Venture philanthropy in rare disease therapy by JA Levine

“…Data sources included (i) stakeholder focus groups to identify key issues in rare disease VP; (ii) semi-structured interviews with 15 stakeholders, including funders, advocates, and biotechnology company executives; (iii) a systematic analysis of 26 VP organizations using 30 investment criteria; and (iv) the application of DACMAR to assess best practices. …”
Get full text

Analysis of critical time delay in active lateral suspension systems for high-speed trains by SHENG Yiqian, SHI Huailong, CHEN Longfei, LIU Zhiqiang, LIU Yanxiu

“…This paper presents a systematic investigation into the issue of time delays, offering guidance for the design and optimization of active suspension systems for high-speed trains.…”
Get full text

An Amperometric Sensor with Anti-Fouling Properties for Indicating Xylazine Adulterant in Beverages by Arielle Vinnikov, Charles W. Sheppard, Ann H. Wemple, Joyce E. Stern, Michael C. Leopold

“…The sensing strategy features layer-by-layer (LBL) modification of glassy carbon electrodes (GCEs) with carbon nanotubes (CNTs) for sensitivity and the engagement of cyclodextrin host–guest chemistry in conjunction with polyurethane (PU) semi-permeable membranes for selectivity. The optimization of different materials and parameters during development created a greater fundamental understanding of the interfacial electrochemistry, allowing for a more informed subsequent design of effective sensors exhibiting XYL selectivity, effective sensitivity, rapid response times (<20 s), and low estimated limits of detection (~1 ppm). …”
Get full text

Complex Dynamics and Intelligent Control: Advances, Challenges, and Applications in Mining and Industrial Processes by Luis Rojas, Víctor Yepes, José Garcia

“…The literature was categorized into six key areas: (i) heat transfer with magnetized fluids, (ii) nonlinear control, (iii) big-data-driven optimization, (iv) energy transition via SOEC, (v) fault detection in control valves, and (vi) stochastic modeling with semi-Markov switching. …”
Get full text

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling. by Matthieu Jacobs, Nicolas Grégoire, William Couet, Jurgen B Bulitta

“…Semi-mechanistic pharmacokinetic-pharmacodynamic (PK-PD) modeling is increasingly used for antimicrobial drug development and optimization of dosage regimens, but systematic simulation-estimation studies to distinguish between competing PD models are lacking. …”
Get full text

A Two-Tier Genetic Algorithm for Real-Time Virtual–Physical Fusion in Unmanned Carrier Aircraft Scheduling by Jian Yin, Bo Sun, Yunsheng Fan, Liran Shen, Zhan Shi

“…Three key innovations are presented: (1) a two-tier genetic algorithm (GA)-based scheduling model is proposed to coordinate global planning and dynamic execution optimization for carrier-based aircraft operations; (2) a systematic constraint integration framework incorporating aircraft taxiing dynamics, deck spatial constraints, and safety clearance requirements into the scheduling system, significantly enhancing tactical feasibility compared to conventional approaches that oversimplify multidimensional operational rules; (3) an integrated virtual–physical simulation architecture merging virtual reality interaction with HIL verification, establishing a collaborative digital twin–physical device platform for immersive visualization of full-process operations and dynamic spatiotemporal evolution characterization. …”
Get full text

Inversion of soil salinization at the branch canal scale in the Hetao Irrigation District based on improved spectral indices by Yi Zhao, Qingfeng Miao, Haibin Shi, Xianyue Li, Jianwen Yan, Shuya Yang, Cong Hou, Cuicui Yu, Weiying Feng, Jiannan Hao

“…The red-edge band and short-wave infrared band are innovatively integrated into the traditional spectral indices for systematic improvement, and the optimal total soil salinity inversion model is constructed through the optimization strategy of different combinations of multiple bands, which effectively enhances the accuracy of soil salinity inversion. …”
Get full text

Performance Studies on a Scaled Model of Dual Oscillating-Buoys WEC with One Pneumatic PTO by Peiyu Liu, Xiang Rao, Bijun Wu, Zhiwen Yuan, Fuming Zhang

“…Flared BBDB and buoy models with spherical, cylindrical, and semi-capsule shapes are designed and tested experimentally in a wave flume using both regular and irregular wave conditions. …”
Get full text

Analyzing the practice of medical humanistic care based on a social learning model: mapping the trajectory of the learning dynamic process from the learner’s perspective by Bilu Gu, Yiming Lv, Jiyu Zhu, Xiaoling Sun, Xiaoling Sun, Kun Li

“…Based on the above two-dimensional analysis, this study proposes an optimization path combining cognitive explicit cultivation and environmental support system reconstruction, which points out the direction for breaking through the dilemma of humanistic care practice.…”
Get full text

