Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…A health economics study analysed measurements made on how long the reporting of cases took using DP in comparison to LM, and an eye-tracking study examined different pathologists’ examination techniques using DP. Methods The main study was a multicentre validation comparison study, with a blinded crossover design measuring intraobserver variability of pathologists’ diagnoses of histopathology samples using LM and DP and interobserver variability measuring pathologists’ diagnoses on LM and DP against consensus ground truth (GT). …”
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A China dataset of soil properties for land surface modelling (version 2, CSDLv2) by G. Shi, W. Sun, W. Shangguan, Z. Wei, H. Yuan, L. Li, X. Sun, Y. Zhang, H. Liang, D. Li, F. Huang, Q. Li, Q. Li, Y. Dai

“…The results showed that the predicted maps were significantly more accurate and detailed compared to traditional soil type linkage methods (i.e. …”
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Symptoms and pathophysiology of post-acute sequelae following COVID-19 (PASC): a cohort studyResearch in context by Olivier Robineau, Sophie Hüe, Mathieu Surenaud, Cédric Lemogne, Céline Dorival, Emmanuel Wiernik, Sebastien Brami, Jerome Nicol, Xavier de Lamballerie, Hélène Blanché, Jean-François Deleuze, Céline Ribet, Marcel Goldberg, Gianluca Severi, Mathilde Touvier, Marie Zins, Yves Levy, Jean-Daniel Lelievre, Fabrice Carrat

“…The hypothesis that different pathophysiological mechanisms could explain the persistent symptoms needs to be explored. Methods: The COPER cohort is a prospective study that included participants with PASC and with a history of COVID-19 without persistent symptoms. …”
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La chirurgie cardiaque mini-invasive vidéo-assistée : une étude comparative à la voie conventionnelle [Less-invasive video-assisted cardiac surgery : a comparative study with the c... by Sami Bouchenafa, Ahmed Zaki Boukli-Hacene, Boukri Hamouda, Mohamed Atbi

“…L’introduction de la caméra a réduit considérablement l’incision. Matériels et méthodes -Dans notre étude, prospective et comparative, 57 patients ont subi une chirurgie cardiaque, répartis en 2 groupes, 30 patients opérés par sternotomie médiane verticale et 27 patients opérés par chirurgie mini-invasive vidéo-assistée. …”
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Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with... by Cai-Ning Zhao, Chi-Leung Chiang, Wan-Hang Keith Chiu, Sik-Kwan Kenneth Chan, Chun-Bong James Li, Wei-Wei Chen, Dan-Yang Zheng, Wen-Qi Chen, Ren Ji, Chung-Mau Lo, Salma K. Jabbour, Chi-Yan Albert Chan, Feng-Ming (Spring) Kong

“…This study aimed to exam the cells in the STIE, their changes after transarterial chemoembolisation (TACE), stereotactic body radiotherapy (SBRT), and immunotherapy (IO) and explore their significance in the treatment response of patients with unresectable HCC. Methods: This is a prospective biomarker study of patients with unresectable HCC. …”
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Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers by Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad

“…We performed untargeted and targeted serum proteomics to delineate processes occurring in adult patients with ALF and to identify potential biomarkers. Methods: Sera of 319 adult patients with ALF (∼50% acetaminophen [APAP]-related cases) were randomly selected from admission samples of the multicenter USA Acute Liver Failure Study Group consortium and subdivided into discovery/validation cohorts. …”
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Pre-assembled ECMO: Enhancing efficiency and reducing stress in refractory cardiac arrest care by Tharusan Thevathasan, Sonia Lech, Andreas Diefenbach, Elisa Bechthold, Tim Gaßmann, Sebastian Fester, Georg Girke, Wulf Knie, Benjamin T. Lukusa, Sebastian Kühn, Steffen Desch, Ulf Landmesser, Carsten Skurk

“…This pragmatic study thought to evaluate whether pre-assembled and pre-primed ECMO circuits (pre-primed group) maintain sterility over a 21-day period, expedite ECMO initiation in ECPR patients and alleviate the psychological burden on the ECPR team, compared to newly assembled and primed ECMO circuits (on-demand group). Methods: In a prospective manner, ECMO circuits were either pre-assembled and pre-primed under sterile conditions, maintained for 21 days with culture samples taken every seventh day, or newly assembled and primed during the acute emergency situation. …”
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Protective Impact of Influenza Vaccination on Healthcare Workers by Yimei Tian, Yue Ma, Jianchao Ran, Lifang Yuan, Xianhu Zeng, Lu Tan, Li Chen, Yifan Xu, Shaxi Li, Ting Huang, Hongzhou Lu

