles Blancho, Simon Ville

“…Using a human skin transplantation model in NSG mice reconstituted with third-party human PBMCs, we evaluated the effects of trametinib on graft survival and the human allogeneic immune response. …”
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Research Note: Novel reassortant avian influenza A(H9N2) Viruses in Wild Birds in Shanghai, China, 2020–2023 by Jie Hu, Yuting Xu, Min Ma, Chenyao Zhao, Yue Yuan, Guimei He

“…These results highlight the importance of active surveillance of AIVs in wild birds to comprehend viral ecology and evaluate potential transmission risk in poultry and humans.…”
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Integrating air microbiome for comprehensive air quality analysis by Sofya Pozdniakova, Akira Uchida, Alejandro Fontal, Lídia Cañas, Samuel Santamaria, Lim Yee Hui, Irvan Luhung, Stephan C. Schuster, Xavier Rodó, Sílvia Borràs

“…Summary: Air quality monitoring typically overlooks the biological composition of airborne particles, despite its relevance to human health. This study evaluated the feasibility of using filters from high-volume air samplers, widely employed in air quality networks, to analyze bioaerosol content through shotgun metagenomic sequencing. …”
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Simultaneous Speech and Eating Behavior Recognition Using Data Augmentation and Two-Stage Fine-Tuning by Toshihiro Tsukagoshi, Masafumi Nishida, Masafumi Nishimura

“…By concatenating speech and eating sounds of varying lengths and sequences, we generated training data that mimic real-world environments where speech and eating behaviors co-exist. …”
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Irregularly Sampled Time Series Interpolation for Detailed Binary Evolution Simulations by Philipp M. Srivastava, Ugur Demir, Aggelos Katsaggelos, Vicky Kalogera, Shamal Lalvani, Elizabeth Teng, Tassos Fragos, Jeff J. Andrews, Simone S. Bavera, Max Briel, Seth Gossage, Konstantinos Kovlakas, Matthias U. Kruckow, Camille Liotine, Kyle A. Rocha, Meng Sun, Zepei Xing, Emmanouil Zapartas

“…Furthermore, we point out and offer solutions to the difficulty surrounding evaluating the performance of signals exhibiting extreme morphologies akin to discontinuities.…”
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Azithromycin Resistance Patterns in Escherichia coli and Shigella before and after COVID-19, Kenya by Elizabeth A. Odundo, Erick C. Kipkirui, Margaret C. Koech, Mary C. Kirui, Ronald K. Kirera, Nancy C. Kipkemoi, Janet N. Ndonye, Alex Ragalo, Collins K. Kigen, James W. Muturi, Vanessa N. Onyonyi, Gathii Kimita, Erick K. Muthanje, Marissa K. Hetrich, Evelyn W. Mahugu, Kirti K. Tiwari, Hunter J. Smith

“…Phenotypic AMR profiles from a subset of isolates were compared with genotypic AMR information derived from whole genome sequencing. The most common AMR gene detected was the macrolide mph(A) gene. …”
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Generating Realistic Vehicle Trajectories Based on Vehicle–Vehicle and Vehicle–Map Interaction Pattern Learning by Peng Li, Biao Yu, Jun Wang, Xiaojun Zhu, Hui Zhang, Chennian Yu, Chen Hua

“…Diversified and realistic traffic scenarios are a crucial foundation for evaluating the safety of autonomous driving systems in simulations. …”
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High-precision immune-related plasma proteomics profiling predicts response to immunotherapy in patients with triple-negative breast cancer by Yuling Xiao, Hang Zhang, Yi Xiao, Ying Wang, Jing Zhang, Qi Hua, Pengchen Hu, Xinyan Lyu, Weihua Shou, Xin Hu, Zhiming Shao, Yizhou Jiang, Wei Huang, Jinxiu Shi

“…Matched single-cell RNA sequencing data were incorporated to correlate peripheral plasma with the tumor microenvironment. …”
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Effects on Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells Engineered to Express Neurotrophic Factors by Yi Wang, Youguo Ying, Xiaoyan Cui

“…The aim of this present study is to evaluate the effects of overexpressing NTFs on proliferation and differentiation of human umbilical cord-derived mesenchymal stem cells (HUMSCs). …”
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Occurrence and Genotypic Characterization of Selected Multidrug-resistant ESKAPE-E Pathogens Isolated from Integrated Smallholder Fresh Produce Farms by Sheldon Viviers, Loandi Richter-Mouton, Jonathan Featherston, Lise Korsten

“…This study aimed to evaluate the presence and characteristics (phenotypic and genotypic AMR profiles) of ESBL/AmpC-producing Enterobacterales and P. aeruginosa isolates obtained from the water-soil-plant nexus on smallholder fresh produce farms in South Africa. …”
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Designing a multi-epitope candidate vaccine against SARS-CoV-2 through in silico approach for producing in plant systems by Fatemeh GOUDARZIASL, Fatemeh KHEIRI, Azam RAHBAR, Reza MOHAMMADHASSAN, Javad MOHAMMADI-ASL, Arsalan JALILI, Melika HAJKAZEMIAN

“…Surface glycoproteins (E, M, and S proteins) and N protein amino acid sequences were analyzed to predict high score of the B and T cell epitopes as antigenic proteins of the virus. …”
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Extracellular vesicles secreted by equine adipose mesenchymal stem cells preconditioned with transforming growth factor β-1 are enriched in anti-fibrotic miRNAs and inhibit the exp... by Yat Sen Wong, Ana Carolina Mançanares, Felipe Navarrete, Pamela Poblete, Lídice Mendez-Pérez, Joel Cabezas, Gonzalo Riadi, Lleretny Rodríguez-Alvarez, Fidel Ovidio Castro

