BUSINESS DEVELOPMENT PROGRAM OPTIMIZATION by B. Gusakov, A. Sotnikova

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Q-Fuzzy Probability Integration on Triangular Modulus and Its Application Model by WANG Yue, ZHAO Hui, WU Lunhua

“…Subsequently, fuzzy probability integrals combined with the principle of maximum probability are used to evaluate the performance optimization state of the medical helmet, and rank the evaluation results. …”
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Genomic analysis of small renal masses reveals mutations linked with renal cell carcinoma and fast-growing tumors by Ieva Vaicekauskaitė, Algirdas Žalimas, Rasa Sabaliauskaitė, Kristina Žukauskaitė, Mantas Trakymas, Jurgita Ušinskienė, Albertas Ulys, Sonata Jarmalaitė

“…Tissue biopsy samples evaluated for mutations in 51 cancer hotspot genes using next generation sequencing and qPCR. …”
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Effects of heterologously overexpressing Manihot esculenta Crantz MeNRT2.6 gene in Arabidopsis thaliana on nitrogen utilization efficiency by Min ZHAI, Yingjie CAO, Chenyu LIN, Pingjuan ZHAO, Wenbin LI, Xiaoling YU, Wenbin LIAO, Mengbin RUAN, Liangping ZOU, Zhuang LI

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Case Report: Retroperitoneal dedifferentiated solitary fibrous tumor with unexpected Pax-2 expression, mimicking high grade clear cell renal cell carcinoma by Jia Wei, Chen-chen Yao, Yue-Fen Zou, Yong-Zhong Wei, Qin-he Fan, Qi-xing Gong

“…Furthermore, next generation sequencing (NGS) disclosed a rare NAB2-STAT6 (N5::S16) gene fusion, accompanied by a C141G missense mutation of TP53 gene. …”
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Development of a bioinformatics tool for identifying members of the Apis mellifera gut microbiome by R. Makovei, N. Shemedyuk, Kh. Malysheva, I. Dvylyuk, M. Chokhan

“…The aim of the study was to develop bioinformatics software for automating the processing and analysis of nucleotide sequence data of the 16S rRNA gene and ITS region, to validate its performance, and to conduct a comparative evaluation based on the results of studying the gut microorganisms of A. mellifera. …”
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Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…Hotspot mutations in patient tissue samples were identified via next-generation sequencing (NGS), whereas mutations in blood CTCs were detected via Sanger sequencing. …”
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Preoperative risk stratification in endometrial cancer using ESGO/ESTRO/ESP 2021 guidelines: accuracy with and without molecular classification by Petra Bretová, Munachiso Iheme Ndukwe, Jan Laco, Hana Vošmiková, Taťána Rešlová, Denisa Pohanková, Klára Balcarová, Jiří Haviger, Jana Marie Havigerová, Igor Sirák

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The clinical and genetic spectrum of twenty-six individuals with hearing loss affected by MYO15A variants by Saeid Morovvati, Mina Mohammadi Sarband, Samaneh Doostmohammadi, Sima Rayat, Hessamaldin Emamdjomeh, Mohammad Farhadi, Alimohamad Asghari, Masoud Garshasbi, Masoumeh Falah

“…Here, we present twenty-six unrelated families with MYO15A variants from an Iranian cohort. Whole exome sequencing (WES) was performed following a comprehensive medical evaluation. …”
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Examination of coal combustion management sites for microbiological and chemical signatures of groundwater impacts by Christopher E. Bagwell, Josué A. Rodríguez-Ramos, Sabrina Hoyle, Shelby Phillips, Frederick D. Day-Lewis, Bruce Hensel

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Broadening the Phenotype Spectrum of MECP2 Variants in Men by Johannes Lötjönen, Venla Kurra, Hannele Laivuori, Nina Bjelogrlić

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Isolation and pathogenicity of the novel porcine reproductive and respiratory syndrome virus 1 strain ZJ01 in South China by Bohua Ren, Ruying Liu, Feibao Huang, Yu Wu, Yu Wu, Xiaopeng Gao, Haishen Zhao, Limiao Lin, Qunhui Li, Qunhui Li, Xiangbin Zhang