The effect of temperature on pyrolysis products during oil shale thermal decomposition by Fajun Zhao, Zian Yang, Lei Zhang, Changjiang Zhang, Tianyu Wang, Hong Zhang

“…This study elucidates the regulatory mechanisms of temperature on oil shale pyrolysis behavior, providing guidance for the targeted optimization of specific products, such as gases, shale oil, or semi-coke. …”
Get full text

Research on artificial intelligence-driven container relocation problem for green ports by Sisi Zheng, Jin Sha, Yinying Kong, Yougan Wang

“…A multi-layer stacked ensemble predicts relocation counts with 90.76% accuracy (R2 = 0.9139), while a dynamic constraint-weighting mechanism balances movement frequency and energy consumption, thereby enhancing green operational efficiency in high-density container yards.DiscussionFrom both theoretical and practical perspectives, this work establishes a multi-stage collaborative optimization pathway by systematically integrating data-driven and model-driven approaches, limits strategy-generation time for 105-container-scale yards to under 60s, and provides a scalable technological paradigm for smart-port development, sustainable logistics, and the attainment of dual-carbon objectives.…”
Get full text

Multiscale analysis of friction behavior at fretting interfaces by Zhinan Zhang, Shuaihang Pan, Nian Yin, Bin Shen, Jie Song

“…The effect of surface separation can be of great significance in predicting the fretting process, selecting the material, and for optimization.…”
Get full text

Developing a Model for Integrating Artificial Intelligence (AI) to Change the Organization’s Public Relations Unit’s Processes, With an Emphasis on Organizational Knowledge Managem... by Seyed Vahab Omat Mohammadi, Ladan Hajianvari, Kimiya Mohaqeq

“…Following each session, the interview content was transcribed from the recorded audio files and manually coded using the systematic approach developed by Corbin and Strauss. …”
Get full text

Challenges and Strategies for Expanding Enterprise-Based Training to Develop Skills for the ICT Industry in the Philippines by Jooyoung Voeller

“…Although enterprise-based training (EBT) is seen as the optimal strategy for supporting transition to a technology-driven economy, it represents less than 4% of TVET offerings. …”
Get full text

Stability Assessment of Rydberg Electromagnetically Induced Transparency Locking via Optical Heterodyne Spectroscopy by Qiuyu Yin, Yanzhao Liang, Haitao Lin, Ning Ji, Thibault Vogt

“…In this work, we carry out a systematic study of this technique using heterodyne beat spectroscopy. …”
Get full text

A study of quantitative content of quercetin in the leaves of the schisandra chinensis by E. H. Galiakhmetova, N. V. Kudashkina, S. R. Khasanova

“…Metrological analysis of the results showed the reproducibility of the technique and the absence of systematic error. Consequently, chromatodensitometric method can be used not only for semi-quantitative, but also for quantitative evaluation of the content of various substances in medicinal plant raw materials.…”
Get full text

The practice of scaling landscape-based fertilizer advisory in Ethiopia: Drivers, pathways, and strategies for upstream-downstream integration for scaling by Gizaw Desta, Mequanint B. Melesse, Murat Sartas, Getachew Agegnehu, Abiro Tigabie, Gizachew Legesse, Henok Desalegn, Tilahun Amede, Mangi Lal Jat, Rebbie Harawa

Get full text

Evaluation and Improvement of Ocean Color Algorithms for Chlorophyll-<i>a</i> and Diffuse Attenuation Coefficients in the Arctic Shelf by Yubin Yao, Tao Li, Qing Xu, Xiaogang Xing, Xingyuan Zhu, Yubao Qiu

“…In this study, we present a systematic multi-year evaluation of commonly used empirical and semi-analytical ocean color algorithms across the western Arctic shelf, based on seven expeditions and 240 in situ observation stations. …”
Get full text

Chaotic demonstration of the twin-core couplers with Kerr law non-linearity employing beta derivative by Adil Jhangeer, Maham Munawar, Mudassar Imran, Atef Abdelkader

“…Various soliton families including semi-bright solitons, solitary dark pitched solitons, single solitons, and mixed hyperbolic, trigonometric, and rational solitons are systematically constructed. …”
Get full text

A Novel 10 MW Floating Wind Turbine Platform—SparFloat: Conceptual Design and Dynamic Response Analysis by Yong Shen, Jian Liu, Xingchun Yan, Huaxing Liu, Yajie Li, Xikun Wang

“…By systematically adjusting the distance between columns and the diameters of the side column and heave plate, the impact of geometrical changes in the platform on its dynamic response is investigated for the purpose of design optimization. …”
Get full text