Exploring the Bioactive Potential and Chemical Profile of <i>Schinus molle</i> Essential Oil: An Integrated <i>In Silico</i> and <i>In Vitro</i> Evaluation by Rómulo Oses, Matías Ferrando, Flavia Bruna, Patricio Retamales, Myriam Navarro, Katia Fernández, Waleska Vera, María José Larrazábal, Iván Neira, Adrián Paredes, Manuel Osorio, Osvaldo Yáñez, Martina Jacobs, Jessica Bravo

“…Based on quantum mechanical calculations, the reactivity of the molecules present in the SM_EO was estimated. …”
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A Simple and Rapid “Turn-On” Fluorescent Probe Based on Binuclear Schiff Base for Zn²⁺ and Its Application in Cell Imaging and Test Strips by Jinghui Cheng, Yi Li, Zhiye Zhu, Huijuan Guan, Jinsong Zhai, Yibing Xiang, Man Wang

“…During the detection process, bis-Et-SA and bis-Ph-SA demonstrate rapid response and high selectivity upon the addition of Zn²⁺. The coordination of Zn²⁺ with the oxygen atom and Schiff base nitrogen atom in a tetrahedral geometry is confirmed by Job’s plot, FT-IR, and ¹H NMR spectroscopy. …”
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Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

“…Seven ML algorithms were systematically compared, with Light Gradient Boosting Machine (LightGBM) ultimately selected as the optimal framework. Model performance was rigorously assessed through area under the receiver operating characteristic (AUROC) analysis, calibration curves, Brier scores, and decision curve analysis. …”
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First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis by Simona Toscano, Tim Spelman, Serkan Ozakbas, Raed Alroughani, Clara G. Chisari, Salvatore Lo Fermo, Alexandre Prat, Marc Girard, Pierre Duquette, Guillermo Izquierdo, Sara Eichau, Pierre Grammond, Cavit Boz, Tomas Kalincik, Yolanda Blanco, Katherine Buzzard, Olga Skibina, Maria Jose Sa, Anneke van der Walt, Helmut Butzkueven, Murat Terzi, Oliver Gerlach, Francois Grand'Maison, Matteo Foschi, Andrea Surcinelli, Michael Barnett, Alessandra Lugaresi, Marco Onofrj, Bassem Yamout, Samia J. Khoury, Julie Prevost, Jeannette Lechner-Scott, Davide Maimone, Maria Pia Amato, Daniele Spitaleri, Vincent Van Pesch, Richard Macdonell, Elisabetta Cartechini, Koen de Gans, Mark Slee, Tamara Castillo-Triviño, Aysun Soysal, Jose Luis Sanchez-Menoyo, Guy Laureys, Liesbeth Van Hijfte, Pamela McCombe, Ayse Altintas, Bianca Weinstock-Guttman, Eduardo Aguera-Morales, Masoud Etemadifar, Cristina Ramo-Tello, Nevin John, Recai Turkoglu, Suzanne Hodgkinson, Sarah Besora, Bart Van Wijmeersch, Ricardo Fernandez-Bolaños, Francesco Patti

“…This study highlights the importance of selecting the appropriate DMT for each patient soon after MS diagnosis, also providing clinicians with a practical tool able to calculate personalized risk estimates for different outcomes.…”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…Intervention costs were calculated to determine Incremental Cost-Effectiveness Ratios (ICERs). …”
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Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis by Eva Azme, Md. Mahmudul Hasan, Md. Liakot Ali, Rashedul Alam, Rashedul Alam, Neamul Hoque, Fabiha Noushin, Mohammed Fazlul Kabir, Ashraful Islam, Tanzina Sharmin Nipun, S. M. Moazzem Hossen, Hea-Jong Chung, Hea-Jong Chung

“…Finally, 150 ns MD simulations and binding free energy (MM-PBSA) calculations were performed to assess the stability and strength of protein-ligand interactions.ResultsThree terpenoid compounds, olean-12-en-3-beta-ol, cabralealactone, and 27-deoxyactein demonstrated strong binding affinities toward MDM2 in ensemble docking studies. …”
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Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer by Yun Wang, Xiao‐qiang Sun, Hao‐cheng Lin, De‐shen Wang, Zhi‐qiang Wang, Qiong Shao, Feng‐hua Wang, Shu‐mei Yan, Jie‐ying Liang, Zhao‐lei Zeng, Huai‐qiang Ju, Rui‐hua Xu, Yu‐hong Li