“…MethodsIn this study, we isolated a novel PRRSV-1 strain, designated ZJ01.ResultsWhole-genome sequencing revealed a genome length of 15,125 bp. Comprehensive phylogenetic analysis based on the complete genome sequence classified ZJ01 within a distinct new sublineage. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Further analytical procedures involved functional enrichment analysis, evaluation of immune infiltration, and examination of the mutation landscape.PTGES3 was identified as a pivotal gene associated with lipid metabolism. …”
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Local adaptation, genetic diversity and key environmental interactions in a collection of novel red clover germplasm by A. D. Heslop, A. D. Heslop, Sai K. Arojju, Rainer W. Hofmann, John L. Ford, M. Zulfi Z. Jahufer, Anna C. Larking, Rachael Ashby, Charles A. Hefer, Ken G. Dodds, A. Saei, Jessica O’Connor, Andrew G. Griffiths

“…It also identifies efficient evaluation methods and key climatic variables that should be considered when developing adaptive red clover cultivars.…”
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Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis by Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke

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Expediting pathogen genomics adoption for enhanced foodborne disease surveillance in Africa by Aquillah M. Kanzi, Stella I. Smith, Chisomo Msefula, John Mwaba, Abraham Ajayi, Geoffrey Kwenda, Collins K. Tanui, Anthony M. Smith, Linda A. Bester, Firehiwot A. Derra, Kaunda Yamba, Daniel L. Banda, John B. Kalule, Happiness H. Kumburu, Yasmina J. Fakim, Nyasha Sithole, Patrick M.K. Njage, Francis F. Chikuse, Pascale Ondoa, Sofonias K. Tessema, Ebenezer Foster-Nyarko

“…Here we highlight the critical components to strengthen and scale-up the integration of whole genome sequencing (WGS) in foodborne disease surveillance across the continent. …”
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Genomic Characterization and Functional Evaluation of <i>Eurotium cristatum</i> EC-520: Impacts on Colon Barrier Integrity, Gut Microbiota, and Metabolite Profile in Rats by Huini Wu, Xiuping Wang, Xiangrui Kong, Ruiyang Shan, Song Peng, Mengshi Zhao, Changsong Chen, Wenquan Yu, Zhaolong Li

“…This study characterized the EC-520 strain through whole genome sequencing and evaluated its effects on rat colons using histomorphology, 16S rRNA sequencing, and untargeted metabolomics. …”
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Screening and evaluation of purines-degrading lactic acid bacteria isolated from traditional fermented foods in Yunnan Province and their uric acid-lowering effects in vivo by Zhen Liu, Xing-Yuan Zou, Jiang Yue, Shan Li, Xia Ou, Chuang Huang, Chen-Jian Liu, Xiao-Ran Li

“…IntroductionTraditional fermented foods have recently been recognized for their potential benefits in managing hyperuricemia (HUA) and gout.MethodsThis study evaluated the purine degradation ability of seventy-eight lactic acid bacteria (LAB) isolated from traditional fermented foods in Yunnan Province, China, by HPLC. …”
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Phenylthiourea synergistically enhances the hepatotoxicity of bavachalcone by interfering with metabolism in zebrafish: A factor to consider when evaluating toxicity of environment... by Te Zheng, Jingcheng Zhao, Chenglong Sun, Chengyue Zhu, Chenqinyao Li, Jiashuo Zhou, Jing Yang, Yun Zhang

“…In this study, the interactive effects of 200 μM PTU and 2.5 μM BavaC on the toxicity of zebrafish larvae were evaluated after 72 h of exposure. PTU significantly increased BavaC-induced hepatotoxicity, which was characterized by liver hypoplasia, hepatocyte vacuolation, and lipid accumulation. …”
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Evaluating the effectiveness of COVID-19 vaccines during a period of Omicron variant predominance among Bangladeshi population: A test-negative design measurement by Md Taufiqul Islam, Farhana Khanam, Faisal Ahmmed, Md Nazmul Hasan Rajib, Md Ismail Hossen, Shahinur Haque, Prasanta Kumar Biswas, Shah Ali Akbar Ashrafi, Ahmed Nawsher Alam, Mallick Masum Billah, Monalisa, Mohammed Ziaur Rahman, Omar Hamza Bin Manjur, Mohammad Tanbir Habib, Mokibul Hassan Afrad, S. M. Shamsuzzaman, Ahmed Abu Saleh, Mostafa Aziz Sumon, Asif Rashed, Tahmina Shirin, John D. Clemens, Firdausi Qadri

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