Constraining Resolved Extragalactic R21 Variation with Well-calibrated ALMA Observations by Jakob den Brok, Elias K. Oakes, Adam K. Leroy, Eric W. Koch, Antonio Usero, Erik W. Rosolowsky, Frank Bigiel, Jiayi Sun, Hao He, Ashley T. Barnes, Yixian Cao, Fu-Heng Liang, Hsi-An Pan, Toshiki Saito, Sumit K. Sarbadhicary, Thomas G. Williams

“…We find strong correlations between R _21 and various galactic parameters, particularly SFR surface density, which shows a power-law slope of 0.10–0.11 depending on the adopted binning/fitting methods. Our findings suggest that, for studies covering main-sequence galaxy samples, assuming a fixed R _21 = 0.64 does not significantly bias kiloparsec-scale molecular gas mass estimates from CO(2–1). …”
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Palynofacies and Sporomorph EcoGroups-based paleoecology implications for the Dalichai Formation, Andariyeh, central Alborz by Firoozeh Hashemi Yazdi, Neda Bashiri, fereshteh sajjadi

“…The purpose of this study was to determine the palaeoenvironmental interpretation of the Dalichai Formation based on SEGs data, and quantitative analysis of the palynofacies in the Dalichai Formation at the Andariyeh stratigraphic section, central Alborz.   Material & Methods Totally 29 palynologically samples collected from the Dalichai Formation at the Andariyeh stratigraphic section, northeast of Andariyeh village, central Alborz Mountains. …”
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Studying and Comparing the Soil Characteristics of Gullies (Case Study: Chabar and Sistan Region) by Mansour Jahantigh, Marzieh Tabe

“…The means of saturation percentage (SP) soil sample in the areas are 47.1 and 46.49, respectively. …”
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Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…Mental health is a complex phenomenon and may be best supported through multicomponent interventions that more holistically consider inner, social and environmental levels. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…This study aims to identify and characterize plasma miRNAs associated with HF and cardiovascular death. Methods: The association between 21 candidate miRNAs and HF or cardiovascular death was evaluated in 4541 patients from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes (MERLIN)-TIMI 36 trial using samples from the time of index hospitalization for ACS. …”
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Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma by Robert G Maki, Martina Bradic, Phillip Wong, William Tap, Vicky Makker, Sandra D’Angelo, Angela Green, Mrinal M Gounder, Evan Rosenbaum, Ciara M Kelly, Jason E Chan, Ping Chi, Mark A Dickson, Mary L Keohan, Sujana Movva, Viswatej Avutu, Martee L Hensley, Maria M Rubinstein, Ronak Shah, Kenneth Seier, Karmelina Charalambous, Seth M Cohen, Lauren B Banks, Sara Saunds, Jae-Mun Cho, Robert A Lefkowitz, Joseph Erinjeri, Li-Xuan Qin

“…Re-staging scans were performed every 8 weeks. Blood and tissue samples were collected at baseline and at week 8 on treatment. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Thus, our aim in this project was to explore the mechanism by which tricin inhibited the progression of KRAS-mutant NSCLC much more deeply.MethodsFirst of all, we detected the acute toxicity of an intraperitoneal injection of tricin in mice according to the improved up-and-down procedure. …”
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Multiomics reveals tumor microenvironment remodeling in locally advanced gastric and gastroesophageal junction cancer following neoadjuvant immunotherapy and chemotherapy by Yong Liu, Xia Wang, Rui Liu, Le Zhang, Hongli Li, Ting Deng, Lijun Ma, Yanhui Zhang, Lan Su, Yi Ba, Zhi Ji, Jiaqi Xin, Duo Zuo, Xinze Lv, Shaohua Ge, Tingting Ding

“…A detailed multiomic investigation is essential to elucidate these mechanisms.Methods We performed whole-exome sequencing, whole-transcriptome sequencing, multiplex immunofluorescence and single-cell RNA sequencing on matched pretreatment and post-treatment samples from 30 patients enrolled in an investigator-initiated Phase 2 clinical trial (NCT04908566). …”
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Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade by Pedro Rocha, Rafael Bach, Laura Masfarré, Sharia Hernandez, Nil Navarro-Gorro, Adrià Rossell, Xavier Villanueva, Mario Giner, Ignacio Sanchéz, Miguel Galindo, Raúl Del Rey-Vergara, Albert Iñañez, Beatriz Sanchéz-Espiridion, Wei Lu, Ariadna Acedo-Terrades, Pau Berenguer-Molins, Albert Sánchez-Font, Roberto Chalela, Victor Curull, Álvaro Taus, Max Hardy-Werbin, Mark Sausen, Andrew Georgiadis, James White, Jennifer B Jackson, Laura Moliner, Sergi Clavé, Beatriz Bellosillo, Ana Rovira, Ignacio Wistuba, Luisa M Solis Soto, Júlia Perera-Bel, Edurne Arriola

“…Long-term (LTR) and short-term responders (STR) were defined as those with a response to ICB lasting more than 24 months or less than 6 months, respectively. …”
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Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series by Olav Dajani, Iain Philips, Ester Kristine Størkson, Trude R. Balstad, Leo R. Brown, Asta Bye, Ross Dolan, Christine Greil, Marianne Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Inger Ottestad, Judith Sayers, Melanie Simpson, Mariana S. Sousa, Ola Magne Vagnildhaug, Michael S. Yule, Barry J. A. Laird, Richard J. E. Skipworth, Tora S. Solheim, Mark Stares, Jann Arends, the Cancer Cachexia Endpoints Working Group

