Exploring the G-Quadruplex Formation of AS1411 Derivatives by Pedro Lourenço, David Moreira, André Miranda, Jéssica Lopes-Nunes, Izamara Maocha, Tiago Santos, Pedro L. Ferreira, Fani Sousa, Artur Paiva, Carla Cruz

“…In this work, we designed six AS1411 derivatives by substituting guanine with thymine in the central linker and modifying the number of thymines either in the linker itself and/or at both ends of the sequence. The G4 formation, stability, and NCL binding were evaluated by several biophysical techniques and computational and cell studies. …”
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Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling by Huiyu Luo, Jiexian Wang, Fengjuan Lin, Yuguo Liu, Xinglong Wu, Gan Li, Chuhong Su, Junbin Chen, Fei Xiong, Jiaqi Mo, Zhongdaixi Zheng, Xiangyi Zheng, Qing Li, Longying Zha

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Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness by Dong Y, Hu J, Meng X, Yang B, Peng C, Zhao W

“…The optimal model was presented as a nomogram and verified through calibration and decision curve analyses.Results: In evaluating radiomics models for predicting TACE refractoriness in HCC, the LR-developed portal venous phase (VP) model achieved optimal single-sequence performance (training AUC: 0.896, 95% CI: 0.843– 0.941; validation: 0.853, 0.727– 0.965). …”
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Protein Kinase-Major Sperm Protein (PK-MSP) Genes Mediate Recognition of the Fungal Necrotrophic Effector SnTox3 to Cause Septoria nodorum Blotch in Wheat by Zengcui Zhang, Katherine L. D. Running, Sudeshi Seneviratne, Amanda R. Peters Haugrud, Agnes Szabo-Hever, Gurminder Singh, Kateřina Holušová, István Molnár, Jaroslav Doležel, Timothy L. Friesen, Justin D. Faris

“…Snn3-B2 was previously shown to govern osmotic stress and salt tolerance, indicating that protein kinase-major sperm protein genes can act in plant defense responses to both biotic and abiotic stresses. Evaluation of a large collection of wheat lines showed that several alleles of each gene, including absent alleles, exist within the germplasm. …”
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Molecular phylogenetic analyses reveal multiple long-distance dispersal events and extensive cryptic speciation in Nervilia (Orchidaceae), an isolated basal Epidendroid genus by Stephan W. Gale, Jihong Li, Somran Suddee, Paweena Traiperm, Craig I. Peter, Tomas Buruwate, Benjamin J. Crain, Melissa K. McCormick, Dennis F. Whigham, Arni Musthofa, Khyanjeet Gogoi, Katsura Ito, Yukio Minamiya, Tatsuya Fukuda, Sven Landrein, Tomohisa Yukawa

“…Using nuclear (ITS) and plastid (matK, trnL-F) sequence data, we conduct phylogenetic (maximum parsimony and Bayesian inference) and ancestral area analysis to infer relationships and resolve probable origin and colonisation routes.ResultsThe genus is strongly supported as monophyletic, as are each of its three sections. …”
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Integrated agro-morphological and molecular characterization for progeny testing to enhance alfalfa breeding in arid regions of Tunisia by Samir Tlahig, Amina Mohamed, Tebra Triki, Yassine Yahia, Jamila Yehmed, Hedi Yahia, Ferdaous Guasmi, Mohamed Loumerem

“…Molecular characterization using six Simple Sequence Repeat (SSR) markers (MTIC185, MTIC249, MTIC259, MTIC297, Endo20, and SucS1) showed moderate genetic diversity with Polymorphism Information Content (PIC) values of 0.215–0.373, supporting the potential for effective selection in breeding programs. …”
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Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system by Jieying Li, Yuxiao Liu, Jingsi Jiang, Fang Chen, Nan Zhang, Xun Kang, Lin Liu, Yingjuan Wang, Qianfeng Xia, Chuanlong Zhu, Dai Kuang

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Mapping of quorum sensing interaction network of commensal and pathogenic staphylococci by Bengt H. Gless, Benjamin S. Sereika-Bejder, Iben Jensen, Martin S. Bojer, Katerina Tsiko, Sabrina H. Schmied, Ludovica Vitolo, Bruno Toledo-Silva, Sarne De Vliegher, Hanne Ingmer, Christian A. Olsen

“…The systematic mapping of AIP activities, structure-activity relationship studies, and evaluation of resistance development provided in this paper, therefore, serve as a resource for the future discovery of inhibitory peptides for the investigation of bacterial communication.…”
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Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress by Zongmao He, Yi Yan, Xijun Guo, Tong Wang, Xinqiao Liu, Ren-Bo Ding, Yuanfeng Fu, Jiaolin Bao, Xingzhu Qi

“…Thioredoxin-1 (Trx-1) is an important redox protein found in almost all prokaryotic and eukaryotic cells, which has a highly conserved active site sequence: Trp-Cys-Gly-Pro-Cys. To investigate whether the Trp31 residue is essential for the antioxidant activity of human Trx-1 (hTrx-1), we mutated Trx-1 by replacing Trp31 with Ala31 (31Ala) or deleting Trp31 residue (31Del). …”
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CO13 | Genetic background in hypercholesterolemic patients framing cardiovascular risk

