Monte Carlo Thompson sampling-guided design for antibody engineering by Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda, Reiji Teramoto

“…To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their sequence space. However, it is practically unfeasible to evaluate all possible combinations of mutations owing to combinatorial explosion when multiple amino acid residues are incorporated. …”
Get full text

Mirror Visual Feedback to Improve Bradykinesia in Parkinson’s Disease by Gaia Bonassi, Elisa Pelosin, Carla Ogliastro, Cecilia Cerulli, Giovanni Abbruzzese, Laura Avanzino

“…Aim of the study was to evaluate whether MVF therapy may improve bradykinesia of the more affected hand in PD patients. …”
Get full text

Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…Here, we evaluated an antibiotic re-sensitization strategy based on CRISPR interference (CRISPRi), which inhibits gene expression without damaging target DNA. …”
Get full text

Development of a strategic plan of a construction organization by A.М. Tkachenko, Ye.L. Malyshev

“…Particular attention is paid to the definition of competitive advantages, risks and opportunities, as well as mechanisms for monitoring and evaluating the implementation of the strategic plan. …”
Get full text

Research on Wellbore Trajectory Prediction Based on a Pi-GRU Model by Hanlin Liu, Yule Hu, Zhenkun Wu

“…The GRU network captures the temporal dependencies of sequence data (such as dip angle and azimuth angle), while the BP neural network extracts deep correlations from non-sequence features (such as stratum lithology), thereby achieving multi-source data fusion modeling. …”
Get full text

DEVELOPMENT OF A METHOD FOR THE INTERACTIVE CONSTRUCTION OF EXPLANATIONS IN INTELLIGENT INFORMATION SYSTEMS BASED ON THE PROBABILISTIC APPROACH by Serhii Chalyi, Volodymyr Leshchynskyi

“…Purpose: development of a method for constructing explanations in intelligent systems with the ability to form and evaluate several alternative interpretations of the results of the operation of such a system. …”
Get full text

Screening and characterization of soil bacteria for lignin and textile dye effluent bioremediation and optimization using response surface methodology by Sarah Milad, Sarra E. Saleh, Mohammad M. Aboulwafa, Nadia A. Hassouna

“…The 16S rRNA sequence analysis was used to identify isolates with the highest decolorizing capacity. …”
Get full text

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer. by Rajesh Kumar, Suprit Deshpande, Leigh M Sewall, Gabriel Ozorowski, Christopher A Cottrell, Wen-Hsin Lee, Lauren G Holden, Sara T Richey, Antra Singh Chandrawacar, Kanika Dhiman, Ashish, Vivek Kumar, Shubbir Ahmed, Nitin Hingankar, Naresh Kumar, Kailapuri G Murugavel, Aylur K Srikrishnan, Devin Sok, Andrew B Ward, Jayanta Bhattacharya

“…Evaluating the structure-function relationship of viral envelope (Env) evolution and the development of broadly cross-neutralizing antibodies (bnAbs) in natural infection can inform rational immunogen design. …”
Get full text

Using the antibody-antigen binding interface to train image-based deep neural networks for antibody-epitope classification. by Daniel R Ripoll, Sidhartha Chaudhury, Anders Wallqvist

“…We evaluated this approach using Ab sequences derived from human HIV and Ebola viral infections to differentiate between two Abs, Abs belonging to specific B-cell family lineages, and Abs with different epitope preferences. …”
Get full text

Introduced Placobdella parasitica in the lower Rogue River, Oregon: origin story by Anna J. Phillips, Jason Reilly, Don Ashton, Dennis J. Richardson, Makiri Sei, William E. Moser

“…Our results agreed with a previous study of morphological and molecular data of P. parasitica samples from throughout its native range in North America that found the species to be widely distributed, morphologically conservative, and molecularly variable. Using COI sequence data with Bayesian Inference, we evaluated species cohesiveness using species delimitation analyses (ABGD, mPTP, bPTP, and GMYC) that revealed 13 species entities that were clustered by geographic region. …”
Get full text

Peptidomimetic inhibitors of the VEGF-A165/NRP-1 complex obtained by modification of the C-terminal arginine by Dagmara Tymecka, Patrycja Redkiewicz, Piotr F. J. Lipiński, Aleksandra Misicka