“…This review examines oncological endpoints in CC clinical trials. Methods An electronic literature search of MEDLINE, Embase and Cochrane databases (1990–2023) was performed. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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STRUCTURAL AND FUNCTIONAL STATE OF THE MYOCARDIUM AND SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE PRESENCE OF ARTERIAL H... by Rostyslav Kovalchuk, Uliana Bahan

“…The results were evaluated using descriptive statistical analysis (arithmetic mean and its standard deviation; median and percentile, proportions and their 95 % confidence intervals calculated using the Wald and Fisher methods), unpaired Student's t-test, and Pearson correlation analysis. …”
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La chirurgie cardiaque mini-invasive vidéo-assistée : une étude comparative à la voie conventionnelle [Less-invasive video-assisted cardiac surgery : a comparative study with the c... by Sami Bouchenafa, Ahmed Zaki Boukli-Hacene, Boukri Hamouda, Mohamed Atbi

“…Conclusion - The minimally invasive video-assisted is a simpler, safer and more effective procedure with excellent results and low morbidity. …”
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Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping by Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Fan Yang, Limei Yu, Limei Yu

“…Furthermore, it seeks to conduct an in-depth analysis of the genetic information within the breakpoint regions, thereby providing a more comprehensive scientific foundation for genetic counseling of RSA couples at both the cellular and genetic levels.Material and MethodsThis study involved the selection of nine subjects from two families who underwent genetic counseling at our hospital. …”
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Shear Strength Characteristics of Soft Soil in Nansha District of Guangzhou by WANG Wei-qi, LIAN Chang-jiang, LI Jian-ping, CHEN Zhi-yong, CHENG Dong-hai, CAI Wei-long, TANG Kai, LI Chao

“…Future research should focus on collecting additional soft soil test samples to obtain more definitive conclusions.…”
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Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastasesResearch in context by Julien Viot, Romain Loyon, Nawfel Adib, Pierre Laurent-Puig, Aurélien de Reyniès, Fabrice André, Franck Monnien, Thierry André, Magali Svrcek, Anthony Turpin, Zohair Selmani, Laurent Arnould, Laura Guyard, Nicolas Gilbert, Anthony Boureux, Olivier Adotevi, Angélique Vienot, Syrine Abdeljaoued, Dewi Vernerey, Christophe Borg, Daniel Gautheret

“…Methods: We collected 400 RNA-seq samples from over 200 patients with primary and liver metastases, including public data and a novel set of 200 samples. …”
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Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with... by Cai-Ning Zhao, Chi-Leung Chiang, Wan-Hang Keith Chiu, Sik-Kwan Kenneth Chan, Chun-Bong James Li, Wei-Wei Chen, Dan-Yang Zheng, Wen-Qi Chen, Ren Ji, Chung-Mau Lo, Salma K. Jabbour, Chi-Yan Albert Chan, Feng-Ming (Spring) Kong

“…This study aimed to exam the cells in the STIE, their changes after transarterial chemoembolisation (TACE), stereotactic body radiotherapy (SBRT), and immunotherapy (IO) and explore their significance in the treatment response of patients with unresectable HCC. Methods: This is a prospective biomarker study of patients with unresectable HCC. …”
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Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers by Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad

“…We performed untargeted and targeted serum proteomics to delineate processes occurring in adult patients with ALF and to identify potential biomarkers. Methods: Sera of 319 adult patients with ALF (∼50% acetaminophen [APAP]-related cases) were randomly selected from admission samples of the multicenter USA Acute Liver Failure Study Group consortium and subdivided into discovery/validation cohorts. …”
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Pre-assembled ECMO: Enhancing efficiency and reducing stress in refractory cardiac arrest care by Tharusan Thevathasan, Sonia Lech, Andreas Diefenbach, Elisa Bechthold, Tim Gaßmann, Sebastian Fester, Georg Girke, Wulf Knie, Benjamin T. Lukusa, Sebastian Kühn, Steffen Desch, Ulf Landmesser, Carsten Skurk

“…This pragmatic study thought to evaluate whether pre-assembled and pre-primed ECMO circuits (pre-primed group) maintain sterility over a 21-day period, expedite ECMO initiation in ECPR patients and alleviate the psychological burden on the ECPR team, compared to newly assembled and primed ECMO circuits (on-demand group). Methods: In a prospective manner, ECMO circuits were either pre-assembled and pre-primed under sterile conditions, maintained for 21 days with culture samples taken every seventh day, or newly assembled and primed during the acute emergency situation. …”
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Protective Impact of Influenza Vaccination on Healthcare Workers by Yimei Tian, Yue Ma, Jianchao Ran, Lifang Yuan, Xianhu Zeng, Lu Tan, Li Chen, Yifan Xu, Shaxi Li, Ting Huang, Hongzhou Lu

“…Additionally, the vaccinated healthcare workers were more inclined to recommend vaccination to their families (80% vs. 48%, <i>p</i> < 0.05). …”
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