“…The expression of anti-fibrotic and pro-fibrotic genes and miRNAs was evaluated in said cells using qPCR and next-generation sequencing. …”
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FASN thioesterase domain mutation and fatty acid profile in Holstein Friesian intramuscular fat by D. Cancino-Baier, D. Cancino-Baier, E. Muñoz-Acuña, E. Muñoz-Acuña, J. Quiñones, R. Diaz, J. F. Beltrán, J. Farías, K. Inostroza, R. Huaiquipan, J. B. Sterman Ferraz, N. Sepúlveda

“…The resulting models were refined with GalaxyRefine and evaluated by generating Ramachandran plots in SWISS-MODEL. …”
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A 15-year study of neuraminidase mutations and the increasing of S247N mutation in Spain by Iván Sanz-Muñoz, Alejandro Martín-Toribio, Adrián García-Concejo, Irene Arroyo-Hernantes, Marina Toquero-Asensio, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Silvia Rojo-Rello, Marta Domínguez-Gil, Eduardo Tamayo-Gómez, Marta Hernández-Pérez, José M Eiros

“…This study aimed to evaluate the evolution of NA mutations over 15 years in Spain. …”
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Validity of the test for attentional performance in neurological post-COVID condition by Susan Seibert, Irina Eckert, Catherine N. Widmann, Taraneh Ebrahimi, Fabian Bösl, Christiana Franke, Harald Prüss, Joachim L. Schultze, Gabor C. Petzold, Omid Shirvani

“…Traditional paper-based tests, like the Trail-Making Test (TMT), may inadequately capture these impairments due to their short duration and dependence on numerical and alphabetic sequencing. This study evaluates the validity of three subtests of the computerized Test for Attentional Performance (TAP) as alternatives for detecting attentional impairments in PCC. …”
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Clinical and In Vitro Safety of <i>Heyndrickxia coagulans</i> AO 1167B: A Double-Blind, Placebo-Controlled Trial by Gissel García, Josanne Soto, Antonio Díaz, Jesús Barreto, Carmen Soto, Ana Beatriz Pérez, Suselys Boffill, Ángela Gutiérrez, Raúl de Jesús Cano

“…Clinical evidence suggests its potential health benefits. This study evaluated the safety of <i>H. coagulans</i> AO1167B as a candidate probiotic supplement. (2) Methods: Strain identification was confirmed through morphological, cultural, and genomic analyses, including 16S RNA and whole genome sequencing to assess antimicrobial resistance and virulence factors. …”
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Rationale and protocol for a longitudinal cohort study of children with cerebral palsy in China assessing functional developmental trends, genetic aetiology and imaging by Jing Zhang, Jinhua Lu, Wenhao Zhou, Yuan Zhang, Hongyu Zhou, Fan Wu, Ting Gao, Jie Luo, Jinling Li, Jingbo Zhang, Lu He, Tingting Peng, Zhaoyao He, Qingfen Hou, Danxia Fan, Mengru Zhong, Yage Zhang, Rongji Liao, Liru Liu, Yun Zheng, Hongmei Tang, Lei Pi, Hongsheng Liu, Kaishou Xu

“…Participants will undergo comprehensive assessments, including motor, cognitive, language, social, behavioural, nutritional, pain, sleep and quality-of-life domains, with regular follow-up evaluations. Trio whole-exome sequencing and detailed neuroimaging and musculoskeletal imaging will also be performed. …”
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Modeling Puerto Rico Grid&#x2019;s Sequential Failures for Hurricanes Using Electric Grid Resilience &#x0026; Assessment System (EGRASS) Tool and Dynamic Contingency Analysis Tool... by Fernando Bereta Dos Reis, Patrick Royer, Xinda Ke, Xiaoyuan Fan, Vishvas Hiren Chalishazar, Marcelo Elizondo, Jeffery Dagle, Alexandre Nassif, Olga Soto, Daniel Haughton

“…Fragility curves play a crucial role in assessing asset vulnerability having a significant impact in all studies that evaluate the power system resilience for extreme events. …”
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Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project. by Almudena Pérez-Rodríguez, Javier Batlle, Irene Corrales, Nina Borràs, Ángela Rodríguez-Trillo, Esther Lourés, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, Rafael Parra, María Eva Mingot-Castellano, Nira Navarro, Carmen Altisent, Rocío Pérez-Montes, Shally Marcellini, Ana Moreto, Sonia Herrero, Inmaculada Soto, Nuria Fernández Mosteirín, Víctor Jiménez-Yuste, Nieves Alonso, Aurora de Andrés Jacob, Emilia Fontanes, Rosa Campos, María José Paloma, Nuria Bermejo, Rubén Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Nerea Castro Quismondo, Belén Iñigo, María Del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Maria Tenorio, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Manuela Dobón, Carlos Aguilar, Fernando Batlle, Francisco Vidal, María Fernanda López-Fernández

“…The centralised study 'Molecular and Clinical Profile of von Willebrand Disease in Spain (PCM-EVW-ES)' has been carried out by including the phenotypic assessment and the genetic analysis by next generation sequencing (NGS) of the VWF gene (VWF). The aim of the present study was to evaluate the role of MA to the diagnosis of these patients and their potential discrepancies. …”
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