“…Objectives: This prospective observational study aimed to assess the protective effect of influenza vaccination among healthcare workers in Shenzhen. Methods: We enrolled 100 participants, with 50 receiving the 2023–2024 quadrivalent influenza vaccine (QIV) and 50 serving as unvaccinated controls. …”
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Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…Finally, we assessed whether areas prone to changing aircraft noise patterns (i.e. with relief periods from aircraft noise) affected the increased risk of cardiovascular disease in areas with higher noise in the evenings and found the higher risks were only seen in areas with more constant noise levels. More research is needed to investigate potential health benefits of relief periods with lower noise. …”
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Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial by Luca Monzo, Masatake Kobayashi, João Pedro Ferreira, Zohra Lamiral, Christian Delles, Andrew L. Clark, Frank Edelmann, Arantxa González, Stephane Heymans, Pierpaolo Pellicori, Johannes Petutschnigg, Job A. J. Verdonschot, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Nicolas Girerd, on behalf of the HOMAGE “Heart Omics in AGEing” Trial Committees and Investigators

“…We aimed to identify the alterations in echocardiographic variables and circulating biomarkers associated with DM, CAD, or both and to assess the effect of spironolactone on them. Methods The “Heart OMics in AGEing” (HOMAGE) trial evaluated the effect of spironolactone on circulating markers of fibrosis over 9 months of follow-up in people at risk for HF. …”
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Industry sponsorship bias in randomized controlled trials of digital cognitive behavioral therapy for insomnia: a meta-research study based on the 2023 Brazilian guidelines on the... by Viviane Akemi Kakazu, Marcia Assis, Andrea Bacelar, Andréia Gomes Bezerra, Giovanna Lira Rosa Ciutti, Silvia Gonçalves Conway, Silvia Gonçalves Conway, Silvia Gonçalves Conway, José Carlos Fernandes Galduróz, Luciano F. Drager, Mariana Pery Khoury, Mariana Pery Khoury, Ingrid Porto Araújo Leite, Ingrid Porto Araújo Leite, Ygor de Matos Luciano, Dalva Poyares, Dalva Poyares, Sergio Tufik, Sergio Tufik, Gabriel Natan Pires, Gabriel Natan Pires, Gabriel Natan Pires

“…This study aimed to assess whether industry sponsorship bias in dCBT-I trials is associated with more favorable outcomes.MethodsThis study was based on the sample of randomized controlled trials (RCTs) included at the “2023 Brazilian Guidelines on the Diagnosis and Treatment of Insomnia in Adults.” …”
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Palynofacies and Sporomorph EcoGroups-based paleoecology implications for the Dalichai Formation, Andariyeh, central Alborz by Firoozeh Hashemi Yazdi, Neda Bashiri, fereshteh sajjadi

“…The purpose of this study was to determine the palaeoenvironmental interpretation of the Dalichai Formation based on SEGs data, and quantitative analysis of the palynofacies in the Dalichai Formation at the Andariyeh stratigraphic section, central Alborz.   Material & Methods Totally 29 palynologically samples collected from the Dalichai Formation at the Andariyeh stratigraphic section, northeast of Andariyeh village, central Alborz Mountains. …”
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Protocol for the Redefining Maternal Anemia in Pregnancy and Postpartum (ReMAPP) study: A multisite, international, population-based cohort study to establish global hemoglobin thr... by Emily R Smith, Zahra Hoodbhoy, Aneeta Hotwani, Fyezah Jehan, Amna Khan, Imran Nisar, Nida Yazdani, Santosh Joseph Benjamin, Anne George Cherian, Venkata Raghava Mohan, Sunitha Varghese, Balakrishnan Vijayalekshmi, Blair J Wylie, Leena Chatterjee, Arjun Dang, R Venketeshwar, Sasha G Baumann, Christopher Mores, Qing Pan, Christopher R Sudfeld, Victor Akelo, Winnie K Mwebia, Kephas Otieno, Gregory Ouma, Harun Owuor, Joyce Were, Dennis Adu-Gyasi, Veronica Agyemang, Sam Newton, Charlotte Tawiah, Arun Singh Jadaun, Sarmila Mazumder, Neeraj Sharma, Lynda G Ugwu, Amma Benneh-Akwasi Kuma, Bethany Freeman, Margaret P Kasaro, Felistas M Mbewe, Humphrey Mwape, Rachel S Resop, M Bridget Spelke, Kwaku Poku Asante, Redefining Maternal Anemia in Pregnancy and Postpartum (ReMAPP) Study Investigators