“…In the current work, we focused on Lys(Har)-Dap/Dab-Pro-Arg sequence. The aim was to examine whether replacing C-terminal Arg with its homologs and mimetics would yield more stable yet still potent inhibitors. …”
Get full text

Newly emerging metronidazole-resistant Clostridioides difficile PCR ribotype 955 identified in Poland, 2021 to 2023 but not in Czechia, 2012 to 2023 and Slovakia, 2015 to 2023 by Hanna Pituch

“…By whole genome multilocus sequence typing, 10 isolates clustered into one clonal complex including a sequence of United Kingdom strain ERR12670107, and shared similar antimicrobial resistance genes/mutations. …”
Get full text

Detection of Leishmania RNA virus in Leishmania parasites. by Haroun Zangger, Catherine Ronet, Chantal Desponds, F Matthew Kuhlmann, John Robinson, Mary-Anne Hartley, Florence Prevel, Patrik Castiglioni, Francine Pratlong, Patrick Bastien, Norbert Müller, Laurent Parmentier, Nancy Gore Saravia, Stephen M Beverley, Nicolas Fasel

“…We evaluate each method as well as demonstrate a successful LRV detection by the J2 antibody in several parasite strains, a freshly isolated patient sample and lesion biopsies of infected mice.…”
Get full text

A Framework for Coverage Path Planning of Outdoor Sweeping Robots Deployed in Large Environments by Braulio Félix Gómez, Akhil Jayadeep, M. A. Viraj J. Muthugala, Mohan Rajesh Elara

“…Once the visiting sequence is determined, a boustrophedon-based CPP is applied within each sub-region. …”
Get full text

Outcomes in Recurrent Rhegmatogenous Retinal Detachment Repair: Does Scleral Buckling at Primary or Secondary Surgery Impact Results? by Hébert M, Garneau J, Doukkali S, Bourgault S, Caissie M, Tourville É, Dirani A

“…Patients were compared based on first and second surgery sequence: PPV then PPVSB (PPV-PPVSB: n = 51, 40%), or PPVSB then PPV (PPVSB-PPV: n = 76, 60%). …”
Get full text

Detoxification of Aflatoxin B1‎ by Isolating and Screening Bacillus species from the Gastrointestinal Tract of Broilers by Mansoureh Abdolmaleki, Aliasghar Saki, Mohammad yousef Alikhani

“…The morphological and biological assayed followed by analysis of 16S rRNA gene sequence were carried out for identification of Bacillus species. …”
Get full text

Molecular analysis of Echinococcus granulosus: A comparison between cattle and sheep isolates in Babylon province, Iraq by Haider H. Alseady, Sahad M. Al-Dabbagh, Enas J. Alhadad

“…The UPGMA method was utilized in MEGA 11 to create a phylogenetic tree and evaluate its reliability. Out of the 20 sequenced samples, the sequencing results indicated that 15 samples belonged to the predominant G1 strain, two to the G2 strain, and three to the G3 strain, which were detected in both cattle and sheep. …”
Get full text

Unlocking Potential Score Insights of Sentimental Analysis with a Deep Learning Revolutionizes by Ibrahim R. Alzahrani

“…The proposed SM-CJ framework further aligns the input sequence lengths fetched from the input layer, enabling the model to focus on specific segments of the input sequence that are most relevant for hate speech detection. …”
Get full text

Joint Extraction of Hazard Source Knowledge in Integrated Utility Corridor Based on Knowledge Graph by Shanshan Wan, Houchen Lv, Yuhan Zhu, Yiran Zhao

“…The joint extraction includes using the BERT model to obtain sentence representations, employing a relation-specific attention network to capture relation-based sentence features, followed by sequence labeling to extract entity pairs. Finally, the proposed model is evaluated using both a collected integrated utility tunnel fault engineering dataset and a public dataset.…”
Get full text

Analysis of Reliability and Efficiency of Information Extraction Using AI-Based Chatbot: The More-for-Less Paradox by Eugene Levner, Boris Kriheli

“…An AI chatbot must perform a sequence of scans over the given databases and continue searching until the human user declares, in some round, that the target has been found. …”
Get full text