“…Fifty-six patients showed LDLR variants classified as uncertain significance (VUS)/likely pathogenic (LP)/pathogenic (P) according to the American College of Medical Genetics guidelines for the interpretation of sequence variants (Richards et al., Genet Med.2015), while the other 111 patients did not carry any or only benign (B)/likely benign (LB) variants in LDLR gene.Among the LDLR negative, n=97 patients (87.4%) showed at least 1 rare variant in one of the other 56 genes of the panel, n=78 patients (70.3%) showed at least 2 variants, n=58 (52.3%) showed at least 3 variants in the other genes.In FH patients investigated, 436 rare variants were found in 53 genes (APOB, PCSK9, LDLRAP1, ABCA1, ABCB1, ABCG2, ABCG5, ABCG8, ANGPTL3, APOA1, APOA4, APOA5, APOC2, APOC3, APOE, BTN2A1, CELSR2, CETP, CH25H, CREB3L3, DAB2, DGAT1, EPHX2, GCKR, GHR, GPD1, GPIHBP1, HFE, HMGCR, INSIG2, ITIH4, LCAT, LIPC, LIPI, LMF1, LPA, LPL, LRP1, MTTP, NPC1, NPC1L1, NPC2, NYNRIN, OSBPL5, PON1, PPP1R17, SCARB1, SLC22A1, SLCO1B1, SREBF1, SREBF2, ST3GAL4, STAP1).We also evaluated the 12 SNPs Talmud genetic risk score (Talmud P et al., Lancet 2013), which takes into account polymorphic variants that have a cumulative effect on raising LDL-C levels to those achieved from patients with a LDLR mutation. …”
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Antibiotic Resistance, Virulence Genes, and Molecular Diversity of Clinical <i>Klebsiella pneumoniae</i> Isolates from Patients of District Hospital in Central Poland by Barbara Kot, Małgorzata Witeska, Piotr Szweda, Małgorzata Piechota, Elżbieta Kondera, Elżbieta Horoszewicz, Izabela Balak, Ahmer Bin Hafeez, Alicja Synowiec

“…The aim of the study was an evaluation of the genetic diversity of 109 <i>K. pneumoniae</i> isolates recovered from patients of a district hospital in central Poland. …”
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CRYPTO-RESISTANT METHODS AND RANDOM NUMBER GENERATORS IN INTERNET OF THINGS (IOT) DEVICES by Petro Klimushyn, Tetiana Solianyk, Oleksandr Mozhaiev, Yurii Gnusov, Oleksandr Manzhai, Vitaliy Svitlychny

“…The article solves the following tasks: analysis of methods and hardware for generating random sequences to protect IoT solutions with limited resources; identification of safe and effective technologies for the implementation of RNG; classification of RNG attacks; analysis of the shortcomings of the practical use of statistical test packages to assess the quality of random sequences of RNG; evaluation of the speed of cryptoaccelerators of hardware support for cryptographic transformations; providing practical guidance on RNG for use in resource-constrained IoT devices. …”
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Reliability Analysis of Hybrid Laser INS Under Multi-Mode Failure Conditions by Bo Zhang, Changhua Hu, Xinhe Wang, Jianqing Wang, Jianxun Zhang, Qing Dong, Xuan Liu, Feng Zhang

“…This analytical approach provides a valuable method for reliability evaluation and design of new hybrid INS structures. …”
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Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese by Chang Lu, Dongmei Cheng, Yunqiu Xie, Minghong Shang, Rongzhen Chen, Yongqiang Zhu, Jian Gong, Huan Zhou

“…The aim of this study was to evaluate the effects of oral Itraconazole capsules and oral Rifampicin capsules on the pharmacokinetic profile and safety and tolerability of a single oral dose of FHND9041 capsules in healthy Chinese male subjects. …”
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Enterovirus D68 Subgenotype B3 Circulation in Children with Acute Respiratory Illness in the State of Alagoas, Brazil by Alex Ranieri Jerônimo Lima, Hazerral de Oliveira Santos, James Siqueira Pereira, Anderson Brandão Leite, Jean Phellipe Marques do Nascimento, Juliana Vanessa Cavalcante Souza, Marlon Breno Zampieri Lima, Mykaella Andrade de Araújo, Marta Giovanetti, Esper Georges Kallas, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Svetoslav Nanev Slavov

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Comparative analysis of actinorhizal nodule and associated soil microorganism diversity and structure in three Alnus species by Aizi Tong, Wei Liu, Xiaoliang Liu, Junyi Zhu, You Zhou, Jianhua Li

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Automatic phenotyping using exhaustive projection pursuit by Wayne A. Moore, Stephen W. Meehan, Connor Meehan, David R. Parks, Guenther Walther, Leonore A. Herzenberg

“…We have developed an automated tool to comprehensively identify these cell populations by Exhaustive Projection Pursuit (EPP). The method evaluates all two-dimensional projections among the suitable data dimensions and creates an optimized sequence of statistically significant gating regions that identify all phenotypes supported by the data. …”
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Data Augmentation for Improving Convergence Speed in Federated Sequential Recommendation System by Donghoon Lee, Hyunsouk Cho

“…To our knowledge, this is the first study to systematically evaluate data augmentation in federated recommendation systems.…”
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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis by Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He, Hongsheng Wang

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Wiener Polynomials for Multi-Rings Paraffin Structures by Ahmed Ali

“…The number of pairs of vertices G which are distance k apart is denoted by d(G,k), it is clear that the number of d(G,k) is graphical invariant, and the Wiener polynomial of graph G is a generating function of the sequence d(G,k). In this paper, we find the Wiener polynomial of multi-circles of paraffin structural, and this formula which we obtained is better than the formula prove in [5] , because we are able to evaluate coefficients for any limited power of x without depending on the number of circles , and we find the Wiener index and average distance for this structural. …”
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