“…Fifty‐five pairs of tumor tissues were selected according to the variation in HDL‐C levels (high or low) and the matched characterizes (ages, T stage, and N stage). …”
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Soil water dynamics in a 450-year-old natural landslide-dammed valley farmland: Insights into precipitation responses by Zhao Jin, Huifeng Wu, Hao Han, Yunchong Fu, Jing Zhang, Guofan Cao, Keyan Xu

“…Based on HYDRUS-1D model calculations, the soil water storage of NLDF remained stable under low precipitation but showed a sharp rise and decline when precipitation exceeded 9.8 mm. …”
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Star photometry with all-sky cameras to retrieve aerosol optical depth at nighttime by R. Román, R. Román, D. González-Fernández, D. González-Fernández, J. C. Antuña-Sánchez, J. C. Antuña-Sánchez, C. Herrero del Barrio, C. Herrero del Barrio, S. Herrero-Anta, S. Herrero-Anta, Á. Barreto, Á. Barreto, V. E. Cachorro, V. E. Cachorro, L. Doppler, R. González, R. González, C. Ritter, C. Ritter, D. Mateos, D. Mateos, N. Kouremeti, G. Copes, A. Calle, A. Calle, M. J. Granados-Muñoz, M. J. Granados-Muñoz, C. Toledano, C. Toledano, Á. M. de Frutos, Á. M. de Frutos

“…This process consists of the following steps: removing the background image, selecting the pixels, and extracting the signal for each star from a predefined list of 56 stars; performing in situ Langley calibration of the instruments and retrieving the total optical depth (TOD); calculating the effective wavelength for each camera channel; deriving the AOD by subtracting the gas contribution to TOD; and averaging, cloud-screening, and quality-assuring the AOD time series. …”
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Investigation and analysis of influencing factors on the economic burden of varicella disease in Qingyang, China, 2024 by Beiqin Liu, Xueping Li, Huailu Shi, Lin Yuan, Yongfeng Jing, Yuelong Hui, Meimei Xu, Yan Zhang, Kangjun Zhao, Qiqi Sun, Jingyu Fan, Mingyu Yang

“…Based on socioeconomic and geographic characteristics, varicella cases reported in 2024 from Xifeng District, Heshui County, and Zhenyuan County were selected for cross-sectional surveys. The direct and indirect economic burdens were analyzed using Excel 2010 and SPSS 20.0 software. …”
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The predictive value of conventional MRI combined with radiomics in the immediate ablation rate of HIFU treatment for uterine fibroids by Chao Wei, Naiyu Li, Bin Shi, Chuanbin Wang, Yaoyuan Wu, Tingting Lin, Yulan Chen, Yaqiong Ge, Yongqiang Yu, Jiangning Dong

“…Baseline clinical and MR parameters acquired before and after HIFU ablation were analyzed, and the NPVR was calculated accordingly. Radiomics features were extracted using A.K. software on T2-weighted imaging (T2WI). …”
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The MaNGA Dwarf Galaxy Sample (MaNDala): Stellar Profiles and Gradients Characterization by M. Cano-Díaz, A. Rodríguez-Puebla, A. C. Robleto-Orús, V. Ávila-Reese, H. M. Hernández-Toledo, J. A. Vázquez-Mata, O. Valenzuela, J. J. González, H. J. Ibarra-Medel, J. C. Clemente-González, L. Pavón-Alvarez

“…While it is not possible to select a single preferred method for determining SP gradients, we suggest using $\,\rm{med}\,\left({\{{\rm{\nabla }}\,{ \mathcal G }\}}_{i}\right)$ for each SP property. …”
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Factors contributing to preventing malaria in children aged 3 to 59 months after the first cycle of seasonal malaria chemoprevention in Tenkodogo Health District of Burkina Faso, J... by Yewayan Larba Berenger Kabore, Watton Rodrigue Diao, Dénis Yelbeogo, Arouna Koidima, Lassane Kafando, Fréderic Dianda, Noaga Sawadogo, Jean-Baptiste Ouedraogo, Yamregma Kabore, Fréderic Kambou, Kodo Albassa, Salfo Ouedraogo, Brahima Traore, Pedwinde Hamadou Seogo

