Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over c... by Sara Rodrigues, Renata Gomes Sanches Verardino, Valéria Costa - Hong, Camila Paixao Jordao, Marcel Jose Andrade da Costa, Luiz Bortolotto

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Development of a Mechanism of Action-Reflective Cell-Based Reporter Gene Assay for Measuring Bioactivities of Therapeutic Glucagon-like Peptide-2 Analogues by Xiaoming Zhang, Chunyan Li, Zhe Deng, Chenggang Liang, Jing Li

“…The establishment of this RGA provides a valuable tool for evaluating the potency of GLP-2 analogues and the screening of potential therapeutic drugs targeting to GLP-2 receptor.…”
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Isolation and Characterization of Enterocin-Producing <i>Enterococcus faecium</i> Strains from Algerian Traditional Food “Dried Figs Marinated in Olive Oil”: Functional and Safety... by Mohamed Merzoug, Keltoum Bendida, Marwa Aireche, Zohra Yasmine Zater, Chaimaa Naila Brakna, Amaria Ilhem Hammadi, Yasmine Saidi, Svetoslav Dimitrov Todorov, Djamal Saidi

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Congenital dyserythropoietic anemia type II—A rare case report by Tejasvi Sharma, Shruti Vaswani, Debasish Barman, Siyaram Didel, Abhishek Purohit

“…Here, we are reporting a case of two-year-old male child who presented with severe anemia, abdominal distension, and delayed milestones. Evaluation of bone marrow aspirate suggested the possibility of CDA which led to molecular work-up by whole exome sequencing with detection of c.1142C>T (p.Thr381lle) variant in SEC23B (NM_006363.6) gene.…”
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Advancing dimensionality reduction for enhanced visualization and clustering in single-cell transcriptomics by P. Sanju

“…To assess the performance of CP-PaCMAP, a variety of evaluation metrics are employed, including reliability, stability, Matthew correlation coefficient, and the Mantel test. …”
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Translating the multifaceted use of liquid biopsy to management of early disease in pancreatic adenocarcinoma by Madison Cox, Madison Cox, Dominic Vitello, Dominic Vitello, Akhil Chawla, Akhil Chawla, Akhil Chawla, Akhil Chawla

“…We review the current literature on the technological advancements in liquid biopsy analysis such as next generation sequencing (NGS) and digital droplet PCR (ddPCR) as well as multi-omics technologies, highlighting their potential for accurate molecular subtyping through ctDNA analysis. …”
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Doubling of triazole resistance rates in invasive aspergillosis over a 10-year period, Belgium, 1 April 2022 to 31 March 2023 by Katrien Lagrou

“…Aim Our objective was to evaluate changes in antifungal susceptibility among Aspergillus species isolates from patients with invasive aspergillosis. …”
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Evaluation of brain microstructure changes in surviving fetus of monochorionic twin pregnancies with single intrauterine fetal death using diffusion weighted imaging: a MRI-based c... by Aonan Wang, Ran Huo, Yuan Wei, Xiaoyue Guo, Zheng Wang, Qiang Zhao, Ying Liu, Huishu Yuan

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Enhancing Black Soil Fertility and Microbial Community Structure via Microbial Agents to Reduce Chemical Fertilizer Dependency: A Strategy to Boost Maize Yield by Fenglin Zhang, Nan Wang, Chenyu Zhao, Luze Yang, Xingmin Zhao, Hongjun Gao, Fugui Zhang, Hongbin Wang, Ning Huang

“…Principal component analysis (PCA) was used for comprehensive evaluation and ranking. Overall, the soil under the MC80 treatment was most conducive to microbial survival and maize growth. …”
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Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer by Hongwei Lan, Hui Liu, Helei Hou, Chuantao Zhang, Jingjuan Zhu, Na Zhou, Xiaochun Zhang

“…In PBMC-PDX models, treatment evaluation showed that anlotinib decreased tumor volume, an effect further enhanced by its combination with aPD-L1. scRNA-seq analysis demonstrated that anlotinib reduced the proportions of myofibroblastic cancer-associated fibroblasts and ESM1+ endothelial cells, resulting in decreased angiogenesis. …”
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Impact of fresh and fermented vegetable consumption on gut microbiota and body composition: insights from diverse data analysis approaches by Susan Pihelgas, Susan Pihelgas, Kristel Ehala-Aleksejev, Mari-Liis Kutti, Rain Kuldjärv, Jekaterina Kazantseva

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Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression by Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah

“…To that end, the development of an organotypic 3D breast TME‐on‐a‐chip (TMEC) model, integrated with single‐cell RNA sequencing analysis, is reported to mechanistically evaluate the progression of triple‐negative breast cancer (TNBC) cells in the presence of patient‐derived CAFs and Mφs. …”
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Assessing pathogenicity of mismatch repair variants of uncertain significance by molecular tumor analysis by Anne-Sophie van der Werf't Lam, Noah C. Helderman, Arnoud Boot, Diantha Terlouw, Hans Morreau, Hailian Mei, Rebecca E.E. Esveldt-van Lange, Inge M.M. Lakeman, Christi J. van Asperen, Emmelien Aten, Nandy Hofland, Pia A.M. de Koning Gans, Emily Rayner, Carli Tops, Niels de Wind, Tom van Wezel, Maartje Nielsen

“…However, the pathogenicity remains unclear for many variants because of conflicting results between clinical, molecular, and functional data. In this study, we evaluated whether whole exome sequencing (WES) could add another layer of evidence to elucidate the pathogenicity of MMR variants with conflicting interpretations. …”
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High-resolution transcriptome analysis on a mouse model of neonatal hypoxic-ischemic encephalopathy using single-nucleus RNA-seq by Nao Wakui, Takashi Shimbo, Morifumi Hanawa, Tomomi Kitayama, Yukari Yamamoto, Yuya Ouchi, Kotaro Saga, Aiko Okada, Kazuya Mimura, Katsuto Tamai, Masayuki Endo

“…Thus, we employed single-nucleus RNA sequencing to evaluate damages in a mouse model of HIE and found pronounced changes in the hippocampus with significantly reduced neuronal populations. …”
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Morphological and Molecular Characterization of Tick Species Infesting Cattle in South Africa by Tsireledzo Goodwill Makwarela, Nkululeko Nyangiwe, Tracy Madimabi Masebe, Appolinaire Djikeng, Lucky Tendani Nesengani, Rae Marvin Smith, Ntanganedzeni Olivia Mapholi

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Novel Splice Variant in the <i>HES7</i> Gene in Vietnamese Patient with Spondylocostal Dysostosis 4: A Case Report and Literature Review by Ha Minh Nguyen, Nguyen Thi Kim Lien, Thinh Huy Tran, Ngoc Lan Nguyen, Suong Bang Thi Nguyen, Thi Hong Chau Bui, Nguyen Van Tung, Le Tat Thanh, Nguyen Thi Xuan, Van Khanh Tran, Nguyen Huy Hoang

“…This study reports a novel homozygous <i>HES7</i> splice variant (c.43-9T>A) detected in an SCDO4 patient by whole-exome sequencing and confirmed by Sanger sequencing. This variant was evaluated as an acceptor loss variant in intron 1 in the HES7 transcript by in silico analysis and was inherited from the patient’s parent. …”
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“Shortening time to pregnancy in infertile women by personalizing treatment of microbial imbalance through Emma & Alice: A multicenter prospective study” by Nanako Iwami, Shinnosuke Komiya, Yoshimasa Asada, Kenichi Tatsumi, Toshihiro Habara, Takeshi Kuramoto, Moritoshi Seki, Hiroaki Yoshida, Kazuhiro Takeuchi, Masahide Shiotani, Tetsunori Mukaida, Yasushi Odawara, Yasuyuki Mio, Hirobumi Kamiya

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Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery by Hai Jiang, Zhipeng Xu, Qi Song, Junjie Tao, Jia Liu, Qiang Wang, Huaisheng Zhang, Heng Zhu, Qiliang Li, Lei Li

“…Methods Transcriptomic data from Gene Expression Omnibus (GEO), including single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing, were analyzed to investigate the molecular mechanisms involved in glucose metabolism dysregulation in AP. …”
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First-Line (1L) Treatment Decision Patterns and Survival of Hormone Receptor (HR)-Positive/HER2-Negative Advanced Breast Cancer (ABC) Patients in a Latin American (LATAM) Public In... by Guillermo Valencia, Patricia Rioja, Miguel Chirito, Olenka Peralta, Jorge Sánchez, Connie Rabanal, Raúl Mantilla, Zaida Morante, Hugo Fuentes, Carlos Castaneda, Tatiana Vidaurre, Cristian Pacheco, Silvia Neciosup, Henry L. Gomez

“…The aim of our study is to evaluate the first-line treatment choices and the factors that influence therapeutic decisions. …”
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Functional characterization of SOX5 variant causing Lamb–Shaffer syndrome and literature review of variants in the SOX5 gene by Ping Wang, Hanbing Xie, Xiao Xiao, He Wang, Yan Wang, Shanling Liu

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