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A Demonstration of Interstellar Navigation Using New Horizons by Tod R. Lauer, David H. Munro, John R. Spencer, Marc W. Buie, Edward L. Gomez, Gregory S. Hennessy, Todd J. Henry, George H. Kaplan, John F. Kielkopf, Brian H. May, Joel W. Parker, Simon B. Porter, Eliot Halley Vrijmoet, Harold A. Weaver, Pontus Brandt, Kelsi N. Singer, S. Alan Stern, Anne. J. Verbiscer, Pedro Acosta, Nicolás Ariel Arias, Sergio Babino, Gustavo Enrique Ballan, Víctor Ángel Buso, Steven J. Conard, Daniel Das Airas, Giorgio Di Scala, César Fornari, Jossiel Fraire, Brian Nicolás Gerard, Federico González, Gerardo Goytea, Emilio Mora Guzmán, William Hanna, William C. Keel, Aldo Kleiman, Anselmo López, Jorge Gerardo Machuca, Leonardo Málaga, Claudio Martínez, Denis Martinez, Raúl Meliá, Marcelo Monópoli, Marc A. Murison, Leandro Emiliano Fernandez Pohle, Mariano Ribas, José Luis Ramón Sánchez, Sergio Scauso, Dirk Terrell, Thomas Traub, Pedro Oscar Valenti, Ángel Valenzuela, Ted von Hippel, Wen Ping Chen, Dennis Zambelis

“…We conclude that the best astrometric approach to navigating spacecraft on their departures to interstellar space is to use a single pair of the closest stars as references, rather than a large sample of more distant stars.…”
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Assessment of the relationship between diabetes treatment intensification and quality measure performance using electronic medical records. by Renée J G Arnold, Shuo Yang, Edward J Gold, Sepehr Farahbakhshian, John J Sheehan

“…., HbA1C levels, among patients with uncontrolled type 2 diabetes.<h4>Materials and methods</h4>Electronic medical records and diabetes registry data from a large, accountable care organization (ACO) were used to isolate a sample of adult patients with type 2 diabetes who received at least one oral antidiabetes agent and had at least one HbA1C level measurement ≥8.0% (64 mmol/mol; i.e., uncontrolled diabetes) between 7/1/2011 and 6/30/2015. …”
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Standardised packaging, minimum excise tax, and RYO focussed tax rise implications for UK tobacco pricing. by Rosemary Hiscock, Nicole H Augustin, J Robert Branston, Anna B Gilmore

“…Here we evaluate the impact of standardised packaging, the MET and the RYO focussed tax changes on price and industry profitability.<h4>Methods and findings</h4>Nielsen electronic point of sale (EPOS) data (May 2015 to April 2018) were used to calculate real (inflation adjusted) monthly price per stick overall, by cigarette type (FM and RYO) and by seven market segments. …”
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A meta-analysis of effect of Traditional Chinese Medicine nursing technology in prevention of deep venous thrombosis after surgery for femoral neck fracture (中医护理技术预防股骨颈骨折术后深静脉血栓形成... by JIA Hui (贾慧), YANG Ge (杨鸽), HUANG Binqian (黄彬倩), PENG Hong (彭鸿), LI Chunbei (李春梅), WANG He (王贺)

“…Conclusion Findings of the study showed an advantage of Traditional Chinese Medicine nursing technology in prevention of deep venous thrombosisafter surgery for femoral neck fracture. More high-quality studies with larger sample size are needed to verify the effect of intervention. …”
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Perioperative, Oncological, and Functional Outcomes of New Multiport Robotic Platforms in Urology: A Systematic Review and Meta-analysis by Giuseppe Reitano, Arianna Tumminello, Umar Ghaffar, Giorgio Saggionetto, Alessandra Taverna, Francesco Mangiacavallo, Mohamed E. Ahmed, Spyridon P. Basourakos, Filippo Carletti, Davide Minardi, Massimo Iafrate, Alessandro Morlacco, Giovanni Betto, R. Jeffrey Karnes, Fabrizio Dal Moro, Fabio Zattoni, Giacomo Novara

“…Background and objective: Robot-assisted surgery (RAS) has steadily become more prevalent in urology. The Da Vinci multiport surgical robot (DVM-SR) continues to lead the field. …”
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High rate of mutations in the BRCA1, BRCA2, CHEK2, NBN, and BLM genes in Russian ovarian cancer patients by Ye. I. Bateneva, M. G. Filippova, A. S. Tyulyandina, A. A. Meshcheryakov, K. I. Zhordania, A. N. Gritsai, V. V. Kadochnikova, D. D. Abramov, A. A. Ragimov, D. Yu. Trofimov, L. N. Lyubchenko

“…Intensive screening of patients from high-risk groups that include OC predisposition gene mutation carriers is indicated.Subjects and methods. An unselected group of 202 patients with OC and two control groups of blood donors: 591 healthy females; 1197 persons (including 591 females, 606 males) were examined. …”
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A Study on the Possibility of Molecular Communication between Honey Bees and Sunflower through the Interspecies Transfer of Small RNAs by Leila Gharehdaghi, Gholamhosein Tahmasbi, Taher Harkinezhad

“…Given the vital role of honeybees in plant pollination, this insect may serve as a more suitable model for studying these interactions. …”
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