“…We used Epi info 7 for calculating averages and proportions and carried out multivariate logistic regression. …”
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Incidence of upper respiratory tract infections with biological therapies in moderate to severe atopic dermatitis: a systematic review and meta-analysis by Rose Alraddadi, Rose Alraddadi, Mulham Kalantan, Mulham Kalantan, Yara Aljefri, Yara Aljefri, Hadeel Maaddawi, Abdulrahman Alsamadani, Abdulrahman Alsamadani, Athoub Kadasa, Athoub Kadasa, Abdulrahman Softah, Abdulrahman Softah, Baraa Tabbakh, Baraa Tabbakh, Rahaf Alturkistani, Abdulhadi Jfri, Abdulhadi Jfri, Abdulhadi Jfri

“…A random-effects meta-analysis was conducted using the Netmeta package in R, calculating odds ratios (ORs) with 95% confidence intervals (CIs).ResultsFrom 413 retrieved records, 21 studies met the inclusion criteria. …”
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Repurposing Anthelmintic Drugs for COVID-19 Treatment: A Comprehensive Meta-Analysis of Randomized Clinical Trials on Ivermectin and Mebendazole by Shakta Mani Satyam, Mohamed El-Tanani, Mohamed Anas Patni, Abdul Rehman, Adil Farooq Wali, Imran Rashid Rangraze, Rasha Babiker, Syed Arman Rabbani, Yahia El-Tanani, Manfredi Rizzo

“…<b>Conclusions</b>: The promising propensities observed in selected studies underscore the potential of ivermectin and mebendazole as adjunct therapies for COVID-19. …”
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Synergy of compress strain and antioxidant of platinum-copper for enhanced the oxygen reduction performance by Jun Zhang, Pingjuan Liang, Xinlan Xu, Rong Wang, Shuyue Liu, Chunyuan Wang, Boyu Liu, Laizheng Luo, Meng Jin, Huan Liu, Huan Yi, Shi-Yu Lu

“…Theoretical calculations elucidate the incorporation of Cu into Pt lattice induces compressive strain, which effectively tailors the d band center of Pt active sites and strengthens the surface chemisorption of O2 molecules on PtCu alloys. …”
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The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional study by Maryam Zarkesh, Romina Saba, Hamidreza Aghazadeh, Farshad Teymoori, Mahdi Akbarzadeh, Golaleh Asghari, Marzieh Montazeri, Asghar Ghasemi, Emad Yuzbashian, Azita Zadeh-Vakili, Mehdi Hedayati, Alireza Khalaj

“…In this cross-sectional study, 118 women, aged ≥ 18 years were selected among patients who were admitted to hospitals (Mostafa Khomeini and Khatam Al-Anbia, Tehran, Iran) for elective and minimal abdominal surgery including appendectomy and umbilical and inguinal hernia repair. …”
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Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases by Tao Chen, Peng Qiu, Yixuan Li, Xinwu Lu, Zhaoyu Wu, Zhijue Xu, Hongji Pu, Jiahao Lei, Zhuojing Zhang, Xinrui Yang, Ruihua Wang

“…A similar result was found for mean 24-hour fluid balance (OR 1.030, 95% CI (1.019, 1.042), p&lt;0.001), and the cut-off was selected to be 5.12 dL (AUC=0.778, OR 3.066, 95% CI (1.634, 5.753), p&lt;0.001).Conclusions This study stresses the importance of fluid balance in the clinical care of AD patients and provides new insights for optimising fluid management and monitoring strategies beyond the conventional focus on blood pressure and heart rate management.…”
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Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis by Kittiya Supradit, Sattrachai Prasopdee, Teva Phanaksri, Sithichoke Tangphatsornruang, Montinee Pholhelm, Siraphatsorn Yusuk, Kritiya Butthongkomvong, Kanokpan Wongprasert, Jutharat Kulsantiwong, Amnat Chukan, Smarn Tesana, Veerachai Thitapakorn

“…The significantly different cir-miRNAs were selected for the validation phase. In the validation phase, cir-miRNA was isolated and analyzed using real time-quantitative polymerase chain reaction (RT-qPCR). …”
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Polysocial risk factors and trajectories of antenatal moderate-to-severe depressive symptoms: a retrospective cohort study in Shenzhen, China by Jintao Xiong, Yan Yu, Xuemei Qin, Yilin Peng, Zhuo Peng, Junzhe Cheng, Weiguo Mao, Yan Wang, Yin Guo, Huiqin Li, Mi Wang, Li Zhang, Yumeng Ju, Jin Liu, Minxue Shen, Bangshan Liu, Yan Zhang

“…Antenatal depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9) across three pregnancy trimesters. The PsRS was selected and calculated by counting established social determinants from four social risk domains, including socioeconomic status, lifestyle behaviors, psychosocial factors, and living conditions. …”
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